CN104529859B - 含苯胺和二烯氟代金刚烷结构的化合物、其制备方法和用途 - Google Patents
含苯胺和二烯氟代金刚烷结构的化合物、其制备方法和用途 Download PDFInfo
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- CN104529859B CN104529859B CN201510017466.7A CN201510017466A CN104529859B CN 104529859 B CN104529859 B CN 104529859B CN 201510017466 A CN201510017466 A CN 201510017466A CN 104529859 B CN104529859 B CN 104529859B
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- CN
- China
- Prior art keywords
- compound
- formula
- diene
- obtains
- fluoroadamantane
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- 0 *c(cc1)ccc1-[n]1c(CNC(C=CC=CC(CC2CC(C3)C4)(C5)C24C35F)=O)ccc1 Chemical compound *c(cc1)ccc1-[n]1c(CNC(C=CC=CC(CC2CC(C3)C4)(C5)C24C35F)=O)ccc1 0.000 description 1
- NGMQUUXTERYKFZ-MGEOUUDKSA-N CCC(CC)CCC1C=CC([n]2c(CNC(/C=C/C=C/C(CC(C3)C4)(CC3C3)CC43F)=O)ccc2)=CC1 Chemical compound CCC(CC)CCC1C=CC([n]2c(CNC(/C=C/C=C/C(CC(C3)C4)(CC3C3)CC43F)=O)ccc2)=CC1 NGMQUUXTERYKFZ-MGEOUUDKSA-N 0.000 description 1
- KLZHHFALWHBCKI-OJTWMYIASA-N CNc(cc1)ccc1-[n]1c(CNC(/C=C/C=C/C(CC(C2)C3)(C4)C2CC34F)=O)ccc1 Chemical compound CNc(cc1)ccc1-[n]1c(CNC(/C=C/C=C/C(CC(C2)C3)(C4)C2CC34F)=O)ccc1 KLZHHFALWHBCKI-OJTWMYIASA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Abstract
Description
化合物 | 血小板凝聚的抑制IC50(μM) |
I-1 | 0.12 |
I-2 | 1.06 |
I-3 | 0.39 |
I-4 | 0.71 |
参比化合物D1 | 0.87 |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510017466.7A CN104529859B (zh) | 2015-01-13 | 2015-01-13 | 含苯胺和二烯氟代金刚烷结构的化合物、其制备方法和用途 |
Applications Claiming Priority (1)
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CN201510017466.7A CN104529859B (zh) | 2015-01-13 | 2015-01-13 | 含苯胺和二烯氟代金刚烷结构的化合物、其制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
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CN104529859A CN104529859A (zh) | 2015-04-22 |
CN104529859B true CN104529859B (zh) | 2016-08-17 |
Family
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CN201510017466.7A Active CN104529859B (zh) | 2015-01-13 | 2015-01-13 | 含苯胺和二烯氟代金刚烷结构的化合物、其制备方法和用途 |
Country Status (1)
Country | Link |
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CN (1) | CN104529859B (zh) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000026186A1 (fr) * | 1998-11-02 | 2000-05-11 | Welfide Corporation | Composes de pyrrolidine et leur utilisation medicinale |
CN1496361A (zh) * | 2001-03-16 | 2004-05-12 | Ĭ��ר���ɷ�����˾ | 苯基衍生物3 |
WO2007107550A1 (en) * | 2006-03-21 | 2007-09-27 | High Point Pharmaceuticals, Llc | Adamantane derivatives for the treatment of the metabolic syndrome |
CN101248041A (zh) * | 2005-06-17 | 2008-08-20 | 艾宝奇生物工艺有限公司 | 鞘氨醇激酶抑制剂 |
CN101553219A (zh) * | 2006-12-06 | 2009-10-07 | 塞诺菲-安万特股份有限公司 | 作为TAFIa抑制剂的脲和磺酰胺衍生物 |
-
2015
- 2015-01-13 CN CN201510017466.7A patent/CN104529859B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000026186A1 (fr) * | 1998-11-02 | 2000-05-11 | Welfide Corporation | Composes de pyrrolidine et leur utilisation medicinale |
CN1496361A (zh) * | 2001-03-16 | 2004-05-12 | Ĭ��ר���ɷ�����˾ | 苯基衍生物3 |
CN101248041A (zh) * | 2005-06-17 | 2008-08-20 | 艾宝奇生物工艺有限公司 | 鞘氨醇激酶抑制剂 |
WO2007107550A1 (en) * | 2006-03-21 | 2007-09-27 | High Point Pharmaceuticals, Llc | Adamantane derivatives for the treatment of the metabolic syndrome |
CN101553219A (zh) * | 2006-12-06 | 2009-10-07 | 塞诺菲-安万特股份有限公司 | 作为TAFIa抑制剂的脲和磺酰胺衍生物 |
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Publication number | Publication date |
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CN104529859A (zh) | 2015-04-22 |
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Denomination of invention: Compound with aniline and diene fluoro adamantane structure and preparation method and application thereof Effective date of registration: 20170816 Granted publication date: 20160817 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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Effective date of registration: 20191028 Address after: 221300 north side of Qingnian East Road, Yunhe Town, Pizhou City, Xuzhou City, Jiangsu Province Patentee after: Pizhou Runhong Industry Co., Ltd. Address before: Chancheng district has 528000 Taiwan public in Guangdong province Foshan City No. 32 first floor 1636, shop No. 1637 Patentee before: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. |
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