CN101559199B - Chinese materia medica preparation for controlling tumor and adjunct tumor radiotherapy and chemotherapy and preparation method thereof - Google Patents
Chinese materia medica preparation for controlling tumor and adjunct tumor radiotherapy and chemotherapy and preparation method thereof Download PDFInfo
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- CN101559199B CN101559199B CN2009100151689A CN200910015168A CN101559199B CN 101559199 B CN101559199 B CN 101559199B CN 2009100151689 A CN2009100151689 A CN 2009100151689A CN 200910015168 A CN200910015168 A CN 200910015168A CN 101559199 B CN101559199 B CN 101559199B
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Abstract
The present invention relates to a Chinese materia medica preparation for controlling tumor and adjunct tumor radiotherapy and chemotherapy, which is prepared by the bulk drugs with weight as follows: 110-130g of bupleurum, 160-200g of curcuma, 560-640g of smilax glabra, 280-320g of dandelions, 140-160g of radix astragali, 280-320g of patrinia scaniosaefolia (dahurian patrinia herb), 160-200g of cattail pollen, 160-200g of two tooth achyranthes root, 220-260g of angelica, 160-200g of rhizoma atractylodis, 100-140g of honey-fried licorice root, 220-260g of rehmannia glutinosa, 100-140g of ginseng and 50-70g of leech. The Chinese materia medica preparation of the invention gives priority to supporting healthy energy, has the efficacy of reinforcing the spleen and regulating the stomach, clearing away heat and toxic material, activating blood circulation and absorbing clots, effectively restores energy of the patients, improves the symptom of deficiency of both qi and yin of the patients, alleviates the toxic side effect brought about by radiotherapy and chemotherapy and improve the quality of lives of the patients. The Chinese materia medica preparation is simple in preparation process and convenient for the patients to take.
Description
Technical field
The present invention relates to the Chinese medicine preparation of a kind of anti-curing oncoma and auxiliary tumor chemoradiotherapy, belong to technical field of Chinese medicines.
Background technology
Tumor is the disease of a kind of serious harm human health and life, and the main treatment means of present clinical employing has operative treatment, radiation and chemotherapy etc.Radiotherapy, chemotherapy are when removing patient's interior tumor cell, lethality to the human normal cell also is very large, the patient is without exception generation such as toxic reaction such as bone marrow depression, leukopenia, digestive tract reaction, hypoimmunity, mucocutaneous infringement almost, and severe patient is forced to therapy discontinued.To this, clinical processing mode commonly used is: at different symptoms supplementing water electrolyte, Energy mixture, Bendectin, anti-infectives etc., the effect of these means is scarcely good.Therefore, how can reduce, to alleviate the toxic and side effects of chemicotherapy to human body effectively, improve patient's immunity of organisms, guarantee the effect of oncotherapy, be problem demanding prompt solution in the present antitumor process.
In recent years, put in tumor, chemotherapy and postoperative, cooperate the dialectical treatment of the traditional Chinese medical science, recover the vigour of tumor patient health gradually, strengthen the immunity of its body, alleviate put, the toxic and side effects of chemotherapy, in oncotherapy, reached common recognition.Therefore, study rational and effective tcm product more, be very important with therapeutic effect and the life quality that improves the patient.
Summary of the invention
At the deficiency of above-mentioned existence, the object of the present invention is to provide the Chinese medicine preparation of a kind of anti-curing oncoma and auxiliary tumor chemoradiotherapy.
The present invention also provides the preparation method of above-mentioned Chinese medicine preparation.
The present invention is achieved by the following technical solutions:
The Chinese medicine preparation of described anti-curing oncoma and auxiliary tumor chemoradiotherapy is to be made by following raw medicaments in portion by weight:
Radix Bupleuri 110-130g Radix Curcumae 160-200g Rhizoma Smilacis Glabrae 560-640g Herba Taraxaci 280-320g Radix Astragali 140-160g Herba Patriniae (Herba Patriniae) 280-320g Pollen Typhae 160-200g Radix Achyranthis Bidentatae 160-200g Radix Angelicae Sinensis 220-260g Rhizoma Atractylodis 160-200g Radix Glycyrrhizae Preparata 100-140g Radix Rehmanniae Preparata 220-260g Radix Ginseng 100-140g Hirudo 50-70g.
For reaching better drug effect, it is to be made by following raw medicaments in portion by weight that above-mentioned Chinese medicine preparation is preferably filled a prescription: Radix Bupleuri 120g Radix Curcumae 180g Rhizoma Smilacis Glabrae 600g Herba Taraxaci 300g Radix Astragali 150g Herba Patriniae (Herba Patriniae) 300g Pollen Typhae 180g Radix Achyranthis Bidentatae 180g Radix Angelicae Sinensis 240g Rhizoma Atractylodis 180g Radix Rehmanniae Preparata 240g Radix Glycyrrhizae Preparata 120g Radix Ginseng 120g Hirudo 60g.
Chinese medicine preparation of the present invention is preferably capsule or granule.
The preparation method of above-mentioned Chinese medicine preparation mainly may further comprise the steps:
(1) all the other 12 flavor medicines that Radix Ginseng, Hirudo is outer decocting of adding 18～20 times of amounts boils 2 times, each 1.5h, and collecting decoction, refining, filter, be concentrated into density and be 1.30～1.35 extractum;
(2) Hirudo, Radix Ginseng powder are broken into fine powder, mix, add dextrin and correctives, add ethanol with above-mentioned extractum, through granulating, drying, behind the granulate promptly.
The present invention is through the research screening and the clinical practice of multiple formulations ratio, determine drug regimen of the present invention, based on strengthening the body resistance, the effect that has spleen reinforcing stomach function regulating, heat-clearing and toxic substances removing, blood circulation promoting competent silt simultaneously, the vigour that the efficient recovery patient can be arranged, improve the symptom of patient's deficiency of both QI and YIN, alleviate the toxicity that chemicotherapy brings, improve patient's life quality.Pharmaceutical preparation of the present invention is simple, makes things convenient for the patient to take.
The invention will be further described below in conjunction with specific embodiment.
Embodiment 1
The Chinese medicine preparation of described anti-curing oncoma and auxiliary tumor chemoradiotherapy is to be made by following raw medicaments in portion by weight: Radix Bupleuri 120g Radix Curcumae 180g Rhizoma Smilacis Glabrae 600g Herba Taraxaci 300g Radix Astragali 150g Herba Patriniae (Herba Patriniae) 300g Pollen Typhae 180g Radix Achyranthis Bidentatae 180g Radix Angelicae Sinensis 240g Rhizoma Atractylodis 180g Radix Rehmanniae Preparata 240g Radix Glycyrrhizae Preparata 120g Radix Ginseng 120g Hirudo 60g.
The specific embodiment
The preparation method of above-mentioned Chinese medicine preparation mainly may further comprise the steps:
(1) decocting that Radix Ginseng, all the other outer 12 flavor medicines of Hirudo is added 20 times of amounts boils 2 times, each 1.5h, and collecting decoction, refining, filter, being concentrated into density is the extractum of 1.35 (50-60 ℃);
(2) Hirudo, Radix Ginseng powder are broken into fine powder, mix with above-mentioned extractum, add dextrin and correctives, add ethanol, through granulating, drying promptly gets brown yellow granule behind the granulate.
Usage and consumption: each 15g, every day 3 times, warm water is taken after mixing it with water, and 20 days is 1 course of treatment,
Embodiment 2
The Chinese medicine preparation of described anti-curing oncoma and auxiliary tumor chemoradiotherapy is to be made by following raw medicaments in portion by weight: Radix Bupleuri 110g Radix Curcumae 160g Rhizoma Smilacis Glabrae 560g Herba Taraxaci 320g Radix Astragali 160g Herba Patriniae (Herba Patriniae) 280g Pollen Typhae 160g Radix Achyranthis Bidentatae 200g Radix Angelicae Sinensis 260g Rhizoma Atractylodis 200g Radix Glycyrrhizae Preparata 100g Radix Rehmanniae Preparata 220g Radix Ginseng 100g Hirudo 50g.
The preparation method of above-mentioned Chinese medicine preparation mainly may further comprise the steps:
(1) decocting that Radix Ginseng, all the other outer 12 flavor medicines of Hirudo is added 18 times of amounts boils 2 times, each 1.5h, and collecting decoction, refining, filter, being concentrated into density is the extractum of 1.33 (50-60 ℃);
(2) Hirudo, Radix Ginseng powder are broken into fine powder, mix with above-mentioned extractum, add dextrin and correctives, add ethanol, through granulating, drying promptly gets brown yellow granule behind the granulate, be distributed into capsule and get final product.
Embodiment 3
The Chinese medicine preparation of described anti-curing oncoma and auxiliary tumor chemoradiotherapy is to be made by following raw medicaments in portion by weight: Radix Bupleuri 130g Radix Curcumae 200g Rhizoma Smilacis Glabrae 640g Herba Taraxaci 280g Radix Astragali 140g Herba Patriniae (Herba Patriniae) 280g Pollen Typhae 200g Radix Achyranthis Bidentatae 160g Radix Angelicae Sinensis 220g Rhizoma Atractylodis 160g Radix Glycyrrhizae Preparata 140g Radix Rehmanniae Preparata 260g Radix Ginseng 140g Hirudo 70g.
The preparation method of above-mentioned Chinese medicine preparation mainly may further comprise the steps:
(1) decocting that Radix Ginseng, all the other outer 12 flavor medicines of Hirudo is added 20 times of amounts boils 2 times, each 1.5h, and collecting decoction, refining, filter, being concentrated into density is the extractum of 1.30 (50-60 ℃);
(2) Hirudo, Radix Ginseng powder are broken into fine powder, mix with above-mentioned extractum, add dextrin and correctives, add ethanol, through granulating, drying promptly gets brown yellow granule behind the granulate, make the dosage form on the pharmaceutics as required.
Clinical observation on the therapeutic effect
(1) physical data
Choose 106 of tumor patients, wherein the male patient is 63,43 of female patients, 35～73 years old age.
The sick kind: pulmonary carcinoma 32 examples, gastric cancer 26 examples, lymphatic cancer 9 examples, mammary cancer 15 examples, colon cancer 12 examples, cancer of pancreas 5 examples, bladder cancer 7 examples.
Accept the chemicotherapy situation: the patient all treats according to the chemicotherapy scheme of routine.
The patient is divided into treatment group and matched group at random, and the grouping situation sees Table 1.
Table 1
| Patient's number | Mean age | The patient treatment situation | |
| Matched group | 48 examples | 50.9 year | Simple chemotherapy person's 21 examples, operation back chemotherapy person's 18 examples, not only radiotherapy but also chemotherapy person's 7 examples after the operation. |
| The treatment group | 58 examples | 54.1 year | Simple chemotherapy person's 19 examples, operation back chemotherapy person's 25 examples, not only radiotherapy but also chemotherapy person's 14 examples after the operation. |
Credit is analysed by statistics, two groups of equal zero differences aspect sex, age, sick kind and treatment situation.
(2) therapeutic scheme
Treatment group: begin the preceding granule that began to take the embodiment of the invention 1 in 1～3 day at chemicotherapy, each 15g, every day 3 times, warm water is taken after mixing it with water, and 20 days is 1 course of treatment, takes 3～5 courses of treatment continuously, or adjust according to the chemicotherapy time, guarantee not interrupt taking of this medicine during the chemicotherapy.
Matched group: do not take medicine of the present invention during the chemicotherapy.
(3) therapeutic evaluation
Produce effects: toxicity is slight during the treatment, and leukocyte is kept normal level, finishes chemicotherapy course of treatment smoothly;
Effectively: toxicity is obvious, but can adhere to finishing the whole course of treatment; Or leukocyte reduces to below the normal level, recovers normal level after 2 weeks gradually but finish chemicotherapy;
Invalid: toxicity surpasses suffertibility, cause and do not finish the whole course of treatment, or leukocyte reduces to below the normal level, and stopping chemicotherapy not having recovery trend more than 2 weeks.
If during the chemicotherapy, leukocyte is reduced to below the normal level, promptly stop treatment, estimate the chemicotherapy performance course of treatment with this.
Table 2
During the observation of curative effect, the most reactions of treatment group patient are with the prolongation of medicine time, and the symptom of spiritlessness and weakness, xerostomia, dysphoria with smothery sensation, inappetence is significantly improved.
To mice S
180The inhibition test of sarcoma growth
(1) gets 36 of Kunming mouses, body weight 20 ± 2g.
(2) the take the logarithm S of trophophase
180Cell is diluted to 10 with physiological saline solution
7The single cell suspension of/ml, it is subcutaneous only to be inoculated in mice left side axil with 0.2ml/.
After (3) 24 hours, mice is divided into high-dose therapy group, middle dosage treatment group and matched group at random, 12 every group.High, middle dosage treatment group gives medicine 10g/kg of the present invention, 5g/kg respectively, and 0.5ml/ only irritates stomach, and matched group gives isopyknic normal saline.
(4) successive administration all takes off neck execution with mice in drug withdrawal after 10 days next day, peels off the subcutaneous tumors piece, weighs, and calculates tumour inhibiting rate.
(5) experimental result: as calculated, high, middle dosage treatment group has certain inhibitory action to tumor, and tumour inhibiting rate is respectively 51.2% and 42.6%.
Toxicity trial
Get 60 of Kunming mouses, body weight 20 ± 2g, male and female half and half give medicine 1g/ml of the present invention, and every of 0.8ml irritates stomach, observes active state, diet, feces, breathing, body weight and the death condition of mice after the medication, observes continuously 14 days.
Result of the test: after the administration mice behavior normal, weight increase, do not see death and overt toxicity the reaction.Mice is put to death the back dissect the no abnormal phenomenon of perusal internal organs.
Claims (4)
1. an anti-curing oncoma reaches the Chinese medicine preparation of assisting tumor chemoradiotherapy, it is characterized in that being made by following raw medicaments in portion by weight:
Radix Bupleuri 110-130g Radix Curcumae 160-200g Rhizoma Smilacis Glabrae 560-640g Herba Taraxaci 280-320g Radix Astragali 140-160g
Herba Patriniae 280-320g Pollen Typhae 160-200g Radix Achyranthis Bidentatae 160-200g Radix Angelicae Sinensis 220-260g Rhizoma Atractylodis 160-200g
Radix Glycyrrhizae Preparata 100-140g Radix Rehmanniae Preparata 220-260g Radix Ginseng 100-140g Hirudo 50-70g.
2. the Chinese medicine preparation of anti-curing oncoma according to claim 1 and auxiliary tumor chemoradiotherapy is characterized in that being made by following raw medicaments in portion by weight:
Radix Bupleuri 120g Radix Curcumae 180g Rhizoma Smilacis Glabrae 600g Herba Taraxaci 300g Radix Astragali 150g Herba Patriniae 300g
Pollen Typhae 180g Radix Achyranthis Bidentatae 180g Radix Angelicae Sinensis 240g Rhizoma Atractylodis 180g Radix Rehmanniae Preparata 240g Radix Glycyrrhizae Preparata 120g
Radix Ginseng 120g Hirudo 60g.
3. the Chinese medicine preparation of anti-curing oncoma according to claim 1 and 2 and auxiliary tumor chemoradiotherapy is characterized in that described Chinese medicine preparation is capsule or granule.
4. the preparation method of claim 1 or 2 described Chinese medicine preparation is characterized in that may further comprise the steps:
(1) all the other 12 flavor medicines that Radix Ginseng, Hirudo is outer decocting of adding 18～20 times of amounts boils 2 times, each 1.5h, and collecting decoction, refining, filter, be concentrated into density and be 1.30～1.35 extractum;
(2) Hirudo, Radix Ginseng powder are broken into fine powder, mix, add dextrin and correctives, add ethanol with above-mentioned extractum, through granulating, drying, behind the granulate promptly.
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| Application Number | Priority Date | Filing Date | Title |
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| CN101559199B true CN101559199B (en) | 2011-09-07 |
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| CN104857276B (en) * | 2015-05-22 | 2018-07-06 | 崔鹏 | A kind of Chinese medicine for treating syndrome of deficiency of both qi and yin after malignant tumour Radiotherapy chemotherapy |
| CN108371704A (en) * | 2018-01-20 | 2018-08-07 | 江西永昇制药股份有限公司 | The interim medicine composition of compound dandelion carcinosis radiotherapy and chemotherapy |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1232682A (en) * | 1998-04-20 | 1999-10-27 | 贾冶 | Chinese medicine for curing malignant tumor and its preparation |
| CN1899585A (en) * | 2006-07-21 | 2007-01-24 | 刘腾飞 | Preparing method for Chinese herbal medicine for treating tumor |
| CN101049484A (en) * | 2007-05-14 | 2007-10-10 | 郝来勤 | Strong effective Chinese traditional medicine for treating lung cancer and other various cancers |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1232682A (en) * | 1998-04-20 | 1999-10-27 | 贾冶 | Chinese medicine for curing malignant tumor and its preparation |
| CN1899585A (en) * | 2006-07-21 | 2007-01-24 | 刘腾飞 | Preparing method for Chinese herbal medicine for treating tumor |
| CN101049484A (en) * | 2007-05-14 | 2007-10-10 | 郝来勤 | Strong effective Chinese traditional medicine for treating lung cancer and other various cancers |
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