CN101679446B - 3,3-螺吲哚满酮衍生物 - Google Patents

3,3-螺吲哚满酮衍生物 Download PDF

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Publication number
CN101679446B
CN101679446B CN2008800164254A CN200880016425A CN101679446B CN 101679446 B CN101679446 B CN 101679446B CN 2008800164254 A CN2008800164254 A CN 2008800164254A CN 200880016425 A CN200880016425 A CN 200880016425A CN 101679446 B CN101679446 B CN 101679446B
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CN
China
Prior art keywords
chloro
phenyl
indoles
diketone
spiral shell
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Expired - Fee Related
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CN2008800164254A
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English (en)
Chinese (zh)
Other versions
CN101679446A (zh
Inventor
刘进军
杰斐逊·赖特·蒂利
张筑明
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of CN101679446A publication Critical patent/CN101679446A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN2008800164254A 2007-05-17 2008-05-06 3,3-螺吲哚满酮衍生物 Expired - Fee Related CN101679446B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93849407P 2007-05-17 2007-05-17
US60/938,494 2007-05-17
PCT/EP2008/055516 WO2008141917A1 (en) 2007-05-17 2008-05-06 3,3-spiroindolinone derivatives

Publications (2)

Publication Number Publication Date
CN101679446A CN101679446A (zh) 2010-03-24
CN101679446B true CN101679446B (zh) 2012-06-27

Family

ID=39645551

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008800164254A Expired - Fee Related CN101679446B (zh) 2007-05-17 2008-05-06 3,3-螺吲哚满酮衍生物

Country Status (16)

Country Link
US (1) US7553833B2 (ja)
EP (1) EP2158205B1 (ja)
JP (1) JP2010527340A (ja)
KR (1) KR101162518B1 (ja)
CN (1) CN101679446B (ja)
AR (1) AR066583A1 (ja)
AT (1) ATE536355T1 (ja)
AU (1) AU2008253154A1 (ja)
BR (1) BRPI0811718A2 (ja)
CA (1) CA2686675A1 (ja)
ES (1) ES2377245T3 (ja)
IL (1) IL201973A0 (ja)
MX (1) MX2009012345A (ja)
PE (1) PE20090279A1 (ja)
TW (1) TW200906832A (ja)
WO (1) WO2008141917A1 (ja)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638548B2 (en) * 2006-11-09 2009-12-29 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US7723372B2 (en) * 2008-03-19 2010-05-25 Hoffman-La Roche Inc. Spiroindolinone derivatives
US20100190814A1 (en) * 2009-01-26 2010-07-29 Li Chen Spiroindolinone derivative prodrugs
US7928233B2 (en) * 2009-02-10 2011-04-19 Hoffmann-La Roche Inc. Spiroindolinone pyridine derivatives
US8217051B2 (en) * 2009-02-17 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US8076482B2 (en) 2009-04-23 2011-12-13 Hoffmann-La Roche Inc. 3,3′-spiroindolinone derivatives
KR20120099462A (ko) * 2009-11-12 2012-09-10 더 리젠츠 오브 더 유니버시티 오브 미시건 스피로-옥신돌 ｍｄｍ2 길항제
US8088815B2 (en) * 2009-12-02 2012-01-03 Hoffman-La Roche Inc. Spiroindolinone pyrrolidines
US8288431B2 (en) * 2010-02-17 2012-10-16 Hoffmann-La Roche Inc. Substituted spiroindolinones
US8217044B2 (en) 2010-04-28 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone pyrrolidines
UY33725A (es) 2010-11-12 2012-06-29 Sanofi Sa Antagonistas de mdm2 de espiro-oxindol
PL2684880T3 (pl) 2011-03-10 2018-07-31 Daiichi Sankyo Company, Limited Pochodna dispiropirolidyny
SG194873A1 (en) 2011-05-11 2013-12-30 Sanofi Sa Spiro-oxindole mdm2 antagonists
TWI586668B (zh) 2012-09-06 2017-06-11 第一三共股份有限公司 二螺吡咯啶衍生物之結晶
WO2014100065A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
CN103992334A (zh) * 2014-05-29 2014-08-20 中国人民解放军第二军医大学 吲哚酮螺四氢硫代吡喃类抗肿瘤衍生物及其制备方法
JP6503386B2 (ja) 2014-07-03 2019-04-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ＭＤＭ２−ｐ５３阻害剤としての新しいスピロ［３Ｈ−インドール−３，２’−ピロリジン］−２（１Ｈ）−オン化合物および誘導体
KR102595395B1 (ko) 2015-02-20 2023-10-27 다이이찌 산쿄 가부시키가이샤 암의 병용 치료법
CN105541716B (zh) 2015-03-26 2024-02-23 Ａｇｃ株式会社 吡唑衍生物的制造方法
CA2982435C (en) 2015-04-13 2020-05-26 Daiichi Sankyo Company, Limited Treatment method by combined use of mdm2 inhibitor and btk inhibitor
CA3000063A1 (en) 2015-10-09 2017-04-13 Boehringer Ingelheim International Gmbh Spiro[3h-indole-3,2'-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors
CA3020281A1 (en) 2016-04-06 2017-10-12 The Regents Of The University Of Michigan Monofunctional intermediates for ligand-dependent target protein degradation
US11192898B2 (en) 2016-04-06 2021-12-07 The Regents Of The University Of Michigan MDM2 protein degraders
WO2017201449A1 (en) 2016-05-20 2017-11-23 Genentech, Inc. Protac antibody conjugates and methods of use
CN109843329A (zh) 2016-10-17 2019-06-04 第一三共株式会社 使用mdm2抑制剂和dna甲基转移酶抑制剂的组合治疗方法
CN107337638A (zh) * 2017-08-14 2017-11-10 侯茜茜 一种吡啶甲酸类食品添加剂的高效合成方法
EP3863720A1 (en) 2018-10-08 2021-08-18 The Regents Of The University Of Michigan Small molecule mdm2 protein degraders
JP2023518423A (ja) 2020-03-19 2023-05-01 カイメラ セラピューティクス， インコーポレイテッド Ｍｄｍ２分解剤およびそれらの使用
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2098212A (en) * 1981-05-12 1982-11-17 Ici Plc Process for preparing 1'-substituted- spiro imidazolidine-4,3'- indoline-2,2',5-triones
EP0947511A1 (en) * 1998-03-30 1999-10-06 F. Hoffmann-La Roche Ag Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY144968A (en) * 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
US20070213341A1 (en) * 2006-03-13 2007-09-13 Li Chen Spiroindolinone derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2098212A (en) * 1981-05-12 1982-11-17 Ici Plc Process for preparing 1'-substituted- spiro imidazolidine-4,3'- indoline-2,2',5-triones
EP0947511A1 (en) * 1998-03-30 1999-10-06 F. Hoffmann-La Roche Ag Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity

Also Published As

Publication number Publication date
AU2008253154A1 (en) 2008-11-27
JP2010527340A (ja) 2010-08-12
BRPI0811718A2 (pt) 2014-11-18
IL201973A0 (en) 2010-06-16
CN101679446A (zh) 2010-03-24
KR101162518B1 (ko) 2012-07-09
EP2158205B1 (en) 2011-12-07
TW200906832A (en) 2009-02-16
US20080287421A1 (en) 2008-11-20
CA2686675A1 (en) 2008-11-27
US7553833B2 (en) 2009-06-30
PE20090279A1 (es) 2009-04-02
AR066583A1 (es) 2009-09-02
ATE536355T1 (de) 2011-12-15
ES2377245T3 (es) 2012-03-23
MX2009012345A (es) 2009-12-01
EP2158205A1 (en) 2010-03-03
KR20090130312A (ko) 2009-12-22
WO2008141917A1 (en) 2008-11-27

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Granted publication date: 20120627

Termination date: 20130506