BRPI0808377B8 - composto, composição e uso de um composto - Google Patents

composto, composição e uso de um composto

Info

Publication number
BRPI0808377B8
BRPI0808377B8 BRPI0808377A BRPI0808377A BRPI0808377B8 BR PI0808377 B8 BRPI0808377 B8 BR PI0808377B8 BR PI0808377 A BRPI0808377 A BR PI0808377A BR PI0808377 A BRPI0808377 A BR PI0808377A BR PI0808377 B8 BRPI0808377 B8 BR PI0808377B8
Authority
BR
Brazil
Prior art keywords
compound
compounds
methods
composition
metabolite
Prior art date
Application number
BRPI0808377A
Other languages
English (en)
Inventor
W Old David
Bin Im Wha
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BRPI0808377A2 publication Critical patent/BRPI0808377A2/pt
Publication of BRPI0808377B1 publication Critical patent/BRPI0808377B1/pt
Publication of BRPI0808377B8 publication Critical patent/BRPI0808377B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

gama lactamas substituídas como agentes terapêuticos. a presente um composto compreendendo ou um sal farmaceuticamente aceitável, profármaco, ou um metabólito do mesmo. y,a, e b são como descritos aqui a invenção refere-se a métodos, composição medicamentos relacionados a esses compostos. métodos, composições e medicamentos relacionados com esses compostos são também revelados.
BRPI0808377A 2007-01-31 2008-01-29 composto, composição e uso de um composto BRPI0808377B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88741507P 2007-01-31 2007-01-31
US60/887,415 2007-01-31
PCT/US2008/052318 WO2008094912A2 (en) 2007-01-31 2008-01-29 Substituted gamma lactams as therapeutic agents

Publications (3)

Publication Number Publication Date
BRPI0808377A2 BRPI0808377A2 (pt) 2014-07-08
BRPI0808377B1 BRPI0808377B1 (pt) 2020-01-21
BRPI0808377B8 true BRPI0808377B8 (pt) 2021-05-25

Family

ID=39639429

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0808377A BRPI0808377B8 (pt) 2007-01-31 2008-01-29 composto, composição e uso de um composto

Country Status (11)

Country Link
US (1) US7960381B2 (pt)
EP (1) EP2121672B1 (pt)
JP (1) JP5566692B2 (pt)
KR (1) KR101561706B1 (pt)
CN (1) CN101595106B (pt)
AU (1) AU2008210559B2 (pt)
BR (1) BRPI0808377B8 (pt)
CA (1) CA2676291C (pt)
MX (1) MX2009008039A (pt)
NZ (1) NZ578698A (pt)
WO (1) WO2008094912A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8377984B2 (en) * 2008-01-29 2013-02-19 Allergan, Inc. Substituted gamma lactams as therapeutic agents
WO2009132097A1 (en) * 2008-04-24 2009-10-29 Allergan, Inc. Substituted gamma lactams as therapeutic agents
ES2399314T3 (es) * 2008-04-24 2013-03-27 Allergan, Inc. Gamma lactamas sustituidas como agentes terapeúticos
EP2288600A1 (en) 2008-04-24 2011-03-02 Allergan, Inc. Substituted arylcyclopentenes as prostaglandin ep2 agonists
CA2728229A1 (en) * 2008-05-09 2009-11-12 Allergan, Inc. Therapeutic substituted thiazolidinones, oxazolidinones, and related compounds
US8124648B2 (en) * 2008-05-20 2012-02-28 Allergan, Inc. Therapeutic lactams

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2288913C2 (ru) * 2001-07-16 2006-12-10 Ф.Хоффманн-Ля Рош Аг Аналоги простагландинов, способ их получения и фармацевтическая композиция, обладающая селективной агонистической активностью в отношении рецептора ep4
MXPA04004164A (es) * 2001-11-05 2004-09-06 Allergan Inc Analogos de omega-cicloalquil 17-heteroaril prostaglandina e2 como agonistas del receptor ep2.
MXPA04008596A (es) * 2002-03-05 2004-12-06 Ono Pharmaceutical Co Compuestos derivados de 8-azaprostaglandina y farmacos que contienen los compuestos como ingrediente activo.
US6573294B1 (en) * 2002-05-14 2003-06-03 Allergan, Inc. 8-azaprostaglandin analogs as agents for lowering intraocular pressure
EP1556347A4 (en) * 2002-06-10 2006-08-09 Applied Research Systems GAMMA LACTAME AS PROSTAGLAND INAGONISTS AND THEIR USE
US7091231B2 (en) * 2004-12-10 2006-08-15 Allergan, Inc. 12-Aryl prostaglandin analogs
PL384090A1 (pl) * 2005-03-10 2008-06-23 Allergan, Inc. Podstawione gamma laktamy jako środki lecznicze
EP1996546B1 (en) * 2006-03-20 2014-11-26 Allergan, Inc. Substituted gamma lactams as prostaglandin ep2 agonists

Also Published As

Publication number Publication date
WO2008094912B1 (en) 2008-11-20
BRPI0808377A2 (pt) 2014-07-08
CA2676291A1 (en) 2008-08-07
WO2008094912A3 (en) 2008-10-09
KR20090104905A (ko) 2009-10-06
BRPI0808377B1 (pt) 2020-01-21
US7960381B2 (en) 2011-06-14
MX2009008039A (es) 2009-08-18
CN101595106A (zh) 2009-12-02
AU2008210559B2 (en) 2014-03-06
EP2121672B1 (en) 2014-12-10
NZ578698A (en) 2012-04-27
CA2676291C (en) 2017-11-28
JP2010516817A (ja) 2010-05-20
KR101561706B1 (ko) 2015-10-19
EP2121672A2 (en) 2009-11-25
US20100093729A1 (en) 2010-04-15
JP5566692B2 (ja) 2014-08-06
AU2008210559A1 (en) 2008-08-07
WO2008094912A2 (en) 2008-08-07
CN101595106B (zh) 2014-05-07

Similar Documents

Publication Publication Date Title
TW200714583A (en) Substituted gamma lactams as therapeutic agents
BR122013025375B8 (pt) compostos orgânicos, seus métodos de preparo e uso, bem como composições farmacêuticas
EA201101672A1 (ru) Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина
UY29963A1 (es) Compuestos terapéuticos: piridinas y pirazinas como andamios
DE602006006712D1 (de) Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren
TN2009000180A1 (en) NOVEL 1,4-BENZOTHIEPIN-l,1-DIOXIDE DERIVATIVES WHICH ARE SUBSTITUTED WITH BENZYL GROUPS, METHOD FOR PRODUCING DRUGS CONTAINING SAID COMPOUNDS AND USE THEREOF
ATE493386T1 (de) Trans-3-aza-bicyclo-ä3.1.0ü-hexan-derivate
ATE483707T1 (de) 2-cyclopropylthiazolderivate
PA8724201A1 (es) Piridin[3,4b] pirazinonas
MX2009011997A (es) Derivados de pirrolopirimidin-7-ona y su uso como farmaceuticos.
EA200971081A1 (ru) Пуриновые производные и их применение в качестве модуляторов толл-подобного рецептора 7
UY30316A1 (es) Derivados sustituidos de benzamidas, nicotinamidas, propanamidas, acetamidas y carboxamidas n-(2-(piperidin-1-ilmetil)ciclohexil)sustituidas, procesos de preparacion, composiciones conteniéndolos y aplicaciones
ECSP13012788A (es) Derivados de biciclo[3,2,1]octilamida y sus usos
EA201101398A1 (ru) Замещенные пиперидины в качестве антагонистов ccr3
AR054347A1 (es) Combinaciones terapeuticas para el tratamiento o la prevencion de la depresion
BRPI0821255A2 (pt) Derivados de espiroindolinona
BRPI0714885B8 (pt) compostos terapêuticos e seu uso
UY30393A1 (es) Derivados sustituidos de la 1-piperidin-1-il-1,3-dihidro-2h-benzimidazol-2-ona, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones
ATE466842T1 (de) 3-substituierte pyridinderivate als h3- antagonisten
DOP2011000134A (es) Lactamas como inhibidores de beta secretasa
MX2010002584A (es) Derivados de piperidina como agonistas de receptores muscarinicos.
BRPI0808377B8 (pt) composto, composição e uso de um composto
ECSP088966A (es) Agonistas del receptor muscarínico que son efectivos en el tratamiento del dolor, la enfermedad de alzheimer y la esquizofrenia
BR112012031340A2 (pt) derivados de cianoquinolina
PH12015501386A1 (en) Tricyclic compounds

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 21/01/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 29/01/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2707 DE 22-11-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.