CN101591344A - 一种抗血栓的化合物、其制备方法和用途 - Google Patents
一种抗血栓的化合物、其制备方法和用途 Download PDFInfo
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- CN101591344A CN101591344A CNA2008100977567A CN200810097756A CN101591344A CN 101591344 A CN101591344 A CN 101591344A CN A2008100977567 A CNA2008100977567 A CN A2008100977567A CN 200810097756 A CN200810097756 A CN 200810097756A CN 101591344 A CN101591344 A CN 101591344A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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CN2008100977567A CN101591344B (zh) | 2008-05-27 | 2008-05-27 | 一种抗血栓的化合物、其制备方法和用途 |
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CN2008100977567A CN101591344B (zh) | 2008-05-27 | 2008-05-27 | 一种抗血栓的化合物、其制备方法和用途 |
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CN101591344A true CN101591344A (zh) | 2009-12-02 |
CN101591344B CN101591344B (zh) | 2012-12-05 |
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Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011079407A1 (zh) * | 2009-12-28 | 2011-07-07 | 北京益君康医药技术有限公司 | 新的具有抗凝血作用的化合物 |
CN102120744A (zh) * | 2010-02-02 | 2011-07-13 | 江苏威凯尔医药科技有限公司 | 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途 |
CN102212068A (zh) * | 2010-04-06 | 2011-10-12 | 刘桂坤 | 噻吩衍生物及其制备方法和在药物上的应用 |
WO2012139422A1 (zh) * | 2011-04-14 | 2012-10-18 | Yan Xiaojing | 新型抗血小板化合物的加成盐 |
CN102775421A (zh) * | 2011-05-10 | 2012-11-14 | 江苏威凯尔医药科技有限公司 | 2-羟基四氢噻吩并吡啶衍生物盐酸盐、其制备方法及医药用途 |
CN102827184A (zh) * | 2011-06-13 | 2012-12-19 | 江苏威凯尔医药科技有限公司 | 2-羟基四氢噻吩并吡啶衍生物的多晶型物和药物组合物 |
CN102838617A (zh) * | 2011-06-21 | 2012-12-26 | 江苏威凯尔医药科技有限公司 | (S)-2-(2-烟酰氧基-6,7-二氢噻吩并[3,2-c]吡啶-5(4H)-基)-2-(2-氯苯基)-乙酸甲酯的多晶型物和药物组合物 |
CN103254211A (zh) * | 2012-02-17 | 2013-08-21 | 江苏威凯尔医药科技有限公司 | 一种制备维卡格雷及其衍生物的方法 |
US8541422B2 (en) | 2010-08-26 | 2013-09-24 | Ipca Laboratories Limited | Methods for the treatment or prophylaxis of thrombosis or embolism |
CN101684124B (zh) * | 2008-09-22 | 2013-11-13 | 广州赫尔氏药物开发有限公司 | 新的具有抗凝血作用的化合物 |
CN105362266A (zh) * | 2014-08-28 | 2016-03-02 | 杭州雷索药业有限公司 | 噻吩并吡啶类化合物或其在药学上可接受的盐在制备治疗或预防癫痫药物中的应用 |
CN103936756B (zh) * | 2008-09-22 | 2017-09-19 | 广州赫尔氏药物开发有限公司 | 具有抗凝血作用的化合物 |
CN107304215A (zh) * | 2016-04-20 | 2017-10-31 | 陕西合成药业股份有限公司 | 噻吩吡啶类衍生物及其制备方法和用途 |
US11130766B2 (en) | 2015-06-23 | 2021-09-28 | Jiangsu Tasly Diyi Pharmaceutical Co., Ltd. | Deuterated thienopiperidine derivatives, manufacturing method, and application thereof |
CN114736215A (zh) * | 2022-04-19 | 2022-07-12 | 中荣凯特(北京)生物科技有限公司 | 四氢噻吩并吡啶氘代衍生物及其制备方法和药物用途 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI101150B (fi) * | 1991-09-09 | 1998-04-30 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi |
CN1318428C (zh) * | 2005-02-23 | 2007-05-30 | 天津药物研究院 | 噻吩并吡啶取代的乙酰肼衍生物 |
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2008
- 2008-05-27 CN CN2008100977567A patent/CN101591344B/zh not_active Expired - Fee Related
Cited By (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101684124B (zh) * | 2008-09-22 | 2013-11-13 | 广州赫尔氏药物开发有限公司 | 新的具有抗凝血作用的化合物 |
CN103936756B (zh) * | 2008-09-22 | 2017-09-19 | 广州赫尔氏药物开发有限公司 | 具有抗凝血作用的化合物 |
WO2011079407A1 (zh) * | 2009-12-28 | 2011-07-07 | 北京益君康医药技术有限公司 | 新的具有抗凝血作用的化合物 |
JP2018002748A (ja) * | 2010-02-02 | 2018-01-11 | 江蘇威凱爾医薬科技有限公司 | 光学活性な2−ヒドロキシテトラヒドロチエノピリジン誘導体、その調製方法及び医薬の製造におけるその使用 |
EP3290423A1 (en) * | 2010-02-02 | 2018-03-07 | Jiangsu Vcare Pharmatech Co., Ltd | Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of medicament thereof |
KR102215429B1 (ko) | 2010-02-02 | 2021-02-16 | 지앙수 브이케어 파마테크 컴퍼니 리미티드 | 광학활성 2-히드록시테트라히드로티에노피리딘 유도체 및 그 제조방법과 제약적 용도 |
KR20190060874A (ko) * | 2010-02-02 | 2019-06-03 | 지앙수 브이케어 파마테크 컴퍼니 리미티드 | 광학활성 2-히드록시테트라히드로티에노피리딘 유도체 및 그 제조방법과 제약적 용도 |
KR101984456B1 (ko) | 2010-02-02 | 2019-05-30 | 지앙수 브이케어 파마테크 컴퍼니 리미티드 | 광학활성 2-히드록시테트라히드로티에노피리딘 유도체 및 그 제조방법과 제약적 용도 |
CN102120744B (zh) * | 2010-02-02 | 2013-01-09 | 江苏威凯尔医药科技有限公司 | 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途 |
CN102863457A (zh) * | 2010-02-02 | 2013-01-09 | 江苏威凯尔医药科技有限公司 | 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途 |
KR20180133934A (ko) * | 2010-02-02 | 2018-12-17 | 지앙수 브이케어 파마테크 컴퍼니 리미티드 | 광학활성 2-히드록시테트라히드로티에노피리딘 유도체 및 그 제조방법과 제약적 용도 |
US10000506B2 (en) * | 2010-02-02 | 2018-06-19 | Jiangsu Vcare Pharmatech Co., Ltd. | Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of medicament thereof |
CN102120744A (zh) * | 2010-02-02 | 2011-07-13 | 江苏威凯尔医药科技有限公司 | 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途 |
CN102863457B (zh) * | 2010-02-02 | 2013-10-09 | 江苏威凯尔医药科技有限公司 | 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途 |
WO2011095049A1 (zh) * | 2010-02-02 | 2011-08-11 | 江苏威凯尔医药科技有限公司 | 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途 |
US20170121341A1 (en) * | 2010-02-02 | 2017-05-04 | Jiangsu Vcare Pharmatech Co., Ltd. | Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of medicament thereof |
JP2016166232A (ja) * | 2010-02-02 | 2016-09-15 | 江蘇威凱爾医薬科技有限公司 | 光学活性な2−ヒドロキシテトラヒドロチエノピリジン誘導体、その調製方法及び医薬の製造におけるその使用 |
US8772489B2 (en) | 2010-02-02 | 2014-07-08 | Jiangsu Vcare PharmaTech Co. Ltd. | Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of medicament thereof |
JP2013518825A (ja) * | 2010-02-02 | 2013-05-23 | 江蘇威凱爾医薬科技有限公司 | 光学活性な2−ヒドロキシテトラヒドロチエノピリジン誘導体、その調製方法及び医薬の製造におけるその使用 |
CN102212068A (zh) * | 2010-04-06 | 2011-10-12 | 刘桂坤 | 噻吩衍生物及其制备方法和在药物上的应用 |
US9321785B2 (en) | 2010-08-26 | 2016-04-26 | Ipca Laboratories Limited | Methods for the treatment or prophylaxis of thrombosis or embolism |
US8541422B2 (en) | 2010-08-26 | 2013-09-24 | Ipca Laboratories Limited | Methods for the treatment or prophylaxis of thrombosis or embolism |
KR101552691B1 (ko) | 2011-04-14 | 2015-09-11 | 광저우 히어쉬 파머 디벨롭먼트 컴퍼니 리미티드 | 신규한 항-혈소판 화합물의 부가염 |
CN103517909A (zh) * | 2011-04-14 | 2014-01-15 | 广州赫尔氏药物开发有限公司 | 新型抗血小板化合物的加成盐 |
WO2012139422A1 (zh) * | 2011-04-14 | 2012-10-18 | Yan Xiaojing | 新型抗血小板化合物的加成盐 |
CN103517909B (zh) * | 2011-04-14 | 2015-04-08 | 广州赫尔氏药物开发有限公司 | 新型抗血小板化合物的加成盐 |
US9556196B2 (en) | 2011-04-14 | 2017-01-31 | Guangzhou Heershi Pharma Development Co., Ltd | Anti-platelet compound addition salt |
CN102775421A (zh) * | 2011-05-10 | 2012-11-14 | 江苏威凯尔医药科技有限公司 | 2-羟基四氢噻吩并吡啶衍生物盐酸盐、其制备方法及医药用途 |
CN102827184A (zh) * | 2011-06-13 | 2012-12-19 | 江苏威凯尔医药科技有限公司 | 2-羟基四氢噻吩并吡啶衍生物的多晶型物和药物组合物 |
CN102838617A (zh) * | 2011-06-21 | 2012-12-26 | 江苏威凯尔医药科技有限公司 | (S)-2-(2-烟酰氧基-6,7-二氢噻吩并[3,2-c]吡啶-5(4H)-基)-2-(2-氯苯基)-乙酸甲酯的多晶型物和药物组合物 |
CN103254211B (zh) * | 2012-02-17 | 2015-12-16 | 江苏威凯尔医药科技有限公司 | 一种制备维卡格雷及其衍生物的方法 |
CN103254211A (zh) * | 2012-02-17 | 2013-08-21 | 江苏威凯尔医药科技有限公司 | 一种制备维卡格雷及其衍生物的方法 |
CN105362266A (zh) * | 2014-08-28 | 2016-03-02 | 杭州雷索药业有限公司 | 噻吩并吡啶类化合物或其在药学上可接受的盐在制备治疗或预防癫痫药物中的应用 |
US11130766B2 (en) | 2015-06-23 | 2021-09-28 | Jiangsu Tasly Diyi Pharmaceutical Co., Ltd. | Deuterated thienopiperidine derivatives, manufacturing method, and application thereof |
CN107304215A (zh) * | 2016-04-20 | 2017-10-31 | 陕西合成药业股份有限公司 | 噻吩吡啶类衍生物及其制备方法和用途 |
CN114736215A (zh) * | 2022-04-19 | 2022-07-12 | 中荣凯特(北京)生物科技有限公司 | 四氢噻吩并吡啶氘代衍生物及其制备方法和药物用途 |
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Owner name: JIANGSU HANSOH MEDICAL GROUP CO.,LTD. Free format text: FORMER OWNER: LIANYUNGANG HENGBANG PHARMACEUTICAL TECHNOLOGY CO., LTD. Effective date: 20131113 |
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Effective date of registration: 20131113 Address after: 222047 Lianyungang Development Zone, Jiangsu Patentee after: Jiangsu Hansoh Medical Group Co.,Ltd. Address before: 222047 tenth Industrial Zone, Lianyungang economic and Technological Development Zone, Jiangsu Patentee before: Lianyungang Hengbang Pharmaceutical Technology Co., Ltd. |
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Effective date of registration: 20160315 Address after: 222047 Lianyungang economic and Technological Development Zone, Jiangsu Patentee after: JIANGSU HANSOH PHARMACEUTICAL GROUP LIANYUNGANG HONGCHUANG PHARMACEUTICAL CO., LTD. Address before: 222047 Lianyungang Development Zone, Jiangsu Patentee before: Jiangsu Hansoh Medical Group Co.,Ltd. |
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