CN101605800B - 锂交换反应方法 - Google Patents

锂交换反应方法 Download PDF

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Publication number
CN101605800B
CN101605800B CN200880004269XA CN200880004269A CN101605800B CN 101605800 B CN101605800 B CN 101605800B CN 200880004269X A CN200880004269X A CN 200880004269XA CN 200880004269 A CN200880004269 A CN 200880004269A CN 101605800 B CN101605800 B CN 101605800B
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reaction
reagent
lithium
alkyl
microreactor
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Chinese (zh)
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CN101605800A (zh
Inventor
多米尼克·罗贝热
威廉·奎特曼
马库斯·埃雅尔泽
伯廷·齐默尔曼
法比奥·拉伊诺内
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Lonza AG
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Lonza AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Catalysts (AREA)
CN200880004269XA 2007-02-06 2008-02-01 锂交换反应方法 Active CN101605800B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07002522 2007-02-06
EP07002522A EP1956023A1 (en) 2007-02-06 2007-02-06 Method for lithium exchange reactions
PCT/EP2008/000808 WO2008095646A1 (en) 2007-02-06 2008-02-01 Method for lithium exchange reactions

Publications (2)

Publication Number Publication Date
CN101605800A CN101605800A (zh) 2009-12-16
CN101605800B true CN101605800B (zh) 2013-01-09

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ID=38179681

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CN200880004269XA Active CN101605800B (zh) 2007-02-06 2008-02-01 锂交换反应方法

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US (1) US8198487B2 (enExample)
EP (2) EP1956023A1 (enExample)
JP (1) JP5394258B2 (enExample)
CN (1) CN101605800B (enExample)
AT (1) ATE478877T1 (enExample)
BR (1) BRPI0807155A2 (enExample)
CA (1) CA2674560A1 (enExample)
DE (1) DE602008002321D1 (enExample)
EA (1) EA015237B1 (enExample)
ES (1) ES2351376T3 (enExample)
HR (1) HRP20100627T1 (enExample)
IL (1) IL199749A (enExample)
MX (1) MX2009008352A (enExample)
PL (1) PL2109616T3 (enExample)
PT (1) PT2109616E (enExample)
SI (1) SI2109616T1 (enExample)
WO (1) WO2008095646A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE035130T2 (en) 2007-09-10 2018-05-02 Janssen Pharmaceutica Nv A method for preparing compounds useful as SGLT inhibitors
US9056850B2 (en) 2008-10-17 2015-06-16 Janssen Pharmaceutica N.V. Process for the preparation of compounds useful as inhibitors of SGLT
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
DK2451797T3 (da) 2009-07-10 2013-06-24 Janssen Pharmaceutica Nv Fremgangsmåde til krystallisation for 1-(b-D-GLUCOPYRANOSYL)-4-METHYL-3-[5-(4-fluorphenyl)-2- thienylmethyl]benzen
EP2488515B1 (en) * 2009-10-14 2017-01-04 Janssen Pharmaceutica NV Process for the preparation of compounds useful as inhibitors of sglt2
TWI599360B (zh) 2010-05-11 2017-09-21 健生藥品公司 醫藥調配物
RS55056B1 (sr) 2011-04-13 2016-12-30 Janssen Pharmaceutica Nv Proces za pripremu jedinjenja koja su korisna kao inhibitori sglt2
TWI542596B (zh) 2011-05-09 2016-07-21 健生藥品公司 （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體
US20170071970A1 (en) 2015-09-15 2017-03-16 Janssen Pharmaceutica Nv Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
JP7754624B2 (ja) * 2017-11-14 2025-10-15 アルベマール・ジャーマニー・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 連続フロー条件下での有機リチウムプロセス
DE102019008481A1 (de) 2018-12-21 2020-06-25 Merck Patent Gmbh Kontinuierliches Verfahren zur Funktionalisierung von fluorierten Benzolverbindungen im Strömungsrohr
CN110510637B (zh) * 2019-08-22 2021-02-23 山东师范大学 一种锂循环合成氨的系统及工艺

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1500649A1 (de) * 2003-07-22 2005-01-26 CPC Cellular Process Chemistry Systems GmbH Verfahren zur Durchführung einer In-Situ-Quench Reaktion

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19858856A1 (de) * 1998-12-19 2000-06-21 Merck Patent Gmbh Verfahren zur Herstellung von Arylmetallverbindungen und deren Umsetzung mit Elektrophilen
DE10028754A1 (de) * 2000-06-09 2001-12-13 Clariant Gmbh Verfahren zur Herstellung von alkoholischen Lösungen von Alkalialkoholaten
JP4639042B2 (ja) * 2003-09-29 2011-02-23 富士フイルムファインケミカルズ株式会社 ハロゲン−リチウム交換反応を用いる有機化合物の製造法
JP4794873B2 (ja) * 2005-03-03 2011-10-19 富士フイルムファインケミカルズ株式会社 ハロゲン−リチウム交換反応を用いる有機化合物の製造法
AT501927B1 (de) * 2005-05-23 2007-06-15 Dsm Fine Chem Austria Gmbh Verbessertes verfahren zur durchführung von ritterreaktionen, elektrophilen additionen an alkenen oder friedel-crafts-alkylierungen
JPWO2008035633A1 (ja) * 2006-09-19 2010-01-28 萬有製薬株式会社 反応装置及び反応方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1500649A1 (de) * 2003-07-22 2005-01-26 CPC Cellular Process Chemistry Systems GmbH Verfahren zur Durchführung einer In-Situ-Quench Reaktion

Also Published As

Publication number Publication date
CA2674560A1 (en) 2008-08-14
IL199749A0 (en) 2010-04-15
EP2109616A1 (en) 2009-10-21
CN101605800A (zh) 2009-12-16
EP2109616B1 (en) 2010-08-25
HK1138008A1 (en) 2010-08-13
ES2351376T3 (es) 2011-02-03
PT2109616E (pt) 2010-11-29
WO2008095646A1 (en) 2008-08-14
HRP20100627T1 (hr) 2010-12-31
EA200901037A1 (ru) 2010-02-26
JP2010518035A (ja) 2010-05-27
MX2009008352A (es) 2009-10-30
IL199749A (en) 2013-02-28
EP1956023A1 (en) 2008-08-13
US20100113839A1 (en) 2010-05-06
ATE478877T1 (de) 2010-09-15
DE602008002321D1 (de) 2010-10-07
JP5394258B2 (ja) 2014-01-22
SI2109616T1 (sl) 2010-12-31
PL2109616T3 (pl) 2011-05-31
US8198487B2 (en) 2012-06-12
BRPI0807155A2 (pt) 2014-04-22
EA015237B1 (ru) 2011-06-30

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