CN101658600B - Compound Chinese herbal medicinal immunoenhancement for juvenile sea cucumber - Google Patents
Compound Chinese herbal medicinal immunoenhancement for juvenile sea cucumber Download PDFInfo
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- CN101658600B CN101658600B CN2009101874153A CN200910187415A CN101658600B CN 101658600 B CN101658600 B CN 101658600B CN 2009101874153 A CN2009101874153 A CN 2009101874153A CN 200910187415 A CN200910187415 A CN 200910187415A CN 101658600 B CN101658600 B CN 101658600B
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Abstract
The invention discloses a compound Chinese herbal medicinal immunoenhancement for juvenile sea cucumber, which has wide source, low cost, low additive amount and convenient usage, and is particularly suitable for cultivation of juvenile sea cucumber; the immunoenhancement has constituents as follows by weight percentage: 27-33 percent of astragalus mongholicus, 27-33 percent of codonopsis pilosula, 7-13 percent of liquorice, 7-13 percent of Chinese angelica, 4-10 percent of rhizoma alismatis, 4-10 percent of fructus forsythia end 4-10 percent of honeysuckle. The immunoenhancement is used for feeding juvenile sea cucumber for two weeks according to 1.5 percent of mass fraction, non-specific immune function and weight of the juvenile sea cucumber can be obviously improved, and the compound Chinese herbal medicine can be used as the immunoenhancement in cultivating production.
Description
Technical field:
The present invention relates to a kind of used for aquiculture compound Chinese herb immunostimulant, especially a kind of wide material sources, with low cost, addition is little, easy to use, be exclusively used in the compound Chinese herb immunostimulant of Radix Morinae Bulleyanae children ginseng in culturing.
Background technology:
Radix Morinae Bulleyanae is the important economic breed variety of northern China coastal area, breed scale in recent years goes from strength to strength, between a few years, Radix Morinae Bulleyanae has been developed into a kind of output value maximum in China's sea-farming, become the fisherman change the line of production be transferred to civilian work, the important channel of increasing both production and income and promote the leading industry that fishery economic increases.Yet overrun development and the running lack of standardization of breed have caused the disease problem outstanding day by day, the multiple manifest symptom and the extensive phenomena of mortality have occurred, have caused heavy economic loss to vast apostichopus japonicus culture dealer.At present, mainly adopt disinfectant and antibiotics, but a large amount of antibiotic use certainly will cause the appearance of Resistant strain, influences the public environment health simultaneously, even is detrimental to health at the control of these diseases.Therefore, the use of antibiotic in apostichopus japonicus culture will more and more be restricted, and the human quality that improves day by day, safety and health theory will propose higher requirement to Radix Morinae Bulleyanae " healthy aquaculture ".The Chinese herbal medicine immunostimulant can reach the purpose that strengthens resistance against diseases by the immunity that improves body self, and its application in aquatic animal has more report.Yet, both at home and abroad at the report of Radix Morinae Bulleyanae special immune reinforcing agent also seldom, especially also be not exclusively used in the compound Chinese herb immunostimulant that strengthens children's ginseng immunity.
Summary of the invention:
The present invention is in order to solve the above-mentioned technical problem of existing in prior technology, provide a kind of wide material sources, with low cost, addition is little, easy to use, be exclusively used in the compound Chinese herb immunostimulant of Radix Morinae Bulleyanae children ginseng in culturing.
Technical solution of the present invention is: a kind of Radix Morinae Bulleyanae children ginseng is used the compound Chinese herb immunostimulant, it is characterized in that each component and percentage by weight are:
Radix Astragali 27-33%
Radix Codonopsis 27-33%
Radix Glycyrrhizae 7-13%
Radix Angelicae Sinensis 7-13%
Rhizoma Alismatis 4-10%
Fructus Forsythiae 4-10%
Flos Lonicerae 4-10%.
The percentage by weight of each component can be selected in its scope, and the percentage by weight sum is 100%.
The optimum weight percentage ratio of each component is:
The Radix Astragali 30%
Radix Codonopsis 30%
Radix Glycyrrhizae 10%
Radix Angelicae Sinensis 10%
Rhizoma Alismatis 7%
Fructus Forsythiae 7%
Flos Lonicerae 6%.
The present invention is a kind of compound Chinese herb immunostimulant that is specifically designed in the Radix Morinae Bulleyanae children ginseng breeding process, contain the Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Alismatis, Fructus Forsythiae and flos lonicerae composition, through pulverizing and filtering with 100 eye mesh screens, make an addition in the Radix Morinae Bulleyanae children ginseng normal feedstuff, be used to strengthen the nonspecific immunity function of Radix Morinae Bulleyanae children ginseng.The component collocation rationally, also have following advantage simultaneously: (1) raw material when strengthening drug effect, does not have toxicity to Radix Morinae Bulleyanae children ginseng according to the formulation principle of Chinese herbal medicine, have two kinds of attributes of nutrition and medicine concurrently, quite remarkable to the nonspecific immunity factor and the promotion growth result that strengthen Radix Morinae Bulleyanae children ginseng; (2) degradable under field conditions (factors) has no side effect, and physical and chemical factor in the water body is not had influence, can not influence the orthobiosis of Radix Morinae Bulleyanae children ginseng, noresidue in the Radix Morinae Bulleyanae body, and consumer does not have harm to Radix Morinae Bulleyanae; (3) addition is little, and is easy to use; (4) raw materials used steady sources is cheap, and production technology is simple.
The specific embodiment:
Embodiment 1:
Take by weighing the Radix Astragali 27 grams, Radix Codonopsis 27 grams, Radix Glycyrrhizae 13 grams, Radix Angelicae Sinensis 13 grams, Rhizoma Alismatis 8 grams, Fructus Forsythiae 4 grams, Flos Lonicerae 4 grams, after crushed, 100 eye mesh screens filter, and make an addition to the Radix Morinae Bulleyanae children ginseng of throwing something and feeding in the feedstuff with 1.5% mass fraction behind the medicated powder mixing.
Embodiment 2:
Take by weighing the Radix Astragali 30 grams, Radix Codonopsis 30 grams, Radix Glycyrrhizae 10 grams, Radix Angelicae Sinensis 10 grams, Rhizoma Alismatis 7 grams, Fructus Forsythiae 7 grams, Flos Lonicerae 6 grams, after crushed, 100 eye mesh screens filter, and make an addition to the Radix Morinae Bulleyanae children ginseng of throwing something and feeding in the feedstuff with 1.5% mass fraction behind the medicated powder mixing.
Embodiment 3:
Take by weighing the Radix Astragali 33 grams, Radix Codonopsis 33 grams, Radix Glycyrrhizae 7 grams, Radix Angelicae Sinensis 7 grams, Rhizoma Alismatis 4 grams, Fructus Forsythiae 6 grams, Flos Lonicerae 10 grams, after crushed, 100 eye mesh screens filter, and make an addition to the Radix Morinae Bulleyanae children ginseng of throwing something and feeding in the feedstuff with 1.5% mass fraction behind the medicated powder mixing.
Experimental result:
Experiment is carried out in the plastic box of 50 * 35 * 20cm, and each embodiment all establishes three parallel laboratory test groups and 1 matched group (throw something and feed and do not contain the feedstuff of Chinese herbal medicine), every group of 30 Radix Morinae Bulleyanaes children's ginseng (3-5cm).Threw something and fed continuously 14 days, 7 days is 1 course of treatment, respectively in the sampling in 7,14 days of experiment beginning back, measure each embodiment Radix Morinae Bulleyanae and respectively organize the activate the phagocytic capacity of neutral and alkali phosphatase, acid phosphatase, superoxide dismutase, coelomocyte and the weightening finish situation of body weight, after 2 weeks finished, pathogen---the Shiva Salmonella carries out the counteracting toxic substances infection experiment " to change the skin disease " with Radix Morinae Bulleyanae, measures the premunition of each embodiment Radix Morinae Bulleyanae children ginseng.
1,2,3 couples of Radix Morinae Bulleyanae childrens of present embodiment ginseng alkaline phosphatase activities (unit: influence U/g) sees Table 1:
Table 1
As shown in table 1, the Radix Morinae Bulleyanae after embodiment 1,2,3 handles respectively organizes the activity of neutral and alkali phosphatase than matched group obvious rising to be arranged all, and the Radix Morinae Bulleyanae after wherein embodiment 2 handles changes the most obvious.
1,2,3 couples of Radix Morinae Bulleyanae childrens of present embodiment ginseng activity of acid phosphatase (unit: influence U/g) sees Table 2:
Table 2
As shown in table 2, activity of acid phosphatase all has obvious rising than matched group in each tissue of embodiment 1,2,3 processed group Radix Morinae Bulleyanaes, and the rising of embodiment 2 processed group is more obvious, and difference is more remarkable in the time of the 14th day.
1,2,3 couples of Radix Morinae Bulleyanae childrens of present embodiment ginseng superoxide dismutase activity (unit: influence U/mg) sees Table 3:
Table 3
As shown in table 3, embodiment 1,2,3 processed group all have obvious rising than matched group, existing significant change in the time of the 7th day, and embodiment 2 processed group Radix Morinae Bulleyanaes respectively organize the superoxide dismutase activity rising more obvious.
The influence that 1,2,3 couples of Radix Morinae Bulleyanae childrens of present embodiment ginseng coelomocyte is engulfed vigor sees Table 4,5:
Table 4 compound Chinese herb is to the influence of Radix Morinae Bulleyanae children's ginseng coelomocyte phagocytic rate (%)
| Group | The 7th day | The 14th day |
| Matched group | 12 | 11 |
| Embodiment 1 | 22 | 34 |
| Embodiment 2 | 30 | 38 |
| Embodiment 3 | 23 | 36 |
Table 5 compound Chinese herb is to the influence of Radix Morinae Bulleyanae children ginseng coelomocyte phagocytic index
| Group | The 7th day | The 14th day |
| Matched group | 1.15 | 1.13 |
| Embodiment 1 | 1.32 | 1.42 |
| Embodiment 2 | 1.48 | 1.53 |
| Embodiment 3 | 1.35 | 1.49 |
Shown in table 4 and 5, the Radix Morinae Bulleyanae cells in vivo phagocytic rate of embodiment 1,2,3 processed group all has obvious rising than matched group, and the phagocytic rate of example 2 processed group has reached 30% in the time of the 7th day, and its phagocytic index is the highest.
The influence of 1,2,3 pairs of Radix Morinae Bulleyanae children's ginseng growths of present embodiment (average weight gain) sees Table 6:
Table 6 (unit: gram)
| Group | The 7th day | The 14th day |
| Matched group | 0.7 | 1.2 |
| Embodiment 1 | 0.7 | 1.8 |
| Embodiment 2 | 0.8 | 2.4 |
| Embodiment 3 | 0.6 | 1.6 |
As shown in table 6, embodiment 1,2,3 is after throwing something and feeding 7 days, and average weight gain situation and matched group do not have significant change; But after throwing something and feeding 14 days, than embodiment 1,2,3 processed group before 7 days obvious rising has been arranged, wherein the weightening finish of embodiment 2 processed group is more obvious.
The influence of 1,2,3 couples of Radix Morinae Bulleyanae childrens of present embodiment ginseng premunition sees Table 7:
Table 7
| Group | The 1st day | The 2nd day | The 3rd day | The 4th day | The 5th day | The 6th day | The 7th day |
| Matched group | ?60 | ?20 | ?0 | ?0 | ?0 | ?0 | ?0 |
| Embodiment 1 | ?80 | ?70 | ?50 | ?20 | ?20 | ?20 | ?10 |
| Embodiment 2 | ?90 | ?80 | ?30 | ?30 | ?30 | ?30 | ?30 |
| Embodiment 3 | ?90 | ?70 | ?30 | ?30 | ?20 | ?20 | ?10 |
As shown in table 7, with the Radix Morinae Bulleyanae after embodiment 1,2,3 processing, survival rate all raises to some extent than matched group after the Shiva Salmonella infects, and wherein embodiment 2 processed group effects are particularly remarkable, infect that survival rate still can reach 30% after 7 days, and matched group is all dead in 3 days.
Experimental result shows that the present invention is made an addition to the Radix Morinae Bulleyanae children that throws something and feeds in the feedstuff by 1.5% mass fraction joined for two weeks, and experimental result shows the nonspecific immunity function and the body weight that can obviously improve Radix Morinae Bulleyanae children ginseng, can be used as immunostimulant in the breeding production and uses.
Claims (2)
1. a Radix Morinae Bulleyanae children ginseng is used the compound Chinese herb immunostimulant, it is characterized in that each component and percentage by weight are:
Radix Astragali 27-33%
Radix Codonopsis 27-33%
Radix Glycyrrhizae 7-13%
Radix Angelicae Sinensis 7-13%
Rhizoma Alismatis 4-10%
Fructus Forsythiae 4-10%
Flos Lonicerae 4-10%.
2. Radix Morinae Bulleyanae children ginseng according to claim 1 is used the compound Chinese herb immunostimulant, it is characterized in that each component and percentage by weight are:
The Radix Astragali 30%
Radix Codonopsis 30%
Radix Glycyrrhizae 10%
Radix Angelicae Sinensis 10%
Rhizoma Alismatis 7%
Fructus Forsythiae 7%
Flos Lonicerae 6%.
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| CN2009101874153A CN101658600B (en) | 2009-09-17 | 2009-09-17 | Compound Chinese herbal medicinal immunoenhancement for juvenile sea cucumber |
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| CN2009101874153A CN101658600B (en) | 2009-09-17 | 2009-09-17 | Compound Chinese herbal medicinal immunoenhancement for juvenile sea cucumber |
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| CN101658600A CN101658600A (en) | 2010-03-03 |
| CN101658600B true CN101658600B (en) | 2011-12-28 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102715371A (en) * | 2012-06-21 | 2012-10-10 | 大连海洋大学 | Feed additive for improving growth and immunity of Apostichopus japonicus |
| CN102716186A (en) * | 2012-06-21 | 2012-10-10 | 大连海洋大学 | Composite immune enhancer for sea cucumber Chinese herbal medicines |
| CN105168371A (en) * | 2015-09-11 | 2015-12-23 | 江苏振宇环保科技有限公司 | Health-care plaster for treating haemorrhoids |
| CN106309866A (en) * | 2016-09-30 | 2017-01-11 | 威海虹润海洋科技有限公司 | Traditional Chinese medicine preparation for preventing and treating stichopus japonicas mouthpart fester diseases and skin ulcerative diseases and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101406525A (en) * | 2007-10-12 | 2009-04-15 | 天津生机集团有限公司 | Chinese medicine feedstuff additive for immunity enhancement of fowl |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101406525A (en) * | 2007-10-12 | 2009-04-15 | 天津生机集团有限公司 | Chinese medicine feedstuff additive for immunity enhancement of fowl |
Non-Patent Citations (1)
| Title |
|---|
| 孙永欣等.饲喂黄芪和黄芪多糖对刺参生长性能的影响.《中国饲料》.2009,(第4期),31-36. * |
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Granted publication date: 20111228 Termination date: 20120917 |