CN106389966A - Globeflower buccal tablets and preparation method thereof - Google Patents
Globeflower buccal tablets and preparation method thereof Download PDFInfo
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- CN106389966A CN106389966A CN201611056832.0A CN201611056832A CN106389966A CN 106389966 A CN106389966 A CN 106389966A CN 201611056832 A CN201611056832 A CN 201611056832A CN 106389966 A CN106389966 A CN 106389966A
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- 230000035784 germination Effects 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- QQGLQYQXUKHWPX-RFEZBLSLSA-N glucotropeolin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1S\C(=N/OS(O)(=O)=O)CC1=CC=CC=C1 QQGLQYQXUKHWPX-RFEZBLSLSA-N 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- PQTCMBYFWMFIGM-UHFFFAOYSA-N gold silver Chemical compound [Ag].[Au] PQTCMBYFWMFIGM-UHFFFAOYSA-N 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000016507 interphase Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- GXMWXESSGGEWEM-UHFFFAOYSA-N isoquercitrin Natural products OCC(O)C1OC(OC2C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)c(O)c4)C(O)C1O GXMWXESSGGEWEM-UHFFFAOYSA-N 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 235000008777 kaempferol Nutrition 0.000 description 1
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempherol Natural products C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 229960004502 levodopa Drugs 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000009438 liyan Substances 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 206010025226 lymphangitis Diseases 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
- 229910052939 potassium sulfate Inorganic materials 0.000 description 1
- 235000011151 potassium sulphates Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- OVSQVDMCBVZWGM-QSOFNFLRSA-N quercetin 3-O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-QSOFNFLRSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
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- 230000002441 reversible effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention belongs to the technical field of medicines and particularly relates to globeflower buccal tablets and a preparation method thereof. The globeflower buccal tablets are prepared from main raw materials in parts by weight as follows: 10-16 parts of sodium carboxymethyl cellulose, 8-13 parts of magnesium stearate, 24-30 parts of globeflowers, 5-8 parts of cape jasmines, 3-6 parts of fresh reed rhizomes, 2-5 parts of lilies, 6-9 parts of boat-fruited sterculia seeds, 4-8 parts of radish seeds, 5-10 parts of malt, 3-7 parts of purslane, 4-8 parts of liquorice roots, 6-9 parts of olive, 2-4 parts of white hyacinth beans, 4-7 parts of konjac powder and 5-8 parts of isomaltose. The globeflower buccal tablets can directly act on affected parts for a longer time, have good throat clearing and nourishing effects and are convenient to carry and eat.
Description
Technical field
The invention belongs to pharmaceutical technology field is and in particular to a kind of Chinese globeflower buccal tablets and preparation method thereof.
Background technology
Song dynasty flood is suitable《Lily feet》：" the green clothing Huang grey hairpin of interior edema, morning and evening rides the waves a pace and a half together.A kind of aloof from politics and material pursuits happy spring stone, moving root be unwilling to
Dirty painting mud." Flos Trollii namies nasturtium again.Its stem hollow is overgrow, Ye Rulian and little, summer-flowering, Semen arachidis hypogaeae in axil, have yellow, red,
Reddish brown, the color such as milky white.Flos Trollii herb acrid in the mouth is cool in nature nontoxic.Function heat-clearing and toxic substances removing.Control conjunctival congestion and swelling pain, vicious large carbuncle(disease).According to existing
For medical research：Its seed contains glucotropaeolin, and peel contains chlorogenic acid and a small amount of flavonoid.In rhizome, petiole, particularly leaf
Containing Isoquercitrin.Flower composition containing multiple carotenoid, kaempferol glycoside etc..Volatility contained by leaf or other parts becomes
Point, it is broad-spectrum antibiotic.To staphylococcus aureuses, streptococcus, escherichia coli, Bacillus typhi, Salmonella paratyphi, dysentery bar
Bacterium, anthrax bacillus, bacillus subtilis and some funguses all have inhibitory action.
Chinese patent application 201210560958.7 discloses a kind of health care buccal tablet and preparation method thereof, including gold silver
Flower, Flos Chrysanthemi, Radix Asparagi, the Radix Angelicae Dahuricae, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Vc, during preparation, first pelletize respectively, then are obtained through special-shaped tabletting machine
Buccal tablet.Chinese patent application 201310608218.0 discloses a kind of pharynx-clearing throat-benefiting buccal tablet and preparation method thereof, by grey felt hair
Radix Ophiopogoniss, Radix Scrophulariae, Radix Scutellariae, mentha leave and Radix Glycyrrhizae composition.Chinese patent application 201410149317.1 provides one kind to be had clearly
The medicine of pharynx throat moistening function, by Flos Lonicerae bacterium zymophyte powder 100-300 weight portion, Herba Pogostemonis 200-400 weight portion, Lasiosphaera Seu Calvatia 50-
100 weight portions, Rhizoma Belamcandae 100-200 weight portion, Radix Scrophulariae 100-400 weight portion, emperor's chrysanthemum 100-300 weight portion, Fructus Phyllanthi 50-200
Weight portion, Herba Melissae officinaliss 100-300 weight portion, Pericarpium Citri Reticulatae 50-100 weight portion is prepared from.
Currently for treatment respiratory inflammation, such as stomatitis, pharyngitis, tonsillitic medicine, there is therapeutic effect not
Shortcoming good, that action time is short.Capsule, peroral tablets treatment are less suitable for, and therapeutic effect is bad；Edible tea or other beverages pair
Inside of human body is adjusted, prevention throat discomfort effect is also good, but action time is short.Therefore, develop one kind when can be long
Between, directly act on affected part, the good cleaning throat and moistening larynx product of effect, is necessary to meet market demand.
Content of the invention
For the deficiencies in the prior art, it is an object of the invention to provide a kind of Chinese globeflower buccal tablets.Lily feet fancy top of the present invention
Buccal tablet can compare for a long time, directly act on affected part, has good cleaning throat and moistening larynx effect, easy to carry, instant.
A kind of Chinese globeflower buccal tablets, are prepared from by the primary raw material of following weight parts：
Sodium carboxymethyl cellulose 10-16 part, magnesium stearate 8-13 part, Flos Trollii 24-30 part, Fructus Gardeniae 5-8 part, fresh Rhizoma Phragmitis 3-
6 parts, Bulbus Lilii 2-5 part, Semen Sterculiae Lychnophorae 6-9 part, Semen Raphani 4-8 part, Fructus Hordei Germinatus 5-10 part, Herba Portulacae 3-7 part, Radix Glycyrrhizae 4-8 part, Fructus Canarii 6-
9 parts, Semen Lablab Album 2-4 part, konjaku powder 4-7 part and hydroxyl isomaltulose 5-8 part.
A kind of Chinese globeflower buccal tablets, preferred scheme is to be prepared from by the primary raw material of following weight parts：
13 parts of sodium carboxymethyl cellulose, 10 parts of magnesium stearate, 26 parts of Flos Trollii, 6 parts of Fructus Gardeniae, 5 parts of fresh Rhizoma Phragmitis, 3 parts of Bulbus Lilii,
7 parts of Semen Sterculiae Lychnophorae, 5 parts of Semen Raphani, 7 parts of Fructus Hordei Germinatus, 5 parts of Herba Portulacae, 6 parts of Radix Glycyrrhizae, 7 parts of Fructus Canarii, 3 parts of Semen Lablab Album, 6 parts of konjaku powder and
7 parts of hydroxyl isomaltulose.
It is a further object of the present invention to provide the preparation method of Chinese globeflower buccal tablets, step is as follows：
S1 depletion Flos Nelumbinis, add water, and the addition of water is 8-11 times of above-mentioned Flos Trollii weight, soak 30-55 minute, decoct
35-50 minute, filtration, add 6-9 times of above-mentioned Flos Trollii weight of water, continue to decoct 25-40 minute, filtration, merge twice
Filtrate, evaporation and concentration to relative density is 1.18-1.23, obtains concentrated solution I；
S2 takes Semen Sterculiae Lychnophorae, is ground into coarse powder, crosses 50 mesh, adds the water of above-mentioned Semen Sterculiae Lychnophorae coarse powder weight 66-72 times, stands 10
Minute, microwave extraction 1-3 minute, microwave power is 450-500 watt, and extracting solution is filtered, and repeats to extract according to same condition
Once, united extraction liquid, evaporation and concentration to relative density is 1.21-1.23, obtains concentrated solution II；
S3 takes Fructus Gardeniae, fresh Rhizoma Phragmitis, Bulbus Lilii, Semen Raphani, Fructus Hordei Germinatus, Herba Portulacae, Radix Glycyrrhizae, Fructus Canarii and Semen Lablab Album to clean, and is placed in and carries
Take in tank, the decocting of 11-14 times of addition above-mentioned 9 kinds of raw materials boils three times, decocts 2 hours for the first time, decoct for the second time and for the third time
1.5 hours, filtration, merging filtrate, being evaporated to relative density is 1.18-1.23, plus 95% ethanol, so that alcohol content is reached
45%, stir, stand 12 hours, take the supernatant, reclaim ethanol, being concentrated into relative density is 1.2-1.25, obtains concentration
Liquid III；
S4 takes sodium carboxymethyl cellulose and konjaku powder, adds water, and the addition of water is above-mentioned sodium carboxymethyl cellulose and evil spirit
42-46 times of taro fine powder gross weight, is heated to 70 DEG C, stirring, until being completely dissolved, obtains mixed liquor；
Step S1 gained concentrated solution I, step S2 gained concentrated solution II and step S3 gained concentrated solution III are mixed by S5, will be different
Maltose alcohol is put on the airflow-distribution board of fluidized bed granulation room, starts aerator and spraying button, in spray-drying pelleting machine
Spray granulation, after solution to be concentrated has sprayed, then sprays step S4 gained mixed liquor and pelletizes again, discharging, crosses 18 mesh sieves, granulate, adds
Magnesium stearate, mixes, tabletting, piece weight 0.5g, obtains final product.
Preferably, the addition of described step S1 water is 10 times of above-mentioned Flos Trollii weight.
Preferably, described step S1 is soaked 45 minutes.
Preferably, described step S1 decocts 40 minutes.
Preferably, described step S1 adds the water of 8 times of above-mentioned Flos Trollii weight.
Preferably, described step S1 continues to decoct 30 minutes.
Preferably, described step S1 evaporation and concentration to relative density is 1.22.
Preferably, described step S2 adds the water of 70 times of above-mentioned Semen Sterculiae Lychnophorae coarse powder weight.
Preferably, described step S2 microwave extraction 2 minutes.
Preferably, described step S2 microwave power is 480 watts.
Preferably, described step S2 evaporation and concentration to relative density is 1.22.
Preferably, described step S3 adds the decocting of 13 times of above-mentioned 9 kinds of raw materials to boil three times.
Preferably, described step S3 is evaporated to relative density is 1.2.
Preferably, described step S3 is concentrated into relative density is 1.22.
Preferably, the addition of described step S4 water is the 45 of above-mentioned sodium carboxymethyl cellulose and konjaku powder gross weight
Times.
The effect of primary raw material used by the present invention：
Flos Trollii：Ji Yuan：For ranunculaceae plant Flos Trollii and party's lobe Flos Trollii, Trollius farreri Stapf, Trollius ledebouri flower.Property
Taste：Bitter in the mouth；Cold nature.Return lung；Stomach.Indication：Heat-clearing and toxic substances removing；Detumescence；Improving eyesight.Cure mainly cold, fever；Laryngopharynx swelling and pain；Mouthful
Skin ulcer；Gingival swelling and pain；Gingival hemorrhage；Conjunctival congestion and swelling pain；Furuncle swelling toxin；Acute myringitis；Acute lymphangitiss.
Fructus Gardeniae：Base：Dry mature fruit for Maguireothamnus speciosus Fructus Gardeniae.The property of medicine：Hardship, trembles with fear.GUIXIN, lung, tri-jiao channel.Work(
With curing mainly：Purging intense heat relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.For Vexed, yellow subcutaneous ulcer dark coloured urine, blood strangury and dry pain, blood-head tells nosebleed, mesh
Red swell and ache, pathogenic fire,toxin and furuncles；External treatment bruise pain.
Fresh Rhizoma Phragmitis：Base：Rhizome for grass phragmites communiss.The property of medicine：Sweet, tremble with fear.Attach to the lung and stomach meridians.Function cures mainly：Clearly
Heat, promotes the production of body fluid, relieving restlessness, preventing or arresting vomiting.Control pyreticosis polydipsia, gastropyretic vomiting, dysphagic, regurgitation, consumptive lung disease, lung abscess.
Bulbus Lilii：Base：Dry meat scale leaf for liliaceous plant tiger lily, Bulbus Lilii or Lilium tenuifolium.The property of medicine：Sweet, tremble with fear.Return
The heart, lung meridian.Function cures mainly：Nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For yin chronic cough, sputum mixed with blood, dysphoria palpitates with fear, insomnia and dreamful sleep, essence
God is in a trance.
Semen Sterculiae Lychnophorae：Base：Dry mature seed for Sterculiaceae plant Semen Sterculiae Lychnophorae.The property of medicine：Sweet, tremble with fear.Return lung, large intestine channel.
Function cures mainly：Clearing heat and moistening lung, liyan jiedu, loosening bowel to relieve constipation.For lung-heat celostomia, dry cough without phlegm, pharyngodynia with dryness, accumulation of heat just closes,
Hot eyes of having a headache.
Semen Raphani：Base：Mature seed for crucifer Radix Raphani.The property of medicine：Acrid in the mouth, sweet, mild-natured.Returns spleen, stomach,
Lung, large intestine channel.Function cures mainly：Dyspepsia and intestinal stasis relieving, lowering the adverse-rising QI to resolve phlegm.Main stagnation of QI due to dyspepsia, distension and fullness in the abdomen, diarrhoea, weight after dysentery, cough is many
Expectorant, QI rising in reverse order dyspnea with fullness of the chest.
Fructus Hordei Germinatus：Another name Fructus Hordei Vulgaris, wheat, Fructus Hordei Vulgaris hair, Fructus Hordei Germinatus, are the germination caryopsis of grass Fructus Hordei Vulgaris.The property of medicine：
Sweet；Flat.Returns spleen, stomach.Function cures mainly：Promoting digestion and removing stagnation；Galactopoiesis.Main dyspepsia, abdominal distention is had loose bowels, nausea and vomiting, inappetence,
Milk smoulders, distending pain of the breast.
Herba Portulacae：Base：Herb for portulacaceous plant Herba Portulacae.Chemical composition of Chinese materia medica：Herb contains nor- kidney in a large number
Upper parathyrine and volume potassium salt (including potassium nitrate, potassium chloride, potassium sulfate and other potassium salt).Also containing DOPA, dopamine, betanidin,
Isobetanidin, different Radix Betae glycoside, oxalic acid, malic acid, citric acid, glutamic acid, aspartic acid, alanine and glucose, Fructose, sugarcane
Sugar etc..And contain substantial amounts of poly- omega-3 unsaturated fatty acid.The property of medicine：Acid, trembles with fear.Return large intestine, Liver Channel.Function cures mainly：Heat-clearing and toxic substances removing is cool
Blood stops blooding.For toxic-heat and blood stasis, carbuncle swells furunculosis, eczema, erysipelas, snake bite and insect sting, have blood in stool, hemorrhoidal bleeding, metrostaxiss.
Radix Glycyrrhizae：Base：Root and rhizome is dried for glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..The property of medicine：Sweet, put down.
GUIXIN, lung, spleen, stomach.Function cures mainly：Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For spleen
Stomach is weak, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, institute's abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviates drug toxicity, strong
Property.
Fructus Canarii：Base：Dry mature fruit for olive subject plant Fructus Canarii albi.The property of medicine：Sweet, sour, put down.Attach to the lung and stomach meridians.Function
Cure mainly：Heat clearing away, sore-throat relieving, promote the production of body fluid, removing toxic substances.For laryngopharynx swelling and pain, cough, excessive thirst, fish and crab poisoning.
Semen Lablab Album：Base：White mature seed for leguminous plant Seem Lablab Album.The property of medicine：Sweet light；Tepor；Flat.Returns spleen, stomach.
Function cures mainly：Spleen invigorating, removing dampness, relieve summer heat.Main insufficiency of the spleen resulting in production of dampness, anorexia and loose stool, leukorrhagia, heat-damp in summer is vomited and diarrhoea, and excessive thirst is uncomfortable in chest.
Chinese globeflower buccal tablets of the present invention are with Flos Trollii, Fructus Gardeniae, fresh Rhizoma Phragmitis and Bulbus Lilii etc. as raw material, through science collocation, system
Standby form, taking convenience.
Compared with prior art, the Chinese globeflower buccal tablets that the present invention provides have the advantage that：
(1) can compare long-time, directly act on affected part, there is good cleaning throat and moistening larynx effect.
(2) easy to carry, instant.
(3) safely, have no side effect.
(4) present invention each raw material interphase interaction, has heat-clearing and toxic substances removing, the preventing or arresting vomiting that promotes the production of body fluid, nourishing YIN and moistening the lung, sore-throat relieving wet one's whistle, dispel
The functions such as phlegm and relieving cough, reducing swelling and alleviating pain, according to clinical verification, for the diseases such as stomatitis, pharyngitis and tonsillitiss, effect is significant.
Specific embodiment
Below by way of the description of specific embodiment, the invention will be further described, but this is not the limit to the present invention
System, according to the basic thought of the present invention, various modifications may be made or improves for those skilled in the art, but without departing from this
The basic thought of invention, all within the scope of the present invention.
Embodiment 1, a kind of Chinese globeflower buccal tablets
Chinese globeflower buccal tablets are prepared from (every part is 1200g) by the primary raw material of following weight parts：
10 parts of sodium carboxymethyl cellulose, 8 parts of magnesium stearate, 24 parts of Flos Trollii, 5 parts of Fructus Gardeniae, 3 parts of fresh Rhizoma Phragmitis, 2 parts of Bulbus Lilii,
6 parts of Semen Sterculiae Lychnophorae, 4 parts of Semen Raphani, 5 parts of Fructus Hordei Germinatus, 3 parts of Herba Portulacae, 4 parts of Radix Glycyrrhizae, 6 parts of Fructus Canarii, 2 parts of Semen Lablab Album, 4 parts of konjaku powder and
5 parts of hydroxyl isomaltulose.
The preparation method of above-mentioned Chinese globeflower buccal tablets is：
S1 depletion Flos Nelumbinis, add water, and the addition of water is 8 times of above-mentioned Flos Trollii weight, soak 30 minutes, decoct 35 points
Clock, filtration, add 6 times of above-mentioned Flos Trollii weight of water, continue to decoct 25 minutes, filtration, merge filtrate twice, evaporation and concentration
It is 1.18 to relative density, obtain concentrated solution I；
S2 takes Semen Sterculiae Lychnophorae, is ground into coarse powder, crosses 50 mesh, the water of 66 times of the above-mentioned Semen Sterculiae Lychnophorae coarse powder weight of addition, stands 10 points
Clock, microwave extraction 1 minute, microwave power is 450 watts, and extracting solution is filtered, and repeats to extract once according to same condition, merges
Extracting solution, evaporation and concentration to relative density is 1.21, obtains concentrated solution II；
S3 takes Fructus Gardeniae, fresh Rhizoma Phragmitis, Bulbus Lilii, Semen Raphani, Fructus Hordei Germinatus, Herba Portulacae, Radix Glycyrrhizae, Fructus Canarii and Semen Lablab Album to clean, and is placed in and carries
Take in tank, the decocting of 11 times of the above-mentioned 9 kinds of raw materials of addition boils three times, decocts 2 hours for the first time, decoct 1.5 for the second time and for the third time
Hour, filtration, merging filtrate, being evaporated to relative density is 1.18, plus 95% ethanol, makes alcohol content reach 45%, stirring
Uniformly, stand 12 hours, take the supernatant, reclaim ethanol, being concentrated into relative density is 1.2, obtains concentrated solution III；
S4 takes sodium carboxymethyl cellulose and konjaku powder, adds water, and the addition of water is above-mentioned sodium carboxymethyl cellulose and evil spirit
42 times of taro fine powder gross weight, are heated to 70 DEG C, stirring, until being completely dissolved, obtain mixed liquor；
Step S1 gained concentrated solution I, step S2 gained concentrated solution II and step S3 gained concentrated solution III are mixed by S5, will be different
Maltose alcohol is put on the airflow-distribution board of fluidized bed granulation room, starts aerator and spraying button, in spray-drying pelleting machine
Spray granulation, after solution to be concentrated has sprayed, then sprays step S4 gained mixed liquor and pelletizes again, discharging, crosses 18 mesh sieves, granulate, adds
Magnesium stearate, mixes, tabletting, piece weight 0.5g, obtains final product.
Embodiment 2, a kind of Chinese globeflower buccal tablets
Chinese globeflower buccal tablets are prepared from (every part is 1200g) by the primary raw material of following weight parts：
16 parts of sodium carboxymethyl cellulose, 13 parts of magnesium stearate, 30 parts of Flos Trollii, 8 parts of Fructus Gardeniae, 6 parts of fresh Rhizoma Phragmitis, 5 parts of Bulbus Lilii,
9 parts of Semen Sterculiae Lychnophorae, 8 parts of Semen Raphani, 10 parts of Fructus Hordei Germinatus, 7 parts of Herba Portulacae, 8 parts of Radix Glycyrrhizae, 9 parts of Fructus Canarii, 4 parts of Semen Lablab Album, 7 parts of konjaku powder
With 8 parts of hydroxyl isomaltulose.
The preparation method of above-mentioned Chinese globeflower buccal tablets is：
S1 depletion Flos Nelumbinis, add water, and the addition of water is 11 times of above-mentioned Flos Trollii weight, soak 55 minutes, decoct 50 points
Clock, filtration, add 9 times of above-mentioned Flos Trollii weight of water, continue to decoct 40 minutes, filtration, merge filtrate twice, evaporation and concentration
It is 1.23 to relative density, obtain concentrated solution I；
S2 takes Semen Sterculiae Lychnophorae, is ground into coarse powder, crosses 50 mesh, the water of 72 times of the above-mentioned Semen Sterculiae Lychnophorae coarse powder weight of addition, stands 10 points
Clock, microwave extraction 3 minutes, microwave power is 500 watts, and extracting solution is filtered, and repeats to extract once according to same condition, merges
Extracting solution, evaporation and concentration to relative density is 1.23, obtains concentrated solution II；
S3 takes Fructus Gardeniae, fresh Rhizoma Phragmitis, Bulbus Lilii, Semen Raphani, Fructus Hordei Germinatus, Herba Portulacae, Radix Glycyrrhizae, Fructus Canarii and Semen Lablab Album to clean, and is placed in and carries
Take in tank, the decocting of 14 times of the above-mentioned 9 kinds of raw materials of addition boils three times, decocts 2 hours for the first time, decoct 1.5 for the second time and for the third time
Hour, filtration, merging filtrate, being evaporated to relative density is 1.23, plus 95% ethanol, makes alcohol content reach 45%, stirring
Uniformly, stand 12 hours, take the supernatant, reclaim ethanol, being concentrated into relative density is 1.25, obtains concentrated solution III；
S4 takes sodium carboxymethyl cellulose and konjaku powder, adds water, and the addition of water is above-mentioned sodium carboxymethyl cellulose and evil spirit
46 times of taro fine powder gross weight, are heated to 70 DEG C, stirring, until being completely dissolved, obtain mixed liquor；
Step S1 gained concentrated solution I, step S2 gained concentrated solution II and step S3 gained concentrated solution III are mixed by S5, will be different
Maltose alcohol is put on the airflow-distribution board of fluidized bed granulation room, starts aerator and spraying button, in spray-drying pelleting machine
Spray granulation, after solution to be concentrated has sprayed, then sprays step S4 gained mixed liquor and pelletizes again, discharging, crosses 18 mesh sieves, granulate, adds
Magnesium stearate, mixes, tabletting, piece weight 0.5g, obtains final product.
Embodiment 3, a kind of Chinese globeflower buccal tablets
Chinese globeflower buccal tablets are prepared from (every part is 1200g) by the primary raw material of following weight parts：
13 parts of sodium carboxymethyl cellulose, 10 parts of magnesium stearate, 26 parts of Flos Trollii, 6 parts of Fructus Gardeniae, 5 parts of fresh Rhizoma Phragmitis, 3 parts of Bulbus Lilii,
7 parts of Semen Sterculiae Lychnophorae, 5 parts of Semen Raphani, 7 parts of Fructus Hordei Germinatus, 5 parts of Herba Portulacae, 6 parts of Radix Glycyrrhizae, 7 parts of Fructus Canarii, 3 parts of Semen Lablab Album, 6 parts of konjaku powder and
7 parts of hydroxyl isomaltulose.
The preparation method of above-mentioned Chinese globeflower buccal tablets is：
S1 depletion Flos Nelumbinis, add water, and the addition of water is 10 times of above-mentioned Flos Trollii weight, soak 45 minutes, decoct 40 points
Clock, filtration, add 8 times of above-mentioned Flos Trollii weight of water, continue to decoct 30 minutes, filtration, merge filtrate twice, evaporation and concentration
It is 1.22 to relative density, obtain concentrated solution I；
S2 takes Semen Sterculiae Lychnophorae, is ground into coarse powder, crosses 50 mesh, the water of 70 times of the above-mentioned Semen Sterculiae Lychnophorae coarse powder weight of addition, stands 10 points
Clock, microwave extraction 2 minutes, microwave power is 480 watts, and extracting solution is filtered, and repeats to extract once according to same condition, merges
Extracting solution, evaporation and concentration to relative density is 1.22, obtains concentrated solution II；
S3 takes Fructus Gardeniae, fresh Rhizoma Phragmitis, Bulbus Lilii, Semen Raphani, Fructus Hordei Germinatus, Herba Portulacae, Radix Glycyrrhizae, Fructus Canarii and Semen Lablab Album to clean, and is placed in and carries
Take in tank, the decocting of 13 times of the above-mentioned 9 kinds of raw materials of addition boils three times, decocts 2 hours for the first time, decoct 1.5 for the second time and for the third time
Hour, filtration, merging filtrate, being evaporated to relative density is 1.2, plus 95% ethanol, makes alcohol content reach 45%, stirring is all
Even, stand 12 hours, take the supernatant, reclaim ethanol, being concentrated into relative density is 1.22, obtains concentrated solution III；
S4 takes sodium carboxymethyl cellulose and konjaku powder, adds water, and the addition of water is above-mentioned sodium carboxymethyl cellulose and evil spirit
45 times of taro fine powder gross weight, are heated to 70 DEG C, stirring, until being completely dissolved, obtain mixed liquor；
Step S1 gained concentrated solution I, step S2 gained concentrated solution II and step S3 gained concentrated solution III are mixed by S5, will be different
Maltose alcohol is put on the airflow-distribution board of fluidized bed granulation room, starts aerator and spraying button, in spray-drying pelleting machine
Spray granulation, after solution to be concentrated has sprayed, then sprays step S4 gained mixed liquor and pelletizes again, discharging, crosses 18 mesh sieves, granulate, adds
Magnesium stearate, mixes, tabletting, piece weight 0.5g, obtains final product.
Comparative example 1, a kind of Chinese globeflower buccal tablets
Chinese globeflower buccal tablets are prepared from (every part is 1200g) by the primary raw material of following weight parts：
13 parts of sodium carboxymethyl cellulose, 10 parts of magnesium stearate, 29 parts of Flos Trollii, 6 parts of Fructus Gardeniae, 5 parts of fresh Rhizoma Phragmitis, 3 parts of Bulbus Lilii,
7 parts of Semen Sterculiae Lychnophorae, 5 parts of Semen Raphani, 7 parts of Fructus Hordei Germinatus, 5 parts of Herba Portulacae, 6 parts of Radix Glycyrrhizae, 7 parts of Fructus Canarii, 6 parts of konjaku powder and hydroxyl isomaltulose
7 parts.
Preparation method is similar to Example 3.
Difference with embodiment 3 is, does not add Semen Lablab Album, increases the parts by weight of Flos Trollii.
Comparative example 2, a kind of buccal tablet
Buccal tablet is prepared from (every part is 1200g) by the primary raw material of following weight parts：
13 parts of sodium carboxymethyl cellulose, 10 parts of magnesium stearate, 26 parts of Flos Lonicerae, 6 parts of Fructus Gardeniae, 5 parts of fresh Rhizoma Phragmitis, 3 parts of Bulbus Lilii,
7 parts of Semen Sterculiae Lychnophorae, 5 parts of Semen Raphani, 7 parts of Fructus Hordei Germinatus, 5 parts of Herba Portulacae, 6 parts of Radix Glycyrrhizae, 7 parts of Fructus Canarii, 3 parts of Semen Lablab Album, 6 parts of konjaku powder and
7 parts of hydroxyl isomaltulose.
Preparation method is similar to Example 3.
Difference with embodiment 3 is, Flos Trollii is replaced with Flos Lonicerae.
Test example one：Quality examination
The embodiment of the present invention 1 gained Chinese globeflower buccal tablets are completely bright and clean, and uniform color, no sand type are dissolved in the oral cavity
Time is 14min, and hardness is 5.75kg.
The embodiment of the present invention 2 gained Chinese globeflower buccal tablets are completely bright and clean, and uniform color, no sand type are dissolved in the oral cavity
Time is 12min, and average hardness is 5.92kg.
The embodiment of the present invention 3 gained Chinese globeflower buccal tablets are completely bright and clean, and uniform color, no sand type are dissolved in the oral cavity
Time is 11min, and average hardness is 5.82kg.
Comparative example 1 gained Chinese globeflower buccal tablets of the present invention are completely bright and clean, and uniform color, no sand type are dissolved in the oral cavity
Time is 15min, and average hardness is 5.9kg.
Comparative example 2 gained buccal tablet of the present invention is completely bright and clean, uniform color, and uniform color, no sand type are molten in the oral cavity
The change time is 18min, and average hardness is 6.12kg.
Embodiment of the present invention 1-3 gained Chinese globeflower buccal tablets, comparative example 1 and comparative example 2 gained buccal tablet all meet mouth containing
The prescription of piece.
Test example two：The effect of Chinese globeflower buccal tablets
Case selection：Select clinical patients 345, wherein male 200, women 145, the range of age 16-64 year, mouth
Chamber inflammation patient 100, pharyngitis patient 195, tonsillitiss patient 50.Stomatitis patient's cardinal symptom is for sialorrhea, appetite not
Shake or search for food slow, oral malodor, oral mucosa flushing, heat, swelling and pain.Pharyngitis patient's cardinal symptom is swallowed for dry pharynx
Bitterly, hoarseness, dry cough, foreign body sensation, itching throat etc..Tonsillitiss patient's cardinal symptom is pharyngalgia, heating and pharyngeal sense of discomfort etc..
It is randomly divided into five groups, experimental group 1-3 and matched group 1, matched group 2.Five groups of cases are in physical data such as sex, age, symptoms
There was no significant difference for aspect.Experimental group 1-3 sucks embodiment of the present invention 1-3 products obtained therefrom, and matched group 1, matched group 2 are sucked respectively
Comparative example 1, comparative example 2 products obtained therefrom.Using method：Three times a day, 3 tablets once.
Curative effect judging standard：Cure：Symptom is disappeared completely with sign；Take a turn for the better：Subjective symptomss disappear or mitigate；Invalid：Disease
Shape is unchanged.Result is as shown in table 1.
Table 1：Experimental group and matched group effectiveness comparison
As shown in Table 1, compared with matched group 1 and matched group 2, experimental group 1, experimental group 2 and experimental group 3 stomatitis patient,
The symptom of pharyngitis patient and tonsillitiss patient significantly improves.This explanation, gained Chinese globeflower buccal tablets of the present invention are to treatment mouth
Chamber is scorching, pharyngitis and tonsillitiss have remarkable result, and patient's reaction Chinese globeflower buccal tablets of the present invention to dry mouth and throat, halitosis,
Hoarseness also has preferable effect.In sum, gained Chinese globeflower buccal tablets of the present invention have preferable cleaning throat and moistening larynx effect
Really.
Claims (10)
1. a kind of Chinese globeflower buccal tablets are it is characterised in that be prepared from by the primary raw material of following weight parts：
Sodium carboxymethyl cellulose 10-16 part, magnesium stearate 8-13 part, Flos Trollii 24-30 part, Fructus Gardeniae 5-8 part, fresh Rhizoma Phragmitis 3-6 part,
Bulbus Lilii 2-5 part, Semen Sterculiae Lychnophorae 6-9 part, Semen Raphani 4-8 part, Fructus Hordei Germinatus 5-10 part, Herba Portulacae 3-7 part, Radix Glycyrrhizae 4-8 part, Fructus Canarii 6-9 part,
Semen Lablab Album 2-4 part, konjaku powder 4-7 part and hydroxyl isomaltulose 5-8 part.
2. Chinese globeflower buccal tablets as claimed in claim 1 it is characterised in that by following weight parts primary raw material prepare and
Become：
13 parts of sodium carboxymethyl cellulose, 10 parts of magnesium stearate, 26 parts of Flos Trollii, 6 parts of Fructus Gardeniae, 5 parts of fresh Rhizoma Phragmitis, 3 parts of Bulbus Lilii is fat big
7 parts of sea, 5 parts of Semen Raphani, 7 parts of Fructus Hordei Germinatus, 5 parts of Herba Portulacae, 6 parts of Radix Glycyrrhizae, 7 parts of Fructus Canarii, 3 parts of Semen Lablab Album, 6 parts of konjaku powder and different wheat
7 parts of bud sugar alcohol.
3. the preparation method of Chinese globeflower buccal tablets as claimed in claim 1 or 2 is it is characterised in that step is as follows：
S1 depletion Flos Nelumbinis, add water, and the addition of water is 8-11 times of above-mentioned Flos Trollii weight, soak 30-55 minute, decoct 35-
50 minutes, filtration, add 6-9 times of above-mentioned Flos Trollii weight of water, continue to decoct 25-40 minute, filtration, merge and filter twice
Liquid, evaporation and concentration to relative density is 1.18-1.23, obtains concentrated solution I；
S2 takes Semen Sterculiae Lychnophorae, is ground into coarse powder, crosses 50 mesh, adds the water of above-mentioned Semen Sterculiae Lychnophorae coarse powder weight 66-72 times, stands 10 points
Clock, microwave extraction 1-3 minute, microwave power is 450-500 watt, extracting solution is filtered, repeats to extract one according to same condition
Secondary, united extraction liquid, evaporation and concentration to relative density is 1.21-1.23, obtains concentrated solution II；
S3 takes Fructus Gardeniae, fresh Rhizoma Phragmitis, Bulbus Lilii, Semen Raphani, Fructus Hordei Germinatus, Herba Portulacae, Radix Glycyrrhizae, Fructus Canarii and Semen Lablab Album to clean, and is placed in extraction pot
In, the decocting of 11-14 times of addition above-mentioned 9 kinds of raw materials boils three times, decocts 2 hours for the first time, decocts 1.5 for the second time and for the third time little
When, filtration, merging filtrate, being evaporated to relative density is 1.18-1.23, plus 95% ethanol, makes alcohol content reach 45%, stirs
Mix uniformly, stand 12 hours, take the supernatant, reclaim ethanol, being concentrated into relative density is 1.2-1.25, obtains concentrated solution III；
S4 takes sodium carboxymethyl cellulose and konjaku powder, adds water, and the addition of water is above-mentioned sodium carboxymethyl cellulose and konjaku essence
42-46 times of powder gross weight, is heated to 70 DEG C, stirring, until being completely dissolved, obtains mixed liquor；
Step S1 gained concentrated solution I, step S2 gained concentrated solution II and step S3 gained concentrated solution III are mixed by S5, by Isomalt
Sugar alcohol is put on the airflow-distribution board of fluidized bed granulation room, starts aerator and spraying button, sprays in spray-drying pelleting machine
Pelletize, after solution to be concentrated spray, then spray step S4 gained mixed liquor and pelletize again, discharging, cross 18 mesh sieves, granulate, addition Hard Fat
Sour magnesium, mixes, tabletting, piece weight 0.5g, obtains final product.
4. the preparation method of Chinese globeflower buccal tablets as claimed in claim 3 is it is characterised in that the addition of described step S1 water
It is 10 times of above-mentioned Flos Trollii weight.
5. the preparation method of Chinese globeflower buccal tablets as claimed in claim 3 is it is characterised in that described step S1 soaks 45 points
Clock.
6. the preparation method of Chinese globeflower buccal tablets as claimed in claim 3 is it is characterised in that described step S1 decocts 40 points
Clock.
7. the preparation method of Chinese globeflower buccal tablets as claimed in claim 3 is it is characterised in that described step S1 adds above-mentioned gold
The water of 8 times of Flos Nelumbinis weight.
8. the preparation method of Chinese globeflower buccal tablets as claimed in claim 3 is it is characterised in that described step S1 continues decoction 30
Minute.
9. Chinese globeflower buccal tablets as claimed in claim 3 preparation method it is characterised in that described step S1 evaporation and concentration extremely
Relative density is 1.22.
10. the preparation method of Chinese globeflower buccal tablets as claimed in claim 3 is it is characterised in that the addition of described step S2 is above-mentioned
The water of 70 times of Semen Sterculiae Lychnophorae coarse powder weight.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018099493A1 (en) * | 2016-11-29 | 2018-06-07 | 广东大鹏医药科技有限公司 | Tropaeolum majus granules and preparation method therefor |
| CN109892463A (en) * | 2019-02-26 | 2019-06-18 | 广东大鹏医药科技有限公司 | A kind of nougat and preparation method thereof with moistening lung function |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1269209A (en) * | 2000-01-14 | 2000-10-11 | 谢春生 | Double-layered buccal tablet of Chinese globeflower and vitamin C and its making process |
| CN101172128A (en) * | 2006-10-31 | 2008-05-07 | 药都制药集团股份有限公司 | Globeflower tablet and preparing technique thereof |
| CN101642493A (en) * | 2009-08-03 | 2010-02-10 | 刘秀英 | Chinese globeflower buccal tablets |
| CN103356891A (en) * | 2013-08-01 | 2013-10-23 | 中国药材公司 | Sugar-free throat-clearing lozenge and preparation method thereof |
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2016
- 2016-11-25 CN CN201611056832.0A patent/CN106389966B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1269209A (en) * | 2000-01-14 | 2000-10-11 | 谢春生 | Double-layered buccal tablet of Chinese globeflower and vitamin C and its making process |
| CN101172128A (en) * | 2006-10-31 | 2008-05-07 | 药都制药集团股份有限公司 | Globeflower tablet and preparing technique thereof |
| CN101642493A (en) * | 2009-08-03 | 2010-02-10 | 刘秀英 | Chinese globeflower buccal tablets |
| CN103356891A (en) * | 2013-08-01 | 2013-10-23 | 中国药材公司 | Sugar-free throat-clearing lozenge and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018099493A1 (en) * | 2016-11-29 | 2018-06-07 | 广东大鹏医药科技有限公司 | Tropaeolum majus granules and preparation method therefor |
| CN109892463A (en) * | 2019-02-26 | 2019-06-18 | 广东大鹏医药科技有限公司 | A kind of nougat and preparation method thereof with moistening lung function |
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