CN101687788A - 取代的吲哚 - Google Patents

取代的吲哚 Download PDF

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Publication number
CN101687788A
CN101687788A CN200780042774A CN200780042774A CN101687788A CN 101687788 A CN101687788 A CN 101687788A CN 200780042774 A CN200780042774 A CN 200780042774A CN 200780042774 A CN200780042774 A CN 200780042774A CN 101687788 A CN101687788 A CN 101687788A
Authority
CN
China
Prior art keywords
compound
deuterium
group
mixture
enantiomorph
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200780042774A
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English (en)
Chinese (zh)
Inventor
T·G·甘特
S·萨沙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Auspex Pharmaceuticals Inc
Original Assignee
Auspex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auspex Pharmaceuticals Inc filed Critical Auspex Pharmaceuticals Inc
Publication of CN101687788A publication Critical patent/CN101687788A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
CN200780042774A 2006-10-19 2007-10-19 取代的吲哚 Pending CN101687788A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85324306P 2006-10-19 2006-10-19
US60/853,243 2006-10-19
PCT/US2007/081977 WO2008049116A2 (en) 2006-10-19 2007-10-19 Substituted indoles

Publications (1)

Publication Number Publication Date
CN101687788A true CN101687788A (zh) 2010-03-31

Family

ID=39192780

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200780042774A Pending CN101687788A (zh) 2006-10-19 2007-10-19 取代的吲哚

Country Status (10)

Country Link
US (1) US20080103189A1 (https=)
EP (1) EP2081893B1 (https=)
JP (1) JP2010507585A (https=)
CN (1) CN101687788A (https=)
AT (1) ATE502921T1 (https=)
AU (1) AU2007310949A1 (https=)
BR (1) BRPI0715579A2 (https=)
CA (1) CA2666149A1 (https=)
DE (1) DE602007013440D1 (https=)
WO (1) WO2008049116A2 (https=)

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CN104829531A (zh) * 2009-10-26 2015-08-12 大塚制药株式会社 苯并氮杂*化合物
CN106397359A (zh) * 2016-08-31 2017-02-15 重庆华森制药股份有限公司 阿莫曲坦中间体4‑（1‑吡咯烷基磺酰甲基)‑苯肼的制备方法
CN108440452A (zh) * 2017-04-05 2018-08-24 嘉兴市第二医院 一种阿莫曲坦的关键中间体1-（4-氨基-苯甲基磺酰基）吡咯烷的制备方法
CN110831551A (zh) * 2017-05-12 2020-02-21 L/N健康与美容有限责任公司 用于指/趾甲矫正的套件
CN115784965A (zh) * 2021-11-22 2023-03-14 宁波大学 一种7-氟-5-取代色胺类化合物及其制备方法和用途

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Cited By (8)

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CN104829531A (zh) * 2009-10-26 2015-08-12 大塚制药株式会社 苯并氮杂*化合物
CN106397359A (zh) * 2016-08-31 2017-02-15 重庆华森制药股份有限公司 阿莫曲坦中间体4‑（1‑吡咯烷基磺酰甲基)‑苯肼的制备方法
CN106397359B (zh) * 2016-08-31 2017-12-05 重庆华森制药股份有限公司 阿莫曲坦中间体4‑(1‑吡咯烷基磺酰甲基)‑苯肼的制备方法
CN108440452A (zh) * 2017-04-05 2018-08-24 嘉兴市第二医院 一种阿莫曲坦的关键中间体1-（4-氨基-苯甲基磺酰基）吡咯烷的制备方法
CN110831551A (zh) * 2017-05-12 2020-02-21 L/N健康与美容有限责任公司 用于指/趾甲矫正的套件
CN110831551B (zh) * 2017-05-12 2022-02-01 L/N健康与美容有限责任公司 用于指/趾甲矫正的套件
CN115784965A (zh) * 2021-11-22 2023-03-14 宁波大学 一种7-氟-5-取代色胺类化合物及其制备方法和用途
WO2023088095A1 (zh) * 2021-11-22 2023-05-25 宁波大学 一种7-氟-5-取代色胺类化合物及其制备方法和用途

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ATE502921T1 (de) 2011-04-15
EP2081893B1 (en) 2011-03-23
WO2008049116A3 (en) 2008-06-05
AU2007310949A1 (en) 2008-04-24
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CA2666149A1 (en) 2008-04-24
JP2010507585A (ja) 2010-03-11

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