SI2104497T1 - Derivati sulfamida kot inhibitorji TAFIa - Google Patents
Derivati sulfamida kot inhibitorji TAFIaInfo
- Publication number
- SI2104497T1 SI2104497T1 SI200731653T SI200731653T SI2104497T1 SI 2104497 T1 SI2104497 T1 SI 2104497T1 SI 200731653 T SI200731653 T SI 200731653T SI 200731653 T SI200731653 T SI 200731653T SI 2104497 T1 SI2104497 T1 SI 2104497T1
- Authority
- SI
- Slovenia
- Prior art keywords
- tafia inhibitors
- sulfamide derivatives
- sulfamide
- derivatives
- tafia
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- NVBFHJWHLNUMCV-UHFFFAOYSA-N sulfamide Chemical class NS(N)(=O)=O NVBFHJWHLNUMCV-UHFFFAOYSA-N 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A61K31/18—Sulfonamides
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
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- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006057413 | 2006-12-06 | ||
PCT/EP2007/010101 WO2008067909A2 (de) | 2006-12-06 | 2007-11-22 | Harnstoff- und sulfamidderivate als inhibitoren von tafia |
EP07856207.1A EP2104497B1 (de) | 2006-12-06 | 2007-11-22 | Sulfamidderivate als inhibitoren von tafia |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2104497T1 true SI2104497T1 (sl) | 2015-06-30 |
Family
ID=39384480
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200731653T SI2104497T1 (sl) | 2006-12-06 | 2007-11-22 | Derivati sulfamida kot inhibitorji TAFIa |
Country Status (28)
Country | Link |
---|---|
US (1) | US8389764B2 (sl) |
EP (1) | EP2104497B1 (sl) |
JP (1) | JP5396279B2 (sl) |
KR (1) | KR20090087044A (sl) |
CN (1) | CN101553219B (sl) |
AR (1) | AR064119A1 (sl) |
AU (1) | AU2007327959B2 (sl) |
BR (1) | BRPI0720241A2 (sl) |
CA (1) | CA2671861C (sl) |
CL (1) | CL2007003494A1 (sl) |
CO (1) | CO6180422A2 (sl) |
CY (1) | CY1116384T1 (sl) |
DK (1) | DK2104497T3 (sl) |
ES (1) | ES2537093T3 (sl) |
HK (1) | HK1137928A1 (sl) |
HR (1) | HRP20150514T1 (sl) |
MA (1) | MA30968B1 (sl) |
MX (1) | MX2009005516A (sl) |
NO (1) | NO20092246L (sl) |
NZ (1) | NZ577312A (sl) |
PE (1) | PE20081349A1 (sl) |
PL (1) | PL2104497T3 (sl) |
PT (1) | PT2104497E (sl) |
RU (1) | RU2459619C2 (sl) |
SI (1) | SI2104497T1 (sl) |
TW (1) | TWI399203B (sl) |
WO (1) | WO2008067909A2 (sl) |
ZA (1) | ZA200903040B (sl) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2726554C (en) | 2008-06-06 | 2015-02-24 | Sanofi-Aventis | Macrocyclic urea and sulfamide derivatives as inhibitors of tafia |
EA018502B1 (ru) | 2008-06-23 | 2013-08-30 | Астразенека Аб | Новые гетероциклические карбоксамиды и фармацевтические композиции, содержащие их |
US8354444B2 (en) | 2008-09-18 | 2013-01-15 | Hoffmann-La Roche Inc. | Substituted pyrrolidine-2-carboxamides |
NZ592764A (en) | 2008-10-29 | 2012-08-31 | Taisho Pharmaceutical Co Ltd | Compound having tafia inhibitory activity |
WO2014198620A1 (en) * | 2013-06-10 | 2014-12-18 | Sanofi | Macrocyclic urea derivatives as inhibitors of tafia, their preparation and their use as pharmaceuticals |
CN104529859B (zh) * | 2015-01-13 | 2016-08-17 | 佛山市赛维斯医药科技有限公司 | 含苯胺和二烯氟代金刚烷结构的化合物、其制备方法和用途 |
RU2687254C1 (ru) * | 2018-10-03 | 2019-05-08 | Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) | N-гетероциклические производные борниламина в качестве ингибиторов ортопоксвирусов |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU667995B2 (en) * | 1993-02-15 | 1996-04-18 | Bayer Aktiengesellschaft | New pseudopeptides having an antiviral action |
TW394760B (en) * | 1993-09-07 | 2000-06-21 | Hoffmann La Roche | Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same |
AU749132B2 (en) * | 1997-08-28 | 2002-06-20 | Biovitrum Ab | Inhibitors of protein tyrosine phosphatase |
US6482921B1 (en) * | 1999-01-28 | 2002-11-19 | Essential Therapeutics, Inc. | Uridyl peptide antibiotic (UPA) derivatives, their synthesis and use |
EP1165531A1 (en) * | 1999-03-19 | 2002-01-02 | Du Pont Pharmaceuticals Company | N-adamant-1-yl-n'- 4-chlorobenzothiazol-2-yl] urea useful in the treatment of inflammation and as an anticancer radiosensitizing agent |
US6359129B1 (en) * | 2000-08-15 | 2002-03-19 | University Of Kansas | Amino acid-derived, 7-membered cyclic sulfamides and methods of synthesizing the same |
PT1311488E (pt) * | 2000-08-17 | 2009-12-30 | Pfizer Ltd | Imidazóis substituídos utilizados como inibidores de tafia |
DE102004020186A1 (de) | 2004-04-22 | 2005-11-17 | Aventis Pharma Deutschland Gmbh | Heterocyclylessigsäuren als Inhibitoren von TAFla |
CA2583089A1 (en) * | 2004-10-05 | 2006-04-20 | Bayer Schering Pharma Aktiengesellschaft | Tafi inhibitors and their use to treat pulmonary fibrosis |
-
2007
- 2007-11-22 AU AU2007327959A patent/AU2007327959B2/en not_active Ceased
- 2007-11-22 MX MX2009005516A patent/MX2009005516A/es active IP Right Grant
- 2007-11-22 ES ES07856207.1T patent/ES2537093T3/es active Active
- 2007-11-22 CA CA2671861A patent/CA2671861C/en not_active Expired - Fee Related
- 2007-11-22 JP JP2009539631A patent/JP5396279B2/ja not_active Expired - Fee Related
- 2007-11-22 RU RU2009125534/15A patent/RU2459619C2/ru not_active IP Right Cessation
- 2007-11-22 BR BRPI0720241-5A patent/BRPI0720241A2/pt not_active IP Right Cessation
- 2007-11-22 CN CN2007800435586A patent/CN101553219B/zh not_active Expired - Fee Related
- 2007-11-22 SI SI200731653T patent/SI2104497T1/sl unknown
- 2007-11-22 NZ NZ577312A patent/NZ577312A/en not_active IP Right Cessation
- 2007-11-22 EP EP07856207.1A patent/EP2104497B1/de active Active
- 2007-11-22 PL PL07856207T patent/PL2104497T3/pl unknown
- 2007-11-22 DK DK07856207.1T patent/DK2104497T3/en active
- 2007-11-22 WO PCT/EP2007/010101 patent/WO2008067909A2/de active Application Filing
- 2007-11-22 KR KR1020097011740A patent/KR20090087044A/ko not_active Application Discontinuation
- 2007-11-22 PT PT78562071T patent/PT2104497E/pt unknown
- 2007-12-04 CL CL200703494A patent/CL2007003494A1/es unknown
- 2007-12-04 TW TW096145997A patent/TWI399203B/zh not_active IP Right Cessation
- 2007-12-04 PE PE2007001712A patent/PE20081349A1/es not_active Application Discontinuation
- 2007-12-04 AR ARP070105408A patent/AR064119A1/es unknown
-
2009
- 2009-05-04 ZA ZA2009/03040A patent/ZA200903040B/en unknown
- 2009-06-03 MA MA31948A patent/MA30968B1/fr unknown
- 2009-06-03 CO CO09057335A patent/CO6180422A2/es active IP Right Grant
- 2009-06-08 US US12/480,348 patent/US8389764B2/en not_active Expired - Fee Related
- 2009-06-10 NO NO20092246A patent/NO20092246L/no not_active Application Discontinuation
-
2010
- 2010-03-29 HK HK10103243.7A patent/HK1137928A1/xx not_active IP Right Cessation
-
2015
- 2015-05-14 HR HRP20150514TT patent/HRP20150514T1/hr unknown
- 2015-05-15 CY CY20151100436T patent/CY1116384T1/el unknown
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