CN101721646B - Medicine composition for treating deficiency of kidney-yang and preparation method thereof - Google Patents
Medicine composition for treating deficiency of kidney-yang and preparation method thereof Download PDFInfo
- Publication number
- CN101721646B CN101721646B CN2008102245046A CN200810224504A CN101721646B CN 101721646 B CN101721646 B CN 101721646B CN 2008102245046 A CN2008102245046 A CN 2008102245046A CN 200810224504 A CN200810224504 A CN 200810224504A CN 101721646 B CN101721646 B CN 101721646B
- Authority
- CN
- China
- Prior art keywords
- ethanol
- pharmaceutical composition
- days
- solution
- standby
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a medicine composition for treating the deficiency of the kidney-yang and a preparation method thereof. The medicine composition takes antler, tokay, herba epimedii, silkworm moth, songaria cynomorium and the like as raw materials. The preparation method of the composition comprises the following steps: percolating silkworm king by ethanol, refluxing by the ethanol, leaching by the ethanol and recovering liquid obtained by the three steps for later use; adding water into the eleven medicines of medlar, desertliving cistanche, herba epimedii, prepared rehmannia root and the like, decocting, taking decoction, precipitating by the ethanol after concentrating, and taking supernatant liquid for later use after filtering; adding the ethanol into the antler, the tokay, dogwood, stinkbug, curculigo orchioides and the like, sealing, steeping and taking liquor for later use; and after mixing the raw liquid of the obtained liquor evenly, recovering the ethanol, concentrating, drying, pulverizing and then mixing with distilled water and honey according to a certain proportion evenly so as to obtain the composition. The invention has the obvious effects of tonifying the kidney and strengthening yang, has moderate price, quick acting, lasting time, small toxic or side effect, simple process, low cost and low energy consumption and is suitable for industrialized production.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly a kind of drug regimen medicine for the treatment of insufficiency of kidney-YANG and preparation method thereof.
Background technology
Impotence and premature ejaculation is a kind of common male sexual dysfunction disease, World Health Organization's updated statistics shows, there is male sexual disorder patient nearly 5.1 hundred million every year in the whole world, only China just has more than 6,000 ten thousand, just have a male to be subjected to the torment of sexual dysfunction in average per 10 families of China, impotence and premature ejaculation has become a social problem that has a strong impact on male body health.Sexual impotence claims ED (ErectileDsyfunction), be divided into functional and organic two kinds, add up according to data from abroad, impotence patient accounts for the 37%-42% of whole male sexual disorder, the incidence rate of sexual impotence rises with the growth at age, the male in the time of 65 years old-70 years old sexual impotence enter the peak period.
Premature ejaculation is one of performance of male sexual disorder, if premature ejaculation can not in time be treated the sexual impotence that then easily causes of a specified duration.The whole world has all ages and classes section male of 27%-34% to have premature ejaculation symptom in various degree approximately at present.Quite a few people sexual impotence occurs owing to long-term premature ejaculation causes.
For a long time, the treatment of male sexual disorder is based on western medicine and medical practitioners, and the kidney invigorating and YANG supporting product of emerge in multitude on the market, mostly contain just like national forbidden amphetamines such as " viagra powder, hormone, chemical hormones ", though the clothes back can be for the moment excited, but overdraw physical ability, to this weak kidney as making the matter worse, with energy approach exhaustion in the body, will cause forfeiture or the depletion of kidney to anti-depressant dependence or function, consequence is more serious, and is huge to the health toxic and side effects, grievous injury self renal function causes sexual function to completely lose.
Present China Chinese medicine strengthening yang and invigorating kidney medicament research and development ground zero, preparation is based on pill and capsule, and the oral liquid kind is fewer.Chinese medicine preparation be subjected to expert and patient's favorable comment, but the preparation technology of some drugs is low, costs an arm and a leg because evident in efficacy and low toxic and side effects, limited its clinically widely-used.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition for the treatment of insufficiency of kidney-YANG; Another object of the present invention is to provide a kind of preparation of drug combination method for the treatment of insufficiency of kidney-YANG.
Pharmaceutical composition crude drug of the present invention consists of:
Pharmaceutical composition crude drug composition of the present invention is preferably:
Pharmaceutical composition crude drug of the present invention is formed and can also be preferably:
Pharmaceutical composition crude drug of the present invention is formed and can also be preferably:
Get the above-mentioned raw materials medicine, add conventional adjuvant, according to common process, make tablet, capsule, powder, soft capsule, drop pill, honeyed pill, pill, granule, soft extract with bee honey agent, slow releasing preparation, quick releasing formulation, controlled release preparation, oral liquid, lyophilized injectable powder or ejection preparation.
Preparation of pharmaceutical compositions method of the present invention comprises the steps:
A, to 400～600 weight portion Bombycis moris with 20～90% ethanol percolation, solution A; 200～300 weight portion Bombycis moris with 10～80% alcohol refluxs, are got solution B; To 400～600 weight portion Bombycis moris with 60～70% ethanol lixiviate, solution C, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back ethanol precipitation, make to contain alcohol amount and reach 20～80%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 70～80% ethanol sealing dipping 13～15 days, preceding 6～8 days, stir every day 1～3 time, back 6～8 days, stir every other day 1～2 time, squeeze medicinal residues after 13～15 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 40～50 ℃ of oven dry 10～30min, pulverize medicated powder, sieve and weigh;
E, get above-mentioned medicated powder 0.3～0.4 weight portion, distilled water 5～15 parts by volume, Lac regis apis 3～5 parts by volume, mixing, pharmaceutical composition of the present invention.
Preparation of pharmaceutical compositions method of the present invention is preferably as follows step:
A, to the Bombycis mori of 514 weight portions with 50% ethanol percolation, solution A; The Bombycis mori of 257 weight portions is used 50% alcohol reflux, get solution B; To the Bombycis mori of 514 weight portions with 65% ethanol lixiviate, solution C, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 50%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 75% ethanol sealing dipping 14 days, and preceding 7 days, stir every day 1 time, back 7 days, stir every other day 1 time, squeeze medicinal residues after 14 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 45 ℃ of oven dry 20min, pulverize medicated powder, sieve and weigh;
E, get above-mentioned medicated powder 0.35 weight portion, distilled water 10 parts by volume, Lac regis apis 4 parts by volume, mixing, pharmaceutical composition of the present invention.
Preparation of pharmaceutical compositions method of the present invention can also be preferably as follows step:
A, to the Bombycis mori of 440 weight portions with 30% ethanol percolation, solution A; The Bombycis mori of 220 weight portions is used 70% alcohol reflux, get solution B; To the Bombycis mori of 440 weight portions with 62% ethanol lixiviate, solution C, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 70%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 72% ethanol sealing dipping 13 days, and preceding 6 days, stir every day 2 times, back 7 days, stir every other day 2 times, squeeze medicinal residues after 13 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 48 ℃ of oven dry 18min, pulverize medicated powder, sieve and weigh;
E, get above-mentioned medicated powder 0.32 weight portion, distilled water 13 parts by volume, Lac regis apis 3 parts by volume, mixing, pharmaceutical composition of the present invention.
Preparation of pharmaceutical compositions method of the present invention can also be preferably as follows step:
A, to the Bombycis mori of 560 weight portions with 70% ethanol percolation, solution A; The Bombycis mori of 280 weight portions is used 30% alcohol reflux, get solution B; To the Bombycis mori of 560 weight portions with 68% ethanol lixiviate, solution C, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 40%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 78% ethanol sealing dipping 15 days, and preceding 7 days, stir every day 1 time, back 8 days, stir every other day 1 time, squeeze medicinal residues after 15 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 42 ℃ of oven dry 28min, pulverize medicated powder, sieve and weigh;
E, get above-mentioned medicated powder 0.38 weight portion, distilled water 8 parts by volume, Lac regis apis 4.5 parts by volume, mixing, pharmaceutical composition of the present invention.
The weight portion in the invention described above pharmaceutical composition and preparation method thereof and the pass of parts by volume are the relation of g/m1.
The present invention is based on Cornu Cervi Pantotrichum, Gecko, Herba Epimedii, Bombycis mori, Herba Cynomorii etc., determined curative effect, and moderate cost, effect is rapidly, the time is lasting, and toxic and side effects is little, and technology of the present invention is simple, with low cost, and energy consumption is low, is applicable to suitability for industrialized production.The present invention has tangible kidney invigorating and YANG supporting effect, can effectively improve aging, the fatigue symptom of the animal model of suffering from a deficiency of the kidney, the content of superoxide dismutase in the secretion of modulability hormone and the serum, the enhancing human body immunity ability, the sexual function improving state enhances metabolism, stimulating appetite; Can strengthen the patient's that suffers from a deficiency of the kidney memory, improve symptoms such as nocturia frequency, the enuresis, the long term effect of its treatment sexual impotence of clinical demonstration is better than viagra, is fit to very much taking for a long time of impotence due to deficiency of the kidney severe patient.
Following experimental example and embodiment are used to further specify but are not limited to the present invention.
Experimental example 1 clinical experiment
Insufficiency of kidney-YANG male patient 60 examples are chosen in this experimental study, with the symptoms of suffering from a deficiency of the kidney such as soreness of the waist and knees, dizziness and blurred vision, spiritlessness and weakness, insomnia forgetfulness, nocturia and sexual impotence in various degree, be divided into two groups at random, every group 30 example, note is made two groups of A, B, the A winding is subjected to (1/time of pharmaceutical composition of the present invention, day twice is oral) treatment, the B winding is subjected to (1/time of viagra, day is once oral) treatment, after treating for 12 weeks, find that A group (pharmaceutical composition of the present invention) the doing well,improving rate of suffering from a deficiency of the kidney is 94.5%, mainly show as full doing well,improving; B group (viagra) the doing well,improving rate of suffering from a deficiency of the kidney is 67.5%, mainly shows as the improvement of sexual impotence and insomnia forgetfulness symptom.As seen, with respect to viagra, pharmaceutical composition of the present invention is except can treating sexual impotence, to the improvement of other symptoms of suffering from a deficiency of the kidney also clearly.
After treatment finishes, 60 routine insufficiency of kidney-YANG patients were followed up a case by regular visits to for 12 weeks, and the bounce-back rate after B group (viagra) treatment is 42%, and the bounce-back rate after A group (pharmaceutical composition of the present invention) treatment is 3.5%, as seen relatively and viagra, the effect after the medicine composite for curing drug withdrawal of the present invention is fine.
The clinical experiment report
1, opened the xx man 44 years old.The main suit: sore waist and aching in the waist and the back, premature ejaculation, limbs fatigue, dizziness and blurred vision, through being diagnosed as impotence, take pharmaceutical composition mixture of the present invention continuously after 6 months, transference cure.
2, Liu xx man is 39 years old.The main suit: marry and had no children in 8 years, after be diagnosed as necrospermia, treating 3 months continuously, the sperm routine examination shows that sperm survival volume, density, sum and sperm motility degree have very big improvement.
The pharmacology pharmacodynamic research of the pharmaceutical composition of the present invention that experimental example 2 embodiment 1 method prepares
Get 3 age in week 80 of SD male rats, under constant temperature, raised for 3 weeks before the test.After 3 weeks, be divided into 2 groups at random, every group 40, be designated as A, B group respectively, wherein B group under the empty stomach condition lumbar injection hydrocortisone (25mg/kg body weight) as model group, A group isopyknic distilled water of lumbar injection under the empty stomach condition, reduce bradykinesia, happiness curling oneself up, crowded heap with activity, fur tarnish, lassitude, sexual function are reduced to the modeling success.After the modeling success, two groups of pharmaceutical composition filling stomaches of the present invention that equivalent embodiment 1 method prepares were treated after 3 weeks, found before and after the treatment:
1. pharmaceutical composition of the present invention can strengthen the body constitution of normal rat, improves aging and the frazzle of insufficiency of kidney-YANG rat, and showing as activity increases before the treatment, fur becomes gloss, reaction is sensitive, and sexual function (autonomous copulation) improves, and swimming time in the swimming test and distance increase.
2. pharmaceutical composition of the present invention is less to the sex hormone level influence of normal rat, can regulate the sex hormone level of insufficiency of kidney-YANG rat, shows as the rising of T (40%), T3 (25%), T4 (21%), LH (35%) level.
3. pharmaceutical composition of the present invention can increase the weight of insufficiency of kidney-YANG rat kidney (11%), adrenal gland's (12%) and thymus (18%).
4. pharmaceutical composition of the present invention can increase complement C in the insufficiency of kidney-YANG rat blood
3(21%) and the level of IgM (45%), IgG (38%).
5. pharmaceutical composition of the present invention can increase the content of superoxide dismutase in the insufficiency of kidney-YANG rat blood (23%).
Above-mentioned pharmacodynamics test data shows that pharmaceutical composition of the present invention has tangible kidney invigorating and YANG supporting effect, can effectively improve aging, the fatigue symptom of insufficiency of kidney-YANG animal model, the content of superoxide dismutase in the secretion of modulability hormone and the blood, enhancing body system, sexual function improving state.
The research of experimental example 3 toxicity tests
SD male rat The acute toxicity tests shows that the pharmaceutical composition of the present invention of embodiment 2 methods preparation is irritated stomach, because of measuring LD
50So carried out the mensuration of maximum tolerated dose, pharmaceutical composition of the present invention is 278.5g crude drug/kg to the maximum tolerated dose of rat oral gavage, considerably beyond 100 times of clinical consumption, untoward reaction and death do not take place in animal, and general situation (situations such as two just, breathing, diet, autonomic activities) is good.
SD male rat long term toxicity test is the result show, 15g, 30g, 3 dosage of 45g/kg were irritated stomach 6 months, death and other untoward reaction do not take place in rat, the body weight normal growth, (situation such as two just, breathing, diet, autonomic activities) generally in order, through the hematological examination no abnormality seen, simultaneously the liver of rat, kidney, lung, the heart, spleen, stomach, duodenum, large intestine, brain, adrenal gland, hypophysis, thyroid, thymus, pancreas etc. have been carried out the pathological examination no abnormality seen.
Acute and long term toxicity test studies show that the present invention has no side effect, and takes safety for a long time.
The pharmacological effect experiment of the pharmaceutical composition of the present invention of experimental example 4 embodiment 2 methods preparation
Get 3 age in week 200 of SD male rats, under constant temperature, raised for 3 weeks before the test.After 3 weeks, be divided into 4 groups at random, 40 every group, be designated as five groups of A, B, C, D, E respectively.Wherein B, C, D, E inject hydrocortisone (25mg/kg body weight) as model group for four groups under the empty stomach condition, the A group is injected the equal-volume distilled water as the normal control group at empty stomach condition hypogastric region, reduce with activity, bradykinesia, happiness curling oneself up, crowded heap, fur tarnish, lassitude, sexual function are reduced to the modeling success.After making the film success, two groups of normal saline of A, B are irritated stomach, three groups of C, D, E are respectively (1/day of the pharmaceutical composition of the present invention of embodiment 2 methods preparation, be 70 times of clinical consumption), viagra aqueous solution (50mg/kg body weight/day, be 70 times of clinical consumption) and JINGUI SHENQI WAN aqueous solution (1 ball/sky, be 70 times of clinical consumption) irritate stomach, five groups is that equal-volume solution is irritated stomach.The result is as follows after 3 weeks of treatment:
1. other insufficiency of kidney-YANG symptoms (activity minimizing before and after the treatment, bradykinesia, happiness curling oneself up, crowded heap, the fur tarnish, fear of cold, emaciated physique, lassitude) improvement rate: B group (model group) is 5%, the improvement rate of C group (medicine composite for curing group of the present invention) is 88.5%, and the improvement rate of D group (viagra treatment group) is 25%, and the improvement rate of E group (pieces of Jin ' gui shenqi pill for curing group) is 65%.
2. sexual function reduction symptom (initiatively mating rate) improvement rate: B group (model group) is 8% before and after the treatment, the improvement rate of C group (medicine composite for curing group of the present invention) is 54%, the improvement rate of D group (viagra treatment group) is 37%, and the improvement rate of E group (pieces of Jin ' gui shenqi pill for curing group) is 29%.
3. the improvement situation of swimming test physical ability before and after treating: B group (model group) improvement rate is 8%, the improvement rate of C group (medicine composite for curing group of the present invention) is 62%, the improvement rate of D group (viagra treatment group) is 25%, and the improvement rate of E group (pieces of Jin ' gui shenqi pill for curing group) is 54%.
By above-mentioned experimental result as can be known, pharmaceutical composition of the present invention is improving other insufficiency of kidney-YANG symptoms and is strengthening the Chinese patent medicine JINGUI SHENQI WAN that is better than the classic treatment insufficiency of kidney-YANG aspect the physical ability, because the Western medicine viagra, and toxic and side effects is few, is more suitable for taking for a long time aspect the therapeutic hypofunction.
In sum, pharmaceutical composition of the present invention is a treatment insufficiency of kidney-YANG and insufficiency of kidney-YANG sexual disorder medicine evident in efficacy, is better than classical Chinese medicine and western medicine.
Following embodiment is used to further specify but is not limited to the present invention.
The specific embodiment
Embodiment 1: the preparation of mixture of the present invention
A, to the 514g Bombycis mori with 50% ethanol percolation, solution A; The 257g Bombycis mori is used 50% alcohol reflux, get solution B; To the 514g Bombycis mori with 65% ethanol lixiviate, solution C, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 50%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 75% ethanol sealing dipping 14 days, and preceding 7 days, stir every day 1 time, back 7 days, stir every other day 1 time, squeeze medicinal residues after 14 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 45 ℃ of oven dry 20min, pulverize medicated powder, sieve and weigh;
E, get above-mentioned medicated powder 0.35g, distilled water 10ml, Lac regis apis 4ml, mixing promptly gets mixture of the present invention.
Embodiment 2: the preparation of oral liquid of the present invention
A, to the 440g Bombycis mori with 50% ethanol percolation, solution A; The 220g Bombycis mori is used 50% alcohol reflux, get solution B; To the 440g Bombycis mori with 62% ethanol lixiviate, solution C, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 50%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 75% ethanol sealing dipping 14 days, and preceding 7 days, stir every day 1 time, back 7 days, stir every other day 1 time, squeeze medicinal residues after 14 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 45 ℃ of oven dry 20min, pulverize medicated powder, sieve and weigh;
E, get above-mentioned medicated powder 0.35g, distilled water 10ml, Lac regis apis 4ml mixing, make oral liquid according to conventional method.
Embodiment 3: the preparation of pill of the present invention
A, to the 560g Bombycis mori with 30% ethanol percolation, solution A; The 280g Bombycis mori is used 70% alcohol reflux, get solution B; To the 560g Bombycis mori with 68% ethanol lixiviate, solution C, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 70%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 72% ethanol sealing dipping 13 days, and preceding 6 days, stir every day 2 times, back 7 days, stir every other day 2 times, squeeze medicinal residues after 13 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously with first three step acquisition, concentrate, 48 ℃ of oven dry 18min get medicated powder after the pulverizing, sieve and weigh;
E, get above-mentioned medicated powder 0.32g, distilled water 13ml, Lac regis apis 3ml, mixing is made pill according to conventional method.
Embodiment 4: the preparation of tablet of the present invention
A, to the 514g Bombycis mori with 70% ethanol percolation, solution A; The 257g Bombycis mori is used 30% alcohol reflux, get solution B; To the 514g Bombycis mori with 67% ethanol lixiviate, solution C, above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 40%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 78% ethanol sealing dipping 15 days, and preceding 7 days, stir every day 1 time, back 8 days, stir every other day 1 time, squeeze medicinal residues after 15 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously, concentrate first three step acquisition, 42 ℃ of oven dry 28min, grinding and sieving is weighed;
E, with 0.38g medicated powder: the 8ml distilled water: the ratio mixing of 4.5ml Lac regis apis, make tablet according to conventional method.
Embodiment 5: the capsular preparation of the present invention
A, to the 560g Bombycis mori with 50% ethanol percolation, solution A; The 280g Bombycis mori is used 50% alcohol reflux, get solution B; To the 560g Bombycis mori with 64% ethanol lixiviate, solution C, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 50%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 75% ethanol sealing dipping 14 days, and preceding 7 days, stir every day 1 time, back 7 days, stir every other day 1 time, squeeze medicinal residues after 14 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 45 ℃ of oven dry 20min, pulverize medicated powder, sieve and weigh;
E, get above-mentioned medicated powder 0.35g, distilled water 10ml, Lac regis apis 4ml mixing, make capsule according to conventional method.
Embodiment 6: the preparation of granule of the present invention
A, to the 514g Bombycis mori with 30% ethanol percolation, solution A; The 257g Bombycis mori is used 70% alcohol reflux, get solution B; To the 514g Bombycis mori with 65% ethanol lixiviate, solution C, above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 70%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 72% ethanol sealing dipping 13 days, and preceding 6 days, stir every day 2 times, back 7 days, stir every other day 2 times, squeeze medicinal residues after 13 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 48 ℃ of oven dry 18min, pulverize medicated powder, sieve and weigh;
E, get above-mentioned medicated powder 0.32g, distilled water 13ml, Lac regis apis 3ml mixing after, make granule according to conventional method.
Embodiment 7: the preparation of powder of the present invention
A, to the 560g Bombycis mori with 30% ethanol percolation, solution A; The 280g Bombycis mori is used 70% alcohol reflux, get solution B; To the 560g Bombycis mori with 68% ethanol lixiviate, solution C, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 70%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 72% ethanol sealing dipping 13 days, and preceding 6 days, stir every day 2 times, back 7 days, stir every other day 2 times, squeeze medicinal residues after 13 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 48 ℃ of oven dry 18min, pulverize medicated powder, sieve and weigh;
E, get above-mentioned medicated powder 0.32g, distilled water 13ml, Lac regis apis 3ml mixing after, make powder according to conventional method.
Embodiment 8: the preparation of suppository of the present invention
Get the above-mentioned raw materials medicine,, add conventional adjuvant and make suppository according to common process.
Claims (26)
1. pharmaceutical composition for the treatment of insufficiency of kidney-YANG is characterized in that the crude drug of this pharmaceutical composition consists of:
This pharmaceutical composition is made by following method: A, to 400～600 weight portion Bombycis moris with 20～90% ethanol percolation, solution A; 200～300 weight portion Bombycis moris with 10～80% alcohol refluxs, are got solution B; To 400～600 weight portion Bombycis moris with 65% ethanol lixiviate, solution C, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 20～80%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 70～80% ethanol sealing dipping 13～15 days, preceding 6～8 days, stir every day 1～3 time, back 6～8 days, stir every other day 1～2 time, squeeze medicinal residues after 13～15 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 40～50 ℃ of oven dry 10～30min, pulverize medicated powder, sieve and weigh;
E, get above-mentioned medicated powder 0.3～0.4 weight portion, distilled water 5～15 parts by volume, Lac regis apis 3～5 parts by volume, mixing promptly gets pharmaceutical composition;
Wherein, the pass of weight portion in pharmaceutical composition and preparation method thereof and parts by volume is the relation of g/ml.
2. pharmaceutical composition as claimed in claim 1 is characterized in that the crude drug of this pharmaceutical composition consists of:
3. pharmaceutical composition as claimed in claim 1 is characterized in that the crude drug of this pharmaceutical composition consists of:
4. pharmaceutical composition as claimed in claim 1 is characterized in that the crude drug of this pharmaceutical composition consists of:
5. as the arbitrary described pharmaceutical composition of claim 1-4, it is characterized in that preparing by the following method:
A, to the Bombycis mori of 514 weight portions with 50% ethanol percolation, solution A; The Bombycis mori of 257 weight portions is used 50% alcohol reflux, get solution B; To the Bombycis mori of 514 weight portions with 65% ethanol lixiviate, the solution C body, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 50%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 75% ethanol sealing dipping 14 days, and preceding 7 days, stir every day 1 time, back 7 days, stir every other day 1 time, squeeze medicinal residues after 14 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 45 ℃ of oven dry 20min, pulverize medicated powder, sieve and weigh;
E, get above-mentioned medicated powder 0.35 weight portion, distilled water 10 parts by volume, Lac regis apis 4 parts by volume mixings, pharmaceutical composition.
6. as the arbitrary described pharmaceutical composition of claim 1-4, it is characterized in that preparing by the following method:
A, to the Bombycis mori of 440 weight portions with 30% ethanol percolation, solution A; The Bombycis mori of 220 weight portions is used 70% alcohol reflux, get solution B; To 440 weight portions Bombycis mori with 62% ethanol lixiviate, the solution C body, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 70%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 72% ethanol sealing dipping 13 days, and preceding 6 days, stir every day 2 times, back 7 days, stir every other day 2 times, squeeze medicinal residues after 13 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 48 ℃ of oven dry 18min, pulverize medicated powder, sieve and weigh;
E, get above-mentioned medicated powder 0.32 weight portion, distillation 13 parts by volume water, Lac regis apis 3 parts by volume, mixing, pharmaceutical composition.
7. as the arbitrary described pharmaceutical composition of claim 1-4, it is characterized in that preparing by the following method:
A, to the Bombycis mori of 560 weight portions with 70% ethanol percolation, solution A; The Bombycis mori of 280 weight portions is used 30% alcohol reflux, get solution B; To the Bombycis mori of 560 weight portions with 68% ethanol lixiviate, solution C, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 40%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 78% ethanol sealing dipping 15 days, and preceding 7 days, stir every day 1 time, back 8 days, stir every other day 1 time, squeeze medicinal residues after 15 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 42 ℃ of oven dry 28min, pulverize medicated powder, sieve and weigh;
E, get said medicine 0.38 weight portion, distilled water 8 parts by volume, Lac regis apis 4.5 parts by volume, mixing, pharmaceutical composition.
8. as the arbitrary described pharmaceutical composition of claim 1-4, it is characterized in that getting crude drug, add conventional adjuvant,, make mixture, tablet, capsule, powder, pill, granule, soft extract with bee honey agent or oral liquid according to common process.
9. as the arbitrary described pharmaceutical composition of claim 1-4, it is characterized in that getting crude drug, add conventional adjuvant,, make soft capsule, drop pill or honeyed pill according to common process.
10. as the arbitrary described pharmaceutical composition of claim 1-4, it is characterized in that getting crude drug, add conventional adjuvant,, make controlled release preparation according to common process.
11., it is characterized in that getting crude drug as the arbitrary described pharmaceutical composition of claim 1-4, add conventional adjuvant, according to common process, make slow releasing preparation or quick releasing formulation.
12. a preparation of drug combination method is characterized in that this method is:
The crude drug of this pharmaceutical composition consists of:
Preparation method: A, to 400～600 weight portion Bombycis moris with 20～90% ethanol percolation, solution A; 200～300 weight portion Bombycis moris with 10～80% alcohol refluxs, are got solution B; To 400～600 weight portion Bombycis moris with 65% ethanol lixiviate, solution C, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 20～80%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 70～80% ethanol sealing dipping 13～15 days, preceding 6～8 days, stir every day 1～3 time, back 6～8 days, stir every other day 1～2 time, squeeze medicinal residues after 13～15 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 40～50 ℃ of oven dry 10～30min, pulverize medicated powder, sieve and weigh;
E, get above-mentioned medicated powder 0.3～0.4 weight portion, distilled water 5～15 parts by volume, Lac regis apis 3～5 parts by volume, mixing promptly gets pharmaceutical composition;
Wherein, the pass of weight portion in pharmaceutical composition and preparation method thereof and parts by volume is the relation of g/ml.
13. preparation of drug combination method as claimed in claim 12 is characterized in that the crude drug of this pharmaceutical composition consists of:
14. preparation of drug combination method as claimed in claim 12 is characterized in that the crude drug of this pharmaceutical composition consists of:
15. preparation of drug combination method as claimed in claim 12 is characterized in that the crude drug of this pharmaceutical composition consists of:
16., it is characterized in that this preparation method is as the described preparation of drug combination method of claim 12-15:
A, to the Bombycis mori of 514 weight portions with 50% ethanol percolation, solution A; The Bombycis mori of 257 weight portions is used 50% alcohol reflux, get solution B; To the Bombycis mori of 514 weight portions with 65% ethanol lixiviate, the solution C body, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 50%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 75% ethanol sealing dipping 14 days, and preceding 7 days, stir every day 1 time, back 7 days, stir every other day 1 time, squeeze medicinal residues after 14 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 45 ℃ of oven dry 20min, pulverize medicated powder, sieve and weigh;
E, get above-mentioned medicated powder 0.35 weight portion, distilled water 10 parts by volume, Lac regis apis 4 parts by volume mixings, pharmaceutical composition.
17., it is characterized in that this preparation method is as the described preparation of drug combination method of claim 12-15:
A, to the Bombycis mori of 440 weight portions with 30% ethanol percolation, solution A; The Bombycis mori of 220 weight portions is used 70% alcohol reflux, get solution B; To 440 weight portions Bombycis mori with 62% ethanol lixiviate, the solution C body, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 70%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 72% ethanol sealing dipping 13 days, and preceding 6 days, stir every day 2 times, back 7 days, stir every other day 2 times, squeeze medicinal residues after 13 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 48 ℃ of oven dry 18min, pulverize medicated powder, sieve and weigh;
E, get above-mentioned medicated powder 0.32 weight portion, distillation 13 parts by volume water, Lac regis apis 3 parts by volume, mixing, pharmaceutical composition.
18., it is characterized in that this preparation method is as the described preparation of drug combination method of claim 12-15:
A, to the Bombycis mori of 560 weight portions with 70% ethanol percolation, solution A; The Bombycis mori of 280 weight portions is used 30% alcohol reflux, get solution B; To the Bombycis mori of 560 weight portions with 68% ethanol lixiviate, solution C, reclaim above-mentioned three kinds of solution, mixing is standby;
B, Fructus Lycii, Herba Cistanches, Herba Epimedii, Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, the Radix Astragali, Radix Ginseng, Radix Bupleuri, Semen Allii Tuberosi, Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae ten medicine simply decoct with water, get decoction liquor and concentrate the back and make with ethanol precipitation and contain the alcohol amount and reach 40%, it is standby to get supernatant after the filtration;
C, Cornu Cervi Pantotrichum, Gecko, Fructus Corni, Aspongopus, Rhizoma Curculiginis, Herba Cynomorii, Radix Polygoni Multiflori Preparata, Cortex Cinnamomi, Semen Oroxyli add 78% ethanol sealing dipping 15 days, and preceding 7 days, stir every day 1 time, back 8 days, stir every other day 1 time, squeeze medicinal residues after 15 days, filter, it is standby to take concoction;
Reclaim ethanol behind D, the medicine juice stock solution mix homogeneously that first three step is obtained, concentrate, 42 ℃ of oven dry 28min, pulverize medicated powder, sieve and weigh;
E, get said medicine 0.38 weight portion, distilled water 8 parts by volume, Lac regis apis 4.5 parts by volume, mixing, pharmaceutical composition.
19. as the application of the arbitrary described pharmaceutical composition of claim 1-4 in the medicine of preparation treatment insufficiency of kidney-YANG.
20. the application of pharmaceutical composition as claimed in claim 5 in the medicine of preparation treatment insufficiency of kidney-YANG.
21. the application of pharmaceutical composition as claimed in claim 6 in the medicine of preparation treatment insufficiency of kidney-YANG.
22. the application of pharmaceutical composition as claimed in claim 7 in the medicine of preparation treatment insufficiency of kidney-YANG.
23. pharmaceutical composition as claimed in claim 5 is characterized in that getting crude drug, adds conventional adjuvant, according to common process, makes mixture, tablet, capsule, powder, pill, granule, soft extract with bee honey agent or oral liquid.
24. pharmaceutical composition as claimed in claim 5 is characterized in that getting crude drug, adds conventional adjuvant, according to common process, makes soft capsule, drop pill or honeyed pill.
25. pharmaceutical composition as claimed in claim 5 is characterized in that getting crude drug, adds conventional adjuvant, according to common process, makes controlled release preparation.
26. pharmaceutical composition as claimed in claim 5 is characterized in that getting crude drug, adds conventional adjuvant, according to common process, makes slow releasing preparation or quick releasing formulation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102245046A CN101721646B (en) | 2008-10-17 | 2008-10-17 | Medicine composition for treating deficiency of kidney-yang and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008102245046A CN101721646B (en) | 2008-10-17 | 2008-10-17 | Medicine composition for treating deficiency of kidney-yang and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101721646A CN101721646A (en) | 2010-06-09 |
| CN101721646B true CN101721646B (en) | 2011-12-07 |
Family
ID=42443596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008102245046A Active CN101721646B (en) | 2008-10-17 | 2008-10-17 | Medicine composition for treating deficiency of kidney-yang and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101721646B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103800448B (en) * | 2014-02-20 | 2016-04-13 | 普洱淞茂制药股份有限公司 | A kind of Balanophora dioica R Br ex Royle, Yunnan Radix Polygoni Multiflori Preparata pharmaceutical composition and preparation method thereof, preparation and application |
| CN104146299B (en) * | 2014-07-25 | 2015-08-26 | 临沂大学 | A kind of can the health beverages of develop immunitypty |
| CN105012638B (en) * | 2015-08-18 | 2018-11-16 | 株洲千金药业股份有限公司 | Application of the Chinese medicine composition in the synergist for preparing medicaments for treating sexual disorder |
| CN106177325A (en) * | 2016-07-29 | 2016-12-07 | 中国农业科学院特产研究所 | A kind of instant Cornu Cervi Pantotrichum sheet improving immunity and preparation method thereof |
| CN109820979A (en) * | 2019-03-25 | 2019-05-31 | 黑龙江双兰星制药有限公司 | A kind of pharmaceutical composition and preparation method thereof for treating kidney-yang deficiency |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1076116A (en) * | 1993-01-01 | 1993-09-15 | 梁世栋 | Treatment male sexual disorder medicine and preparation method |
| CN1255361A (en) * | 1999-09-10 | 2000-06-07 | 刘福明 | Multifunctional health-care wine |
-
2008
- 2008-10-17 CN CN2008102245046A patent/CN101721646B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1076116A (en) * | 1993-01-01 | 1993-09-15 | 梁世栋 | Treatment male sexual disorder medicine and preparation method |
| CN1255361A (en) * | 1999-09-10 | 2000-06-07 | 刘福明 | Multifunctional health-care wine |
Non-Patent Citations (1)
| Title |
|---|
| 伍觐麟.近五年来中医药治疗阳痿概述.《湖北中医杂志》.1994,第16卷(第110期),53-55. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101721646A (en) | 2010-06-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106883972B (en) | A herbal wine with kidney invigorating and yang supporting effects | |
| CN102266520B (en) | Traditional Chinese medicine composition for treating diabetes | |
| CN105663607B (en) | Traditional Chinese medicine composition and preparation method and application thereof | |
| CN101721646B (en) | Medicine composition for treating deficiency of kidney-yang and preparation method thereof | |
| CN102293927B (en) | Compound Chinese medicinal preparation with antifatigue and antioxidation effects, and preparation method thereof | |
| CN103223104B (en) | A kind of Chinese medicine composition treating diabetes and preparation method thereof | |
| CN102784292B (en) | Constitution consolidating and life prolonging medicinal preparation and preparation method thereof | |
| CN102526680A (en) | Traditional Chinese medicine composition for treating children autumn diarrhea | |
| CN102302609A (en) | Compound traditional Chinese drug preparation for improving subhealth | |
| CN104083640A (en) | Traditional Chinese medicinal composition for treating diabetes mellitus and preparation method thereof | |
| CN102784230B (en) | Pharmaceutical composition preparation for treating nutritional anemia | |
| CN105664108A (en) | Medical composition for treating climacteric syndrome and preparation thereof | |
| CN112494569A (en) | Traditional Chinese medicine composition for improving immunity and preparation method and application thereof | |
| CN100509019C (en) | Application of Baji capsule in preparing immune enhancement medicament | |
| CN102198251B (en) | Chinese medicinal composition for treating climacteric syndrome and preparation method thereof | |
| CN111388584A (en) | Composition for treating impotence and preparation method thereof | |
| CN101040914B (en) | Chinese traditional medicine compound for treating insafficiencg of kidney-yang and hypogastric blood stasis and its preparation method | |
| CN110420258A (en) | A kind of cherokee rose root extract and its preparation method and application with establishing-Yang | |
| CN109876127A (en) | A kind of blood-nourishing angelica capsules and preparation method thereof | |
| CN104162090B (en) | Pharmaceutical composition and preparation method thereof | |
| CN103751692B (en) | Special invigorating capsule of a kind of Testis et penis callorhini and preparation method thereof | |
| CN103405617B (en) | Chinese medicine composition of a kind of kidney invigorating and YANG supporting and preparation method thereof | |
| CN104491411B (en) | Treat the Chinese medicine composition and its Chinese medicine preparation, preparation method and application of stomach trouble | |
| CN108653526B (en) | Traditional Chinese medicine formula for treating myasthenia gravis | |
| CN1062745C (en) | Shuangshi Zaishengjing oral liquor and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20100609 Assignee: Heilongjiang double star Pharmaceutical Co., Ltd. Assignor: Hou Fengxiang Contract record no.: 2013230001798 Denomination of invention: Medicine composition for treating deficiency of kidney-yang and preparation method thereof Granted publication date: 20111207 License type: Exclusive License Record date: 20130918 |
|
| LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model |