CN101578296A - 结合btla的人类单克隆抗体及使用方法 - Google Patents

结合btla的人类单克隆抗体及使用方法 Download PDF

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Publication number
CN101578296A
CN101578296A CNA2007800494156A CN200780049415A CN101578296A CN 101578296 A CN101578296 A CN 101578296A CN A2007800494156 A CNA2007800494156 A CN A2007800494156A CN 200780049415 A CN200780049415 A CN 200780049415A CN 101578296 A CN101578296 A CN 101578296A
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antibody
variable region
seq
chain variable
human
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A·科曼
M·塞尔比
K·B·图迪乌姆
E·哈尔克
M·斯里尼瓦桑
D·B·帕斯莫尔
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ER Squibb and Sons LLC
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Medarex LLC
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61P33/00—Antiparasitic agents
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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CNA2007800494156A 2006-11-15 2007-11-15 结合btla的人类单克隆抗体及使用方法 Pending CN101578296A (zh)

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US60/866,058 2006-11-15

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EP (1) EP2097447A4 (enExample)
JP (1) JP2010509920A (enExample)
KR (1) KR20090088891A (enExample)
CN (1) CN101578296A (enExample)
AR (1) AR063840A1 (enExample)
AU (1) AU2007334264A1 (enExample)
CA (1) CA2669921A1 (enExample)
CL (1) CL2007003291A1 (enExample)
EA (1) EA200970477A1 (enExample)
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CN104974253A (zh) * 2014-04-01 2015-10-14 上海中信国健药业股份有限公司 抗ctla-4/pd-1双特异性抗体、其制备方法及应用
CN107043419A (zh) * 2016-12-13 2017-08-15 无锡傲锐东源生物科技有限公司 抗btla蛋白单克隆抗体及其用途
WO2018068756A1 (en) * 2016-10-14 2018-04-19 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric btla
CN108925136A (zh) * 2015-12-02 2018-11-30 斯特赛恩斯公司 特异于糖基化的btla（b和t淋巴细胞衰减因子）的抗体
CN110121508A (zh) * 2016-10-25 2019-08-13 法国国家健康和医学研究院 与cd160跨膜同种型结合的单克隆抗体
CN110526973A (zh) * 2016-12-21 2019-12-03 南京金斯瑞生物科技有限公司 高亲和力、高特异性、多抗原识别表位的具有更高功能性的抗人ctla4抗体
CN110621699A (zh) * 2017-05-19 2019-12-27 伊莱利利公司 Btla激动剂抗体及其用途
CN111423511A (zh) * 2013-05-31 2020-07-17 索伦托治疗有限公司 与pd-1结合的抗原结合蛋白
CN111465615A (zh) * 2017-08-21 2020-07-28 天演药业公司 抗cd137分子及其用途
CN112533948A (zh) * 2018-05-31 2021-03-19 台湾醣联生技医药股份有限公司 与双触角Lewis B以及Lewis Y抗原结合的治疗性抗体
CN112566935A (zh) * 2018-05-23 2021-03-26 百济神州有限公司 抗ox40抗体和使用方法
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CN113939539A (zh) * 2019-05-15 2022-01-14 博奥信生物技术（南京）有限公司 结合csf-1r的抗体及其用途
CN114409786A (zh) * 2017-12-20 2022-04-29 和铂医药(上海)有限责任公司 结合ctla-4的抗体及其用途
CN114457025A (zh) * 2020-10-30 2022-05-10 未来智人再生医学研究院(广州)有限公司 一种表达btla阻断物的多能干细胞或其衍生物及应用
CN114657137A (zh) * 2020-12-22 2022-06-24 未来智人再生医学研究院(广州)有限公司 一种表达靶向BTLA的shRNA和/或shRNA-miR的多能干细胞或其衍生物
CN115141279A (zh) * 2018-09-26 2022-10-04 福州拓新天成生物科技有限公司 抗b7-h3的单克隆抗体及其在细胞治疗中的应用

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