JP2010520915A - アミド化合物および抗腫瘍剤としてのその使用 - Google Patents
アミド化合物および抗腫瘍剤としてのその使用 Download PDFInfo
- Publication number
- JP2010520915A JP2010520915A JP2009553140A JP2009553140A JP2010520915A JP 2010520915 A JP2010520915 A JP 2010520915A JP 2009553140 A JP2009553140 A JP 2009553140A JP 2009553140 A JP2009553140 A JP 2009553140A JP 2010520915 A JP2010520915 A JP 2010520915A
- Authority
- JP
- Japan
- Prior art keywords
- nmr
- mhz
- mmol
- cdcl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC(*)C(N(*)C(C)=C(*)*)=O Chemical compound CC(*)C(N(*)C(C)=C(*)*)=O 0.000 description 14
- NLRKCXQQSUWLCH-UHFFFAOYSA-N O=Nc1ccccc1 Chemical compound O=Nc1ccccc1 NLRKCXQQSUWLCH-UHFFFAOYSA-N 0.000 description 3
- AQPZNQPTSMSNOL-UHFFFAOYSA-N COC(CCCCCCC(C(Nc1ccccc1)=O)O)=O Chemical compound COC(CCCCCCC(C(Nc1ccccc1)=O)O)=O AQPZNQPTSMSNOL-UHFFFAOYSA-N 0.000 description 2
- DRAVDPWPYMLGBK-UHFFFAOYSA-N CC(C)(OC1CCCCCC(OC)=O)OC1=O Chemical compound CC(C)(OC1CCCCCC(OC)=O)OC1=O DRAVDPWPYMLGBK-UHFFFAOYSA-N 0.000 description 1
- PBKDGNNYGOLMMX-UHFFFAOYSA-N CC(CCCCCC(NO)=O)OCc1ccc(C)cc1 Chemical compound CC(CCCCCC(NO)=O)OCc1ccc(C)cc1 PBKDGNNYGOLMMX-UHFFFAOYSA-N 0.000 description 1
- QVYVUOKEKMQSDO-UHFFFAOYSA-N COC(CCCCCC(C(N(Cc(cc1)ccc1OC)c1ccccc1)=O)OCc1cc(OC)ccc1)=O Chemical compound COC(CCCCCC(C(N(Cc(cc1)ccc1OC)c1ccccc1)=O)OCc1cc(OC)ccc1)=O QVYVUOKEKMQSDO-UHFFFAOYSA-N 0.000 description 1
- RNFUZEBPZQPFHS-UHFFFAOYSA-N COC(CCCCCC(C(Nc1ccccc1)=O)OCc(cc1)ccc1OC)=O Chemical compound COC(CCCCCC(C(Nc1ccccc1)=O)OCc(cc1)ccc1OC)=O RNFUZEBPZQPFHS-UHFFFAOYSA-N 0.000 description 1
- YWHCKJVIMMXZAJ-UHFFFAOYSA-N COC(CCCCCC(C(Nc1ccccc1)=O)OCc1cc(Oc2ccccc2)ccc1)=O Chemical compound COC(CCCCCC(C(Nc1ccccc1)=O)OCc1cc(Oc2ccccc2)ccc1)=O YWHCKJVIMMXZAJ-UHFFFAOYSA-N 0.000 description 1
- HAVHATIMYXFAPH-UHFFFAOYSA-N COC(CCCCCCC(C(Nc1ccccc1)=O)OCC=C)=O Chemical compound COC(CCCCCCC(C(Nc1ccccc1)=O)OCC=C)=O HAVHATIMYXFAPH-UHFFFAOYSA-N 0.000 description 1
- LVKZFFZWSSWNMK-UHFFFAOYSA-N COC(CCCCCCC(C(Nc1ccccc1)=O)OCc(cc1)ccc1OC)=O Chemical compound COC(CCCCCCC(C(Nc1ccccc1)=O)OCc(cc1)ccc1OC)=O LVKZFFZWSSWNMK-UHFFFAOYSA-N 0.000 description 1
- GTYJNCDOILRMGX-LBPRGKRZSA-N CO[C@@H](CCCCC(NO)=O)C(Nc1ccccc1)=O Chemical compound CO[C@@H](CCCCC(NO)=O)C(Nc1ccccc1)=O GTYJNCDOILRMGX-LBPRGKRZSA-N 0.000 description 1
- JRKLDYQREJAUNQ-UHFFFAOYSA-N COc1ccc(C(CC=C)O)cc1 Chemical compound COc1ccc(C(CC=C)O)cc1 JRKLDYQREJAUNQ-UHFFFAOYSA-N 0.000 description 1
- HICLENFYWKCMFN-UHFFFAOYSA-N COc1ccc(C(CC=C)Oc2ccccc2N)cc1 Chemical compound COc1ccc(C(CC=C)Oc2ccccc2N)cc1 HICLENFYWKCMFN-UHFFFAOYSA-N 0.000 description 1
- MKCLFDVNWUXOBU-UHFFFAOYSA-N COc1ccc(CN(C(C(CCCCCC(NO)=O)OCc2cc(OC)ccc2)=O)c2ccccc2)cc1 Chemical compound COc1ccc(CN(C(C(CCCCCC(NO)=O)OCc2cc(OC)ccc2)=O)c2ccccc2)cc1 MKCLFDVNWUXOBU-UHFFFAOYSA-N 0.000 description 1
- PVSDQSZFQNIDIP-UHFFFAOYSA-N COc1ccc(COC(CCCCC(NO)=O)C[NH+](c2ccccc2)[O-])cc1 Chemical compound COc1ccc(COC(CCCCC(NO)=O)C[NH+](c2ccccc2)[O-])cc1 PVSDQSZFQNIDIP-UHFFFAOYSA-N 0.000 description 1
- FQAZXPMITHVSOG-UHFFFAOYSA-N COc1ccc(COC(CCCCCC(NO)=O)C(Nc2ccccc2)=O)cc1 Chemical compound COc1ccc(COC(CCCCCC(NO)=O)C(Nc2ccccc2)=O)cc1 FQAZXPMITHVSOG-UHFFFAOYSA-N 0.000 description 1
- OYQSMPNKPPIDON-UHFFFAOYSA-N COc1ccc(COC(CCCCCCC(NO)=O)C(Nc2ccccc2)=O)cc1 Chemical compound COc1ccc(COC(CCCCCCC(NO)=O)C(Nc2ccccc2)=O)cc1 OYQSMPNKPPIDON-UHFFFAOYSA-N 0.000 description 1
- YXSDLYXEYKSNBG-UHFFFAOYSA-N ONC(CCCCCC(C(Nc1ccccc1)=O)OCc1cc(Oc2ccccc2)ccc1)=O Chemical compound ONC(CCCCCC(C(Nc1ccccc1)=O)OCc1cc(Oc2ccccc2)ccc1)=O YXSDLYXEYKSNBG-UHFFFAOYSA-N 0.000 description 1
- CBIANVGXIGULEA-UHFFFAOYSA-N ONC(CCCCCC(C(Nc1ccccc1)=O)OCc1ccc(C(F)(F)F)cc1)=O Chemical compound ONC(CCCCCC(C(Nc1ccccc1)=O)OCc1ccc(C(F)(F)F)cc1)=O CBIANVGXIGULEA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/01—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07104071 | 2007-03-13 | ||
| PCT/EP2008/052965 WO2008110583A1 (en) | 2007-03-13 | 2008-03-12 | Amide compounds and their use as antitumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010520915A true JP2010520915A (ja) | 2010-06-17 |
| JP2010520915A5 JP2010520915A5 (enExample) | 2011-04-28 |
Family
ID=39535770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009553140A Withdrawn JP2010520915A (ja) | 2007-03-13 | 2008-03-12 | アミド化合物および抗腫瘍剤としてのその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100113504A1 (enExample) |
| EP (1) | EP2137169A1 (enExample) |
| JP (1) | JP2010520915A (enExample) |
| KR (1) | KR20100014974A (enExample) |
| CN (1) | CN101641341A (enExample) |
| AU (1) | AU2008225833A1 (enExample) |
| BR (1) | BRPI0809000A2 (enExample) |
| CA (1) | CA2677874A1 (enExample) |
| EA (1) | EA200970848A1 (enExample) |
| IL (1) | IL200188A0 (enExample) |
| MX (1) | MX2009009374A (enExample) |
| WO (1) | WO2008110583A1 (enExample) |
| ZA (1) | ZA200907077B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2230227A1 (en) * | 2009-03-20 | 2010-09-22 | Bracco Imaging S.p.A | Process for the preparation of triiodinated carboxylic aromatic derivatives |
| JP2013508323A (ja) * | 2009-10-21 | 2013-03-07 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ | 合成大環状アミドｈｄａｃ６阻害剤化合物およびそれらの治療剤としての用途 |
| CN109516926B (zh) * | 2018-07-27 | 2021-09-17 | 四川大学 | 一种荜茇明碱衍生物制备及用途 |
| EP3941457A4 (en) * | 2019-03-21 | 2023-04-26 | Merck Sharp & Dohme LLC | HISTONE-DEACETYLASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF HIV INFECTION |
| CN120924186B (zh) * | 2025-10-14 | 2025-12-23 | 长沙市芯星新能源科技有限公司 | 负极粘结剂、锂离子电池负极及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0014254A (pt) * | 1999-09-08 | 2002-08-27 | Sloan Kettering Inst Cancer | Nova classe de agentes de citodiferenciação e inibidores de desacetilase de histona, e métodos de uso dos mesmos |
| US20060264415A1 (en) * | 2005-04-01 | 2006-11-23 | Methylgene Inc. | Inhibitors of histone deacetylase |
-
2008
- 2008-03-12 JP JP2009553140A patent/JP2010520915A/ja not_active Withdrawn
- 2008-03-12 AU AU2008225833A patent/AU2008225833A1/en not_active Abandoned
- 2008-03-12 CA CA002677874A patent/CA2677874A1/en not_active Abandoned
- 2008-03-12 US US12/528,912 patent/US20100113504A1/en not_active Abandoned
- 2008-03-12 BR BRPI0809000-9A2A patent/BRPI0809000A2/pt not_active IP Right Cessation
- 2008-03-12 WO PCT/EP2008/052965 patent/WO2008110583A1/en not_active Ceased
- 2008-03-12 CN CN200880008093A patent/CN101641341A/zh active Pending
- 2008-03-12 KR KR1020097018936A patent/KR20100014974A/ko not_active Withdrawn
- 2008-03-12 MX MX2009009374A patent/MX2009009374A/es not_active Application Discontinuation
- 2008-03-12 EA EA200970848A patent/EA200970848A1/ru unknown
- 2008-03-12 EP EP08717710A patent/EP2137169A1/en not_active Withdrawn
-
2009
- 2009-07-30 IL IL200188A patent/IL200188A0/en unknown
- 2009-10-12 ZA ZA200907077A patent/ZA200907077B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200907077B (en) | 2010-07-28 |
| EA200970848A1 (ru) | 2010-02-26 |
| US20100113504A1 (en) | 2010-05-06 |
| EP2137169A1 (en) | 2009-12-30 |
| KR20100014974A (ko) | 2010-02-11 |
| WO2008110583A1 (en) | 2008-09-18 |
| IL200188A0 (en) | 2010-04-15 |
| BRPI0809000A2 (pt) | 2014-11-11 |
| CA2677874A1 (en) | 2008-09-18 |
| MX2009009374A (es) | 2009-09-21 |
| AU2008225833A1 (en) | 2008-09-18 |
| CN101641341A (zh) | 2010-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110310 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20110310 |
|
| A761 | Written withdrawal of application |
Free format text: JAPANESE INTERMEDIATE CODE: A761 Effective date: 20111125 |