EA200970848A1 - Амидосодержащие соединения и их применение в качестве противоопухолевых агентов - Google Patents
Амидосодержащие соединения и их применение в качестве противоопухолевых агентовInfo
- Publication number
- EA200970848A1 EA200970848A1 EA200970848A EA200970848A EA200970848A1 EA 200970848 A1 EA200970848 A1 EA 200970848A1 EA 200970848 A EA200970848 A EA 200970848A EA 200970848 A EA200970848 A EA 200970848A EA 200970848 A1 EA200970848 A1 EA 200970848A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- amido
- application
- containing compounds
- tumor agents
- differentiation
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 201000011510 cancer Diseases 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 102000003964 Histone deacetylase Human genes 0.000 abstract 1
- 108090000353 Histone deacetylase Proteins 0.000 abstract 1
- 230000011712 cell development Effects 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000005170 neoplastic cell Anatomy 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000011571 secondary malignant neoplasm Diseases 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/01—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07104071 | 2007-03-13 | ||
| PCT/EP2008/052965 WO2008110583A1 (en) | 2007-03-13 | 2008-03-12 | Amide compounds and their use as antitumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200970848A1 true EA200970848A1 (ru) | 2010-02-26 |
Family
ID=39535770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200970848A EA200970848A1 (ru) | 2007-03-13 | 2008-03-12 | Амидосодержащие соединения и их применение в качестве противоопухолевых агентов |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100113504A1 (enExample) |
| EP (1) | EP2137169A1 (enExample) |
| JP (1) | JP2010520915A (enExample) |
| KR (1) | KR20100014974A (enExample) |
| CN (1) | CN101641341A (enExample) |
| AU (1) | AU2008225833A1 (enExample) |
| BR (1) | BRPI0809000A2 (enExample) |
| CA (1) | CA2677874A1 (enExample) |
| EA (1) | EA200970848A1 (enExample) |
| IL (1) | IL200188A0 (enExample) |
| MX (1) | MX2009009374A (enExample) |
| WO (1) | WO2008110583A1 (enExample) |
| ZA (1) | ZA200907077B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2230227A1 (en) * | 2009-03-20 | 2010-09-22 | Bracco Imaging S.p.A | Process for the preparation of triiodinated carboxylic aromatic derivatives |
| JP2013508323A (ja) * | 2009-10-21 | 2013-03-07 | シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ | 合成大環状アミドｈｄａｃ６阻害剤化合物およびそれらの治療剤としての用途 |
| CN109516926B (zh) * | 2018-07-27 | 2021-09-17 | 四川大学 | 一种荜茇明碱衍生物制备及用途 |
| EP3941457B1 (en) * | 2019-03-21 | 2026-01-21 | Merck Sharp & Dohme LLC | Inhibitors of histone deacetylase useful for the treatment or prevention of hiv infection |
| CN120924186B (zh) * | 2025-10-14 | 2025-12-23 | 长沙市芯星新能源科技有限公司 | 负极粘结剂、锂离子电池负极及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0014254A (pt) * | 1999-09-08 | 2002-08-27 | Sloan Kettering Inst Cancer | Nova classe de agentes de citodiferenciação e inibidores de desacetilase de histona, e métodos de uso dos mesmos |
| AU2006228957A1 (en) * | 2005-04-01 | 2006-10-05 | Methylgene Inc. | Inhibitors of histone deacetylase |
-
2008
- 2008-03-12 CA CA002677874A patent/CA2677874A1/en not_active Abandoned
- 2008-03-12 KR KR1020097018936A patent/KR20100014974A/ko not_active Withdrawn
- 2008-03-12 MX MX2009009374A patent/MX2009009374A/es not_active Application Discontinuation
- 2008-03-12 JP JP2009553140A patent/JP2010520915A/ja not_active Withdrawn
- 2008-03-12 EA EA200970848A patent/EA200970848A1/ru unknown
- 2008-03-12 BR BRPI0809000-9A2A patent/BRPI0809000A2/pt not_active IP Right Cessation
- 2008-03-12 AU AU2008225833A patent/AU2008225833A1/en not_active Abandoned
- 2008-03-12 CN CN200880008093A patent/CN101641341A/zh active Pending
- 2008-03-12 WO PCT/EP2008/052965 patent/WO2008110583A1/en not_active Ceased
- 2008-03-12 EP EP08717710A patent/EP2137169A1/en not_active Withdrawn
- 2008-03-12 US US12/528,912 patent/US20100113504A1/en not_active Abandoned
-
2009
- 2009-07-30 IL IL200188A patent/IL200188A0/en unknown
- 2009-10-12 ZA ZA200907077A patent/ZA200907077B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20100113504A1 (en) | 2010-05-06 |
| WO2008110583A1 (en) | 2008-09-18 |
| AU2008225833A1 (en) | 2008-09-18 |
| IL200188A0 (en) | 2010-04-15 |
| KR20100014974A (ko) | 2010-02-11 |
| CA2677874A1 (en) | 2008-09-18 |
| ZA200907077B (en) | 2010-07-28 |
| JP2010520915A (ja) | 2010-06-17 |
| MX2009009374A (es) | 2009-09-21 |
| EP2137169A1 (en) | 2009-12-30 |
| BRPI0809000A2 (pt) | 2014-11-11 |
| CN101641341A (zh) | 2010-02-03 |
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