CN101773477B - 一种畜禽用头孢噻呋的肺靶向微球及制备方法 - Google Patents
一种畜禽用头孢噻呋的肺靶向微球及制备方法 Download PDFInfo
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- CN101773477B CN101773477B CN2010101263947A CN201010126394A CN101773477B CN 101773477 B CN101773477 B CN 101773477B CN 2010101263947 A CN2010101263947 A CN 2010101263947A CN 201010126394 A CN201010126394 A CN 201010126394A CN 101773477 B CN101773477 B CN 101773477B
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- Prior art keywords
- ceftiofur
- gelatin
- microsphere
- medicine
- solution
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- 239000004005 microsphere Substances 0.000 title claims abstract description 57
- ZBHXIWJRIFEVQY-IHMPYVIRSA-N ceftiofur Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC(=O)C1=CC=CO1 ZBHXIWJRIFEVQY-IHMPYVIRSA-N 0.000 title claims abstract description 37
- 229960005229 ceftiofur Drugs 0.000 title claims abstract description 37
- 230000008685 targeting Effects 0.000 title abstract description 14
- 238000002360 preparation method Methods 0.000 title abstract description 12
- 210000004072 lung Anatomy 0.000 title abstract description 10
- 108010010803 Gelatin Proteins 0.000 claims abstract description 35
- 229920000159 gelatin Polymers 0.000 claims abstract description 35
- 239000008273 gelatin Substances 0.000 claims abstract description 35
- 235000019322 gelatine Nutrition 0.000 claims abstract description 35
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 35
- 239000002994 raw material Substances 0.000 claims abstract description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 28
- 239000000243 solution Substances 0.000 claims description 25
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 18
- 238000001914 filtration Methods 0.000 claims description 15
- 229940057995 liquid paraffin Drugs 0.000 claims description 14
- 239000002245 particle Substances 0.000 claims description 13
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 10
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 10
- 230000001804 emulsifying effect Effects 0.000 claims description 10
- 238000005303 weighing Methods 0.000 claims description 10
- 244000144977 poultry Species 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000003995 emulsifying agent Substances 0.000 claims description 7
- 230000008859 change Effects 0.000 claims description 6
- 239000004471 Glycine Substances 0.000 claims description 5
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims description 5
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 230000018044 dehydration Effects 0.000 claims description 5
- 238000006297 dehydration reaction Methods 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 230000008961 swelling Effects 0.000 claims description 5
- 239000011259 mixed solution Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 2
- 239000012188 paraffin wax Substances 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 229920000053 polysorbate 80 Polymers 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 44
- 230000000694 effects Effects 0.000 abstract description 11
- 230000002685 pulmonary effect Effects 0.000 abstract description 8
- 231100000331 toxic Toxicity 0.000 abstract description 6
- 230000002588 toxic effect Effects 0.000 abstract description 6
- 241001465754 Metazoa Species 0.000 abstract description 4
- 208000015181 infectious disease Diseases 0.000 abstract description 3
- 239000002699 waste material Substances 0.000 abstract description 3
- 238000005538 encapsulation Methods 0.000 abstract 2
- 239000000969 carrier Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 13
- 238000011068 loading method Methods 0.000 description 9
- 238000004090 dissolution Methods 0.000 description 5
- 238000009826 distribution Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000009827 uniform distribution Methods 0.000 description 2
- RFLHUYUQCKHUKS-JUODUXDSSA-M Ceftiofur sodium Chemical compound [Na+].S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC(=O)C1=CC=CO1 RFLHUYUQCKHUKS-JUODUXDSSA-M 0.000 description 1
- 229930186147 Cephalosporin Natural products 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 229960004467 ceftiofur sodium Drugs 0.000 description 1
- 229940124587 cephalosporin Drugs 0.000 description 1
- 150000001780 cephalosporins Chemical class 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000000385 dialysis solution Substances 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 238000002296 dynamic light scattering Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN2010101263947A CN101773477B (zh) | 2010-03-18 | 2010-03-18 | 一种畜禽用头孢噻呋的肺靶向微球及制备方法 |
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CN2010101263947A CN101773477B (zh) | 2010-03-18 | 2010-03-18 | 一种畜禽用头孢噻呋的肺靶向微球及制备方法 |
Publications (2)
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CN101773477A CN101773477A (zh) | 2010-07-14 |
CN101773477B true CN101773477B (zh) | 2012-06-13 |
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CN2010101263947A Expired - Fee Related CN101773477B (zh) | 2010-03-18 | 2010-03-18 | 一种畜禽用头孢噻呋的肺靶向微球及制备方法 |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107308118B (zh) * | 2017-07-07 | 2020-04-28 | 青岛农业大学 | 一种肺靶向硫酸头孢喹诺plga微球及其制备方法 |
CN107157940B (zh) * | 2017-07-07 | 2020-05-05 | 青岛农业大学 | 一种肺靶向硫酸头孢喹诺明胶微球及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1813760A (zh) * | 2005-12-12 | 2006-08-09 | 浙江升华拜克生物股份有限公司 | 一种含头孢噻呋的兽用粉针注射剂 |
CN1985832A (zh) * | 2005-12-21 | 2007-06-27 | 天津市润拓生物技术有限公司 | 一种畜禽使用的头孢哌酮肺靶向微球及其制备方法 |
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2010
- 2010-03-18 CN CN2010101263947A patent/CN101773477B/zh not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1813760A (zh) * | 2005-12-12 | 2006-08-09 | 浙江升华拜克生物股份有限公司 | 一种含头孢噻呋的兽用粉针注射剂 |
CN1985832A (zh) * | 2005-12-21 | 2007-06-27 | 天津市润拓生物技术有限公司 | 一种畜禽使用的头孢哌酮肺靶向微球及其制备方法 |
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Owner name: QINGDAO KDN ANIMAL PHARMACEUTICAL CO., LTD. QINGDA Free format text: FORMER OWNER: QINGDAO LIUHE MEDICINE CO., LTD. Effective date: 20120525 Owner name: QINGDAO KDN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: QINGDAO CONTINENT BIOTECH CO., LTD. Effective date: 20120525 |
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Effective date of registration: 20120525 Address after: 266061 Shandong city of Qingdao province high tech park of Laoshan district by the No. 29 Shandong Road, building 605 high speed Co-patentee after: QINGDAO KDN BIOTECH Co.,Ltd. Patentee after: QINGDAO KDN PHARMACEUTICAL Co.,Ltd. Co-patentee after: Qingdao Agricultural University Address before: 266061 Shandong city of Qingdao province high tech park of Laoshan district by the No. 29 Shandong Road, building 605 high speed Co-patentee before: Qingdao Liuhe Pharmaceuticals Ltd. Patentee before: Qingdao Vland Biotech INC. |
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C56 | Change in the name or address of the patentee |
Owner name: QINGDAO WEILAN BIOLOGY CO., LTD. Free format text: FORMER NAME: QINGDAO KDN PHARMACEUTICAL CO., LTD. |
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Address after: 266061 Shandong city of Qingdao province Chengyang Qingda Industrial Park, the first northbound dual Patentee after: QINGDAO VLAND BIOTECH Inc. Patentee after: QINGDAO KDN BIOTECH Co.,Ltd. Patentee after: Qingdao Agricultural University Address before: 266061 Shandong city of Qingdao province high tech park of Laoshan district by the No. 29 Shandong Road, building 605 high speed Patentee before: QINGDAO KDN PHARMACEUTICAL Co.,Ltd. Patentee before: QINGDAO KDN BIOTECH Co.,Ltd. Patentee before: Qingdao Agricultural University |
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