CN101757253B - 含格列喹酮的中西药组合物 - Google Patents
含格列喹酮的中西药组合物 Download PDFInfo
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- CN101757253B CN101757253B CN201010131333XA CN201010131333A CN101757253B CN 101757253 B CN101757253 B CN 101757253B CN 201010131333X A CN201010131333X A CN 201010131333XA CN 201010131333 A CN201010131333 A CN 201010131333A CN 101757253 B CN101757253 B CN 101757253B
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- CN
- China
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- chinese medicine
- gliquidone
- diabetes
- traditional chinese
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- 239000003814 drug Substances 0.000 title claims abstract description 27
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- LLJFMFZYVVLQKT-UHFFFAOYSA-N 1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-2-isoquinolinyl)ethyl]phenyl]sulfonylurea Chemical compound C=1C(OC)=CC=C(C(C2=O)(C)C)C=1C(=O)N2CCC(C=C1)=CC=C1S(=O)(=O)NC(=O)NC1CCCCC1 LLJFMFZYVVLQKT-UHFFFAOYSA-N 0.000 title claims abstract description 13
- 229960003468 gliquidone Drugs 0.000 title claims abstract description 10
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 15
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 8
- 229940079593 drug Drugs 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 102000004877 Insulin Human genes 0.000 description 4
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- 229940125396 insulin Drugs 0.000 description 4
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- 150000004283 biguanides Chemical class 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- WVAKABMNNSMCDK-UHFFFAOYSA-N sulfacarbamide Chemical compound NC(=O)NS(=O)(=O)C1=CC=C(N)C=C1 WVAKABMNNSMCDK-UHFFFAOYSA-N 0.000 description 2
- 229950010053 sulfacarbamide Drugs 0.000 description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 2
- 201000010000 Agranulocytosis Diseases 0.000 description 1
- 244000307697 Agrimonia eupatoria Species 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
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- 206010018687 Granulocytopenia Diseases 0.000 description 1
- 206010020660 Hyperlactacidaemia Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
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- 208000022329 Protein metabolism disease Diseases 0.000 description 1
- 244000179560 Prunella vulgaris Species 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 229940100389 Sulfonylurea Drugs 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
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- 230000002079 cooperative effect Effects 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
- 229940000351 hemocyte Drugs 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 208000006443 lactic acidosis Diseases 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 206010062198 microangiopathy Diseases 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
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- 230000035945 sensitivity Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010131333XA CN101757253B (zh) | 2010-03-24 | 2010-03-24 | 含格列喹酮的中西药组合物 |
Applications Claiming Priority (1)
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CN201010131333XA CN101757253B (zh) | 2010-03-24 | 2010-03-24 | 含格列喹酮的中西药组合物 |
Publications (2)
Publication Number | Publication Date |
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CN101757253A CN101757253A (zh) | 2010-06-30 |
CN101757253B true CN101757253B (zh) | 2011-09-21 |
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CN201010131333XA Expired - Fee Related CN101757253B (zh) | 2010-03-24 | 2010-03-24 | 含格列喹酮的中西药组合物 |
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Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105796952A (zh) * | 2016-03-27 | 2016-07-27 | 济南邦文医药科技有限公司 | 一种含有格列喹酮的治疗糖尿病的药物组合物及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1077642A (zh) * | 1993-02-18 | 1993-10-27 | 广东省石龙华南制药厂 | 治疗糖尿病的中药组方、制剂及其制备方法 |
-
2010
- 2010-03-24 CN CN201010131333XA patent/CN101757253B/zh not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1077642A (zh) * | 1993-02-18 | 1993-10-27 | 广东省石龙华南制药厂 | 治疗糖尿病的中药组方、制剂及其制备方法 |
Non-Patent Citations (1)
Title |
---|
王英珍等.糖尿病研究进展.《山东中医杂志》.1994,第13卷(第10期),476-478. * |
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Publication number | Publication date |
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CN101757253A (zh) | 2010-06-30 |
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Effective date of registration: 20140611 Address after: 226600 No. 8 Yingbin Road, Haian County, Nantong, Jiangsu Patentee after: Haian Changzhou University Technology Transfer Center Co., Ltd. Address before: 226000 No. 8 Yingbin Road, Haian County, Jiangsu, Nantong Patentee before: Nantong Huake Intellectual Property Service Co.,Ltd. |
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