CN101688869B - 利用NT-proET-1的诊断和风险分层 - Google Patents

利用NT-proET-1的诊断和风险分层 Download PDF

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Publication number
CN101688869B
CN101688869B CN200880018171.XA CN200880018171A CN101688869B CN 101688869 B CN101688869 B CN 101688869B CN 200880018171 A CN200880018171 A CN 200880018171A CN 101688869 B CN101688869 B CN 101688869B
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China
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patient
patients
proet
cardiac
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CN200880018171.XA
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Chinese (zh)
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CN101688869A (zh
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A·贝格曼
J·施特鲁克
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BRAHMS GmbH
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BRAHMS GmbH
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/5754—Endothelin, vasoactive intestinal contractor [VIC]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/12—Pulmonary diseases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/12—Pulmonary diseases
    • G01N2800/122—Chronic or obstructive airway disorders, e.g. asthma COPD
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
CN200880018171.XA 2007-05-08 2008-05-08 利用NT-proET-1的诊断和风险分层 Expired - Fee Related CN101688869B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410468160.9A CN104374926B (zh) 2007-05-08 2008-05-08 利用NT‑proET‑1的诊断和风险分层

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007021443A DE102007021443A1 (de) 2007-05-08 2007-05-08 Diagnose und Risikostratifizierung mittels NT-proET-1
DE102007021443.1 2007-05-08
PCT/DE2008/000781 WO2008135038A2 (de) 2007-05-08 2008-05-08 Diagnose und risikostratifizierung mittels nt-proet-1

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201410468160.9A Division CN104374926B (zh) 2007-05-08 2008-05-08 利用NT‑proET‑1的诊断和风险分层

Publications (2)

Publication Number Publication Date
CN101688869A CN101688869A (zh) 2010-03-31
CN101688869B true CN101688869B (zh) 2014-09-17

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CN200880018171.XA Expired - Fee Related CN101688869B (zh) 2007-05-08 2008-05-08 利用NT-proET-1的诊断和风险分层
CN201410468160.9A Expired - Fee Related CN104374926B (zh) 2007-05-08 2008-05-08 利用NT‑proET‑1的诊断和风险分层

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Country Link
US (2) US9261516B2 (enExample)
EP (2) EP2306203B1 (enExample)
JP (2) JP5717442B2 (enExample)
CN (2) CN101688869B (enExample)
DE (1) DE102007021443A1 (enExample)
ES (2) ES2388055T3 (enExample)
WO (1) WO2008135038A2 (enExample)

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US8906857B2 (en) * 2005-12-01 2014-12-09 B.R.A.H.M.S. Gmbh Methods for the diagnosis and treatment of critically ill patients with endothelin, endothelin agonists and adrenomedullin antagonists
EP2472258A3 (en) 2006-04-04 2012-11-28 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
DE102006046996A1 (de) * 2006-10-01 2008-04-03 Brahms Aktiengesellschaft Diagnose von Infektionen oder Entzündungserkrankungen der Atemwege und Lunge assoziiert mit Herzinsuffizienz
JP5320294B2 (ja) * 2006-10-26 2013-10-23 ベー．エル．アー．ハー．エム．エス ゲーエムベーハー プロバソプレシンまたはその断片および部分ペプチド、特にコペプチンまたはニューロフィジンｉｉを使用する、急性冠動脈症候群についてのリスク層化
DE102006053442A1 (de) * 2006-11-12 2008-05-15 Brahms Aktiengesellschaft Diagnose und Risikostratifizierung von Infektionen und chronischen Erkrankungen der Atemwege und Lunge mittels proVasopressin, insbesondere Copeptin oder Neurophysin II
DE102006060112A1 (de) 2006-12-20 2008-06-26 Brahms Aktiengesellschaft Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM
DE102007021443A1 (de) * 2007-05-08 2008-11-13 Brahms Aktiengesellschaft Diagnose und Risikostratifizierung mittels NT-proET-1
US9229013B2 (en) * 2009-05-05 2016-01-05 B.R.A.H.M.S Gmbh Vasoactive hormone-based stratification of patients suffering from diseases related to endothelial function/dysfunction
AU2010259022B2 (en) 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
WO2012059477A1 (en) * 2010-11-01 2012-05-10 B.R.A.H.M.S Gmbh Prognosis and risk assessment of patients with non-specific complaints
EP2637023A1 (en) * 2012-03-08 2013-09-11 B.R.A.H.M.S GmbH Prediction of outcome in patients with chronic obstructive pulmonary disease
KR101531835B1 (ko) * 2013-10-16 2015-06-29 한국표준과학연구원 화학적 동위원소 치환법을 이용한 혈액 내 뇌성 나트륨 이뇨 펩타이드 질량분석법
CN106370856B (zh) * 2016-08-16 2019-04-02 北京师范大学 肺纤维化的尿液蛋白标志物及其在诊断和预后中的用途
US11446009B2 (en) 2018-12-11 2022-09-20 Eko.Ai Pte. Ltd. Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images
US12322100B2 (en) 2018-12-11 2025-06-03 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity
US12400762B2 (en) 2018-12-11 2025-08-26 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy
US12001939B2 (en) 2018-12-11 2024-06-04 Eko.Ai Pte. Ltd. Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views
US11931207B2 (en) 2018-12-11 2024-03-19 Eko.Ai Pte. Ltd. Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1564558A1 (de) * 2004-02-13 2005-08-17 B.R.A.H.M.S Aktiengesellschaft Verfahren zur Bestimmung der Bildung von Endothelinen zu Zwecken der medizinischen Diagnostik, sowie Antikörper und Kits für die Durchführung eines solchen Verfahrens
CN1950521A (zh) * 2004-04-29 2007-04-18 香港大学 作为诊断、预后和治疗肝细胞癌(hcc)的目标的颗粒体蛋白－内皮素前体(gep)超表达

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JP3519139B2 (ja) * 1993-10-19 2004-04-12 武田薬品工業株式会社 エンドセリン拮抗阻害剤スクリーニング用キット及びスクリーニング方法
DE19847690A1 (de) * 1998-10-15 2000-04-20 Brahms Diagnostica Gmbh Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen
KR20020068262A (ko) * 1999-03-05 2002-08-27 에피제네시스 파마슈티칼스 아이엔씨 타겟 및 경로 유효/무효화 방법
AUPR005600A0 (en) * 2000-09-12 2000-10-05 University Of Sydney, The Diagnostic assay
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
EP2386863A1 (en) * 2002-10-09 2011-11-16 DMI Biosciences, Inc. Diagnosis and monitoring of multiple organ failure
JP2007503393A (ja) * 2003-08-22 2007-02-22 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド Ｃｏｐｄ及び肺高血圧の治療方法
EP1619505B1 (en) * 2004-07-22 2008-04-16 BRAHMS Aktiengesellschaft Method for the diagnosis of critically ill patients
DE102004051847B4 (de) * 2004-10-25 2008-09-18 Dade Behring Marburg Gmbh Verhältnis von PIGF und Flt-1 als prognostischer Parameter bei kardio-vaskulären Erkrankungen
CA2596986A1 (en) * 2005-02-14 2006-08-24 Wyeth Use of il-17f in diagnosis and therapy of airway inflammation
JP2006292623A (ja) * 2005-04-13 2006-10-26 Univ Of Dundee 心不全における突然死のマーカー
UA11822U (en) * 2005-06-21 2006-01-16 L T Malaia Inst Of Therapy Of Method for determining the risk of the development and progressing of chronic obstructive pulmonary disease
WO2007013041A2 (en) * 2005-07-29 2007-02-01 Koninklijke Philips Electronics, N.V. Monitoring of cardiac natriuretic peptides during diagnosis, managment, and treatment of cardiac diseases
DE102006046996A1 (de) * 2006-10-01 2008-04-03 Brahms Aktiengesellschaft Diagnose von Infektionen oder Entzündungserkrankungen der Atemwege und Lunge assoziiert mit Herzinsuffizienz
DE102006060835A1 (de) * 2006-12-22 2008-06-26 Brahms Aktiengesellschaft Diagnose und Risikostratifizierung des akuten Koronarsyndroms mittels CT-proET-1 in Kombination mit NT-proBNP
DE102007021443A1 (de) * 2007-05-08 2008-11-13 Brahms Aktiengesellschaft Diagnose und Risikostratifizierung mittels NT-proET-1

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
EP1564558A1 (de) * 2004-02-13 2005-08-17 B.R.A.H.M.S Aktiengesellschaft Verfahren zur Bestimmung der Bildung von Endothelinen zu Zwecken der medizinischen Diagnostik, sowie Antikörper und Kits für die Durchführung eines solchen Verfahrens
CN1918473A (zh) * 2004-02-13 2007-02-21 B.R.A.H.M.S股份公司 出于医学诊断目的而测定内皮素形成的方法,以及用于实施所述方法的抗体和试剂盒
CN1950521A (zh) * 2004-04-29 2007-04-18 香港大学 作为诊断、预后和治疗肝细胞癌(hcc)的目标的颗粒体蛋白－内皮素前体(gep)超表达

Also Published As

Publication number Publication date
ES2388055T3 (es) 2012-10-08
HK1203089A1 (en) 2015-10-16
US20110039283A1 (en) 2011-02-17
CN101688869A (zh) 2010-03-31
HK1139733A1 (en) 2010-09-24
EP2147316B1 (de) 2013-07-10
JP5932924B2 (ja) 2016-06-08
WO2008135038A3 (de) 2009-02-05
JP2015007653A (ja) 2015-01-15
EP2306203A1 (de) 2011-04-06
JP2010526305A (ja) 2010-07-29
JP5717442B2 (ja) 2015-05-13
EP2306203B1 (de) 2012-07-11
EP2147316A2 (de) 2010-01-27
US9261516B2 (en) 2016-02-16
US20160161505A1 (en) 2016-06-09
WO2008135038A2 (de) 2008-11-13
DE102007021443A1 (de) 2008-11-13
CN104374926B (zh) 2017-05-17
CN104374926A (zh) 2015-02-25
ES2430218T3 (es) 2013-11-19

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