CA2673972C - Dbait and its standalone uses thereof - Google Patents
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- CA2673972C CA2673972C CA2673972A CA2673972A CA2673972C CA 2673972 C CA2673972 C CA 2673972C CA 2673972 A CA2673972 A CA 2673972A CA 2673972 A CA2673972 A CA 2673972A CA 2673972 C CA2673972 C CA 2673972C
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/13—Decoys
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/31—Chemical structure of the backbone
- C12N2310/312—Phosphonates
- C12N2310/3125—Methylphosphonates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/53—Physical structure partially self-complementary or closed
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
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- Organic Chemistry (AREA)
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- Biotechnology (AREA)
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- Wood Science & Technology (AREA)
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- Plant Pathology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07300728.8 | 2007-01-12 | ||
| EP07300728A EP1944369A1 (en) | 2007-01-12 | 2007-01-12 | Dbait and its standalone uses thereof |
| PCT/EP2008/050265 WO2008084087A2 (en) | 2007-01-12 | 2008-01-11 | Dbait and its standalone uses thereof |
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| CA2673972A1 CA2673972A1 (en) | 2008-07-17 |
| CA2673972C true CA2673972C (en) | 2016-03-22 |
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| CA2673972A Active CA2673972C (en) | 2007-01-12 | 2008-01-11 | Dbait and its standalone uses thereof |
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|---|---|
| US (1) | US8093366B2 (enExample) |
| EP (2) | EP1944369A1 (enExample) |
| JP (1) | JP5462632B2 (enExample) |
| CN (1) | CN101622351B (enExample) |
| AU (1) | AU2008204486C1 (enExample) |
| CA (1) | CA2673972C (enExample) |
| EA (1) | EA016053B1 (enExample) |
| WO (1) | WO2008084087A2 (enExample) |
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| CN104788523B (zh) | 2010-06-22 | 2017-09-08 | 欧恩科斯欧公司 | 用于核酸结合物的具有内涵体溶解剂的优化的体内递送系统 |
| AU2015202211B2 (en) * | 2010-06-22 | 2016-09-01 | Centre National De La Recherche Scientifique | Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates |
| EP2527440A1 (en) * | 2011-05-27 | 2012-11-28 | Institut Curie | Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia |
| ES2879434T3 (es) | 2015-07-23 | 2021-11-22 | Inst Curie | Uso de una combinación de molécula Dbait e inhibidores de PARP para tratamiento del cáncer |
| US10821128B2 (en) * | 2016-03-01 | 2020-11-03 | Onxeo | Treatment of cancer by systemic administration of Dbait molecules |
| WO2017186882A1 (en) * | 2016-04-29 | 2017-11-02 | Onxeo | A method of predicting a response to an anti-tumor treatment by means of signal interfering dna molecules |
| WO2018162439A1 (en) | 2017-03-08 | 2018-09-13 | Onxeo | New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule |
| KR20200028392A (ko) * | 2017-06-12 | 2020-03-16 | 유니버시티 오브 마이애미 | 질환의 치료를 위한 sting-의존성 활성화제 |
| CN107793468A (zh) * | 2017-06-26 | 2018-03-13 | 上海悦良生物科技有限公司 | 一种检测dna损伤的方法 |
| EP3461488A1 (en) | 2017-09-27 | 2019-04-03 | Onxeo | Combination of a dbait molecule and a hdac inhibitor for treating cancer |
| US20200407720A1 (en) * | 2018-03-13 | 2020-12-31 | Onxeo | A dbait molecule against acquired resistance in the treatment of cancer |
| CN109321585B (zh) * | 2018-09-30 | 2021-08-06 | 山东大学 | 一种利用t4脱氧核糖核酸连接酶提高原核微生物诱变育种效率的方法 |
| MX2021007271A (es) | 2018-12-21 | 2021-07-15 | Onxeo | Nuevas moleculas de acido nucleico conjugado y sus usos. |
| BR112021018168B1 (pt) * | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
| EP4075980B1 (en) | 2019-12-18 | 2025-07-23 | Stinginn LLC | Substituted 1,2, 4-triazoles and methods of use |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| US20230095192A1 (en) * | 2020-03-03 | 2023-03-30 | University Of Washington | Synthetic agonists of dna-pk and their use |
| US11897888B1 (en) | 2020-04-30 | 2024-02-13 | Stinginn Llc | Small molecular inhibitors of sting signaling compositions and methods of use |
| TW202210633A (zh) | 2020-06-05 | 2022-03-16 | 法商昂席歐公司 | 用於治療癌症之dbait分子與kras抑制劑的組合 |
| TW202214857A (zh) | 2020-06-19 | 2022-04-16 | 法商昂席歐公司 | 新型結合核酸分子及其用途 |
| US20240294926A1 (en) | 2021-12-16 | 2024-09-05 | Valerio Therapeutics | New conjugated nucleic acid molecules and their uses |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
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| EP1526177A1 (en) * | 2003-10-24 | 2005-04-27 | Institut Curie | Nucleic acids useful for triggering tumor cell lethality |
| JP2005247807A (ja) * | 2004-03-08 | 2005-09-15 | Japan Science & Technology Agency | Ｎｓａｉｄを利用した癌治療用組成物 |
| US20060276423A1 (en) * | 2005-04-18 | 2006-12-07 | Rachel Altura | Survivin-directed RNA interference-compositions and methods |
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2007
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Also Published As
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| EP2102343B1 (en) | 2015-07-08 |
| WO2008084087A2 (en) | 2008-07-17 |
| AU2008204486C1 (en) | 2013-05-16 |
| US20100022622A1 (en) | 2010-01-28 |
| CN101622351A (zh) | 2010-01-06 |
| EP1944369A9 (en) | 2008-10-15 |
| JP2010515707A (ja) | 2010-05-13 |
| CA2673972A1 (en) | 2008-07-17 |
| AU2008204486B2 (en) | 2012-11-29 |
| US8093366B2 (en) | 2012-01-10 |
| WO2008084087A3 (en) | 2009-01-08 |
| EP1944369A1 (en) | 2008-07-16 |
| EA016053B1 (ru) | 2012-01-30 |
| JP5462632B2 (ja) | 2014-04-02 |
| CN101622351B (zh) | 2014-05-14 |
| AU2008204486A1 (en) | 2008-07-17 |
| EP2102343A2 (en) | 2009-09-23 |
| EA200900989A1 (ru) | 2009-12-30 |
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