CN101772302B - 含硼小分子 - Google Patents

含硼小分子 Download PDF

Info

Publication number
CN101772302B
CN101772302B CN200880101464.4A CN200880101464A CN101772302B CN 101772302 B CN101772302 B CN 101772302B CN 200880101464 A CN200880101464 A CN 200880101464A CN 101772302 B CN101772302 B CN 101772302B
Authority
CN
China
Prior art keywords
compound
salt
exemplary embodiment
substituted
och
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200880101464.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN101772302A (zh
Inventor
S·J·贝克
V·S·赫南德兹
R·沙尔玛
J·A·尼曼
赤间勉
张永康
J·J·普拉特纳
M·R·K·阿利
R·辛格
M·哈
X·卢
周虎臣
夏奕
R·莫哈迈德
E·M·克拉梅恩
J·G·菲利普斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anakol Pharmaceutical Co ltd
Original Assignee
Anacor Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40156702&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101772302(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Anacor Pharmaceuticals LLC filed Critical Anacor Pharmaceuticals LLC
Publication of CN101772302A publication Critical patent/CN101772302A/zh
Application granted granted Critical
Publication of CN101772302B publication Critical patent/CN101772302B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200880101464.4A 2007-06-20 2008-06-19 含硼小分子 Active CN101772302B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US94529407P 2007-06-20 2007-06-20
US60/945,294 2007-06-20
US4117808P 2008-03-31 2008-03-31
US61/041,178 2008-03-31
PCT/US2008/067550 WO2008157726A1 (en) 2007-06-20 2008-06-19 Boron-containing small molecules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201410134063.6A Division CN104017008A (zh) 2007-06-20 2008-06-19 含硼小分子

Publications (2)

Publication Number Publication Date
CN101772302A CN101772302A (zh) 2010-07-07
CN101772302B true CN101772302B (zh) 2014-05-07

Family

ID=40156702

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200880101464.4A Active CN101772302B (zh) 2007-06-20 2008-06-19 含硼小分子
CN201410134063.6A Pending CN104017008A (zh) 2007-06-20 2008-06-19 含硼小分子

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201410134063.6A Pending CN104017008A (zh) 2007-06-20 2008-06-19 含硼小分子

Country Status (29)

Country Link
US (4) US7816344B2 (enExample)
EP (1) EP2164331B1 (enExample)
JP (3) JP5530923B2 (enExample)
KR (3) KR101578351B1 (enExample)
CN (2) CN101772302B (enExample)
AR (1) AR067105A1 (enExample)
AU (1) AU2008265630B2 (enExample)
BR (1) BRPI0813450B8 (enExample)
CA (1) CA2692135C (enExample)
CL (1) CL2008001855A1 (enExample)
CO (1) CO6251209A2 (enExample)
CR (1) CR11224A (enExample)
DK (1) DK2164331T3 (enExample)
DO (1) DOP2009000281A (enExample)
EA (1) EA020530B1 (enExample)
ES (1) ES2655299T3 (enExample)
IL (1) IL202379A (enExample)
JO (1) JO3396B1 (enExample)
MA (1) MA31675B1 (enExample)
MX (1) MX347688B (enExample)
MY (1) MY162692A (enExample)
NO (1) NO2164331T3 (enExample)
NZ (1) NZ582706A (enExample)
PE (1) PE20090840A1 (enExample)
SG (1) SG182219A1 (enExample)
TW (1) TW200911822A (enExample)
UY (1) UY31171A1 (enExample)
WO (1) WO2008157726A1 (enExample)
ZA (2) ZA200909003B (enExample)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006214247C1 (en) 2005-02-16 2012-11-08 Anacor Pharmaceuticals, Llc Boron-containing small molecules
BRPI0621279B1 (pt) * 2005-12-30 2021-07-20 Anacor Pharmaceuticals, Inc Moléculas pequenas contendo boro
CA2642583C (en) 2006-02-16 2016-08-23 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-inflammatory agents
WO2007131072A2 (en) 2006-05-02 2007-11-15 Anacor Pharmaceuticals, Inc. Hydrolytically-resistant boron-containing therapeutics and methods of use
JO3396B1 (ar) 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
CN102014927A (zh) 2008-03-06 2011-04-13 安纳考尔医药公司 作为抗炎药的含硼的小分子
EP2285384A4 (en) * 2008-05-12 2012-04-25 Anacor Pharmaceuticals Inc BORN SMALL MOLECULES
WO2010027975A1 (en) * 2008-09-04 2010-03-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2010028005A1 (en) 2008-09-04 2010-03-11 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
US9493489B2 (en) * 2008-10-15 2016-11-15 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agents
AU2009335744A1 (en) 2008-12-17 2010-07-15 Anacor Pharmaceuticals, Inc. Polymorphs of (S)-3-aminomethyl-7-(3-hydroxy-propoxy) -3H-benzo[c][1,2] oxaborol-1-ol
US8668911B2 (en) * 2009-05-14 2014-03-11 The Regents Of The University Of Michigan Streptococcus vaccine compositions and methods of using the same
JP2013500974A (ja) 2009-07-28 2013-01-10 アナコール ファーマシューティカルズ，インコーポレイテッド 三置換ホウ素含有分子
AP4039A (en) 2009-08-14 2017-02-28 Daitao Chen Boron-containing small molecules as antiprotozoal agents
WO2011019616A1 (en) 2009-08-14 2011-02-17 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
WO2011019612A1 (en) 2009-08-14 2011-02-17 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
MX2012002031A (es) * 2009-08-19 2012-07-04 Anacor Pharmaceuticals Inc Moleculas pequeñas que contienen boro como agentes antiprotozoarios.
US20110124597A1 (en) * 2009-09-25 2011-05-26 Anacor Pharmaceuticals, Inc. Boron containing small molecules
US8979820B2 (en) 2009-10-09 2015-03-17 Cynthia S. Bailey Method and apparatus for improving the appearance of nails affected by onychomycosis through the topical application of an aqueous solution containing boric acid and camphor or other terpenes
US9346834B2 (en) 2009-10-20 2016-05-24 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as antiprotozoal agents
WO2011060199A1 (en) * 2009-11-11 2011-05-19 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2011094450A1 (en) 2010-01-27 2011-08-04 Anacor Pharmaceuticals, Inc Boron-containing small molecules
WO2011116348A1 (en) 2010-03-19 2011-09-22 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-protozoal agent
AU2011237681B2 (en) * 2010-04-07 2015-01-22 Glaxosmithkline Llc Process for preparing benzoxaboroles
SMT202100643T1 (it) 2010-09-07 2022-01-10 Anacor Pharmaceuticals Inc Derivati del benzossaborolo per il trattamento delle infezioni batteriche
WO2013025975A1 (en) * 2011-08-17 2013-02-21 Glaxosmithkline Llc Combination treatments for hepatitis c
US9162999B2 (en) 2011-09-28 2015-10-20 Wisconsin Alumni Research Foundation Catalytic conversion of cellulose to fuels and chemicals using boronic acids
AR088669A1 (es) 2011-11-21 2014-06-25 Lilly Co Eli Derivados de dihidrodibenzo[c][1,2]oxaborol y dihidroisoxazol utiles para el control de ectoparasitos
AR088668A1 (es) 2011-11-21 2014-06-25 Lilly Co Eli Moleculas pequeñas que contienen boro
JP6031122B2 (ja) * 2011-12-22 2016-11-24 ミクウルク ファーマシューティカルズ，インコーポレイテッド 抗微生物療法のための三環式ホウ素化合物
US20150080342A1 (en) * 2012-04-14 2015-03-19 Anacor Pharmaceuticals, Inc. Benzoxaborole compounds and uses thereof
US9585396B2 (en) 2013-01-30 2017-03-07 Agrofresh Inc. Volatile applications against pathogens
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
US8669207B1 (en) 2013-01-30 2014-03-11 Dow Agrosciences, Llc. Compounds and compositions
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
EP2950644B1 (en) 2013-01-30 2017-07-19 AgroFresh Inc. Use of benzoxaboroles as volatile antimicrobial agents on meats, plants, or plant parts
US9452173B2 (en) 2013-01-31 2016-09-27 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US8778365B1 (en) 2013-01-31 2014-07-15 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US9433680B2 (en) 2013-01-31 2016-09-06 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US9446131B2 (en) 2013-01-31 2016-09-20 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US9598443B2 (en) 2013-02-01 2017-03-21 Anacor Pharmaceuticals, Inc. Boron containing small molecules as antiprotozoal agents
AU2014202928B1 (en) * 2013-06-05 2014-09-11 Agrofresh Inc. Compounds and compositions
KR101636431B1 (ko) 2013-07-30 2016-07-05 동아에스티 주식회사 트리사이클릭 벤즈옥사보롤 화합물, 이의 제조방법 및 용도
WO2015021396A2 (en) * 2013-08-09 2015-02-12 Glaxosmithkline Intellectual Property (No.2) Limited Tricyclic benzoxaborole compounds and uses thereof
EA038093B1 (ru) * 2013-12-20 2021-07-05 Глаксосмитклайн Интеллекчуал Проперти (№2) Лимитед Способ лечения заболевания, вызванного инфекцией комплекса mycobacterium tuberculosis, с использованием (s)-(3-хлор-7,8-дигидро-2h-1,6,9-триокса-9a-борабензо[cd]азулен-2-ил)метанамина или его фармацевтически приемлемой соли
US10040806B2 (en) * 2014-02-17 2018-08-07 Syngenta Participations Ag Microbiocidally active benzoxaboroles
ES2732465T3 (es) * 2014-07-01 2019-11-22 Daiichi Sankyo Co Ltd Benzoxaboroles tricíclicos como agentes antibacterianos
US9738664B2 (en) * 2014-10-29 2017-08-22 Wisconsin Alumni Research Foundation Boronic acid inhibitors of HIV protease
MA41495A (fr) 2015-02-12 2017-12-19 Anacor Pharmaceuticals Inc Composés benzoxaborole et leurs utilisations
BR112017021478B1 (pt) 2015-04-09 2022-04-19 The Penn State Research Foundation Composição antifúngica sinérgica que contém benzoxaborol
WO2017024022A1 (en) * 2015-08-06 2017-02-09 The Penn State Research Foundation Benzoxaborole-containing coating resistant to cellulose-supportable fungus
US10874679B2 (en) 2016-03-02 2020-12-29 Bill & Melinda Gates Foundation Boron-containing small molecules
WO2017151489A1 (en) 2016-03-02 2017-09-08 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
WO2017151492A1 (en) 2016-03-02 2017-09-08 Anacor Pharmaceuticals, Inc. Boron-containing small molecules
EP3426029B1 (en) 2016-03-07 2023-08-30 AgroFresh Inc. Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
UA120999C2 (uk) 2016-05-12 2020-03-10 Анакор Фармасутікалз, Інк. Естери оксаборолу та їх використання
MA52337A (fr) 2017-03-01 2021-03-03 Anacor Pharmaceuticals Inc Nouveaux analogues d'oxaborole et utilisations de ces derniers
CN107090000B (zh) * 2017-04-27 2019-07-12 上海交通大学 一种苯并硼唑7位脂肪酸的衍生物及其制备与用途
CA3067372A1 (en) * 2017-06-13 2018-12-20 Veterinary Diagnostics Institute, Inc. System and procedure for stabilizing, storing and recovering blood samples
CA3120976A1 (en) * 2017-11-30 2019-06-06 Boragen, Inc. Benzoxaborole compounds and formulations thereof
CA3120974A1 (en) * 2017-11-30 2019-06-06 Boragen, Inc. Combinatorial compositions of benzoxaboroles and biologic agents
MX2021001904A (es) 2018-08-18 2021-05-27 Boragen Inc Formas solidas de benzoxaborol sustituido y composiciones de las mismas.
AR116305A1 (es) * 2018-09-07 2021-04-21 Boragen Inc Compuestos que contienen boro y sus usos
US11058695B2 (en) * 2019-11-08 2021-07-13 Myongji University Industry And Academia Cooperation Foundation Inhibitor of carbapenem-hydrolyzing class D beta-lactamases
US20230340530A1 (en) 2020-08-31 2023-10-26 Pfizer Inc. Methods of Protecting RNA
JP2025520237A (ja) * 2022-06-23 2025-07-03 ミクウルク ファーマシューティカルズ， インコーポレイテッド ホウ素化合物を用いて非結核性マイコバクテリア感染症を治療する方法及びその用途、並びに同じ疾患を治療するための医薬組成物
CA3239097A1 (en) * 2022-06-23 2023-12-28 Shanghai Micurx Pharmaceutical Co., Ltd. Prodrugs of boron compounds and their use in treating bacterial infections
US12482208B2 (en) 2023-05-30 2025-11-25 Snap Inc. Mirroring 3D assets for virtual experiences

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1829521A (zh) * 2003-06-16 2006-09-06 安纳考尔医药公司 耐水解的含硼治疗剂和使用方法
US20060234981A1 (en) * 2005-02-16 2006-10-19 Anacor Pharmaceuticals Boron-containing small molecules

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2260336A (en) * 1939-10-16 1941-10-28 Dow Chemical Co Method of preparation of organic borates
GB1396904A (en) 1972-08-11 1975-06-11 Ici Ltd Method for the control of micro-organisms
US5962498A (en) * 1986-06-11 1999-10-05 Procyon Pharmaceuticals, Inc. Protein kinase C modulators. C. indolactam structural-types with anti-inflammatory activity
US4919934A (en) 1989-03-02 1990-04-24 Richardson-Vicks Inc. Cosmetic sticks
US5594151A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexing reagents derived from aminosalicylic acid
GB9411587D0 (en) 1994-06-09 1994-08-03 Zeneca Ltd Compound, composition and use
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US5831046A (en) * 1996-08-05 1998-11-03 Prolinx, Incorporated Boronic acid-contaning nucleic acid monomers
US6306628B1 (en) * 1999-08-25 2001-10-23 Ambergen, Incorporated Methods for the detection, analysis and isolation of Nascent proteins
AU7995300A (en) * 1999-10-05 2001-05-10 Bethesda Pharmaceuticals, Inc. Dithiolane derivatives
CA2415938A1 (en) * 2000-07-14 2002-01-24 Zycos Inc. Alpha-msh related compounds and methods of use
US6537733B2 (en) * 2001-02-23 2003-03-25 Applied Materials, Inc. Method of depositing low dielectric constant silicon carbide layers
GB0117645D0 (en) * 2001-07-19 2001-09-12 Isis Innovation Therapeutic stratergies for prevention and treatment of alzheimers disease
DE10143979A1 (de) 2001-09-07 2003-03-27 Clariant Gmbh Verfahren zur Herstellung von Bisallylboranen und nicht-aromatischen Boronsäuren
WO2003033002A1 (en) * 2001-10-11 2003-04-24 Ono Pharmaceutical Co Intracellular calcium concentration increase inhibitors
CA2473238A1 (en) 2002-01-10 2003-07-24 The Penn State Research Foundation Methods for the preparation of alkyl diaryl borinates and complexed diarylboronic acids
ZA200408711B (en) * 2002-05-28 2006-10-25 Dimensional Pharamaceuticals I Novel thiophene amidines, composition thereof, and methods of treating complement-mediated diseases and conditions
DK1755661T3 (da) * 2004-05-12 2014-06-16 Brigham & Womens Hospital Gelsolin til anvendelse til behandling af infektioner
BRPI0621279B1 (pt) * 2005-12-30 2021-07-20 Anacor Pharmaceuticals, Inc Moléculas pequenas contendo boro
CA2642583C (en) * 2006-02-16 2016-08-23 Anacor Pharmaceuticals, Inc. Boron-containing small molecules as anti-inflammatory agents
US20070286822A1 (en) * 2006-06-12 2007-12-13 Anacor Pharmaceuticals Inc. Compounds for the Treatment of Periodontal Disease
WO2007146965A2 (en) * 2006-06-12 2007-12-21 Anacor Pharmaceuticals, Inc. Compounds for the treatment of periodontal disease
DE102006038471A1 (de) 2006-08-17 2008-04-10 Wala-Heilmittel Gmbh Platanencreme, Verfahren zu ihrer Herstellung und Verwendung
JO3396B1 (ar) * 2007-06-20 2019-10-20 Anacor Pharmaceuticals Inc جزيئات صغيرة تحتوي على البورون
EP2285384A4 (en) * 2008-05-12 2012-04-25 Anacor Pharmaceuticals Inc BORN SMALL MOLECULES

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1829521A (zh) * 2003-06-16 2006-09-06 安纳考尔医药公司 耐水解的含硼治疗剂和使用方法
US20060234981A1 (en) * 2005-02-16 2006-10-19 Anacor Pharmaceuticals Boron-containing small molecules

Also Published As

Publication number Publication date
DK2164331T3 (da) 2018-01-29
KR20100051615A (ko) 2010-05-17
BRPI0813450B1 (pt) 2019-05-07
UY31171A1 (es) 2009-04-30
WO2008157726A1 (en) 2008-12-24
BRPI0813450B8 (pt) 2021-05-25
US8895534B2 (en) 2014-11-25
EA200901617A1 (ru) 2010-06-30
CR11224A (es) 2010-06-28
EP2164331A4 (en) 2011-09-07
EA020530B1 (ru) 2014-11-28
CO6251209A2 (es) 2011-02-21
KR20160049025A (ko) 2016-05-04
US20090227541A1 (en) 2009-09-10
MY162692A (en) 2017-07-14
SG182219A1 (en) 2012-07-30
IL202379A (en) 2016-02-29
JP2016040275A (ja) 2016-03-24
KR20150100945A (ko) 2015-09-02
EP2164331A1 (en) 2010-03-24
DOP2009000281A (es) 2010-07-31
JP2014148531A (ja) 2014-08-21
BRPI0813450A2 (pt) 2014-12-30
AU2008265630B2 (en) 2013-06-20
CN104017008A (zh) 2014-09-03
ES2655299T3 (es) 2018-02-19
KR101685656B1 (ko) 2016-12-12
CA2692135C (en) 2017-01-24
CA2692135A1 (en) 2008-12-24
ZA201104573B (en) 2014-03-26
US10533021B2 (en) 2020-01-14
NZ582706A (en) 2012-07-27
US20150133402A1 (en) 2015-05-14
JP2010530881A (ja) 2010-09-16
CL2008001855A1 (es) 2009-05-29
JP5530923B2 (ja) 2014-06-25
AR067105A1 (es) 2009-09-30
MX347688B (es) 2017-05-09
ZA200909003B (en) 2022-03-30
NO2164331T3 (enExample) 2018-04-28
EP2164331B1 (en) 2017-11-29
AU2008265630A1 (en) 2008-12-24
IL202379A0 (en) 2010-06-30
MA31675B1 (fr) 2010-09-01
US20100292504A1 (en) 2010-11-18
JO3396B1 (ar) 2019-10-20
TW200911822A (en) 2009-03-16
US7816344B2 (en) 2010-10-19
KR101578351B1 (ko) 2015-12-17
US9796735B2 (en) 2017-10-24
CN101772302A (zh) 2010-07-07
PE20090840A1 (es) 2009-07-08
US20180016285A1 (en) 2018-01-18
JP6570391B2 (ja) 2019-09-04

Similar Documents

Publication Publication Date Title
CN101772302B (zh) 含硼小分子
JP6491294B2 (ja) 細菌感染治療用のベンゾオキサボロール誘導体
US20100256092A1 (en) Boron-containing small molecules
HK1141681A (en) Boron-containing small molecules
HK1141681B (en) Boron-containing small molecules
HK1247841B (en) Benzoxaborole derivatives for treating bacterial infections

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CP03 Change of name, title or address
CP03 Change of name, title or address

Address after: USA New York

Patentee after: Anakol Pharmaceutical Co.,Ltd.

Country or region after: U.S.A.

Address before: California, USA

Patentee before: Anacor Pharmaceuticals, Inc.

Country or region before: U.S.A.