CN101796074B - 抗刻缺蛋白1nrr抗体及其使用方法 - Google Patents

抗刻缺蛋白1nrr抗体及其使用方法 Download PDF

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CN101796074B
CN101796074B CN200880101359.0A CN200880101359A CN101796074B CN 101796074 B CN101796074 B CN 101796074B CN 200880101359 A CN200880101359 A CN 200880101359A CN 101796074 B CN101796074 B CN 101796074B
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antibody
seq
hvr
sequence
albumen
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CN101796074A (zh
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克里斯琴·W·西贝尔
吴雁
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Genentech Inc
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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CN200880101359.0A 2007-06-04 2008-06-03 抗刻缺蛋白1nrr抗体及其使用方法 Expired - Fee Related CN101796074B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US93307207P 2007-06-04 2007-06-04
US60/933,072 2007-06-04
US99464607P 2007-09-20 2007-09-20
US60/994,646 2007-09-20
PCT/US2008/007000 WO2008150525A1 (en) 2007-06-04 2008-06-03 Anti-notch1 nrr antibodies and methods using same

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CN101796074A CN101796074A (zh) 2010-08-04
CN101796074B true CN101796074B (zh) 2014-05-28

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US (5) US8846871B2 (enExample)
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US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
PL2032166T3 (pl) 2006-06-13 2013-09-30 Oncomed Pharm Inc Kompozycje i sposoby diagnozowania i leczenia nowotworów
CL2007002989A1 (es) 2006-10-19 2008-05-16 Genentech Inc Anticuerpos anti-notch3; acido nucleico que los codifica; vector y celula que lo comprende; metodo de produccion; y su uso para el diagnostico de enfermedades relacionadas con notch3.
JP5478254B2 (ja) 2006-10-19 2014-04-23 ジェネンテック， インコーポレイテッド 抗ノッチ３アゴニスト抗体とノッチ３関連疾患の治療におけるその使用
JP5386364B2 (ja) 2006-12-18 2014-01-15 ジェネンテック， インコーポレイテッド 抗Ｎｏｔｃｈ３アンタゴニスト抗体とＮｏｔｃｈ３関連疾患の予防及び治療におけるその使用
CA2676008A1 (en) 2007-01-24 2008-07-31 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
CN102316897B (zh) 2008-07-08 2014-11-05 昂考梅德药品有限公司 Notch结合剂和拮抗剂及其应用方法
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
AR073717A1 (es) * 2008-10-01 2010-11-24 Genentech Inc Anticuerpos anti-notch2 de murino y humano, y metodos de uso
CA2765989C (en) 2009-06-18 2016-11-29 Pfizer Inc. Anti notch-1 antibodies
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