CN101657441A - 作为pde4抑制剂的吡唑啉酮衍生物 - Google Patents
作为pde4抑制剂的吡唑啉酮衍生物 Download PDFInfo
- Publication number
- CN101657441A CN101657441A CN200880011947A CN200880011947A CN101657441A CN 101657441 A CN101657441 A CN 101657441A CN 200880011947 A CN200880011947 A CN 200880011947A CN 200880011947 A CN200880011947 A CN 200880011947A CN 101657441 A CN101657441 A CN 101657441A
- Authority
- CN
- China
- Prior art keywords
- diketone
- dihydro
- oxo
- piperidines
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4152—1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
Abstract
Description
化合物 | PDE4抑制作用 |
1 | 8.29 |
2 | 8.09 |
3 | 7.75 |
4 | 7.74 |
5 | 7.15 |
6 | 6.84 |
7 | 7.65 |
8 | 8.53 |
9 | 8.23 |
11 | 8.08 |
12 | 7.46 |
13 | 7.79 |
14 | 9.06 |
15 | 7.90 |
16 | 7.48 |
17 | 8.27 |
18 | 8.42 |
19 | 7.48 |
20 | 8.24 |
Claims (17)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310349480.8A CN103463086B (zh) | 2007-05-16 | 2008-05-14 | 作为pde4抑制剂的吡唑啉酮衍生物 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07108314.1 | 2007-05-16 | ||
EP07108314 | 2007-05-16 | ||
PCT/EP2008/055867 WO2008138939A1 (en) | 2007-05-16 | 2008-05-14 | Pyrazolone derivatives as pde4 inhibitors |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310349480.8A Division CN103463086B (zh) | 2007-05-16 | 2008-05-14 | 作为pde4抑制剂的吡唑啉酮衍生物 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101657441A true CN101657441A (zh) | 2010-02-24 |
CN101657441B CN101657441B (zh) | 2013-09-11 |
Family
ID=38179942
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008800119475A Expired - Fee Related CN101657441B (zh) | 2007-05-16 | 2008-05-14 | 作为pde4抑制剂的吡唑啉酮衍生物 |
CN201310349480.8A Expired - Fee Related CN103463086B (zh) | 2007-05-16 | 2008-05-14 | 作为pde4抑制剂的吡唑啉酮衍生物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310349480.8A Expired - Fee Related CN103463086B (zh) | 2007-05-16 | 2008-05-14 | 作为pde4抑制剂的吡唑啉酮衍生物 |
Country Status (31)
Country | Link |
---|---|
US (3) | US8304436B2 (zh) |
EP (3) | EP2148876B1 (zh) |
JP (2) | JP5529010B2 (zh) |
KR (1) | KR101601284B1 (zh) |
CN (2) | CN101657441B (zh) |
AR (1) | AR066576A1 (zh) |
AT (1) | ATE526326T1 (zh) |
AU (1) | AU2008250069B2 (zh) |
BR (1) | BRPI0811214A2 (zh) |
CA (1) | CA2686909C (zh) |
CO (1) | CO6220956A2 (zh) |
CY (1) | CY1112152T1 (zh) |
DK (1) | DK2148876T3 (zh) |
EA (1) | EA018984B1 (zh) |
EC (1) | ECSP099738A (zh) |
ES (2) | ES2374337T3 (zh) |
HK (2) | HK1141017A1 (zh) |
HR (1) | HRP20110940T1 (zh) |
IL (1) | IL201959A (zh) |
ME (1) | ME00952B (zh) |
MX (1) | MX2009012062A (zh) |
MY (1) | MY154498A (zh) |
NZ (1) | NZ581547A (zh) |
PL (1) | PL2148876T3 (zh) |
PT (1) | PT2148876E (zh) |
RS (1) | RS52074B (zh) |
SI (1) | SI2148876T1 (zh) |
TW (2) | TWI460174B (zh) |
UA (1) | UA100019C2 (zh) |
WO (1) | WO2008138939A1 (zh) |
ZA (1) | ZA200906423B (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2374337T3 (es) * | 2007-05-16 | 2012-02-15 | Nycomed Gmbh | Derivados de pirazolona como inhibidores de pde4. |
AR074318A1 (es) * | 2008-11-14 | 2011-01-05 | Nycomed Gmbh | Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias. |
JP5642661B2 (ja) * | 2009-03-05 | 2014-12-17 | 塩野義製薬株式会社 | Npyy5受容体拮抗作用を有するピペリジンおよびピロリジン誘導体 |
WO2011136752A1 (en) * | 2010-04-26 | 2011-11-03 | Mahmut Bilgic | Combined pharmaceutical composition comprising carmoterol and ciclesonide for the treatment of respiratory diseases |
JP5609614B2 (ja) * | 2010-12-15 | 2014-10-22 | 東ソー株式会社 | 新規アリールアミンデンドリマー状化合物、その製造方法およびその用途 |
US10202366B2 (en) | 2013-03-15 | 2019-02-12 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using CRM1 inhibitors |
WO2021245192A1 (en) | 2020-06-04 | 2021-12-09 | Topadur Pharma Ag | Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2903460A (en) | 1956-04-07 | 1959-09-08 | Sandoz Ag | Pyrazolone derivatives |
US4550119A (en) | 1983-05-23 | 1985-10-29 | Warner-Lambert Company | 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones |
IE71647B1 (en) | 1991-01-28 | 1997-02-26 | Rhone Poulenc Rorer Ltd | Benzamide derivatives |
CA2140441C (en) | 1992-07-28 | 2006-11-21 | Garry Fenton | Inhibitors of c-amp phosphodiesterase and tnf |
CZ290266B6 (cs) | 1993-07-02 | 2002-06-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituované benzamidy, způsob jejich výroby a farmaceutické prostředky s jejich obsahem |
US6121274A (en) | 1994-07-22 | 2000-09-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Dihydrobenzofurane |
WO1998031674A1 (en) * | 1997-01-15 | 1998-07-23 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phthalazinones |
US6418201B1 (en) | 2000-02-22 | 2002-07-09 | Intel Corporation | Multiple platform voice processing system with optimized resource allocation |
EA200300836A1 (ru) | 2001-02-15 | 2004-02-26 | Алтана Фарма Аг | Производные фталазинон-пиперидина в качестве ингибиторов pde4 |
KR100551183B1 (ko) | 2001-04-20 | 2006-02-13 | 화이자 프로덕츠 인크. | 1,3-치환 인덴 및 아릴-융합 아자폴리시클릭 화합물의제조 방법 |
CA2445233A1 (en) | 2001-04-25 | 2002-10-31 | Altana Pharma Ag | Phthalazinones derivatives useful as pde4/7 inhibitors |
CA2494650A1 (en) * | 2002-08-10 | 2004-03-04 | Altana Pharma Ag | Pyridazinone-derivatives as pde4 inhibitors |
JP4555684B2 (ja) | 2002-08-10 | 2010-10-06 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | Pde4阻害剤としての、ピロリジンジオンにより置換されたピペリジン−フタラゾン |
AU2003255376A1 (en) | 2002-08-10 | 2004-03-11 | Altana Pharma Ag | Piperidine-derivatives as pde4 inhibitors |
NZ538646A (en) | 2002-08-20 | 2008-03-28 | Biosurface Eng Tech Inc | A synthetic heparin-binding growth factor analog |
CA2537185A1 (en) * | 2003-08-29 | 2005-03-10 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type-iv |
AU2005210042B2 (en) | 2004-02-04 | 2011-04-21 | Takeda Gmbh | 2-(piperidin-4-yl) -4, 5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors |
WO2005075457A1 (en) * | 2004-02-04 | 2005-08-18 | Altana Pharma Ag | Phthalazinone-derivatives as pde4 inhibitors |
JP2006169138A (ja) * | 2004-12-14 | 2006-06-29 | Kyorin Pharmaceut Co Ltd | ピラゾロピリジンピラゾロン誘導体とその付加塩及びpde阻害剤 |
ES2374337T3 (es) * | 2007-05-16 | 2012-02-15 | Nycomed Gmbh | Derivados de pirazolona como inhibidores de pde4. |
-
2008
- 2008-05-14 ES ES08759563T patent/ES2374337T3/es active Active
- 2008-05-14 JP JP2010507909A patent/JP5529010B2/ja not_active Expired - Fee Related
- 2008-05-14 MX MX2009012062A patent/MX2009012062A/es active IP Right Grant
- 2008-05-14 PT PT08759563T patent/PT2148876E/pt unknown
- 2008-05-14 US US12/451,348 patent/US8304436B2/en not_active Expired - Fee Related
- 2008-05-14 CN CN2008800119475A patent/CN101657441B/zh not_active Expired - Fee Related
- 2008-05-14 EA EA200901504A patent/EA018984B1/ru not_active IP Right Cessation
- 2008-05-14 ES ES11182678T patent/ES2427442T3/es active Active
- 2008-05-14 NZ NZ581547A patent/NZ581547A/en not_active IP Right Cessation
- 2008-05-14 UA UAA200912770A patent/UA100019C2/uk unknown
- 2008-05-14 EP EP08759563A patent/EP2148876B1/en active Active
- 2008-05-14 ME MEP-2009-327A patent/ME00952B/me unknown
- 2008-05-14 DK DK08759563.3T patent/DK2148876T3/da active
- 2008-05-14 BR BRPI0811214-2A2A patent/BRPI0811214A2/pt active Search and Examination
- 2008-05-14 SI SI200830491T patent/SI2148876T1/sl unknown
- 2008-05-14 PL PL08759563T patent/PL2148876T3/pl unknown
- 2008-05-14 EP EP12174018A patent/EP2508520A1/en not_active Withdrawn
- 2008-05-14 CA CA2686909A patent/CA2686909C/en not_active Expired - Fee Related
- 2008-05-14 RS RS20110570A patent/RS52074B/en unknown
- 2008-05-14 AT AT08759563T patent/ATE526326T1/de active
- 2008-05-14 MY MYPI20094317A patent/MY154498A/en unknown
- 2008-05-14 EP EP11182678.0A patent/EP2402330B1/en active Active
- 2008-05-14 AU AU2008250069A patent/AU2008250069B2/en not_active Ceased
- 2008-05-14 KR KR1020097025745A patent/KR101601284B1/ko not_active IP Right Cessation
- 2008-05-14 CN CN201310349480.8A patent/CN103463086B/zh not_active Expired - Fee Related
- 2008-05-14 WO PCT/EP2008/055867 patent/WO2008138939A1/en active Application Filing
- 2008-05-15 AR ARP080102055A patent/AR066576A1/es not_active Application Discontinuation
- 2008-05-16 TW TW102129216A patent/TWI460174B/zh not_active IP Right Cessation
- 2008-05-16 TW TW097118165A patent/TWI414521B/zh not_active IP Right Cessation
-
2009
- 2009-09-15 ZA ZA200906423A patent/ZA200906423B/xx unknown
- 2009-10-16 CO CO09115665A patent/CO6220956A2/es active IP Right Grant
- 2009-11-05 IL IL201959A patent/IL201959A/en not_active IP Right Cessation
- 2009-11-13 EC EC2009009738A patent/ECSP099738A/es unknown
-
2010
- 2010-08-03 HK HK10107416.9A patent/HK1141017A1/xx not_active IP Right Cessation
-
2011
- 2011-12-15 HR HR20110940T patent/HRP20110940T1/hr unknown
- 2011-12-20 CY CY20111101261T patent/CY1112152T1/el unknown
-
2012
- 2012-09-14 US US13/618,026 patent/US8865745B2/en not_active Expired - Fee Related
-
2014
- 2014-04-16 JP JP2014084704A patent/JP5850972B2/ja not_active Expired - Fee Related
- 2014-05-28 HK HK14105008.3A patent/HK1191574A1/zh not_active IP Right Cessation
- 2014-08-29 US US14/473,338 patent/US9090597B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101657441B (zh) | 作为pde4抑制剂的吡唑啉酮衍生物 | |
CN102421739A (zh) | 羧酸化合物 | |
WO2005035534A1 (ja) | 複素ビシクロ環および複素トリシクロ環化合物およびその医薬 | |
JP2011207909A (ja) | フラザノベンゾイミダゾール | |
CN102076671B (zh) | 三唑衍生物或其盐 | |
CN1615305A (zh) | 香豆素衍生物、生产它们的方法及其用途 | |
US20230295122A1 (en) | 1h-benzo[d]imidazole derivatives as tlr9 inhibitors for the treatment of fibrosis | |
CN102369194B (zh) | 吡唑啉酮衍生物及其作为pd4抑制剂的用途 | |
AU2013234404B2 (en) | Pyrazolone Derivatives as PDE4 Inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1141017 Country of ref document: HK |
|
C14 | Grant of patent or utility model | ||
C53 | Correction of patent of invention or patent application | ||
CB02 | Change of applicant information |
Address after: Konstanz Applicant after: TAKEDA GmbH Address before: Konstanz Applicant before: Nycomed GmbH |
|
COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: NYCOMED INC. TO: TAKEDA GMBH |
|
GR01 | Patent grant | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1141017 Country of ref document: HK |
|
ASS | Succession or assignment of patent right |
Owner name: NYCOMED GERMANY HOLDING GMBH Free format text: FORMER OWNER: NYCOMED ASSET MANAGEMENT GMBH Effective date: 20150703 Owner name: NYCOMED ASSET MANAGEMENT GMBH Free format text: FORMER OWNER: TAKEDA GMBH Effective date: 20150703 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C56 | Change in the name or address of the patentee |
Owner name: TAKEDA GMBH Free format text: FORMER NAME: NYCOMED GERMANY HOLDING GMBH |
|
CP01 | Change in the name or title of a patent holder |
Address after: Konstanz Patentee after: TAKEDA GmbH Address before: Konstanz Patentee before: Nycomed Germany holding LLC |
|
TR01 | Transfer of patent right |
Effective date of registration: 20150703 Address after: Konstanz Patentee after: Nycomed Germany holding LLC Address before: Konstanz Patentee before: Nycomed asset management LLC Effective date of registration: 20150703 Address after: Konstanz Patentee after: Nycomed asset management LLC Address before: Konstanz Patentee before: TAKEDA GmbH |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130911 Termination date: 20190514 |
|
CF01 | Termination of patent right due to non-payment of annual fee |