CN102836407B

CN102836407B - Medicament for treating chronic colitis

Info

Publication number: CN102836407B
Application number: CN2012103293895A
Authority: CN
Inventors: 闫钧
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-09-08
Filing date: 2012-09-08
Publication date: 2013-11-27
Anticipated expiration: 2032-09-08
Also published as: CN102836407A

Abstract

The invention relates to a medicament for treating chronic colitis, in particular to a Chinese medicament prepared from Chinese medicinal raw materials for treating chronic colitis. The medicament has the functions of raising yang qi, astringing the intestines, checking diarrhea, relieving pain and has the advantages of high constipation cure rate and low recurrence rate. The medicament is prepared from morinda officinalis, fructus psoraleae, dangshen, honey-fried astragalus mongholicus, white paeony root, radix bupleuri, cimicifugae foetidae, rhizoma atractylodis, bighead atractylodes rhizome, Chinese yam, myristica fragrans, honey-fried licorice root, ginger and Chinese date by the steps of uniformly mixing all the Chinese medicinal raw materials in parts by weight; grinding into 100-120 meshes of medicine powder; sterilizing and disinfecting; and using a binder to prepare into water-paste pills according to a conventional method.

Description

A kind of medicine for the treatment of chronic colitis

Technical field

The present invention relates to a kind of medicine for the treatment of chronic colitis, particularly relate to a kind of Chinese medicine of take treatment chronic colitis prepared as crude drug by Chinese medicine.

Background technology

Chronic colitis is a kind of chronic, repeatability, multiplely take colon, sigmoid colon and rectum and be site of pathological change.Refer to that the rectum colon causes the inflammatory edema of intestinal, ulcer, hemorrhage pathological changes because of various pathogenesiss.Symptom be left lower quadrant pain, diarrhoea, tenesmus, the time bad when just being stained with down liquid, constipation or having loose bowels alternately property generation, fashion, touching lower disconnected, outbreak repeatedly.Chronic colitis is that chronic colon is divided into specificity according to pathogenesis usually, and the colitis of obvious cause is namely arranged, and non-specific be the not clear colitis of pathogenesis.

The chronic colitis onset is slow, does not sustainablely alleviate or movable and staticly alternately is chronic the reaction.Constipation or the symptom of having loose bowels can appear in the patient, have that defecation frequency increases, difficult defecation, just lower a large amount of mucus or band blood, the time tenesmus phenomenon is arranged, follow left lower quadrant pain, be and have a dull ache, weight loss, become thin, lassitude.Symptom can be eased after the conventional therapy medication, sx↓, easily recurrence after drug withdrawal.

Summary of the invention

The purpose of this invention is to provide a kind of medicine for the treatment of chronic colitis, this medicine elevate a turnable ladder yang-energy, the astringing intestine to stop diarrhea emergency, the antidiarrheal pain relieving, treatment constipation cure rate is high, and relapse rate is low.

Medicine of the present invention is that the Chinese medicine by following parts by weight is that crude drug prepares:

Radix Morindae Officinalis 10-20 Fructus Psoraleae 10-20 Radix Codonopsis 10-20

Radix Astragali Preparata 15-25 Radix Paeoniae Alba 15-25 Radix Bupleuri 5-15

Rhizoma Cimicifugae 5-15 Rhizoma Atractylodis 10-20 Rhizoma Atractylodis Macrocephalae 10-20

Rhizoma Dioscoreae 15-25 Semen Myristicae 5-15 Radix Glycyrrhizae Preparata 3-10

Rhizoma Zingiberis Recens 1-8 Fructus Jujubae 1-8.

Medicine of the present invention is that the raw material of Chinese medicine medicine by following preferred weight umber prepares:

Radix Morindae Officinalis 12-18 Fructus Psoraleae 12-18 Radix Codonopsis 12-18

Radix Astragali Preparata 17-22 Radix Paeoniae Alba 17-22 Radix Bupleuri 7-13

Rhizoma Cimicifugae 7-13 Rhizoma Atractylodis 12-18 Rhizoma Atractylodis Macrocephalae 12-18

Rhizoma Dioscoreae 17-22 Semen Myristicae 7-13 Radix Glycyrrhizae Preparata 4-8

Rhizoma Zingiberis Recens 2-5 Fructus Jujubae 2-5.

Medicine of the present invention is that the raw material of Chinese medicine medicine by following optimum weight umber prepares:

Radix Morindae Officinalis 15 Fructus Psoraleae 15 Radix Codonopsis 15

Radix Astragali Preparata 20 Radix Paeoniae Alba 20 Radix Bupleuri 10

Rhizoma Cimicifugae 10 Rhizoma Atractylodis 15 Rhizoma Atractylodis Macrocephalaes 15

Rhizoma Dioscoreae 20 Semen Myristicae 10 Radix Glycyrrhizae Preparatas 6

Rhizoma Zingiberis Recens 3 Fructus Jujubaes 3.

The medicine of above-mentioned each component can be made said peroral dosage form on any pharmaceuticss such as tablet, pill, powder, capsule, and the preferred dosage form of the present invention is water pill.

The concrete preparation method of medicine water pill of the present invention agent is: said medicine, by described parts by weight mix homogeneously, is ground into to 100～120 purpose medicated powder, and sterilization is used binding agent to make the water pill product according to a conventional method.

In prescription of the present invention: the Radix Morindae Officinalis nature and flavor: hot, sweet, warm, return kidney, Liver Channel, function warming and recuperating the kidney-YANG, expelling wind and removing dampness; The Fructus Psoraleae nature and flavor: acrid, bitter, warm, return kidney, spleen channel.Function warming spleen and stomach for dispelling cold stomach function regulating; The Radix Codonopsis nature and flavor: sweet, flat, return spleen, lung meridian, function invigorating the spleen and replenishing QI, strengthening spleen and nourishing blood; The Radix Astragali Preparata nature and flavor: sweet, tepor, return spleen, lung meridian, the function tonifying Qi and lifting yang, be mainly used in the disease of deficiency-weakness of spleen-QI, sinking of QI of middle-JIAO; Radix Paeoniae Alba nature and flavor: sweet, bitter, sour, be slightly cold, return liver, spleen channel, the pain relieving of function suppressing the hyperactive liver, nourishing blood for regulating menstruation, astringing YIN to stop sweating; The Radix Bupleuri nature and flavor: bitter, hot, be slightly cold, return liver, gallbladder meridian, function is soothing the liver, yang invigorating; The Rhizoma Cimicifugae nature and flavor: hot, micro-sweet, be slightly cold, return lung, spleen, stomach, large intestine channel, function elevate a turnable ladder yang-energy, Rhizoma Cimicifugae and Radix Bupleuri, Radix Astragali Preparata mutually 5, can invigorating the spleen and replenishing QI, ascending up spleen-Qi and Yang, control anorexia and loose stool, the chronic diarrhea asthenia; The Rhizoma Atractylodis nature and flavor: acrid, bitter, warm, return spleen, stomach, Liver Channel, function is drying damp and strengthening spleen, and expelling wind and cold, for abdominal distention, have loose bowels; Rhizoma Atractylodis Macrocephalae nature and flavor: bitter, sweet, warm, return spleen, stomach warp, the function air making-up and spleen enlivening, the dampness stomach function regulating, with Rhizoma Atractylodis phase 5, the treatment taste are strong, receive and transport not normal abdominal distention, have loose bowels; The Rhizoma Dioscoreae nature and flavor: sweet, flat, return spleen, lung, kidney channel, the function supplementing QI and nourishing YIN, spleen reinforcing, lung, kidney, treat insufficiency of the spleen insufficiency of blood, fatigue and weakness, have loose bowels in loose stool, clinical and the Radix Astragali, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis phase 5, effect is stronger; The Semen Myristicae nature and flavor: hot, warm, return spleen, stomach, large intestine channel, function warming middle-JIAO to promote flow of QI, relieving diarrhea with astringents, abdominal distention; The Radix Glycyrrhizae Preparata nature and flavor: sweet, flat, GUIXIN, lung, spleen, stomach warp, the invigorating middle warmer of function QI invigorating, relieving spasm to stop pain, the mediation property of medicine, for insufficiency of the spleen asthenia, gastralgia; The Rhizoma Zingiberis Recens nature and flavor: hot, tepor, return lung, spleen, stomach warp, function warming spleen and stomach for dispelling cold stomach function regulating; The Fructus Jujubae nature and flavor: sweet, warm, return spleen, stomach warp, the function invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, be mainly used in weakness of the spleen and stomach, anorexia and loose stool, blood deficiency and yellow complexion.Above all medicines share, and warming and recuperating the kidney-YANG, enliven temper, the elevate a turnable ladder yang-energy, the astringing intestine to stop diarrhea emergency, be used for the treatment of chronic colitis, cure rate is high, relapse rate is low, without other Western medicine preparations to side reactions such as liver, renal damages, the also drug resistance of antibiotic-free etc.

Drug action mechanism of the present invention: intemperance of taking food, cold temperature is uncomfortable, and taste are impaired, and the terrified feelings will of susceptible to anger is become estranged, and forced labour excessively suffers tremendous loss in strength or resources.Insufficiency of kidney-YANG can not warm temper, Deficiency and coldness of spleen and stomach, and food stagnating, clear sun sink, and is the main cause of primary disease.Therefore, with Radix Morindae Officinalis, Fructus Psoraleae, Radix Codonopsis, Radix Astragali Preparata, Rhizoma Atractylodis, Rhizoma Atractylodis Macrocephalae warming and recuperating the kidney-YANG, enliven temper, Zhi Qiben, Rhizoma Dioscoreae, Semen Myristicae, Rhizoma Cimicifugae, Radix Bupleuri, the Radix Paeoniae Alba, Radix Glycyrrhizae Preparata elevate a turnable ladder yang-energy, the astringing intestine to stop diarrhea emergency, its mark is known in the antidiarrheal pain relieving, Rhizoma Zingiberis Recens, Fructus Jujubae the spleen and stomach regulating are just being answered it.And reach the purpose of healing.

For further investigating clinical efficacy and the safety of medicine of the present invention, select 100 routine patients with chronic colitis to carry out clinical observation to the curative effect of medicine of the present invention.

Include the case standard in: according to " guideline of clinical investigations of new Chinese medicine treatment chronic colitis " regulation, meet chronic colitis Western medicine diagnose standard and Chinese medical discrimination person, can include the test case in.

100 routine cases are divided into two groups at random, and matched group 50 examples are used the routine of western medicine treatment, take Amoxicillin Capsules, 1 0.5g, and every 6～8 hours 1 time, every daily dose is no more than 4g.Treatment group 50 examples, adopt medicine of the present invention to treat, adult every day 3 times, each 10 balls, each 15 balls of sick severe one.

Criterion of therapeutical effect: according to " guideline of clinical investigations of new Chinese medicine treatment chronic colitis " regulation, 1. fully recover: clinical symptom disappearance, colonoscope etc. check that intestinal mucosa recovers normal.After drug withdrawal, observe 6 months without recurrence.2. produce effects: clinical symptoms disappears substantially, and colonoscope etc. check that the reaction of intestinal mucosa mild inflammation and part pseudopolyp form.3. effective: clinical symptoms takes a turn for the better, and the inspection intestinal mucosal lesions such as colonoscope take a turn for the better to some extent.4. invalid: clinical symptoms and colonoscope etc. check without improving.

After treatment, efficacy result is in Table 1.

After table 1 liang group case treatment, curative effect relatively

Group

Number of cases

Recovery from illness n(%)

Produce effects n(%)

Effective n(%)

Invalid n(%)

Total effective rate n(%)

Matched group

50

32（64.0）

6（12.0）

2（4.0）

10（20.0）

40（80.0）

Treatment group

50

42（84.0）

2（4.0）

1（2.0）

5（10.0）

45（90.0）

Clinical test results shows, medicine of the present invention obviously is better than matched group, has no any untoward reaction.

The specific embodiment

Embodiment 1

Get Radix Morindae Officinalis 15kg, Fructus Psoraleae 15 kg, Radix Codonopsis 15 kg, Radix Astragali Preparata 20 kg, the Radix Paeoniae Alba 20 kg, Radix Bupleuri 10 kg, Rhizoma Cimicifugae 10 kg, Rhizoma Atractylodis 15 kg, the Rhizoma Atractylodis Macrocephalae 15 kg, Rhizoma Dioscoreae 20 kg, Semen Myristicae 10 kg, Radix Glycyrrhizae Preparata 6 kg, Rhizoma Zingiberis Recens 3 kg, Fructus Jujubae 3kg, press described parts by weight mix homogeneously by said medicine, be ground into 100～120 purpose medicated powder, sterilization is used binding agent to make the water pill product according to a conventional method.

Embodiment 2

Get Radix Morindae Officinalis 20kg, Fructus Psoraleae 20kg, Radix Codonopsis 20 kg, Radix Astragali Preparata 25 kg, the Radix Paeoniae Alba 25 kg, Radix Bupleuri 15kg, Rhizoma Cimicifugae 15 kg, Rhizoma Atractylodis 20 kg, the Rhizoma Atractylodis Macrocephalae 20 kg, Rhizoma Dioscoreae 25 kg, Semen Myristicae 15 kg, Radix Glycyrrhizae Preparata 10 kg, Rhizoma Zingiberis Recens 8 kg, Fructus Jujubae 8kg, press described parts by weight mix homogeneously by said medicine, be ground into 100～120 purpose medicated powder, sterilization is used binding agent to make the water pill product according to a conventional method.

Claims

1. medicine for the treatment of chronic colitis is that crude drug prepares by the Chinese medicine of following portions by weight: