CN101595106B - 作为治疗药物的取代的γ内酰胺 - Google Patents

作为治疗药物的取代的γ内酰胺 Download PDF

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Publication number
CN101595106B
CN101595106B CN200880003507.5A CN200880003507A CN101595106B CN 101595106 B CN101595106 B CN 101595106B CN 200880003507 A CN200880003507 A CN 200880003507A CN 101595106 B CN101595106 B CN 101595106B
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CN
China
Prior art keywords
another embodiment
phenyl
compound
och
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200880003507.5A
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English (en)
Chinese (zh)
Other versions
CN101595106A (zh
Inventor
D·W·奥尔德
W·B·艾姆
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Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of CN101595106A publication Critical patent/CN101595106A/zh
Application granted granted Critical
Publication of CN101595106B publication Critical patent/CN101595106B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CN200880003507.5A 2007-01-31 2008-01-29 作为治疗药物的取代的γ内酰胺 Expired - Fee Related CN101595106B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88741507P 2007-01-31 2007-01-31
US60/887,415 2007-01-31
PCT/US2008/052318 WO2008094912A2 (en) 2007-01-31 2008-01-29 Substituted gamma lactams as therapeutic agents

Publications (2)

Publication Number Publication Date
CN101595106A CN101595106A (zh) 2009-12-02
CN101595106B true CN101595106B (zh) 2014-05-07

Family

ID=39639429

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880003507.5A Expired - Fee Related CN101595106B (zh) 2007-01-31 2008-01-29 作为治疗药物的取代的γ内酰胺

Country Status (11)

Country Link
US (1) US7960381B2 (cg-RX-API-DMAC7.html)
EP (1) EP2121672B1 (cg-RX-API-DMAC7.html)
JP (1) JP5566692B2 (cg-RX-API-DMAC7.html)
KR (1) KR101561706B1 (cg-RX-API-DMAC7.html)
CN (1) CN101595106B (cg-RX-API-DMAC7.html)
AU (1) AU2008210559B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0808377B8 (cg-RX-API-DMAC7.html)
CA (1) CA2676291C (cg-RX-API-DMAC7.html)
MX (1) MX2009008039A (cg-RX-API-DMAC7.html)
NZ (1) NZ578698A (cg-RX-API-DMAC7.html)
WO (1) WO2008094912A2 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8377984B2 (en) * 2008-01-29 2013-02-19 Allergan, Inc. Substituted gamma lactams as therapeutic agents
WO2009132085A1 (en) * 2008-04-24 2009-10-29 Allergan, Inc. Substituted arylcyclopentenes as prostaglandin ep2 agonists
AU2009239381A1 (en) * 2008-04-24 2009-10-29 Allergan, Inc. Substituted gamma lactams as therapeutic agents
MX2010011636A (es) * 2008-04-24 2010-11-25 Allergan Inc Gamma lactamas sustituidas como agentes terapeuticos.
BRPI0912342A2 (pt) * 2008-05-09 2015-10-06 Allergan Inc tiazolidinonas, oxazolidinonas substituídas terapêuticas, e compostos relacionados
WO2009142969A1 (en) * 2008-05-20 2009-11-26 Allergan, Inc. Therapeutic lactams

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1653046A (zh) * 2002-03-05 2005-08-10 小野药品工业株式会社 8－氮杂前列腺素衍生化合物以及包含该化合物作为活性成分的药物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1409455B1 (en) * 2001-07-16 2006-01-04 F. Hoffmann-La Roche Ag Prostaglandin analogues-as ep4 receptor agonists
MXPA04004164A (es) * 2001-11-05 2004-09-06 Allergan Inc Analogos de omega-cicloalquil 17-heteroaril prostaglandina e2 como agonistas del receptor ep2.
US6573294B1 (en) * 2002-05-14 2003-06-03 Allergan, Inc. 8-azaprostaglandin analogs as agents for lowering intraocular pressure
US7419999B2 (en) * 2002-06-10 2008-09-02 Applied Research Systems Ars Holding N.V. Gamma lactams as prostaglandin agonists and use thereof
US7091231B2 (en) * 2004-12-10 2006-08-15 Allergan, Inc. 12-Aryl prostaglandin analogs
MX2007010818A (es) * 2005-03-10 2007-11-12 Allergan Inc Gamma lactamas sustituidas como agentes terapeuticos.
CA2645867A1 (en) * 2006-03-20 2007-09-27 Allergan, Inc. Substituted gamma lactams as prostaglandin ep2 agonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1653046A (zh) * 2002-03-05 2005-08-10 小野药品工业株式会社 8－氮杂前列腺素衍生化合物以及包含该化合物作为活性成分的药物

Also Published As

Publication number Publication date
AU2008210559A1 (en) 2008-08-07
EP2121672B1 (en) 2014-12-10
JP2010516817A (ja) 2010-05-20
WO2008094912A3 (en) 2008-10-09
BRPI0808377B8 (pt) 2021-05-25
US20100093729A1 (en) 2010-04-15
AU2008210559B2 (en) 2014-03-06
KR101561706B1 (ko) 2015-10-19
EP2121672A2 (en) 2009-11-25
BRPI0808377B1 (pt) 2020-01-21
MX2009008039A (es) 2009-08-18
US7960381B2 (en) 2011-06-14
CA2676291C (en) 2017-11-28
KR20090104905A (ko) 2009-10-06
NZ578698A (en) 2012-04-27
WO2008094912B1 (en) 2008-11-20
BRPI0808377A2 (pt) 2014-07-08
CA2676291A1 (en) 2008-08-07
JP5566692B2 (ja) 2014-08-06
WO2008094912A2 (en) 2008-08-07
CN101595106A (zh) 2009-12-02

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20140507

Termination date: 20220129