CN101642493A - Chinese globeflower buccal tablets - Google Patents
Chinese globeflower buccal tablets Download PDFInfo
- Publication number
- CN101642493A CN101642493A CN200910164815A CN200910164815A CN101642493A CN 101642493 A CN101642493 A CN 101642493A CN 200910164815 A CN200910164815 A CN 200910164815A CN 200910164815 A CN200910164815 A CN 200910164815A CN 101642493 A CN101642493 A CN 101642493A
- Authority
- CN
- China
- Prior art keywords
- flos trollii
- extract powder
- flos
- filler
- correctives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides buccal tablets which is prepared from the Ranunculaceae medicinal plant Chinese globeflower and the tablets are used for curing acute and chronic tonsillitis and particularly for curing chronic upper respir atory tract infection particularly; the tablets are prepared by the following components: 10-75wt% Chinese globeflower extract powder, 10-85wt% of filler, 0.1-10wt% of flavoring agent, 0-15wt% of disintegrant, 0-5wt% of adhesive and 0-2wt% of lubricant. The tablets have comfortable mouthfeel and continue the ancient traditional administration of 'Chinese globeflower can be boiled to take instead of to drink tea'. The tablets have rapid absorption and high partial drug effect and can definitely improve the symptoms of chronic pharyngitis.
Description
Technical field
The present invention relates to drug world, be specifically related to a kind of Flos Trollii buccal tablet and method for making thereof.
Background technology
Ranunculaceae platymiscium Flos Trollii Trolliuschinensis Bunge and short lobe Flos Trollii T.ledebouriReichb. are used as medicine with flower.Summer, the flowers are in blossom adopts when putting, and dries its nature and flavor: hardship, cold; Heat-clearing and toxic substances removing.Contain veratric acid, vanillic acid, daucosterol, Quercetin, orientin etc., be used for acute and chronic tonsillitis, acute otitis media, acute myringitis, acute conjunctivitis, acute lymphangitis especially is usually used in the upper respiratory tract chronic inflammatory disease.It is swollen that supplementary Amplifications of the Compendium of Materia Medica record Flos Trollii is controlled the aphtha larynx, superficial heat gingival atrophy, otalgia ophthalmalgia.Its usage is: " frying in shallow oil this Dai Ming ".
Flos Trollii has been made into multiple single or compound preparation and has been used for clinically, and main preparation has trollius chinensis granular agent, Flos Trollii flavone membrane, jinlianhua pian, Flos Trollii chewable tablet, drop pills of Chinese globeflower, globeflower capsule, Chinese globe flower injection etc.
Market demand is easy to use, can continue the modern preparation of its instructions of taking of " frying in shallow oil this Dai Ming " again.
The invention scheme:
Preparation of the present invention is to realize by following steps
Depletion Flos Nelumbinis 1500g decocts with water secondary, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and drying promptly gets the Flos Trollii extract powder;
Or depletion Flos Nelumbinis 1500g, decoct with water secondary, each 1 hour, filter, merging filtrate adds 25～85% ethanol equimultiples, and the leaching supernatant is concentrated into the thick paste shape, and drying promptly gets the Flos Trollii extract powder;
Buccal tablet of the present invention can also be achieved in that
Depletion Flos Nelumbinis 1500g decocts with water secondary, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape,
By constituent content be by weight percentage: Flos Trollii extract powder 10～75wt%, filler 10～85wt%, correctives 0.1～10wt%, disintegrating agent 0～15wt%, binding agent, 0～5wt%, lubricant 0～2wt%;
Or more preferably:
Flos Trollii extract powder 10～75wt%,
Filler 10～85wt%,
Correctives 4～35wt%,
Disintegrating agent 0.5～45wt%,
Binding agent, 0.5～5wt%;
Lubricant 0～2wt%
The preparation method of its buccal tablet comprises following key step:
A. prepare the Flos Trollii extract powder: the depletion Flos Nelumbinis decocts with water, and filters, and merging filtrate is condensed into the thick paste shape, is dried to dry extract, pulverizes 80～200 mesh sieves, makes the Flos Trollii extract powder;
B. prepare the Flos Trollii content: filler, correctives, the disintegrating agent of depletion Flos Nelumbinis extract powder additional proportion amount, binding agent, granulation, drying, standby;
C. add lubricant, mix grain; Tabletting, coating, promptly.
Buccal tablet of the present invention can also be achieved in that
Its constituent content is by weight percentage:
Flos Trollii extract powder 45wt%,
Filler 25wt%,
Correctives 14wt%,
Disintegrating agent 15wt%,
Binding agent 1wt%.
Buccal tablet of the present invention can also be achieved in that
Its constituent content is by weight percentage:
Flos Trollii extract powder 55wt%,
Filler 20wt%,
Correctives 8wt%,
Disintegrating agent 15wt%,
Binding agent 1wt%,
Lubricant 1wt%.
Its filler of Flos Trollii buccal tablet is selected from one or more in lactose, glucose, Sorbitol, mannitol, maltose alcohol, the xylitol; Its correctives is selected from sucrose, citric acid, one or more in aspartame, stevioside, fructose, vitamin C, protein sugar, rose essence, flavoring pineapple essence, almond essence, Mentholum, the Oleum menthae.
Beneficial effect of the present invention:
The research of Flos Trollii buccal tablet effects of clearing and nourishing throat
The sample Flos Trollii is sucked, and traditional Chinese medicines joint-stock company in Luofu Mountain provides.Study subject selects the age at 18～60 years old, and 96 routine chronic pharyngitis examination persons of complication such as no severe cardiac, liver, kidney adopt the own control design.
The experimenter includes standard in
Symptom histories of repeated attack such as medical history has pharyngalgia, itching throat, dry pharynx is puckery, expectoration is not well, dry cough.Check pharyngeal congestion, mucosa edema, retropharyneal folliculosis has secretions to adhere to.Have above-mentioned symptom and check the finding volunteer, all can carry out test-meal through medical fitness and observe.
Exclusion standard: confirm to have person due to some invisible pathological changes of oropharynx, nasopharynx, throat, nose, larynx, esophagus, cervical region and whole body on inspection.Age is under-18s or person more than 60 years old, gestation or women breast-feeding their children and to this product allergy sufferers.Be associated with serious primary disease such as cardiovascular, liver, kidney and hemopoietic system, the psychotic.Do not meet the standard of including in, do not take in accordance with regulations and tried thing, can't judge that effect or data are not congruent influences effect or safety judgement person.
Instructions of taking: suck, contained a slice in per 2～3 hours, 9～12 slices/day, continuous 7d.
| Sign and symptom | Case load | The produce effects profit | Effectively routine | Invalid example |
| Pharyngeal congestion | ??86 | ??55 | ??20 | ??11 |
| Pharynx rear wall follicle hypertrophy | ??66 | ??52 | ??8 | ??6 |
| Myxedema | ??50 | ??42 | ??6 | ??2 |
| Pharyngalgia | ??90 | ??85 | ??4 | ??1 |
| Itching throat | ??80 | ??65 | ??12 | ??3 |
| Dry pharynx is puckery | ??82 | ??58 | ??10 | ??14 |
| Dry cough | ??60 | ??42 | ??10 | ??8 |
The Flos Trollii buccal tablet is than other tablets, capsule formulation, effect directly, the disease sites medicine effective concentration is higher, thereby to intractable to chronic pharyngitis examination trencherman pharyngalgia, itching throat, swallow in cardinal symptom such as puckery good improvement effect arranged, signs such as pharyngeal congestion, edema, secretions are had the improvement effect.And the effect that globeflower capsule, tablet etc. all do not have the pharyngeal symptom of remarkable improvement is in a short time used in contrast.Buccal tablet mouthfeel of the present invention is pure and mild, and it is refrigerant to enter the mouth, and melting is good, and the patient is easy to accept.
Specific embodiment
Embodiment 1
Preparation of the present invention is to realize by following steps
Depletion Flos Nelumbinis 1500g decocts with water secondary, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and drying promptly gets the Flos Trollii extract powder;
By constituent content be by weight percentage:
Flos Trollii extract powder 45wt%,
Lactose 5wt%,
Sorbitol 5wt%,
Vitamin C 10wt%,
Disintegrating agent 25wt%,
75% ethanol 3wt%;
Micropowder silica gel 2wt%
Filler, correctives, the disintegrating agent of depletion Flos Nelumbinis extract powder additional proportion amount, binding agent, granulation, drying, standby; Add lubricant, mix grain; Tabletting, coating, promptly.
Embodiment 2
Preparation of the present invention is to realize by following steps
Depletion Flos Nelumbinis 1500g decocts with water secondary, and each 1 hour, filter, merging filtrate adds 25～85% ethanol equimultiples, and the leaching supernatant is concentrated into the thick paste shape, and drying promptly gets the Flos Trollii extract powder;
By constituent content be by weight percentage:
Flos Trollii extract powder 65wt%,
Sorbitol 10wt%,
Aspartame 5wt%,
Disintegrating agent 16wt%,
Binding agent 3wt%;
Micropowder silica gel 1wt%
Filler, correctives, the disintegrating agent of depletion Flos Nelumbinis extract powder additional proportion amount, binding agent, granulation, drying, standby; Add lubricant, mix grain; Tabletting, promptly.
Embodiment 3
Preparation of the present invention is to realize by following steps
Depletion Flos Nelumbinis 1500g decocts with water secondary, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and drying promptly gets the Flos Trollii extract powder;
By constituent content be by weight percentage:
Its constituent content is by weight percentage:
Flos Trollii extract powder 65wt%,
CMC-Na?15wt％，
Sucrose 15wt%
Glucose 8wt%,
Disintegrating agent 1wt%,
Micropowder silica gel 1wt%.
Filler, correctives, the disintegrating agent of depletion Flos Nelumbinis extract powder additional proportion amount, binding agent, granulation, drying, standby; Add lubricant, mix grain; Tabletting, promptly.
Embodiment 4
Preparation of the present invention is to realize by following steps
Depletion Flos Nelumbinis 1500g decocts with water secondary, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and drying promptly gets the Flos Trollii extract powder;
By constituent content be by weight percentage:
Its constituent content is by weight percentage:
Flos Trollii extract powder 50wt%,
Lactose 10wt%,
Microcrystalline Cellulose 15wt%
Sucrose 7wt%,
Oleum menthae 1%
Polyvinylpyrrolidone 2wt%,
Polyvinylpyrrolidone 1wt%,
Pulvis Talci 1wt%.
Filler, correctives, the disintegrating agent of depletion Flos Nelumbinis extract powder additional proportion amount, binding agent, granulation, drying, standby; Add lubricant, mix grain; Tabletting, promptly.
Embodiment 5
Preparation of the present invention is to realize by following steps
Depletion Flos Nelumbinis 1500g decocts with water secondary, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and drying promptly gets the Flos Trollii extract powder;
By constituent content be by weight percentage:
Its constituent content is by weight percentage:
Flos Trollii extract powder 55wt%,
Lactose 10wt%,
Microcrystalline Cellulose 10wt%
Sucrose 8wt%,
Polyvinylpyrrolidone 15wt%,
75% ethanol 1wt%,
Micropowder silica gel 1wt%.
Filler, correctives, the disintegrating agent of depletion Flos Nelumbinis extract powder additional proportion amount, binding agent, granulation, drying, standby; Add lubricant, mix grain; Tabletting, coating, promptly.
Embodiment 6
Preparation of the present invention is to realize by following steps
Depletion Flos Nelumbinis 1500g decocts with water secondary, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and drying promptly gets the Flos Trollii extract powder;
By constituent content be by weight percentage:
Its constituent content is by weight percentage:
Flos Trollii extract powder 55wt%,
Lactose 10wt%,
Mannitol 10wt%,
Citric acid 8wt%,
Carboxymethyl starch sodium 15wt%,
2% polyvinylpyrrolidone ethanol liquid 1wt%,
Magnesium stearate 1wt%.
Filler, correctives, the disintegrating agent of depletion Flos Nelumbinis extract powder additional proportion amount, binding agent, granulation, drying, standby; Add lubricant, mix grain; Tabletting, promptly.
Embodiment 7
Preparation of the present invention is to realize by following steps
Depletion Flos Nelumbinis 1500g decocts with water secondary, and each 1 hour, filter, merging filtrate is concentrated into the thick paste shape, and drying promptly gets the Flos Trollii extract powder;
By constituent content be by weight percentage:
Its constituent content is by weight percentage:
Flos Trollii extract powder 20wt%,
Sucrose 30wt%,
Glucose 20wt%,
Xylitol 10wt%
Citric acid 3wt%,
Carboxymethyl starch sodium 15wt%,
2% polyvinylpyrrolidone ethanol liquid 1wt%,
Magnesium stearate 1wt%.
Filler, correctives, the disintegrating agent of depletion Flos Nelumbinis extract powder additional proportion amount, binding agent, granulation, drying, standby; Add lubricant, mix grain; Tabletting, coating, promptly.
Claims (5)
1, a kind of Flos Trollii buccal tablet, its drug component is the extract powder of Flos Trollii water extraction, it is characterized in that:
1. its troche is filler, correctives, disintegrating agent, binding agent, the lubricant that adds proportional quantity in extract powder, is pressed into the Flos Trollii buccal tablet;
2. its constituent content is by weight percentage: 10～75wt% Flos Trollii extract powder, filler 10～85wt%, correctives 0.1～10wt%, disintegrating agent 0～15wt%, binding agent, 0～5wt%, lubricant 0～2wt%;
3. the preparation method of its buccal tablet comprises following key step:
A. prepare the Flos Trollii extract powder: the depletion Flos Nelumbinis decocts with water, and filters, and merging filtrate is condensed into the thick paste shape, is dried to dry extract, pulverizes 80～200 mesh sieves, makes the Flos Trollii extract powder;
B. prepare the Flos Trollii content: filler, correctives, the disintegrating agent of depletion Flos Nelumbinis extract powder additional proportion amount, binding agent, granulation, drying, standby;
C. add lubricant, mix grain; Tabletting, that is, or coating again.
2, a kind of Flos Trollii buccal tablet, its drug component is the extract powder of Flos Trollii water extraction, it is characterized in that:
Its constituent content is by weight percentage: 45wt% Flos Trollii extract powder, filler 25wt%, correctives 14wt%, disintegrating agent 15wt%, binding agent 1wt%.
3, a kind of Flos Trollii buccal tablet, its drug component is the extract powder of Flos Trollii water extraction, it is characterized in that:
Its constituent content is by weight percentage: 55wt% Flos Trollii extract powder, filler 20wt%, correctives 8wt%, disintegrating agent 15wt%, binding agent 1wt%, lubricant 1wt%.
4, a kind of its filler of Flos Trollii buccal tablet according to claim 1 and 2 is selected from one or more in lactose, glucose, Sorbitol, mannitol, maltose alcohol, the xylitol.
5, a kind of its correctives of Flos Trollii buccal tablet according to claim 1 and 2 is selected from sucrose, citric acid, one or more in aspartame, stevioside, fructose, vitamin C, protein sugar, rose essence, flavoring pineapple essence, almond essence, Mentholum, the Oleum menthae.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910164815A CN101642493A (en) | 2009-08-03 | 2009-08-03 | Chinese globeflower buccal tablets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910164815A CN101642493A (en) | 2009-08-03 | 2009-08-03 | Chinese globeflower buccal tablets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101642493A true CN101642493A (en) | 2010-02-10 |
Family
ID=41654652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910164815A Pending CN101642493A (en) | 2009-08-03 | 2009-08-03 | Chinese globeflower buccal tablets |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101642493A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106389966A (en) * | 2016-11-25 | 2017-02-15 | 广东大鹏医药科技有限公司 | Globeflower buccal tablets and preparation method thereof |
| CN107773588A (en) * | 2016-08-30 | 2018-03-09 | 北京盈科瑞创新医药股份有限公司 | A kind of trollflower Neulized inhalation pharmaceutical solutions and preparation method thereof |
-
2009
- 2009-08-03 CN CN200910164815A patent/CN101642493A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107773588A (en) * | 2016-08-30 | 2018-03-09 | 北京盈科瑞创新医药股份有限公司 | A kind of trollflower Neulized inhalation pharmaceutical solutions and preparation method thereof |
| CN106389966A (en) * | 2016-11-25 | 2017-02-15 | 广东大鹏医药科技有限公司 | Globeflower buccal tablets and preparation method thereof |
| CN106389966B (en) * | 2016-11-25 | 2019-06-18 | 广东大鹏医药科技有限公司 | A kind of Chinese globeflower buccal tablets and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101264177B (en) | Tablet forming candy with refreshing, pharynx-clearing and throat-smoothing action | |
| CN105031294A (en) | Dendrobium candidum polysaccharide and Cyclocarya paliurus buccal tablets and preparation method thereof | |
| CN104042947A (en) | Preparation with effect of clearing heat from throat and preparation method thereof | |
| CN102657791B (en) | Chinese medicinal composition containing pale butterflybush flower and preparation method thereof | |
| CN103356891A (en) | Sugar-free throat-clearing lozenge and preparation method thereof | |
| CN105616590A (en) | Composition capable of clearing heat from throat, and preparation method thereof | |
| CN102670707A (en) | Buccal tablet with functions of moistening throat and dispelling effects of alcohol and preparation of same | |
| CN101690602A (en) | Method for making ballonflower beverage | |
| CN101904489A (en) | Preparation method and application of phylloporia ribis ryvarden series preparations | |
| CN106177190A (en) | A kind of guttural tablets and preparation method thereof | |
| CN106538779A (en) | A kind of merceration legal system globeflower tea and preparation method thereof | |
| CN108174945B (en) | Throat clearing food for smokers and preparation method thereof | |
| CN104248663B (en) | A kind of buckwheat fruit mouth-keeping tablet for reliving sore-throat and preparation method thereof | |
| CN107929393A (en) | Chitosan oligosaccharide wets one's whistle oral cavity tabletting and preparation method thereof | |
| CN102302672A (en) | Honeysuckle flower buccal tablets and preparation method thereof | |
| CN104225196B (en) | Traditional Chinese medicine effervescent tablet for treating respiratory diseases and preparation method of traditional Chinese medicine effervescent tablet | |
| CN101642493A (en) | Chinese globeflower buccal tablets | |
| CN116941700A (en) | Throat-clearing and throat-moistening candy rich in vitamin C and preparation method thereof | |
| CN110151851A (en) | Compound and its application based on a kind of Radix Glycyrrhizae medicine pair by honeysuckle | |
| CN106360664A (en) | Exocarpium Citri Rubrum health food with effects of relieving cough, resisting bacteria, diminishing inflammation, clearing voice and treating pharyngolaryngitis | |
| CN103623120B (en) | A kind of pharynx-clearing throat-benefiting buccal tablet and preparation method thereof | |
| CN105250843A (en) | Medicament for treating cough due to wind-heat evil | |
| CN102178792B (en) | Shiqi exogenous Chinese medicinal buccal tablets | |
| CN104383232B (en) | Clearing heat and detoxicating buccal lozenge of lectuce tea and its production method | |
| CN104491372A (en) | Radix scrophulariae buccal tablet |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20100210 |