CN101565694B - 丹酚酸酶及丹酚酸酶和人参皂苷混合酶的制备方法及用所制得的酶转化药材的方法 - Google Patents
丹酚酸酶及丹酚酸酶和人参皂苷混合酶的制备方法及用所制得的酶转化药材的方法 Download PDFInfo
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- CN101565694B CN101565694B CN200810052882.0A CN200810052882A CN101565694B CN 101565694 B CN101565694 B CN 101565694B CN 200810052882 A CN200810052882 A CN 200810052882A CN 101565694 B CN101565694 B CN 101565694B
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- 239000006286 aqueous extract Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- PYXFVCFISTUSOO-UHFFFAOYSA-N betulafolienetriol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC(C(C)(O)CCC=C(C)C)C4C(O)CC3C21C PYXFVCFISTUSOO-UHFFFAOYSA-N 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000009514 concussion Effects 0.000 description 1
- 239000012084 conversion product Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 229930004069 diterpene Natural products 0.000 description 1
- 150000004141 diterpene derivatives Chemical class 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229940107131 ginseng root Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- SWQINCWATANGKN-UHFFFAOYSA-N protopanaxadiol Natural products CC(CCC=C(C)C)C1CCC2(C)C1C(O)CC1C3(C)CCC(O)C(C)(C)C3CCC21C SWQINCWATANGKN-UHFFFAOYSA-N 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 238000010563 solid-state fermentation Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 235000015961 tonic Nutrition 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 229960000716 tonics Drugs 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
人参皂苷 | R1 | R2 |
Rb1 | Glc1-2Glc- | Glc1-6Glc-(S) |
Rd | Glc1-2Glc- | Glc-(S) |
F2 | Glc- | Glc-(S) |
Rg3 | Glc1-2Glc- | H-(R,S) |
Rh2 | Glc- | H-(R,S) |
C-K | H- | Glc-(S) |
Ginsenoside | R1 | R2 |
Re | Rha1-2Glc- | Glc-(S) |
R1 | Xyl1-2Glc | Glc-(S) |
Rg1 | Glc- | Glc-(S) |
Rg2 | Rha1-2Glc- | H-(S,R) |
Rh1 | Glc- | H-(S,R) |
Claims (4)
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CN200810052882.0A CN101565694B (zh) | 2008-04-25 | 2008-04-25 | 丹酚酸酶及丹酚酸酶和人参皂苷混合酶的制备方法及用所制得的酶转化药材的方法 |
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CN200810052882.0A CN101565694B (zh) | 2008-04-25 | 2008-04-25 | 丹酚酸酶及丹酚酸酶和人参皂苷混合酶的制备方法及用所制得的酶转化药材的方法 |
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Families Citing this family (14)
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CN102154185B (zh) * | 2011-03-31 | 2012-08-15 | 黑龙江大学 | 一株产咖啡酸的刺五加内生细菌 |
CN104894204B (zh) * | 2015-05-27 | 2018-04-17 | 金凤燮 | 微生物酶转化人参茎叶皂苷制备人参稀有皂苷的方法 |
CN104873433B (zh) * | 2015-05-28 | 2018-04-20 | 郑州市嘉蓓丽生物科技有限公司 | 一种艾草护肤霜及其制备方法 |
CN104840476B (zh) * | 2015-06-08 | 2018-01-30 | 大连医科大学 | 人参稀有皂苷c‑k的抗急性缺血性脑卒中的神经保护和损伤修复应用 |
KR20170047007A (ko) * | 2015-10-22 | 2017-05-04 | (주)아모레퍼시픽 | 효소적 방법에 의하여 인삼의 사포닌으로부터 진세노사이드 F2, 컴파운드 Mc 및 컴파운드 O를 선택적으로 제조하는 방법 |
CN108949655B (zh) * | 2018-04-19 | 2019-10-25 | 江南大学 | 一种工程菌及其在丹参素和丙酮酸联产中的应用 |
JP7075505B2 (ja) | 2018-04-19 | 2022-05-25 | 江南大学 | 組換え大腸菌、及び組換え大腸菌を用いたサルビアノリン酸aの生産方法 |
CN108949650B (zh) * | 2018-04-19 | 2019-10-25 | 江南大学 | 一种丹参素的生产方法及工程菌 |
CN108949657B (zh) * | 2018-04-19 | 2019-10-25 | 江南大学 | 一种工程菌及其在丹参素和α-酮戊二酸联产中的应用 |
CN108949648B (zh) * | 2018-04-19 | 2019-10-25 | 江南大学 | 一种工程菌及其以廉价底物生产丹参素的应用 |
CN108588054B (zh) * | 2018-05-11 | 2021-11-26 | 上海中医药大学 | 一种三七皂苷糖苷水解酶及其突变体在生产越南人参皂苷r7中的应用 |
CN112138040B (zh) * | 2020-09-28 | 2021-10-01 | 上海长征富民金山制药有限公司 | 一种丹参提取物、注射剂及其用途 |
US20240043901A1 (en) * | 2021-10-19 | 2024-02-08 | Mingzhiyuan (Hangzhou) Biological Technology Co., Ltd | A method for preparing ginsenoside preparation by biological engineering technology |
CN115286682B (zh) * | 2022-09-02 | 2023-07-25 | 大连工业大学 | 一种3-o-阿拉伯糖基美商陆酸皂苷及其制备方法与应用 |
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