CN101701028A - 一种吲哚苷的制备方法 - Google Patents
一种吲哚苷的制备方法 Download PDFInfo
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- CN101701028A CN101701028A CN200910113500A CN200910113500A CN101701028A CN 101701028 A CN101701028 A CN 101701028A CN 200910113500 A CN200910113500 A CN 200910113500A CN 200910113500 A CN200910113500 A CN 200910113500A CN 101701028 A CN101701028 A CN 101701028A
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- water
- indole glycoside
- ethanol
- indole
- room temperature
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Links
- 229930182470 glycoside Natural products 0.000 title claims abstract description 34
- SIKJAQJRHWYJAI-UHFFFAOYSA-N benzopyrrole Natural products C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title claims abstract description 33
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title claims abstract description 33
- -1 indole glycoside Chemical class 0.000 title claims abstract description 33
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 39
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000012528 membrane Substances 0.000 claims abstract description 18
- 239000000843 powder Substances 0.000 claims abstract description 12
- 239000011347 resin Substances 0.000 claims abstract description 12
- 229920005989 resin Polymers 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 11
- 238000002425 crystallisation Methods 0.000 claims abstract description 9
- 230000008025 crystallization Effects 0.000 claims abstract description 9
- 239000012530 fluid Substances 0.000 claims abstract description 9
- 239000012043 crude product Substances 0.000 claims abstract description 8
- 238000000605 extraction Methods 0.000 claims abstract description 8
- 238000001728 nano-filtration Methods 0.000 claims abstract description 8
- 238000000108 ultra-filtration Methods 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 83
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 51
- 238000010790 dilution Methods 0.000 claims description 12
- 239000012895 dilution Substances 0.000 claims description 12
- 239000000835 fiber Substances 0.000 claims description 11
- 239000013078 crystal Substances 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 9
- 238000010828 elution Methods 0.000 claims description 8
- 230000015572 biosynthetic process Effects 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 239000000243 solution Substances 0.000 claims description 7
- 238000003809 water extraction Methods 0.000 claims description 7
- 239000002131 composite material Substances 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- 239000012141 concentrate Substances 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 7
- 239000002537 cosmetic Substances 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 3
- 239000000047 product Substances 0.000 abstract description 2
- 238000007865 diluting Methods 0.000 abstract 2
- 241000334160 Isatis Species 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 238000005303 weighing Methods 0.000 description 5
- JHFAEUICJHBVHB-UHFFFAOYSA-N 1h-indol-2-ol Chemical class C1=CC=C2NC(O)=CC2=C1 JHFAEUICJHBVHB-UHFFFAOYSA-N 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 235000000177 Indigofera tinctoria Nutrition 0.000 description 3
- 241000334154 Isatis tinctoria Species 0.000 description 3
- 229940097275 indigo Drugs 0.000 description 3
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- XVARCVCWNFACQC-RKQHYHRCSA-N indican Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CNC2=CC=CC=C12 XVARCVCWNFACQC-RKQHYHRCSA-N 0.000 description 2
- 244000144725 Amygdalus communis Species 0.000 description 1
- 235000011437 Amygdalus communis Nutrition 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010014080 Ecchymosis Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 201000000297 Erysipelas Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 208000004044 Hypesthesia Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 208000005647 Mumps Diseases 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000004709 eyebrow Anatomy 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- BXFFHSIDQOFMLE-UHFFFAOYSA-N indoxyl sulfate Natural products C1=CC=C2C(OS(=O)(=O)O)=CNC2=C1 BXFFHSIDQOFMLE-UHFFFAOYSA-N 0.000 description 1
- XVARCVCWNFACQC-UHFFFAOYSA-N indoxyl-beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1=CNC2=CC=CC=C12 XVARCVCWNFACQC-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 208000010805 mumps infectious disease Diseases 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
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CN2009101135005A CN101701028B (zh) | 2009-10-26 | 2009-10-26 | 一种吲哚苷的制备方法 |
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CN2009101135005A CN101701028B (zh) | 2009-10-26 | 2009-10-26 | 一种吲哚苷的制备方法 |
Publications (2)
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CN101701028A true CN101701028A (zh) | 2010-05-05 |
CN101701028B CN101701028B (zh) | 2012-03-14 |
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CN2009101135005A Active CN101701028B (zh) | 2009-10-26 | 2009-10-26 | 一种吲哚苷的制备方法 |
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103429249A (zh) * | 2011-03-14 | 2013-12-04 | 太阳星光齿磨公司 | 用于制造靛蓝植物叶提取物的方法 |
CN104873562A (zh) * | 2015-06-10 | 2015-09-02 | 罗洋 | 一种制备含菘蓝苷的水溶性制剂的方法及其在治疗高原性脱发的应用 |
CN107047567A (zh) * | 2017-05-12 | 2017-08-18 | 青岛金尔农化研制开发有限公司 | 一种应用于酸化土壤的抗病型植物萃取生物农药的制造方法 |
CN109942649A (zh) * | 2019-04-30 | 2019-06-28 | 西安交通大学 | 一种吲哚苷类化合物及其提取分离方法和应用 |
CN111518149A (zh) * | 2020-05-22 | 2020-08-11 | 西安交通大学 | 一种生物碱类化合物、制备方法及应用 |
CN113666974A (zh) * | 2021-09-08 | 2021-11-19 | 常州云卿生物科技有限公司 | 一种靛苷的制备方法 |
CN115819482A (zh) * | 2022-09-20 | 2023-03-21 | 江苏本草新萃生物科技有限公司 | 一种让马蓝叶成为水溶性吲哚苷提取原料的加工方法 |
CN116410242A (zh) * | 2023-05-30 | 2023-07-11 | 中国林业科学研究院林产化学工业研究所 | 一种高吲哚苷含量的马蓝干燥叶及其吲哚苷提取物的制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1891252A (zh) * | 2005-07-04 | 2007-01-10 | 深圳市天一誉医药投资咨询有限公司 | 板蓝根的抗病毒有效部位 |
-
2009
- 2009-10-26 CN CN2009101135005A patent/CN101701028B/zh active Active
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103429249A (zh) * | 2011-03-14 | 2013-12-04 | 太阳星光齿磨公司 | 用于制造靛蓝植物叶提取物的方法 |
CN103429249B (zh) * | 2011-03-14 | 2015-12-23 | 太阳星光齿磨公司 | 用于制造靛蓝植物叶提取物的方法 |
US9700556B2 (en) | 2011-03-14 | 2017-07-11 | Sunstar Inc. | Method for producing indigo-plant leaf extract |
CN104873562A (zh) * | 2015-06-10 | 2015-09-02 | 罗洋 | 一种制备含菘蓝苷的水溶性制剂的方法及其在治疗高原性脱发的应用 |
CN104873562B (zh) * | 2015-06-10 | 2018-08-21 | 罗洋 | 一种制备含菘蓝苷的水溶性制剂的方法及其在治疗高原性脱发的应用 |
CN107047567A (zh) * | 2017-05-12 | 2017-08-18 | 青岛金尔农化研制开发有限公司 | 一种应用于酸化土壤的抗病型植物萃取生物农药的制造方法 |
CN109942649A (zh) * | 2019-04-30 | 2019-06-28 | 西安交通大学 | 一种吲哚苷类化合物及其提取分离方法和应用 |
CN111518149A (zh) * | 2020-05-22 | 2020-08-11 | 西安交通大学 | 一种生物碱类化合物、制备方法及应用 |
CN113666974A (zh) * | 2021-09-08 | 2021-11-19 | 常州云卿生物科技有限公司 | 一种靛苷的制备方法 |
CN115819482A (zh) * | 2022-09-20 | 2023-03-21 | 江苏本草新萃生物科技有限公司 | 一种让马蓝叶成为水溶性吲哚苷提取原料的加工方法 |
CN116410242A (zh) * | 2023-05-30 | 2023-07-11 | 中国林业科学研究院林产化学工业研究所 | 一种高吲哚苷含量的马蓝干燥叶及其吲哚苷提取物的制备方法 |
CN116410242B (zh) * | 2023-05-30 | 2023-08-29 | 中国林业科学研究院林产化学工业研究所 | 一种马蓝干燥叶及其吲哚苷提取物的制备方法 |
Also Published As
Publication number | Publication date |
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CN101701028B (zh) | 2012-03-14 |
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Owner name: OSMEN BIOIOGY COSMETIC CO., LTD. Free format text: FORMER OWNER: AOSIMAN BIO-TECHNOLOGY CO LTD, XINJIANG Effective date: 20100823 |
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Free format text: CORRECT: ADDRESS; FROM: 830011 NO. 188, CHANGSHA ROAD, URUMQI NEW+HIGH ZONE, URUMQI CITY, XINJIANG UYGHUR AUTONOMOUS REGION TO: 830011 NO. 15, CHANGSHA ROAD, URUMQI CITY, XINJIANG |
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Address after: 830026, Xinjiang, Urumqi economic and Technological Development Zone, North Central Road No. 57 Sedum business floor 6 Patentee after: XINJIANG OSMAN BIOLOGICAL RESOURCE CO.,LTD. Address before: 830011 No. 15, Changsha Road, Urumqi, Xinjiang Patentee before: XINJIANG OSMAN BIOLOGICAL RESOURCE CO.,LTD. |
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