CN101801357A - 耐受乙醇的影响的pH依赖性受控释放的药物组合物 - Google Patents
耐受乙醇的影响的pH依赖性受控释放的药物组合物 Download PDFInfo
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- CN101801357A CN101801357A CN200780100727A CN200780100727A CN101801357A CN 101801357 A CN101801357 A CN 101801357A CN 200780100727 A CN200780100727 A CN 200780100727A CN 200780100727 A CN200780100727 A CN 200780100727A CN 101801357 A CN101801357 A CN 101801357A
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- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000004172 quinoline yellow Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 229940116351 sebacate Drugs 0.000 description 1
- CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- AZLXCBPKSXFMET-UHFFFAOYSA-M sodium 4-[(4-sulfophenyl)diazenyl]naphthalen-1-olate Chemical compound [Na+].C12=CC=CC=C2C(O)=CC=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 AZLXCBPKSXFMET-UHFFFAOYSA-M 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000004173 sunset yellow FCF Substances 0.000 description 1
- 235000012751 sunset yellow FCF Nutrition 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000004149 tartrazine Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229950004288 tosilate Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- SWGJCIMEBVHMTA-UHFFFAOYSA-K trisodium;6-oxido-4-sulfo-5-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C(S([O-])(=O)=O)C2=C1 SWGJCIMEBVHMTA-UHFFFAOYSA-K 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 1
- 229960004688 venlafaxine Drugs 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 229920003176 water-insoluble polymer Polymers 0.000 description 1
- 235000015041 whisky Nutrition 0.000 description 1
- 235000020097 white wine Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/501—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (17)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2130/CHE/2007 | 2007-09-21 | ||
IN2130CH2007 | 2007-09-21 | ||
PCT/EP2007/060131 WO2009036812A1 (en) | 2007-09-21 | 2007-09-25 | Ph-dependent controlled release pharmaceutical opioid composition with resistance against the influence of ethanol |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101801357A true CN101801357A (zh) | 2010-08-11 |
CN101801357B CN101801357B (zh) | 2013-08-07 |
Family
ID=39232916
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Application Number | Title | Priority Date | Filing Date |
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CN2007801007275A Expired - Fee Related CN101801357B (zh) | 2007-09-21 | 2007-09-25 | 耐受乙醇的影响的pH依赖性受控释放的药物组合物 |
Country Status (13)
Country | Link |
---|---|
US (1) | US9700520B2 (zh) |
EP (1) | EP2187876B1 (zh) |
JP (1) | JP5204847B2 (zh) |
KR (1) | KR101424653B1 (zh) |
CN (1) | CN101801357B (zh) |
BR (1) | BRPI0721990B8 (zh) |
CA (1) | CA2699227C (zh) |
ES (1) | ES2393934T3 (zh) |
IL (1) | IL203901A (zh) |
MX (1) | MX2010003032A (zh) |
PL (1) | PL2187876T3 (zh) |
SI (1) | SI2187876T1 (zh) |
WO (1) | WO2009036812A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103068376A (zh) * | 2010-08-18 | 2013-04-24 | 赢创罗姆有限公司 | 包含一种或多种藻酸盐的抗胃液的药物或营养制剂 |
CN103501768A (zh) * | 2011-06-17 | 2014-01-08 | 赢创罗姆有限公司 | 具有抗乙醇影响抗性的抗胃酸的药物或营养组合物 |
CN108822816A (zh) * | 2018-06-25 | 2018-11-16 | 中国石油集团渤海钻探工程有限公司 | 一种疏松砂岩用可酸溶凝胶堵漏剂及其制备方法 |
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US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
CN1407884B (zh) | 1999-10-29 | 2012-06-20 | 欧罗赛铁克股份有限公司 | 控释氢可酮制剂 |
WO2002036099A1 (en) | 2000-10-30 | 2002-05-10 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
US20080069891A1 (en) | 2006-09-15 | 2008-03-20 | Cima Labs, Inc. | Abuse resistant drug formulation |
US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
CA2696341C (en) * | 2007-08-13 | 2016-05-17 | Abuse Deterrent Pharmaceutical Llc | Abuse resistant drugs, method of use and method of making |
US9757343B2 (en) * | 2008-09-24 | 2017-09-12 | Evonik Röhm Gmbh | PH-dependent controlled release pharmaceutical opioid composition with resistance against the influence of ethanol |
PL2326313T3 (pl) | 2008-09-24 | 2015-08-31 | Evonik Roehm Gmbh | Kompozycja farmaceutyczna o zależnym od pH kontrolowanym uwalnianiu dla nieopioidów z odpornością przed wpływem etanolu |
BRPI0924427A2 (pt) * | 2009-03-18 | 2016-01-26 | Evonik Roehm Gmbh | composição farmacêutica de liberação controlada, seu processo de preparação e uso da mesma |
MX2011009667A (es) * | 2009-03-18 | 2011-12-14 | Evonik Roehm Gmbh | Composición farmacéutica de liberación controlada con resistencia a la influencia de etanol mediante el uso de un revestimiento compuesto de polímeros de vinilo neutrales y excipientes. |
DE102009028076A1 (de) * | 2009-07-29 | 2011-02-03 | Evonik Röhm Gmbh | Beschichtungsmittel zum Tauchbeschichten von Kapselhälften |
US9107451B2 (en) | 2009-07-29 | 2015-08-18 | Evonik Röhm Gmbh | Coating composition for the dip coating of capsule halves |
FR2951378B1 (fr) * | 2009-10-16 | 2012-06-01 | Flamel Tech Sa | Forme pharmaceutique orale solide anti-mesusage et dotee d'un profil specifique de liberation modifiee |
EP2371356B1 (en) | 2010-03-12 | 2012-12-19 | Phoeme GmbH | Multi-particle pharmaceutical formulation for colon absorption |
JP2013526523A (ja) | 2010-05-11 | 2013-06-24 | シマ ラブス インク. | メトプロロールを含むアルコール耐性持続放出性経口剤形 |
CA2839494C (en) | 2011-06-17 | 2018-11-06 | Evonik Roehm Gmbh | Coating composition suitable for pharmaceutical or nutraceutical dosage forms |
BR112013032095A8 (pt) * | 2011-06-17 | 2022-07-05 | Evonik Roehm Gmbh | Composição de revestimento adequada para formas de dosagem farmacêuticas ou nutracêuticas |
WO2013000578A1 (en) * | 2011-06-30 | 2013-01-03 | Develco Pharma Schweiz Ag | Controlled release oral dosage form comprising oxycodone |
CA2852848C (en) * | 2011-10-18 | 2017-04-11 | Purdue Pharma L.P. | Acrylic polymer formulations |
US20140275150A1 (en) | 2013-03-15 | 2014-09-18 | Inspirion Delivery Technologies, Llc | Abuse deterrent compositions and methods of use |
CA3042642A1 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
US20150118300A1 (en) | 2013-10-31 | 2015-04-30 | Cima Labs Inc. | Immediate Release Abuse-Deterrent Granulated Dosage Forms |
US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
WO2015095391A1 (en) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
GB201411704D0 (en) * | 2014-07-01 | 2014-08-13 | Lucideon Ltd | Coated particles |
EP3169315B1 (en) | 2014-07-17 | 2020-06-24 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
US10729685B2 (en) | 2014-09-15 | 2020-08-04 | Ohemo Life Sciences Inc. | Orally administrable compositions and methods of deterring abuse by intranasal administration |
CA2964628A1 (en) | 2014-10-20 | 2016-04-28 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
CA3018328A1 (en) | 2014-10-31 | 2016-04-30 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
WO2018044895A1 (en) * | 2016-08-29 | 2018-03-08 | Cima Labs Inc. | Immediate release dosage forms with abuse deterrence and alcohol resistance |
KR20200057019A (ko) | 2017-09-14 | 2020-05-25 | 에보닉 오퍼레이션스 게엠베하 | 서방성 및 에탄올의 영향에 대한 내성을 갖는 중합체 및 투여 형태 |
WO2019170485A1 (en) | 2018-03-09 | 2019-09-12 | Evonik Röhm Gmbh | Polymer mixture with resistance against the influence of ethanol |
US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
EP3965733A4 (en) | 2019-05-07 | 2023-01-11 | Clexio Biosciences Ltd. | ABUSE DETERRENT DOSAGE FORMS CONTAINING ESKETAMINE |
US20220062200A1 (en) | 2019-05-07 | 2022-03-03 | Clexio Biosciences Ltd. | Abuse-deterrent dosage forms containing esketamine |
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JPH08143476A (ja) * | 1994-11-18 | 1996-06-04 | Japan Tobacco Inc | 薬物放出制御膜及び固形製剤 |
FR2759293B1 (fr) * | 1997-02-11 | 1999-04-30 | Ethypharm Lab Prod Ethiques | Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie |
TR200001828T2 (tr) * | 1997-12-22 | 2000-11-21 | Euro-Celtique, S.A. | Opioid dozaj şekillerinin kötüye kullanımını önlemeye yönelik bir yöntem. |
US7374779B2 (en) | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
US6623758B2 (en) * | 2000-02-24 | 2003-09-23 | Advancis Pharmaceutical Corp. | Cephalosporin-metronidazole antibiotic composition |
WO2003024430A1 (en) | 2001-09-21 | 2003-03-27 | Egalet A/S | Morphine polymer release system |
DE10211289A1 (de) * | 2002-03-14 | 2003-09-25 | Basf Ag | Kombination von Polyvinylacetat von wasserunlöslichen, säureunlöslichen oder alkaliunlöslichen Polymeren zur Hestellung von Filmüberzügen mit sehr kontrollierter Freisetzung und hoher Stabilität |
BR0312445A (pt) | 2002-06-07 | 2005-05-10 | Ranbaxy Lab Ltd | Sistemas multiunitários para disponibilização de fármaco de liberação modificada |
ATE549015T1 (de) * | 2003-10-31 | 2012-03-15 | Hexal Ag | Pharmazeutische wirkstoffhaltige formulierung mit überzug |
WO2005107716A1 (en) | 2004-03-25 | 2005-11-17 | Cadila Healthcare Limited | Controlled release paroxetine-containing tablets based on a core and a coating |
JP5704789B2 (ja) * | 2005-01-28 | 2015-04-22 | ユーロ−セルティーク エス.エイ. | 耐アルコール性剤形 |
DE102005024614A1 (de) * | 2005-05-25 | 2006-11-30 | Röhm Gmbh | Verwendung von Polymermischungen zur Herstellung von überzogenen Arzneiformen sowie Arzneiform mit polymerem Mischüberzug |
HU227490B1 (en) | 2005-08-26 | 2011-07-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Sustained release pharmaceutical preparation containing carvedilol |
-
2007
- 2007-09-25 CA CA2699227A patent/CA2699227C/en not_active Expired - Fee Related
- 2007-09-25 SI SI200731082T patent/SI2187876T1/sl unknown
- 2007-09-25 WO PCT/EP2007/060131 patent/WO2009036812A1/en active Application Filing
- 2007-09-25 KR KR1020107006071A patent/KR101424653B1/ko active IP Right Grant
- 2007-09-25 US US12/678,406 patent/US9700520B2/en active Active
- 2007-09-25 JP JP2010525210A patent/JP5204847B2/ja not_active Expired - Fee Related
- 2007-09-25 EP EP07820537A patent/EP2187876B1/en active Active
- 2007-09-25 PL PL07820537T patent/PL2187876T3/pl unknown
- 2007-09-25 MX MX2010003032A patent/MX2010003032A/es active IP Right Grant
- 2007-09-25 ES ES07820537T patent/ES2393934T3/es active Active
- 2007-09-25 BR BRPI0721990A patent/BRPI0721990B8/pt not_active IP Right Cessation
- 2007-09-25 CN CN2007801007275A patent/CN101801357B/zh not_active Expired - Fee Related
-
2010
- 2010-02-11 IL IL203901A patent/IL203901A/en active IP Right Grant
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103068376A (zh) * | 2010-08-18 | 2013-04-24 | 赢创罗姆有限公司 | 包含一种或多种藻酸盐的抗胃液的药物或营养制剂 |
CN103068376B (zh) * | 2010-08-18 | 2016-04-20 | 赢创罗姆有限公司 | 包含一种或多种藻酸盐的抗胃液的药物或营养制剂 |
US9492394B2 (en) | 2010-08-18 | 2016-11-15 | Evonik Roehm Gmbh | Gastric resistant pharmaceutical or nutraceutical formulation comprising one or more salts of alginic acid |
CN103501768A (zh) * | 2011-06-17 | 2014-01-08 | 赢创罗姆有限公司 | 具有抗乙醇影响抗性的抗胃酸的药物或营养组合物 |
CN103501768B (zh) * | 2011-06-17 | 2016-11-09 | 赢创罗姆有限公司 | 具有抗乙醇影响抗性的抗胃酸的药物或营养组合物 |
US9775815B2 (en) | 2011-06-17 | 2017-10-03 | Evonik Roehm Gmbh | Gastric resistant pharmaceutical or nutraceutical composition with resistance against the influence of ethanol |
CN108822816A (zh) * | 2018-06-25 | 2018-11-16 | 中国石油集团渤海钻探工程有限公司 | 一种疏松砂岩用可酸溶凝胶堵漏剂及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
US20100226978A1 (en) | 2010-09-09 |
BRPI0721990B1 (pt) | 2019-12-10 |
ES2393934T3 (es) | 2013-01-02 |
SI2187876T1 (sl) | 2012-12-31 |
WO2009036812A1 (en) | 2009-03-26 |
MX2010003032A (es) | 2010-04-09 |
EP2187876A1 (en) | 2010-05-26 |
EP2187876B1 (en) | 2012-08-22 |
KR20100059885A (ko) | 2010-06-04 |
CA2699227C (en) | 2014-12-02 |
IL203901A (en) | 2015-03-31 |
US9700520B2 (en) | 2017-07-11 |
JP2010539197A (ja) | 2010-12-16 |
CA2699227A1 (en) | 2009-03-26 |
PL2187876T3 (pl) | 2013-01-31 |
BRPI0721990B8 (pt) | 2022-07-05 |
BRPI0721990A2 (pt) | 2014-03-18 |
CN101801357B (zh) | 2013-08-07 |
KR101424653B1 (ko) | 2014-08-06 |
JP5204847B2 (ja) | 2013-06-05 |
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Address after: Darmstadt Patentee after: Roma Chemical Co.,Ltd. Address before: Darmstadt Patentee before: EVONIK ROHM GmbH Address after: Essen, Germany Patentee after: Evonik Operations Ltd. Address before: Essen, Germany Patentee before: EVONIK DEGUSSA GmbH |
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