CN101782524B - 细胞图像处理装置、细胞图像处理方法以及计算机系统 - Google Patents

细胞图像处理装置、细胞图像处理方法以及计算机系统 Download PDF

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CN101782524B
CN101782524B CN2009102637051A CN200910263705A CN101782524B CN 101782524 B CN101782524 B CN 101782524B CN 2009102637051 A CN2009102637051 A CN 2009102637051A CN 200910263705 A CN200910263705 A CN 200910263705A CN 101782524 B CN101782524 B CN 101782524B
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CN101782524A (zh
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山田和宏
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Sysmex Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/98—Detection or correction of errors, e.g. by rescanning the pattern or by human intervention; Evaluation of the quality of the acquired patterns
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/98—Detection or correction of errors, e.g. by rescanning the pattern or by human intervention; Evaluation of the quality of the acquired patterns
    • G06V10/987—Detection or correction of errors, e.g. by rescanning the pattern or by human intervention; Evaluation of the quality of the acquired patterns with the intervention of an operator
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/693—Acquisition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N1/312—Apparatus therefor for samples mounted on planar substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N2015/1472—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle with colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N2035/00891—Displaying information to the operator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N2035/0097—Control arrangements for automatic analysers monitoring reactions as a function of time
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G01N35/00613—Quality control
    • G01N35/00623—Quality control of instruments
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G01N35/00693—Calibration

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  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CN2009102637051A 2009-01-21 2009-12-30 细胞图像处理装置、细胞图像处理方法以及计算机系统 Active CN101782524B (zh)

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JP2009011303A JP5426181B2 (ja) 2009-01-21 2009-01-21 検体処理システム、細胞画像分類装置、及び検体処理方法
JP2009-011303 2009-01-21

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Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8781201B2 (en) * 2009-03-04 2014-07-15 Robert E. Sandstrom Method of operating a pathology laboratory
US9522396B2 (en) 2010-12-29 2016-12-20 S.D. Sight Diagnostics Ltd. Apparatus and method for automatic detection of pathogens
CN102735609A (zh) * 2011-03-31 2012-10-17 西门子公司 一种体液成像系统、方法及景深扩展成像装置
CN108318409A (zh) 2011-06-17 2018-07-24 罗氏血液诊断股份有限公司 用于样本显示与查看的系统和方法
JP5869239B2 (ja) 2011-06-21 2016-02-24 浜松ホトニクス株式会社 光測定装置、光測定方法、及び光測定プログラム
WO2012176783A1 (ja) * 2011-06-21 2012-12-27 浜松ホトニクス株式会社 光測定装置、光測定方法、及び光測定プログラム
US9459196B2 (en) 2011-07-22 2016-10-04 Roche Diagnostics Hematology, Inc. Blood analyzer calibration and assessment
WO2013098821A1 (en) 2011-12-29 2013-07-04 Parasight Ltd. Methods and systems for detecting a pathogen in a biological sample
US9164015B2 (en) * 2012-06-29 2015-10-20 General Electric Company Systems and methods for processing and imaging of biological samples
US9817221B2 (en) 2012-06-29 2017-11-14 General Electric Company Systems and methods for processing and imaging of biological samples
US9389229B2 (en) 2012-07-18 2016-07-12 Theranos, Inc. Methods for detecting and measuring aggregation
JP5376024B1 (ja) * 2012-08-23 2013-12-25 富士ゼロックス株式会社 画像処理装置、プログラム及び画像処理システム
JP5333635B1 (ja) * 2012-08-23 2013-11-06 富士ゼロックス株式会社 画像処理装置、プログラム及び画像処理システム
EP3869257B1 (en) 2013-05-23 2024-05-08 S.D. Sight Diagnostics Ltd. Method and system for imaging a cell sample
IL227276A0 (en) 2013-07-01 2014-03-06 Parasight Ltd A method and system for preparing a monolayer of cells, particularly suitable for diagnosis
CN103364242B (zh) * 2013-07-11 2015-05-13 四川美生科技有限公司 全自动医学检验血液推片染色机
WO2015013605A1 (en) * 2013-07-26 2015-01-29 Abbott Point Of Care, Inc. Method and apparatus for producing an image of undiluted whole blood sample having wright stain coloration
EP3955042B1 (en) 2013-08-26 2024-08-21 S.D. Sight Diagnostics Ltd. Digital microscopy systems, methods and computer program products
WO2015182256A1 (ja) * 2014-05-30 2015-12-03 株式会社日立ハイテクノロジーズ 自動分析装置
US10482595B2 (en) 2014-08-27 2019-11-19 S.D. Sight Diagnostics Ltd. System and method for calculating focus variation for a digital microscope
US9298968B1 (en) * 2014-09-12 2016-03-29 Flagship Biosciences, Inc. Digital image analysis of inflammatory cells and mediators of inflammation
JP6342285B2 (ja) 2014-09-30 2018-06-13 シスメックス株式会社 粒子分析装置における異常判定方法、分析装置における精度管理方法、および粒子分析装置
CN104459172B (zh) * 2014-11-28 2016-08-17 武汉兰丁医学高科技有限公司 一种自动化骨髓样本处理装置及其自动化分析、阅片方法
JP6134348B2 (ja) 2015-03-31 2017-05-24 シスメックス株式会社 細胞撮像装置及び細胞撮像方法
JP2017009314A (ja) * 2015-06-17 2017-01-12 株式会社Ｓｃｒｅｅｎホールディングス 教示データの作成支援方法、作成支援装置、プログラムおよびプログラム記録媒体
CN107924462A (zh) * 2015-08-24 2018-04-17 皇家飞利浦有限公司 数字病理学中的服务器‑客户机架构
US11085940B2 (en) * 2015-08-26 2021-08-10 Hitachi High-Tech Corporation Automatic analyzer
AU2016322966B2 (en) 2015-09-17 2021-10-14 S.D. Sight Diagnostics Ltd Methods and apparatus for detecting an entity in a bodily sample
WO2017168411A1 (en) 2016-03-30 2017-10-05 S.D. Sight Diagnostics Ltd Image processing device for identifying blood parasites
CN109564209B (zh) 2016-05-11 2022-05-31 思迪赛特诊断有限公司 对样品实施的光学测量
US11307196B2 (en) 2016-05-11 2022-04-19 S.D. Sight Diagnostics Ltd. Sample carrier for optical measurements
EP3321851A3 (en) * 2016-11-09 2018-08-01 AmCad BioMed Corporation Cytological image processing device, and method for quantifying characteristics of cytological image
CN108537092B (zh) * 2017-03-02 2020-11-10 爱威科技股份有限公司 变异红细胞识别方法及装置
EP3710810B1 (en) 2017-11-14 2023-09-06 S.D. Sight Diagnostics Ltd. Sample carrier for optical measurements
CA3082718A1 (en) * 2017-11-22 2019-05-31 Grifols Diagnostic Solutions Inc. Systems and methods for biological sample laboratory screening
KR102122068B1 (ko) * 2018-11-19 2020-06-12 노을 주식회사 이미지 분석 시스템 및 분석 방법
JP7376245B2 (ja) * 2019-03-29 2023-11-08 シスメックス株式会社 蛍光画像分析装置及び蛍光画像分析方法
JP7403965B2 (ja) * 2019-03-29 2023-12-25 シスメックス株式会社 蛍光画像分析装置及び蛍光画像分析方法
JP2021040590A (ja) 2019-09-13 2021-03-18 シスメックス株式会社 細胞画像解析方法、細胞画像解析装置、プログラム、及び細胞画像解析システム
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AU2020400401A1 (en) 2019-12-12 2022-06-02 S.D. Sight Diagnostics Ltd Analyzing an analyte disposed within a medium
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CN113515077A (zh) * 2021-04-23 2021-10-19 重庆德方信息技术有限公司 人体细胞染色过程监控系统及方法
US20230289962A1 (en) * 2022-03-09 2023-09-14 Sysmex Corporation Method of generating quality control information, apparatus for generating quality control information, and program
CN116481981A (zh) * 2023-04-28 2023-07-25 苏州睿仟科技有限公司 一种细胞玻片成像系统、方法及计算机设备
CN118465292B (zh) * 2024-07-15 2024-09-10 深圳市贝安特医疗技术有限公司 设备染色稳定性周期自查方法及系统

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761075A (en) * 1985-12-10 1988-08-02 Hitachi, Ltd. Cellular analysis system
CN1399131A (zh) * 2002-08-28 2003-02-26 彭黎明 无创性血细胞参数定量测定方法
EP0725268B1 (en) * 1995-02-01 2005-04-20 Hitachi, Ltd. Flow type particle image analyzing method
CN101137046A (zh) * 2006-08-31 2008-03-05 索尼株式会社 图像处理装置、图像处理方法和图像处理程序

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4097845A (en) * 1976-11-01 1978-06-27 Rush-Presbyterian-St. Luke's Medical Center Method of and an apparatus for automatic classification of red blood cells
JPS5379599A (en) * 1976-12-23 1978-07-14 Toa Medical Electronics Automatic blood analyzer
JPS60162955A (ja) * 1984-02-03 1985-08-24 Hitachi Ltd 血球自動分析装置
ATE67044T1 (de) * 1987-02-05 1991-09-15 Contraves Ag Verfahren und vorrichtung zum bestimmen von schwellenwerten bei der teilchenanalyse einer fluessigkeit.
JP3169598B2 (ja) * 1990-07-06 2001-05-28 株式会社日立製作所 自動分析方法および自動分析装置
JPH055733A (ja) * 1991-06-28 1993-01-14 Sanyo Electric Co Ltd 血液像検査装置
US5768412A (en) * 1994-09-19 1998-06-16 Hitachi, Ltd. Region segmentation method for particle images and apparatus thereof
JPH09257689A (ja) * 1996-03-27 1997-10-03 Hitachi Ltd 粒子解析装置
JPH10275150A (ja) * 1997-03-28 1998-10-13 Toa Medical Electronics Co Ltd 画像ファイリングシステム
JP2002140692A (ja) * 2000-10-30 2002-05-17 Sysmex Corp 画像解析装置
US20050051723A1 (en) * 2003-07-23 2005-03-10 Neagle Bradley D. Examination systems for biological samples
JP4649828B2 (ja) * 2003-10-17 2011-03-16 Ｊｆｅスチール株式会社 画像処理装置の異常の判定方法
JP4528529B2 (ja) * 2004-01-20 2010-08-18 株式会社東芝 超音波診断装置及び超音波画像データ処理方法
JP4542386B2 (ja) * 2004-07-30 2010-09-15 シスメックス株式会社 画像表示システム、画像提供装置、画像表示装置、およびコンピュータプログラム
JP4964446B2 (ja) * 2005-09-14 2012-06-27 シスメックス株式会社 分析装置及び検体情報処理プログラム
JP5063999B2 (ja) * 2006-11-30 2012-10-31 シスメックス株式会社 血液像分析装置
JP2008212017A (ja) * 2007-03-01 2008-09-18 Nikon Corp 細胞状態判定装置、および細胞状態判定方法
WO2009009779A2 (en) * 2007-07-11 2009-01-15 Cualing Hernani D Automated bone marrow cellularity determination

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761075A (en) * 1985-12-10 1988-08-02 Hitachi, Ltd. Cellular analysis system
EP0725268B1 (en) * 1995-02-01 2005-04-20 Hitachi, Ltd. Flow type particle image analyzing method
CN1399131A (zh) * 2002-08-28 2003-02-26 彭黎明 无创性血细胞参数定量测定方法
CN101137046A (zh) * 2006-08-31 2008-03-05 索尼株式会社 图像处理装置、图像处理方法和图像处理程序

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EP2211165B1 (en) 2017-07-26
JP5426181B2 (ja) 2014-02-26
EP2211165A3 (en) 2015-07-08
CN101782524A (zh) 2010-07-21
EP2211165A2 (en) 2010-07-28
US20100183216A1 (en) 2010-07-22

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