CN101641341A - 酰胺化合物及其作为抗肿瘤剂的用途 - Google Patents

酰胺化合物及其作为抗肿瘤剂的用途 Download PDF

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Publication number
CN101641341A
CN101641341A CN200880008093A CN200880008093A CN101641341A CN 101641341 A CN101641341 A CN 101641341A CN 200880008093 A CN200880008093 A CN 200880008093A CN 200880008093 A CN200880008093 A CN 200880008093A CN 101641341 A CN101641341 A CN 101641341A
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CN
China
Prior art keywords
nmr
cdcl
mmol
alkyl
yield
Prior art date
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Pending
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CN200880008093A
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English (en)
Chinese (zh)
Inventor
S·哈尼斯安
L·奥扎斯
G·吉安尼尼
C·皮萨诺
L·韦希
W·卡布里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of CN101641341A publication Critical patent/CN101641341A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/01—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN200880008093A 2007-03-13 2008-03-12 酰胺化合物及其作为抗肿瘤剂的用途 Pending CN101641341A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07104071 2007-03-13
EP07104071.1 2007-03-13

Publications (1)

Publication Number Publication Date
CN101641341A true CN101641341A (zh) 2010-02-03

Family

ID=39535770

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880008093A Pending CN101641341A (zh) 2007-03-13 2008-03-12 酰胺化合物及其作为抗肿瘤剂的用途

Country Status (13)

Country Link
US (1) US20100113504A1 (enExample)
EP (1) EP2137169A1 (enExample)
JP (1) JP2010520915A (enExample)
KR (1) KR20100014974A (enExample)
CN (1) CN101641341A (enExample)
AU (1) AU2008225833A1 (enExample)
BR (1) BRPI0809000A2 (enExample)
CA (1) CA2677874A1 (enExample)
EA (1) EA200970848A1 (enExample)
IL (1) IL200188A0 (enExample)
MX (1) MX2009009374A (enExample)
WO (1) WO2008110583A1 (enExample)
ZA (1) ZA200907077B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109516926A (zh) * 2018-07-27 2019-03-26 四川大学 一种荜茇明碱衍生物的制备与抗肿瘤活性
CN120924186A (zh) * 2025-10-14 2025-11-11 长沙市芯星新能源科技有限公司 负极粘结剂、锂离子电池负极及其制备方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2230227A1 (en) * 2009-03-20 2010-09-22 Bracco Imaging S.p.A Process for the preparation of triiodinated carboxylic aromatic derivatives
JP2013508323A (ja) * 2009-10-21 2013-03-07 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 合成大環状アミドｈｄａｃ６阻害剤化合物およびそれらの治療剤としての用途
EP3941457A4 (en) * 2019-03-21 2023-04-26 Merck Sharp & Dohme LLC HISTONE-DEACETYLASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF HIV INFECTION

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0014254A (pt) * 1999-09-08 2002-08-27 Sloan Kettering Inst Cancer Nova classe de agentes de citodiferenciação e inibidores de desacetilase de histona, e métodos de uso dos mesmos
US20060264415A1 (en) * 2005-04-01 2006-11-23 Methylgene Inc. Inhibitors of histone deacetylase

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109516926A (zh) * 2018-07-27 2019-03-26 四川大学 一种荜茇明碱衍生物的制备与抗肿瘤活性
CN109516926B (zh) * 2018-07-27 2021-09-17 四川大学 一种荜茇明碱衍生物制备及用途
CN120924186A (zh) * 2025-10-14 2025-11-11 长沙市芯星新能源科技有限公司 负极粘结剂、锂离子电池负极及其制备方法
CN120924186B (zh) * 2025-10-14 2025-12-23 长沙市芯星新能源科技有限公司 负极粘结剂、锂离子电池负极及其制备方法

Also Published As

Publication number Publication date
ZA200907077B (en) 2010-07-28
EA200970848A1 (ru) 2010-02-26
US20100113504A1 (en) 2010-05-06
EP2137169A1 (en) 2009-12-30
KR20100014974A (ko) 2010-02-11
WO2008110583A1 (en) 2008-09-18
IL200188A0 (en) 2010-04-15
BRPI0809000A2 (pt) 2014-11-11
CA2677874A1 (en) 2008-09-18
MX2009009374A (es) 2009-09-21
AU2008225833A1 (en) 2008-09-18
JP2010520915A (ja) 2010-06-17

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