CN104147523A

CN104147523A - Traditional Chinese medicine preparation for treating cholecystitis

Info

Publication number: CN104147523A
Application number: CN201410412895.XA
Authority: CN
Inventors: 李友芹; 葛秀萍
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-08-15
Filing date: 2014-08-15
Publication date: 2014-11-19

Abstract

The invention discloses a traditional Chinese medicine preparation for treating cholecystitis. The preparation is composed of the following raw materials by weight: 20 to 30 grams of oriental wormwood, 10 to 20 grams of gentian, 10 to 20 grams of white peony root, 10 to 20 grams of folium isatidis, 10 to 20 grams of Indian strawberry, 10 to 20 grams of angelica citriodora hance, 10 to 20 grams of desmodium, 10 to 20 grams of curcuma tuber, 8 to 12 grams of curcuma rhizome, 8 to 15 grams of plantain seed, 8 to 12 grams of centipeda, 8 to 12 grams of prepared rhubarb, 8 to 12 grams of licorice, 8 to 12 grams of radix scutellariae, 8 to 12 grams of banksia rose, 8 to 12 grams of fructus forsythiae, and 8 to 12 grams of safflower. The raw material mentioned above is scientifically compounded to have the functions of clearing heat, removing toxicity, clearing gallbladder, purging fire, regulating qi, removing dampness, soothing the liver, and draining the gallbladder. The preparation has the advantages of rapid effect, short treatment course, no side effect, and high cure rate on treating cholecystitis, and is worthy for promotion and application in clinic.

Description

A kind of Chinese medicine preparation for the treatment of cholecystitis

Technical field

The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine preparation that can treat cholecystitis.

Background technology

Cholecystitis is the gallbladder inflammatory lesion that bacterial infection or chemical irritation (bile component change) cause, is the commonly encountered diseases of gallbladder.In abdominal surgery, its sickness rate is only second to appendicitis, and primary disease is more common in the middle age of 35～55 years old, and women's morbidity is many compared with male, is especially more common in the women of obesity and multiple pregnancies.

Cholecystitis divides acute and chronic two kinds.The symptom of acute cholecystitis, mainly contains upper right abdomen pain, feels sick, vomiting and heating etc.Acute cholecystitis can cause right Upper abdominal pain, pain and biliary colic are closely similar at the beginning, but its lasting time of the stomachache that acute cholecystitis causes is often longer, breathe and change position usually to make pain increase the weight of, therefore patient likes reposing to the right more, to alleviate abdomen pain.Chronic cholecystitis is modal a kind of gallbladder disease, and patient generally has cholelithiasis simultaneously, but sees China is quite a few without the chronic cholecystitis patient of calculus.Chronic cholecystitis can be the sequela of acute cholecystitis sometimes, but most patient was not suffered from acute cholecystitis in the past, due to the long-term inflammation of gallbladder, can there is fiber and thicken in gallbladder wall, cicatrix shrinks, and causes atrophy of gallbladder, and blister cavities can be completely closed, cause gallbladder function to go down, even completely lose function.

Clinical treatment cholecystitis is mainly with the spasmolytic such as atropine, pethidine or methadone, analgesic treatment at present, be aided with the antibiotic medicines such as ampicillin, ciprofloxacin, metronidazole simultaneously, although obvious in these medicine curative effect short time, but easily recurrence, thoroughly cure rate is lower, and easily produces drug resistance.Although Chinese medicine has no side effect little, often exist take effect slow, the course for the treatment of is long, the easy drawback such as recurrence, DeGrain aspect the various acute and chronic cholecystitis of healing, seems unable to do what one wishes.

Summary of the invention

The present invention has overcome at present in the defect existing aspect treatment cholecystitis, a kind of instant effect, short treating period is provided, has had no side effect and Chinese medicine preparation that cure rate is high.

The technical solution adopted in the present invention is: a kind of Chinese medicine preparation for the treatment of cholecystitis, it is characterized in that, and described Chinese medicine preparation is comprised of the Chinese herb of following weight portion:

Herba Artemisiae Scopariae 20-30 gram, Radix Gentianae 10-20 gram, Radix Paeoniae Alba 10-20 gram, Folium Isatidis 10-20 gram, Herba Duchesneae Indicae 10-20 gram, Radix osterici citriodori (Radix Angelicae Citriodorae) 10-20 gram, Herba Lysimachiae 10-20 gram, Radix Curcumae 10-20 gram, Rhizoma Curcumae 8-12 gram, Semen Plantaginis 8-15 gram, Herba Centipedae 8-12 gram, Radix et Rhizoma Rhei (processed) 8-12 gram, Radix Glycyrrhizae 8-12 gram, Radix Scutellariae 8-12 gram, Radix Aucklandiae 8-12 gram, Fructus Forsythiae 8-12 gram, Flos Carthami 8-12 gram.

As this kind of prioritization scheme:

Described Chinese medicine preparation is comprised of the Chinese herb of following weight portion:

20 grams of Herba Artemisiae Scopariaes, 10 grams of Radix Gentianaes, 10 grams of the Radix Paeoniae Albas, 10 grams of Folium Isatidiss, 10 grams of Herba Duchesneae Indicaes, 10 grams of Radix osterici citriodori (Radix Angelicae Citriodorae)s, 10 grams of Herba Lysimachiaes, 10 grams of Radix Curcumaes, 8 grams of Rhizoma Curcumae, 8 grams of Semen Plantaginiss, 8 grams of Herba Centipedae, 8 grams of Radix et Rhizoma Rhei (processed), 8 grams, Radix Glycyrrhizae, 8 grams of Radix Scutellariaes, 8 grams of the Radix Aucklandiae, 8 grams of Fructus Forsythiaes, 8 grams, Flos Carthami.

As this kind of prioritization scheme:

25 grams of Herba Artemisiae Scopariaes, 15 grams of Radix Gentianaes, 15 grams of the Radix Paeoniae Albas, 15 grams of Folium Isatidiss, 15 grams of Herba Duchesneae Indicaes, 15 grams of Radix osterici citriodori (Radix Angelicae Citriodorae)s, 15 grams of Herba Lysimachiaes, 15 grams of Radix Curcumaes, 10 grams of Rhizoma Curcumae, 12 grams of Semen Plantaginiss, 10 grams of Herba Centipedae, 10 grams of Radix et Rhizoma Rhei (processed), 10 grams, Radix Glycyrrhizae, 10 grams of Radix Scutellariaes, 10 grams of the Radix Aucklandiae, 10 grams of Fructus Forsythiaes, 10 grams, Flos Carthami.

As this kind of prioritization scheme:

30 grams of Herba Artemisiae Scopariaes, 20 grams of Radix Gentianaes, 20 grams of the Radix Paeoniae Albas, 20 grams of Folium Isatidiss, 20 grams of Herba Duchesneae Indicaes, 20 grams of Radix osterici citriodori (Radix Angelicae Citriodorae)s, 20 grams of Herba Lysimachiaes, 20 grams of Radix Curcumaes, 12 grams of Rhizoma Curcumae, 15 grams of Semen Plantaginiss, 12 grams of Herba Centipedae, 12 grams of Radix et Rhizoma Rhei (processed), 12 grams, Radix Glycyrrhizae, 12 grams of Radix Scutellariaes, 12 grams of the Radix Aucklandiae, 12 grams of Fructus Forsythiaes, 12 grams, Flos Carthami.

The instructions of taking of above-mentioned Chinese medicine preparation is: after the raw material Chinese medicine of above-mentioned weight proportion is mixed, according to the method for the fried Chinese medicine of tradition, get its medicine juice, 1 dose of every day, minutes 2～3 times oral.20 doses was 1 course for the treatment of.

The raw material Chinese medicine of above-mentioned Chinese medicine preparation:

Herba Artemisiae Scopariae, bitter in the mouth, cold nature; Return spleen, stomach, liver, gallbladder meridian.There is clearing away heat-damp and promoting diuresis, the effect of promoting the function of the gallbladder to alleviate jaundice.

Radix Gentianae, bitter in the mouth, cold in nature; Return liver, gallbladder, urinary bladder channel.There is heat clearing and damp drying, eliminating pathogen in the liver gallbladder effect of fire.

The Radix Paeoniae Alba, bitter in the mouth, acid, cold nature; Return Liver Channel.There is the yin fluid astringing of nourishing blood, easing the affected liver to relieve pain, the effect of suppressing the hyperactive liver and subsiding YANG.

Folium Isatidis, bitter in the mouth, cold in nature; GUIXIN, lung, stomach warp.There is heat-clearing and toxic substances removing, the effect of blood cooling and ecchymoses removing.

Herba Duchesneae Indicae, sweet in the mouth, acid, cold nature; Return lung, liver, large intestine channel.There is heat-clearing and toxic substances removing, the effect of removing heat from blood detumescence.

Radix osterici citriodori (Radix Angelicae Citriodorae), acrid in the mouth, hardship, slightly warm in nature; Return lung, the heart, stomach warp.There are promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, the effect of eliminating damp, detoxifying.

Herba Lysimachiae, sweet in the mouth, salty, cold nature; Return liver, gallbladder, kidney, urinary bladder channel.There is relieving stranguria by diuresis, dampness removing jaundice eliminating, the effect of removing toxic substances and promoting subsidence of swelling.

Radix Curcumae, acrid in the mouth, hardship, cold in nature; GUIXIN, liver, gallbladder meridian.There is promoting blood circulation and stopping pain, promoting QI circulation for relieving depression, clearing away heat and cooling blood, removing heat from the heart to restore the consciousness, the effect of dampness removing jaundice eliminating.

Rhizoma Curcumae, acrid in the mouth, hardship, warm in nature; Return liver, spleen channel.There is removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving, the effect of expelling wind and removing dampness.

Semen Plantaginis, sweet in the mouth, cold in nature; Return kidney, liver, lung meridian.There is relieving stranguria by diuresis, dampness removing antidiarrheal, liver heat removing and eyesight improving, the effect of removing heat from the lung and dissipating phlegm.

Herba Centipedae, acrid in the mouth, warm in nature; Return lung, Liver Channel.There is logical the stealing of dispeling the wind, the effect of removing toxic substances and promoting subsidence of swelling.

Radix et Rhizoma Rhei (processed), bitter in the mouth, cold in nature; Return spleen, stomach, large intestine, liver, pericardium channel.There is heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, the effect of blood circulation promoting and blood stasis dispelling.

Radix Scutellariae, bitter in the mouth, cold in nature; Return lung, gallbladder, stomach, large intestine channel.There is heat clearing and damp drying, eliminating fire and detoxication, the effect of cooling blood for hemostasis.

The Radix Aucklandiae, acrid in the mouth, hardship, warm in nature; Return spleen, stomach, lung meridian.There are promoting the circulation of QI to relieve pain, the effect of intestinal stasis relieving in tune.

Fructus Forsythiae, bitter in the mouth, cold nature; Return lung, heart channel.The effect with heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, benefiting QI for strengthening the superficies.

Flos Carthami, acrid in the mouth, warm in nature; GUIXIN, Liver Channel.There is promoting blood circulation to restore menstrual flow, the effect of eliminating stasis to stop pain.

Radix Glycyrrhizae, sweet in the mouth, property is flat; GUIXIN, spleen, lung, stomach warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the effect of coordinating the actions of various ingredients in a prescription.

Cholecystitis clinical can pain, tell, heat, yellow four diseases summarize it, its cause of disease is the factors such as, eating and drinking without temperance not normal with gas, blood, worm, stone, cold, heat, wet, food, feelings will, weather, causes " stagnation of QI and blood may bring about pain " due to QI stagnation of the liver and galibladder, damp-heat accumulation.Pathologic process is the functional disorder with gallbladder, the liver failing to maintain the normal flow of QI, dysfunction of the spleen in transportation and cause melancholia; Strongly fragrant obstructed for a long time, gastrointestinal mechanism of qi is disorderly contrary, then becomes knot card; Strongly fragrant heat-transformation of a specified duration, heat is wrapped up in its wet damp-heat syndrome; Syndrome of qi stagnation and blood stasis due to excessive noxious heat, above " strongly fragrant, knot, heat, the stasis of blood " four cards conversion each other, glue is stagnant to be difficult to resolve, and QI and blood is contrary, and disorderly pyretic toxicity caves in, or becomes the raw card of fainting, therefore take " depressed liver-energy dispersing and function of gallbladder promoting, clearing away heat-damp and promoting diuresis, eliminating heat pathogen by purging the bowels, promoting the circulation of QI to relieve pain " as its principle for the treatment of.

In Chinese medicine preparation of the present invention, Herba Artemisiae Scopariae, Radix Gentianae, the Radix Paeoniae Alba can clearing away heat-damp and promoting diuresis, depressed liver-energy dispersing and function of gallbladder promoting; Folium Isatidis, Herba Duchesneae Indicae can heat-clearing and toxic substances removing, removing heat from blood detumescence; Radix osterici citriodori (Radix Angelicae Citriodorae), Herba Lysimachiae can promoting the circulation of QI to relieve pain, eliminating damp, detoxifying, relieving stranguria by diuresis; Radix Curcumae, Rhizoma Curcumae can promoting blood circulation and stopping pain, clearing away heat and cooling blood; Semen Plantaginis, Herba Centipedae can relieving stranguria by diuresis, eliminating heat pathogen by purging the bowels, removing toxic substances and promoting subsidence of swelling; Radix et Rhizoma Rhei (processed), Radix Scutellariae can be captured by Tongli, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body; The Radix Aucklandiae, Fructus Forsythiae, Flos Carthami can promoting blood circulation to restore menstrual flow, dispersing swelling and dissipating binds, promoting the circulation of QI to relieve pain; Radix Glycyrrhizae can invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, and relieving spasm to stop pain, again can coordinating the actions of various ingredients in a prescription.All medicines share invigorating the spleen and replenishing QI, liver heat removing function of gallbladder promoting, and promoting the circulation of QI to relieve pain, heat-clearing and toxic substances removing, spleen rises stomach and falls, and mechanism of qi is in harmonious proportion, and wet reducing phlegm and internal heat disappears, and all diseases are removed.We belong to Chinese medicine preparation, through clinical medicine checking, have no side effect, and easy to use, reasonable price, is easy to be accepted by patient, is worthy of promotion and application.

For further investigating clinical efficacy and the safety of medicine of the present invention, we have selected 98 routine patients to carry out clinical trial, male's 63 examples wherein, women's 35 examples; The oldest person is 69 years old, reckling 19 years old, 44 years old mean age.Patient has upper abdomen distension in varying degrees mostly, swollen, the bitter taste, indigestion and loss of appetite of the hypochondriac pain back of the body, and upper right abdomen murphy sign is positive, or edible oil is greasy, anger is brought out and increased the weight of; oliguria with reddish urine, constipation, red tongue with yellow fur; stringy pulse, all through ultrasound diagnosis, is diagnosed as cholecystitis, or and cholelithiasis.All patients are divided into treatment group and matched group at random, every group of 49 examples, two groups of patients' age, sex, body weight, sick time, disease symptom isobase data be Epidemiological Analysis by statistics, and difference not statistically significant (P > 0.05), has comparability.

Diagnostic criteria: 1. continue upper right abdomen dull pain or sense of discomfort, Huo Banyou omoplate district pain.2. there are the indigestion symptoms such as nauseating, belch, acid regurgitation, abdominal distention or scorching hot, the postemphasis of feed greasy food.3. the course of disease is long, and the state of an illness is through having acute attack or alleviating feature alternately.4. can there be mild tenderness and percussion pain in gallbladder area.5. the visible gallbladder of ultrasound diagnosis increases, and wall thickening is fuzzy or have a calculus in capsule.

Therapeutic Method:

Treatment group adds uses Chinese medicine preparation of the present invention, takes after adding decocting system, and 1 dose of every day, minutes 2～3 times oral.20 doses was 1 course for the treatment of.Matched group routine is given spasmolytic, analgesia, anti-inflammation, and with 654-2 or atropine intramuscular injection, it is oral that abdominal distention constipation gives 50% magnesium sulfate 30ml, and antimicrobial drug is selected the intravenous drips or oral such as pioneer's class, quinolones and first nitre file, within 20 days, is 1 course for the treatment of.All treat 2 courses for the treatment of for two groups.

Criterion of therapeutical effect (with reference to < < new Chinese medicine guideline of clinical investigations > >):

Recovery from illness: clinical symptoms sign disappears, B ultrasonic check gallbladder wall is smooth, and contractile function is normal;

Effective: clinical symptoms sign disappears, B ultrasonic check gallbladder contraction function is abnormal;

Invalid: clinical symptoms sign is not improved.

Efficacy result:

1. clinical efficacy result: after treatment, treatment group 15 examples of fully recovering, effective 26 examples, invalid 8 examples (turning operative treatment), total effective rate is 83.7%.Matched group 8 examples of fully recovering, effective 25 examples, invalid 18 examples (turning operative treatment), total effective rate is 76.0%.Learn and process by statistics, difference has significance (P < 0.005).Detailed results is in Table 1.

Table 1: clinical efficacy result synopsis after two groups of case treatments

Group	Number of cases	Recovery from illness n (%)	Effective n (%)	Invalid n (%)	Effective percentage n (%)
						Treatment group	49	15(30.6)	26(53.10)	8(16.3)	41(83.7)
Matched group	49	8(16.3)	25(16.8)	16(32.7)	33(67.4)

2. untoward reaction comparison:

Add up two groups of patients in treatment bad should, wherein treatment group 2 examples have nausea and vomiting, 3 routine leukopenia, 4 example diarrhoea, drug withdrawal above-mentioned symptom is all died away.Matched group has 6 routine skin pruritus, 5 example headaches, and there is pancreatitis in 7 examples, and 8 routine leukopenia, have not big harm after symptomatic treatment.

Result shows, the Chinese medicine preparation of the present invention pathogenesis that can effectively hit, having instant effect, short treating period aspect the various acute and chronic cholecystitis for the treatment of, cure rate is high and the advantage that has no side effect, clinic promotion and application.

The specific embodiment

Embodiment 1: a kind of Chinese medicine preparation for the treatment of cholecystitis, choose 20 grams of Herba Artemisiae Scopariaes, 10 grams of Radix Gentianaes, 10 grams of the Radix Paeoniae Albas, 10 grams of Folium Isatidiss, 10 grams of Herba Duchesneae Indicaes, 10 grams of Radix osterici citriodori (Radix Angelicae Citriodorae)s, 10 grams of Herba Lysimachiaes, 10 grams of Radix Curcumaes, 8 grams of Rhizoma Curcumae, 8 grams of Semen Plantaginiss, 8 grams of Herba Centipedae, 8 grams of Radix et Rhizoma Rhei (processed), 8 grams, Radix Glycyrrhizae, 8 grams of Radix Scutellariaes, 8 grams of the Radix Aucklandiae, 8 grams of Fructus Forsythiaes, 8 grams, Flos Carthami.

Embodiment 2: a kind of Chinese medicine preparation for the treatment of cholecystitis, choose 25 grams of Herba Artemisiae Scopariaes, 15 grams of Radix Gentianaes, 15 grams of the Radix Paeoniae Albas, 15 grams of Folium Isatidiss, 15 grams of Herba Duchesneae Indicaes, 15 grams of Radix osterici citriodori (Radix Angelicae Citriodorae)s, 15 grams of Herba Lysimachiaes, 15 grams of Radix Curcumaes, 10 grams of Rhizoma Curcumae, 12 grams of Semen Plantaginiss, 10 grams of Herba Centipedae, 10 grams of Radix et Rhizoma Rhei (processed), 10 grams, Radix Glycyrrhizae, 10 grams of Radix Scutellariaes, 10 grams of the Radix Aucklandiae, 10 grams of Fructus Forsythiaes, 10 grams, Flos Carthami.

Embodiment 3: a kind of Chinese medicine preparation for the treatment of cholecystitis, choose 30 grams of Herba Artemisiae Scopariaes, 20 grams of Radix Gentianaes, 20 grams of the Radix Paeoniae Albas, 20 grams of Folium Isatidiss, 20 grams of Herba Duchesneae Indicaes, 20 grams of Radix osterici citriodori (Radix Angelicae Citriodorae)s, 20 grams of Herba Lysimachiaes, 20 grams of Radix Curcumaes, 12 grams of Rhizoma Curcumae, 15 grams of Semen Plantaginiss, 12 grams of Herba Centipedae, 12 grams of Radix et Rhizoma Rhei (processed), 12 grams, Radix Glycyrrhizae, 12 grams of Radix Scutellariaes, 12 grams of the Radix Aucklandiae, 12 grams of Fructus Forsythiaes, 12 grams, Flos Carthami.

Below by concrete case, Chinese medicine preparation curative effect of the present invention is further verified:

Case 1

In certain, man, 36 years old.Patient occurred before 3 years that upper right abdominal distention and pain also repeatedly shows effect and reaches, and after two weeks, symptom increases the weight of, and during every outbreak, pain is traction shoulder back, and companion is off one's feed, and malaise is nauseating, belch.While examining, through ultrasound diagnosis, show: gallbladder enlargement, thickening of capsule wall of gallbladder, coarse; Check: shallow complexion, there is tenderness gallbladder area, and Murphy's sign is positive, and body of the tongue is partially red, the micro-Huang of thin fur, deep pulse stringy and thready pulse, really breaks as chronic cholecystitis.Take Chinese medicine preparation of the present invention after 5 days symptom obviously improve, continue to take after 10 days, all diseases disappears, B ultrasonic shows normal.Follow up a case by regular visits to and have no recurrence half a year.

Case 2

Ji, female, 41 years old.Patient before half a year without obvious inducement burst feel sick, vomiting, often have abdominal distention, upper abdomen or right epigastric discomfort, heartburn, belch, return a series of dyspeptic symptoms such as acid, in local hospital diagnosis and treatment, be diagnosed as gastritis, do not give treatment, still feel uncomfortable.Go to local people's hospital admission, check and find that there are mild tenderness and sense of discomfort in abdomen gallbladder area, upper right, be diagnosed as chronic cholecystitis, doctor gives and opens multiple oral drug therapy (specifically not quite clear), poor effect, feel right side shoulder and back ache before January, the state of an illness is outbreak repeatedly still.After being introduced, start to take medicine of the present invention and treat, after 2 weeks, patient's readme symptom is obviously improved; Continue to take after 10 days, all diseases of patient disappear, and check that gallbladder area is without tenderness, and ultrasound diagnosis prompting gallbladder wall polishes, and patient cures.Follow up a case by regular visits to and within three months, have no recurrence.

Case 3

Wang, man, 40 years old.Patient suffers from chronic cholecystitis more than 10 years, during informal dress XIAOYAN LIDAN PIAN, Fel Ursi powder, the state of an illness often rises and falls.Right hypochondrial region increases the weight of the year before, goes examination in hospital to be diagnosed as " chronic cholecystitis, multiple gallbladder polyp ", and doctor advised operative treatment, because patient fears operation, adopts expectant treatment nearly half a year without positive effect.After being introduced, start to take medicine of the present invention and treat, after 1 course for the treatment of, patient's symptom is improved obviously, and spirit greatly rouses oneself, and improvement is obviously improved; Continue to take after 1 course for the treatment of, patient is conscious, and all diseases disappear, the thorough rehabilitation of the state of an illness, and examination in hospital B ultrasonic, gallbladder wall is polished by coarse, and gallbladder swelling disappears, patient's recovery from illness.Follow up a case by regular visits to and within four months, have no recurrence.

Claims

1. a Chinese medicine preparation for the treatment of cholecystitis, is characterized in that, described Chinese medicine preparation is comprised of the Chinese herb of following weight portion:

2. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is comprised of the Chinese herb of following weight portion:

3. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is comprised of the Chinese herb of following weight portion:

4. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is comprised of the Chinese herb of following weight portion: