CN104478782B - 一类含烷氧苯基和二烯氟代金刚烷结构的化合物和用途 - Google Patents
一类含烷氧苯基和二烯氟代金刚烷结构的化合物和用途 Download PDFInfo
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- CN104478782B CN104478782B CN201510017460.XA CN201510017460A CN104478782B CN 104478782 B CN104478782 B CN 104478782B CN 201510017460 A CN201510017460 A CN 201510017460A CN 104478782 B CN104478782 B CN 104478782B
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- compound
- diene
- fluoroadamantane
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
化合物 | 血小板凝聚的抑制IC50(μM) |
I-1 | 0.53 |
I-2 | 1.19 |
I-3 | 0.72 |
I-4 | 1.55 |
I-5 | 1.86 |
I-6 | 0.97 |
参比化合物D1 | 0.87 |
Claims (4)
Priority Applications (1)
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CN201510017460.XA CN104478782B (zh) | 2015-01-13 | 2015-01-13 | 一类含烷氧苯基和二烯氟代金刚烷结构的化合物和用途 |
Applications Claiming Priority (1)
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CN201510017460.XA CN104478782B (zh) | 2015-01-13 | 2015-01-13 | 一类含烷氧苯基和二烯氟代金刚烷结构的化合物和用途 |
Publications (2)
Publication Number | Publication Date |
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CN104478782A CN104478782A (zh) | 2015-04-01 |
CN104478782B true CN104478782B (zh) | 2016-03-16 |
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CN201510017460.XA Active CN104478782B (zh) | 2015-01-13 | 2015-01-13 | 一类含烷氧苯基和二烯氟代金刚烷结构的化合物和用途 |
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CN (1) | CN104478782B (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101119967A (zh) * | 2005-02-17 | 2008-02-06 | 赛诺菲-安万特 | 1,5-二芳基吡咯衍生物、它们的制备与治疗用途 |
CN102177137A (zh) * | 2008-10-08 | 2011-09-07 | 埃克塞利希斯股份有限公司 | 1-苯基吡咯化合物 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2917622B1 (fr) * | 2007-06-19 | 2009-10-23 | Pierre Fabre Medicament Sa | Utilisation d'un antagoniste par1 dans le traitement de la fibrillation atriale. |
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2015
- 2015-01-13 CN CN201510017460.XA patent/CN104478782B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101119967A (zh) * | 2005-02-17 | 2008-02-06 | 赛诺菲-安万特 | 1,5-二芳基吡咯衍生物、它们的制备与治疗用途 |
CN102177137A (zh) * | 2008-10-08 | 2011-09-07 | 埃克塞利希斯股份有限公司 | 1-苯基吡咯化合物 |
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CN104478782A (zh) | 2015-04-01 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Class of compound containing alcoxyl phenyl group and diene fluoro adamantane structure and application Effective date of registration: 20170816 Granted publication date: 20160316 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20190604 Granted publication date: 20160316 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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Effective date of registration: 20191028 Address after: 221300 north side of Qingnian East Road, Yunhe Town, Pizhou City, Xuzhou City, Jiangsu Province Patentee after: Pizhou Runhong Industry Co., Ltd. Address before: Chancheng district has 528000 Taiwan public in Guangdong province Foshan City No. 32 first floor 1636, shop No. 1637 Patentee before: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. |