CN101781226A - 阿戈美拉汀及其药物组合物 - Google Patents
阿戈美拉汀及其药物组合物 Download PDFInfo
- Publication number
- CN101781226A CN101781226A CN200910245029A CN200910245029A CN101781226A CN 101781226 A CN101781226 A CN 101781226A CN 200910245029 A CN200910245029 A CN 200910245029A CN 200910245029 A CN200910245029 A CN 200910245029A CN 101781226 A CN101781226 A CN 101781226A
- Authority
- CN
- China
- Prior art keywords
- agomelatine
- crystal
- preparation
- agomelatine crystal
- filtrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
2θ | I/I0 |
12.84 | 25 |
13.84 | 23 |
16.14 | 37 |
18.56 | 100 |
2θ | I/I0 |
19.12 | 27 |
20.86 | 75 |
21.20 | 30 |
23.84 | 64 |
Claims (7)
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009102450295A CN101781226B (zh) | 2009-12-23 | 2009-12-23 | 阿戈美拉汀及其药物组合物 |
EP10838509.7A EP2474522B1 (en) | 2009-12-23 | 2010-12-13 | Agomelatine and pharmaceutical compositions thereof |
PL10838509T PL2474522T3 (pl) | 2009-12-23 | 2010-12-13 | Agomelatyna i jej kompozycje farmaceutyczne |
ES10838509.7T ES2468801T3 (es) | 2009-12-23 | 2010-12-13 | Agomelatina y composiciones farmacéuticas de la misma |
JP2012521934A JP5611344B2 (ja) | 2009-12-23 | 2010-12-13 | アゴメラチン及びその薬物組成物 |
PT108385097T PT2474522E (pt) | 2009-12-23 | 2010-12-13 | Agomelatina e composições farmacêuticas que contêm a mesma |
CA2776342A CA2776342C (en) | 2009-12-23 | 2010-12-13 | Agomelatine and pharmaceutical compositions thereof |
US13/504,769 US9029420B2 (en) | 2009-12-23 | 2010-12-13 | Agomelatine and pharmaceutical compositions thereof |
PCT/CN2010/002026 WO2011075943A1 (zh) | 2009-12-23 | 2010-12-13 | 阿戈美拉汀及其药物组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009102450295A CN101781226B (zh) | 2009-12-23 | 2009-12-23 | 阿戈美拉汀及其药物组合物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101781226A true CN101781226A (zh) | 2010-07-21 |
CN101781226B CN101781226B (zh) | 2012-03-28 |
Family
ID=42521392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009102450295A Active CN101781226B (zh) | 2009-12-23 | 2009-12-23 | 阿戈美拉汀及其药物组合物 |
Country Status (9)
Country | Link |
---|---|
US (1) | US9029420B2 (zh) |
EP (1) | EP2474522B1 (zh) |
JP (1) | JP5611344B2 (zh) |
CN (1) | CN101781226B (zh) |
CA (1) | CA2776342C (zh) |
ES (1) | ES2468801T3 (zh) |
PL (1) | PL2474522T3 (zh) |
PT (1) | PT2474522E (zh) |
WO (1) | WO2011075943A1 (zh) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101921205A (zh) * | 2010-08-30 | 2010-12-22 | 江苏恩华药业股份有限公司 | 阿戈美拉汀ⅰ晶型的制备方法 |
WO2011075943A1 (zh) * | 2009-12-23 | 2011-06-30 | 天津泰普药品科技发展有限公司 | 阿戈美拉汀及其药物组合物 |
CN101704763B (zh) * | 2009-11-25 | 2012-03-28 | 天津泰普药品科技发展有限公司 | 阿戈美拉汀i型晶体的制备方法 |
CN102432490A (zh) * | 2011-11-02 | 2012-05-02 | 江西施美制药有限公司 | 一种阿戈美拉汀晶型d及其制备方法 |
CN102452952A (zh) * | 2010-11-03 | 2012-05-16 | 天津药物研究院 | 一种高纯度的i型阿戈美拉汀晶体制备方法 |
CN103130673A (zh) * | 2011-11-28 | 2013-06-05 | 重庆医药工业研究院有限责任公司 | 一种阿戈美拉晶型i的制备方法 |
CN103360275A (zh) * | 2012-03-30 | 2013-10-23 | 上海希迈医药科技有限公司 | 一种制备阿戈美拉汀ⅰ型晶体的方法 |
WO2015096186A1 (zh) | 2013-12-23 | 2015-07-02 | 天津泰普药品科技发展有限公司 | 一种稳定的晶x型阿戈美拉汀片剂及其制备方法 |
MD4391C1 (ro) * | 2011-03-23 | 2016-08-31 | Hanghai Institute Of Pharmaceutical Industry | Formă cristalină nouă VII a agomelatinei, procedeu de preparare şi utilizarea acesteia, şi compoziţie farmaceutică care o conţine |
MD4484C1 (ro) * | 2011-03-23 | 2017-12-31 | Hanghai Institute Of Pharmaceutical Industry | Forma cristalină VIII a agomelatinei, procedeu de preparare, utilizarea acesteia şi compoziţie farmaceutică care o conţine |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20111078A1 (it) | 2011-06-15 | 2012-12-16 | Laboratorio Chimico Int Spa | Procedimento per la preparazione di forme cristalline dell?agomelatina e nuovo polimorfo |
FR2978916B1 (fr) | 2011-08-10 | 2013-07-26 | Servier Lab | Composition pharmaceutique solide pour administration buccale d'agomelatine |
FR3001894A1 (fr) | 2013-02-08 | 2014-08-15 | Servier Lab | Composition pharmaceutique solide pour administration buccale d'agomelatine |
EP3154522A1 (en) * | 2014-06-10 | 2017-04-19 | Laboratorio Chimico Internazionale S.p.A. | Agomelatine in solution adsorbates and compositions |
EP3466413A1 (en) | 2017-10-09 | 2019-04-10 | KRKA, d.d., Novo mesto | Pharmaceutical composition containing agomelatine and process for the preparation thereof |
EP3466923A1 (en) | 2017-10-09 | 2019-04-10 | KRKA, d.d., Novo mesto | Process for the preparation of agomelatine in crystalline form |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2658818B1 (fr) | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2866335B1 (fr) * | 2004-02-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
FR2889523B1 (fr) | 2005-08-03 | 2007-12-28 | Servier Lab | Nouvelle forme cristalline v de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2889522B1 (fr) * | 2005-08-03 | 2007-12-28 | Servier Lab | Nouvelle forme cristalline iv de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2889521B1 (fr) | 2005-08-03 | 2007-12-28 | Servier Lab | Nouvelle forme cristalline iii de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2894475B1 (fr) | 2005-12-14 | 2008-05-16 | Servier Lab | Composition pharmaceutique orodispersible pour administra- -tion oromucosale ou sublinguale d'agomelatine |
FR2923482B1 (fr) | 2007-11-09 | 2010-01-29 | Servier Lab | Nouvelle forme cristalline vi de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent |
FR2934856B1 (fr) | 2008-08-05 | 2010-08-13 | Servier Lab | Nouveau procede d'obtention de la forme cristalline v de l'agomelatine |
EP2319827A1 (en) | 2009-11-09 | 2011-05-11 | Ratiopharm GmbH | Process for the production of polymorph form I of agomelatine |
CN101781226B (zh) | 2009-12-23 | 2012-03-28 | 天津泰普药品科技发展有限公司 | 阿戈美拉汀及其药物组合物 |
CN101792400B (zh) * | 2010-03-16 | 2013-01-30 | 华东师范大学 | 一种阿戈美拉汀的合成方法 |
CL2011001405A1 (es) | 2010-06-10 | 2012-03-30 | Gador S A Conicet | Procedimiento para la preparacion de n-[2-(7-metoxi-1-naftil)etil]acetamida, agometalina. |
-
2009
- 2009-12-23 CN CN2009102450295A patent/CN101781226B/zh active Active
-
2010
- 2010-12-13 EP EP10838509.7A patent/EP2474522B1/en not_active Revoked
- 2010-12-13 JP JP2012521934A patent/JP5611344B2/ja not_active Expired - Fee Related
- 2010-12-13 PT PT108385097T patent/PT2474522E/pt unknown
- 2010-12-13 WO PCT/CN2010/002026 patent/WO2011075943A1/zh active Application Filing
- 2010-12-13 PL PL10838509T patent/PL2474522T3/pl unknown
- 2010-12-13 ES ES10838509.7T patent/ES2468801T3/es active Active
- 2010-12-13 CA CA2776342A patent/CA2776342C/en not_active Expired - Fee Related
- 2010-12-13 US US13/504,769 patent/US9029420B2/en not_active Expired - Fee Related
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101704763B (zh) * | 2009-11-25 | 2012-03-28 | 天津泰普药品科技发展有限公司 | 阿戈美拉汀i型晶体的制备方法 |
WO2011075943A1 (zh) * | 2009-12-23 | 2011-06-30 | 天津泰普药品科技发展有限公司 | 阿戈美拉汀及其药物组合物 |
US9029420B2 (en) | 2009-12-23 | 2015-05-12 | Tianjin Taipu Pharmaceutical Science & Technology Development Co., Ltd. | Agomelatine and pharmaceutical compositions thereof |
CN101921205B (zh) * | 2010-08-30 | 2013-11-20 | 江苏恩华药业股份有限公司 | 阿戈美拉汀ⅰ晶型的制备方法 |
CN101921205A (zh) * | 2010-08-30 | 2010-12-22 | 江苏恩华药业股份有限公司 | 阿戈美拉汀ⅰ晶型的制备方法 |
CN102452952A (zh) * | 2010-11-03 | 2012-05-16 | 天津药物研究院 | 一种高纯度的i型阿戈美拉汀晶体制备方法 |
MD4391C1 (ro) * | 2011-03-23 | 2016-08-31 | Hanghai Institute Of Pharmaceutical Industry | Formă cristalină nouă VII a agomelatinei, procedeu de preparare şi utilizarea acesteia, şi compoziţie farmaceutică care o conţine |
MD4484C1 (ro) * | 2011-03-23 | 2017-12-31 | Hanghai Institute Of Pharmaceutical Industry | Forma cristalină VIII a agomelatinei, procedeu de preparare, utilizarea acesteia şi compoziţie farmaceutică care o conţine |
CN102432490A (zh) * | 2011-11-02 | 2012-05-02 | 江西施美制药有限公司 | 一种阿戈美拉汀晶型d及其制备方法 |
CN103130673A (zh) * | 2011-11-28 | 2013-06-05 | 重庆医药工业研究院有限责任公司 | 一种阿戈美拉晶型i的制备方法 |
CN103130673B (zh) * | 2011-11-28 | 2017-05-03 | 重庆医药工业研究院有限责任公司 | 一种阿戈美拉晶型i的制备方法 |
CN103360275A (zh) * | 2012-03-30 | 2013-10-23 | 上海希迈医药科技有限公司 | 一种制备阿戈美拉汀ⅰ型晶体的方法 |
CN103360275B (zh) * | 2012-03-30 | 2015-04-22 | 上海创诺制药有限公司 | 一种制备阿戈美拉汀ⅰ型晶体的方法 |
WO2015096186A1 (zh) | 2013-12-23 | 2015-07-02 | 天津泰普药品科技发展有限公司 | 一种稳定的晶x型阿戈美拉汀片剂及其制备方法 |
US20160120825A1 (en) * | 2013-12-23 | 2016-05-05 | Tianjin Taipu Pharmaceutical Science & Technology Development Co., Ltd | Stable crystal x-form agomelatine tablet and preparation method thereof |
EP3087976A4 (en) * | 2013-12-23 | 2017-08-02 | Tianjin Taipu Pharmaceutical Science & Technology Development Co., Ltd. | Stable crystal x-form agomelatine tablet and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
EP2474522A1 (en) | 2012-07-11 |
PT2474522E (pt) | 2014-05-02 |
WO2011075943A1 (zh) | 2011-06-30 |
ES2468801T3 (es) | 2014-06-17 |
US9029420B2 (en) | 2015-05-12 |
JP5611344B2 (ja) | 2014-10-22 |
CA2776342A1 (en) | 2011-06-30 |
EP2474522A4 (en) | 2013-03-20 |
PL2474522T3 (pl) | 2014-08-29 |
CN101781226B (zh) | 2012-03-28 |
EP2474522B1 (en) | 2014-04-09 |
CA2776342C (en) | 2014-10-14 |
JP2013500276A (ja) | 2013-01-07 |
US20120252901A1 (en) | 2012-10-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101781226B (zh) | 阿戈美拉汀及其药物组合物 | |
CN102812033B (zh) | N6-取代腺苷衍生物和n6-取代腺嘌呤衍生物及其用途 | |
CN101704763B (zh) | 阿戈美拉汀i型晶体的制备方法 | |
CN102452951B (zh) | 阿戈美拉汀及其药物组合物 | |
CN102050755B (zh) | 阿戈美拉汀的晶型及其制备方法 | |
EP4045507A1 (en) | Salts and forms of an estrogen receptor modulator | |
MX2013010634A (es) | Cristal mixto de agomelatina (forma-viii), sus metodos de preparacion y aplicaciones y composiciones farmaceuticas que le contienen. | |
JP5903166B2 (ja) | ブチルフタリドの誘導体、並びにその製造法及び使用 | |
WO2015092720A1 (en) | Metabolites of sonidegib (lde225) | |
TWI326679B (en) | New naphthalene compounds, a process for their preparation and pharmaceutical compositions containing them | |
CN110590779B (zh) | 3,10二对氯苯基6,12二氮杂四高立方烷类化合物及其合成方法、应用和药物组合物 | |
CN101429154B (zh) | 无水阿维莫泮及其药物组合物 | |
CN110105323B (zh) | 二芳基丙烷二聚体类衍生物及其药物组合物和其应用 | |
CN109476584B (zh) | N-(2-(取代-萘-1-基)乙基)取代酰胺类化合物、其制备及其用途 | |
CN102786458B (zh) | 吡咯甲酰胺衍生物、其制备方法和用途 | |
CN102267952B (zh) | 喹唑啉类化合物、其制备方法和用途 | |
CN111777577A (zh) | 一类紫杉醇衍生物及其在制备防治人恶性肿瘤药物中的用途 | |
CN103992272B (zh) | 一种盐酸喷他佐辛酯、其制备方法及其用途 | |
CN103570669B (zh) | 脑靶向o-去甲基文拉法辛酚酯类前药及制备方法和用途 | |
CN115160399B (zh) | 一种皂皮酸类化合物及其制备方法和医用用途 | |
EA012282B1 (ru) | Новые соединения нафталина, способ их получения и фармацевтические композиции, содержащие их | |
CN116082302A (zh) | 氘代吲唑-吡啶-苯基-三氟乙基四取代烯烃类化合物及其用途 | |
CN117586192A (zh) | 一种化合物及其制备方法和用途 | |
CN103288805B (zh) | 含有苯并呋喃的嘧啶类化合物及其制备方法和用途 | |
CN117800938A (zh) | 一种羟基取代贝前列素衍生物、合成方法及其应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
DD01 | Delivery of document by public notice | ||
DD01 | Delivery of document by public notice |
Addressee: Zhao Jian Document name: payment instructions |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20220401 Address after: 300451 No. 29, Huixin Road, Binhai Science Park, Binhai New Area, Tianjin Patentee after: TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH PHARMACEUTICAL RESPONSIBLE CO.,LTD. Address before: 300193 Tianjin City, Nankai District Anshan West Road No. 308 Patentee before: TIANJIN TAIPU PHARMACEUTICAL SCIENCE & TECHNOLOGY DEVELOPMENT Co.,Ltd. |
|
DD01 | Delivery of document by public notice | ||
DD01 | Delivery of document by public notice |
Addressee: Patent of Tianjin Taipu Pharmaceutical Technology Development Co.,Ltd. The person in charge Document name: Notification of qualified procedures |