CN101553219B - 作为TAFIa抑制剂的脲和磺酰胺衍生物 - Google Patents

作为TAFIa抑制剂的脲和磺酰胺衍生物 Download PDF

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CN101553219B
CN101553219B CN2007800435586A CN200780043558A CN101553219B CN 101553219 B CN101553219 B CN 101553219B CN 2007800435586 A CN2007800435586 A CN 2007800435586A CN 200780043558 A CN200780043558 A CN 200780043558A CN 101553219 B CN101553219 B CN 101553219B
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amino
alkylene
alkyl
phenyl
cyclohexyl
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CN101553219A (zh
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C·卡鲁斯
M·布伦斯特鲁普
W·克泽齐迪斯基
A·埃弗斯
M·弗尔曼
N·哈兰
H·施罗伊德
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Sanofi Aventis France
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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US8354444B2 (en) 2008-09-18 2013-01-15 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
AU2009310841A1 (en) * 2008-10-29 2010-05-06 Taisho Pharmaceutical Co., Ltd. Compounds having TAFIa inhibitory activity
RU2015156612A (ru) * 2013-06-10 2017-07-17 Санофи Макроциклические производные мочевины в качестве ингибиторов tafia, их получение и их применение в качестве фармацевтических средств
CN104529859B (zh) * 2015-01-13 2016-08-17 佛山市赛维斯医药科技有限公司 含苯胺和二烯氟代金刚烷结构的化合物、其制备方法和用途
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KR20090087044A (ko) 2009-08-14
TW200838498A (en) 2008-10-01
PL2104497T3 (pl) 2015-07-31
SI2104497T1 (sl) 2015-06-30
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