CN101610997A - 用作金属蛋白酶抑制剂的具有芳基-磺酰氨结构的化合物 - Google Patents
用作金属蛋白酶抑制剂的具有芳基-磺酰氨结构的化合物 Download PDFInfo
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- CN101610997A CN101610997A CNA200880004727XA CN200880004727A CN101610997A CN 101610997 A CN101610997 A CN 101610997A CN A200880004727X A CNA200880004727X A CN A200880004727XA CN 200880004727 A CN200880004727 A CN 200880004727A CN 101610997 A CN101610997 A CN 101610997A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07104393.9 | 2007-03-19 | ||
| EP07104393A EP1972617A1 (en) | 2007-03-19 | 2007-03-19 | Compounds having aryl-sulphonamidic structure useful as metalloproteases inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101610997A true CN101610997A (zh) | 2009-12-23 |
Family
ID=38626433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200880004727XA Pending CN101610997A (zh) | 2007-03-19 | 2008-03-14 | 用作金属蛋白酶抑制剂的具有芳基-磺酰氨结构的化合物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8329751B2 (https=) |
| EP (2) | EP1972617A1 (https=) |
| JP (1) | JP2010521529A (https=) |
| KR (1) | KR20090121329A (https=) |
| CN (1) | CN101610997A (https=) |
| AU (1) | AU2008228260B2 (https=) |
| CA (1) | CA2680239A1 (https=) |
| IL (1) | IL200951A0 (https=) |
| MX (1) | MX2009009409A (https=) |
| RU (1) | RU2488580C2 (https=) |
| WO (1) | WO2008113756A2 (https=) |
| ZA (1) | ZA200905263B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2149568A1 (en) | 2008-07-22 | 2010-02-03 | Bracco Imaging S.p.A | Aryl-sulphonamidic dimers as metalloproteases inhibitors |
| EP2147684A1 (en) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Diagnostic Agents Selective Against Metalloproteases |
| US20240207415A1 (en) | 2022-11-08 | 2024-06-27 | Montelino Therapeutics, Inc. | Bi-functional compounds and methods for targeted ubiquitination of androgen receptor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5058026A (https=) * | 1973-09-26 | 1975-05-20 | ||
| RU2208609C2 (ru) * | 1998-02-04 | 2003-07-20 | Новартис Аг | Сульфониламинопроизводные, которые ингибируют разлагающие матрикс металлопротеиназы |
| RU2217418C2 (ru) * | 1998-04-03 | 2003-11-27 | Санкио Компани, Лимитед | Сульфонамидное производное, лекарственное средство, способы лечения |
| WO2006101828A1 (en) * | 2005-03-15 | 2006-09-28 | Bayer Cropscience Ag | Insecticidal alkylamino phenyl sulfonamide derivatives |
-
2007
- 2007-03-19 EP EP07104393A patent/EP1972617A1/en not_active Withdrawn
-
2008
- 2008-03-14 WO PCT/EP2008/053078 patent/WO2008113756A2/en not_active Ceased
- 2008-03-14 CA CA002680239A patent/CA2680239A1/en not_active Abandoned
- 2008-03-14 MX MX2009009409A patent/MX2009009409A/es active IP Right Grant
- 2008-03-14 EP EP08717820A patent/EP2121590A2/en not_active Withdrawn
- 2008-03-14 CN CNA200880004727XA patent/CN101610997A/zh active Pending
- 2008-03-14 RU RU2009138346/04A patent/RU2488580C2/ru not_active IP Right Cessation
- 2008-03-14 AU AU2008228260A patent/AU2008228260B2/en not_active Ceased
- 2008-03-14 US US12/531,119 patent/US8329751B2/en not_active Expired - Fee Related
- 2008-03-14 JP JP2010500190A patent/JP2010521529A/ja active Pending
- 2008-03-14 KR KR1020097019222A patent/KR20090121329A/ko not_active Ceased
-
2009
- 2009-07-05 ZA ZA200905263A patent/ZA200905263B/xx unknown
- 2009-09-15 IL IL200951A patent/IL200951A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008228260B2 (en) | 2012-11-22 |
| WO2008113756A3 (en) | 2008-12-18 |
| JP2010521529A (ja) | 2010-06-24 |
| MX2009009409A (es) | 2009-09-14 |
| ZA200905263B (en) | 2010-06-30 |
| WO2008113756A2 (en) | 2008-09-25 |
| IL200951A0 (en) | 2010-05-17 |
| RU2009138346A (ru) | 2011-04-27 |
| KR20090121329A (ko) | 2009-11-25 |
| RU2488580C2 (ru) | 2013-07-27 |
| AU2008228260A1 (en) | 2008-09-25 |
| CA2680239A1 (en) | 2008-09-25 |
| WO2008113756A8 (en) | 2008-11-06 |
| US20100087505A1 (en) | 2010-04-08 |
| US8329751B2 (en) | 2012-12-11 |
| EP2121590A2 (en) | 2009-11-25 |
| EP1972617A1 (en) | 2008-09-24 |
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