CN101578296A - 结合btla的人类单克隆抗体及使用方法 - Google Patents

结合btla的人类单克隆抗体及使用方法 Download PDF

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Publication number
CN101578296A
CN101578296A CNA2007800494156A CN200780049415A CN101578296A CN 101578296 A CN101578296 A CN 101578296A CN A2007800494156 A CNA2007800494156 A CN A2007800494156A CN 200780049415 A CN200780049415 A CN 200780049415A CN 101578296 A CN101578296 A CN 101578296A
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antibody
variable region
seq
chain variable
human
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A·科曼
M·塞尔比
K·B·图迪乌姆
E·哈尔克
M·斯里尼瓦桑
D·B·帕斯莫尔
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ER Squibb and Sons LLC
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Medarex LLC
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
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    • A61P33/00—Antiparasitic agents
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    • A61P33/00—Antiparasitic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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CNA2007800494156A 2006-11-15 2007-11-15 结合btla的人类单克隆抗体及使用方法 Pending CN101578296A (zh)

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EP (1) EP2097447A4 (enExample)
JP (1) JP2010509920A (enExample)
KR (1) KR20090088891A (enExample)
CN (1) CN101578296A (enExample)
AR (1) AR063840A1 (enExample)
AU (1) AU2007334264A1 (enExample)
CA (1) CA2669921A1 (enExample)
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Cited By (18)

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CN104974253A (zh) * 2014-04-01 2015-10-14 上海中信国健药业股份有限公司 抗ctla-4/pd-1双特异性抗体、其制备方法及应用
CN107043419A (zh) * 2016-12-13 2017-08-15 无锡傲锐东源生物科技有限公司 抗btla蛋白单克隆抗体及其用途
WO2018068756A1 (en) * 2016-10-14 2018-04-19 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric btla
CN108925136A (zh) * 2015-12-02 2018-11-30 斯特赛恩斯公司 特异于糖基化的btla（b和t淋巴细胞衰减因子）的抗体
CN110121508A (zh) * 2016-10-25 2019-08-13 法国国家健康和医学研究院 与cd160跨膜同种型结合的单克隆抗体
CN110526973A (zh) * 2016-12-21 2019-12-03 南京金斯瑞生物科技有限公司 高亲和力、高特异性、多抗原识别表位的具有更高功能性的抗人ctla4抗体
CN110621699A (zh) * 2017-05-19 2019-12-27 伊莱利利公司 Btla激动剂抗体及其用途
CN111423511A (zh) * 2013-05-31 2020-07-17 索伦托治疗有限公司 与pd-1结合的抗原结合蛋白
CN111465615A (zh) * 2017-08-21 2020-07-28 天演药业公司 抗cd137分子及其用途
CN112533948A (zh) * 2018-05-31 2021-03-19 台湾醣联生技医药股份有限公司 与双触角Lewis B以及Lewis Y抗原结合的治疗性抗体
CN112566935A (zh) * 2018-05-23 2021-03-26 百济神州有限公司 抗ox40抗体和使用方法
CN113583131A (zh) * 2014-08-19 2021-11-02 默沙东公司 抗tigit抗体
CN113939539A (zh) * 2019-05-15 2022-01-14 博奥信生物技术（南京）有限公司 结合csf-1r的抗体及其用途
CN114409786A (zh) * 2017-12-20 2022-04-29 和铂医药(上海)有限责任公司 结合ctla-4的抗体及其用途
CN114457025A (zh) * 2020-10-30 2022-05-10 未来智人再生医学研究院(广州)有限公司 一种表达btla阻断物的多能干细胞或其衍生物及应用
CN114657137A (zh) * 2020-12-22 2022-06-24 未来智人再生医学研究院(广州)有限公司 一种表达靶向BTLA的shRNA和/或shRNA-miR的多能干细胞或其衍生物
CN115141279A (zh) * 2018-09-26 2022-10-04 福州拓新天成生物科技有限公司 抗b7-h3的单克隆抗体及其在细胞治疗中的应用
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