CN101622351B - 双链断裂诱饵及其单独的用途 - Google Patents

双链断裂诱饵及其单独的用途 Download PDF

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CN101622351B
CN101622351B CN200880002041.7A CN200880002041A CN101622351B CN 101622351 B CN101622351 B CN 101622351B CN 200880002041 A CN200880002041 A CN 200880002041A CN 101622351 B CN101622351 B CN 101622351B
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dna
seq
dbait
cancer
molecule
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CN101622351A (zh
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马里·迪特雷
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Centre National de la Recherche Scientifique CNRS
Institut Curie
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN200880002041.7A 2007-01-12 2008-01-11 双链断裂诱饵及其单独的用途 Active CN101622351B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07300728A EP1944369A1 (en) 2007-01-12 2007-01-12 Dbait and its standalone uses thereof
EP07300728.8 2007-01-12
PCT/EP2008/050265 WO2008084087A2 (en) 2007-01-12 2008-01-11 Dbait and its standalone uses thereof

Publications (2)

Publication Number Publication Date
CN101622351A CN101622351A (zh) 2010-01-06
CN101622351B true CN101622351B (zh) 2014-05-14

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US (1) US8093366B2 (enExample)
EP (2) EP1944369A1 (enExample)
JP (1) JP5462632B2 (enExample)
CN (1) CN101622351B (enExample)
AU (1) AU2008204486C1 (enExample)
CA (1) CA2673972C (enExample)
EA (1) EA016053B1 (enExample)
WO (1) WO2008084087A2 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015202211B2 (en) * 2010-06-22 2016-09-01 Centre National De La Recherche Scientifique Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates
EP3689381A1 (en) 2010-06-22 2020-08-05 Onxeo Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates
EP2527440A1 (en) 2011-05-27 2012-11-28 Institut Curie Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia
EP3325623B3 (en) 2015-07-23 2021-01-20 Institut Curie Use of a combination of dbait molecule and parp inhibitors to treat cancer
KR20220127360A (ko) * 2016-03-01 2022-09-19 옹쎄오 Ｄｂａｉｔ 분자의 전신 투여에 의한 암 치료법
WO2017186882A1 (en) * 2016-04-29 2017-11-02 Onxeo A method of predicting a response to an anti-tumor treatment by means of signal interfering dna molecules
WO2018162439A1 (en) 2017-03-08 2018-09-13 Onxeo New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
KR20200028392A (ko) * 2017-06-12 2020-03-16 유니버시티 오브 마이애미 질환의 치료를 위한 sting-의존성 활성화제
CN107793468A (zh) * 2017-06-26 2018-03-13 上海悦良生物科技有限公司 一种检测dna损伤的方法
EP3461488A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dbait molecule and a hdac inhibitor for treating cancer
WO2019175132A1 (en) * 2018-03-13 2019-09-19 Onxeo A dbait molecule against acquired resistance in the treatment of cancer
CN109321585B (zh) * 2018-09-30 2021-08-06 山东大学 一种利用t4脱氧核糖核酸连接酶提高原核微生物诱变育种效率的方法
MX2021007271A (es) 2018-12-21 2021-07-15 Onxeo Nuevas moleculas de acido nucleico conjugado y sus usos.
JP2022526713A (ja) * 2019-03-21 2022-05-26 オンクセオ がんの処置のための、キナーゼ阻害剤と組み合わせたＤｂａｉｔ分子
EP4075980B1 (en) 2019-12-18 2025-07-23 Stinginn LLC Substituted 1,2, 4-triazoles and methods of use
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2021178295A1 (en) * 2020-03-03 2021-09-10 University Of Washington Synthetic agonists of dna-pk and their use
US11897888B1 (en) 2020-04-30 2024-02-13 Stinginn Llc Small molecular inhibitors of sting signaling compositions and methods of use
TW202210633A (zh) 2020-06-05 2022-03-16 法商昂席歐公司 用於治療癌症之dbait分子與kras抑制劑的組合
TW202214857A (zh) 2020-06-19 2022-04-16 法商昂席歐公司 新型結合核酸分子及其用途
CN118660964A (zh) 2021-12-16 2024-09-17 瓦莱里奥治疗公司 新型缀合核酸分子及其用途
WO2024240858A1 (en) 2023-05-23 2024-11-28 Valerio Therapeutics Protac molecules directed against dna damage repair system and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1871350A (zh) * 2003-10-24 2006-11-29 法国居里学院 用于引发肿瘤细胞致死的核酸

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
JP2005247807A (ja) * 2004-03-08 2005-09-15 Japan Science & Technology Agency Ｎｓａｉｄを利用した癌治療用組成物
US20060276423A1 (en) * 2005-04-18 2006-12-07 Rachel Altura Survivin-directed RNA interference-compositions and methods

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1871350A (zh) * 2003-10-24 2006-11-29 法国居里学院 用于引发肿瘤细胞致死的核酸

Non-Patent Citations (1)

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Title
Li zhang, 等.Targeting Ku protein for sensitizing of breast cancer cells to DNA-damage.《International Journal of molecular medicine》.2004,(第14期),153－159. *

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EP2102343B1 (en) 2015-07-08
AU2008204486A1 (en) 2008-07-17
JP2010515707A (ja) 2010-05-13
WO2008084087A2 (en) 2008-07-17
JP5462632B2 (ja) 2014-04-02
EP1944369A1 (en) 2008-07-16
US8093366B2 (en) 2012-01-10
EA200900989A1 (ru) 2009-12-30
AU2008204486B2 (en) 2012-11-29
US20100022622A1 (en) 2010-01-28
WO2008084087A3 (en) 2009-01-08
CN101622351A (zh) 2010-01-06
EA016053B1 (ru) 2012-01-30
CA2673972A1 (en) 2008-07-17
AU2008204486C1 (en) 2013-05-16
EP1944369A9 (en) 2008-10-15
CA2673972C (en) 2016-03-22
EP2102343A2 (en) 2009-09-23

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