CN101547905B - 抗菌的喹啉衍生物 - Google Patents
抗菌的喹啉衍生物 Download PDFInfo
- Publication number
- CN101547905B CN101547905B CN200780044895.7A CN200780044895A CN101547905B CN 101547905 B CN101547905 B CN 101547905B CN 200780044895 A CN200780044895 A CN 200780044895A CN 101547905 B CN101547905 B CN 101547905B
- Authority
- CN
- China
- Prior art keywords
- alkyl
- aryl
- compound
- formula
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 0 CCN1CC*CC1 Chemical compound CCN1CC*CC1 0.000 description 3
- MTVRNCKPEVTTQY-UHFFFAOYSA-N CC(C=C1)=CCC1c1cccc(C(CCCCN(C)C)=O)c1 Chemical compound CC(C=C1)=CCC1c1cccc(C(CCCCN(C)C)=O)c1 MTVRNCKPEVTTQY-UHFFFAOYSA-N 0.000 description 1
- YXSALMKVRBPFHP-CCEZHUSRSA-N CN(C)CCCCC(c1cc(/C=C/c2ccccc2)ccc1)O Chemical compound CN(C)CCCCC(c1cc(/C=C/c2ccccc2)ccc1)O YXSALMKVRBPFHP-CCEZHUSRSA-N 0.000 description 1
- RSTMYKMXJNGFBX-UHFFFAOYSA-N CN1CCN(CCCCC(COc2ccccc2)=O)CC1 Chemical compound CN1CCN(CCCCC(COc2ccccc2)=O)CC1 RSTMYKMXJNGFBX-UHFFFAOYSA-N 0.000 description 1
- CEKDANABZLSKPU-UHFFFAOYSA-N OC(CCCCCCl)c1cc(Br)ccc1 Chemical compound OC(CCCCCCl)c1cc(Br)ccc1 CEKDANABZLSKPU-UHFFFAOYSA-N 0.000 description 1
- YJWIDPBXOPPPQH-UHFFFAOYSA-N Oc1nc2ccccc2cc1Cc(cc1)ccc1Br Chemical compound Oc1nc2ccccc2cc1Cc(cc1)ccc1Br YJWIDPBXOPPPQH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06125510 | 2006-12-06 | ||
| EP06125510.5 | 2006-12-06 | ||
| PCT/EP2007/063314 WO2008068268A1 (en) | 2006-12-06 | 2007-12-04 | Antibacterial quinoline derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101547905A CN101547905A (zh) | 2009-09-30 |
| CN101547905B true CN101547905B (zh) | 2015-01-28 |
Family
ID=37909392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200780044895.7A Active CN101547905B (zh) | 2006-12-06 | 2007-12-04 | 抗菌的喹啉衍生物 |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US8293732B2 (https=) |
| EP (1) | EP2099760B1 (https=) |
| JP (1) | JP5466012B2 (https=) |
| KR (3) | KR101574642B1 (https=) |
| CN (1) | CN101547905B (https=) |
| AP (1) | AP2670A (https=) |
| AR (1) | AR064147A1 (https=) |
| BR (1) | BRPI0719939B8 (https=) |
| CA (1) | CA2668517C (https=) |
| CL (1) | CL2007003515A1 (https=) |
| CY (1) | CY1114384T1 (https=) |
| DK (1) | DK2099760T3 (https=) |
| EA (1) | EA022344B1 (https=) |
| ES (1) | ES2407824T3 (https=) |
| HR (1) | HRP20130372T1 (https=) |
| IL (2) | IL199078A (https=) |
| JO (1) | JO2970B1 (https=) |
| ME (1) | ME01521B (https=) |
| MX (1) | MX2009005979A (https=) |
| MY (1) | MY150411A (https=) |
| NO (1) | NO342095B1 (https=) |
| NZ (1) | NZ577128A (https=) |
| PL (1) | PL2099760T3 (https=) |
| PT (1) | PT2099760E (https=) |
| RS (1) | RS52753B (https=) |
| SG (1) | SG10201405650SA (https=) |
| SI (1) | SI2099760T1 (https=) |
| TW (1) | TWI396536B (https=) |
| UA (1) | UA101306C2 (https=) |
| WO (1) | WO2008068268A1 (https=) |
| ZA (1) | ZA200903946B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2970B1 (en) * | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| CN104254527B (zh) | 2012-04-27 | 2017-05-31 | 詹森药业有限公司 | 抗菌的喹啉衍生物 |
| ES2607879T3 (es) | 2012-04-27 | 2017-04-04 | Janssen Pharmaceutica N.V. | Derivados de quinolina antibacterianos |
| BR122023025283A2 (pt) * | 2016-03-07 | 2024-02-20 | Global Alliance For Tb Drug Development Inc | Compostos antibacterianos e seus usos |
| US11857352B2 (en) | 2016-09-06 | 2024-01-02 | The Research Foundation For The State University Of New York | Positron imaging tomography imaging agent composition and method for bacterial infection |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998018326A1 (en) * | 1996-10-28 | 1998-05-07 | Department Of The Army, U.S. Government | Compounds, compositions and methods for treating antibiotic-resistant infections |
| US6103905A (en) | 1997-06-19 | 2000-08-15 | Sepracor, Inc. | Quinoline-indole antimicrobial agents, uses and compositions related thereto |
| ATE463482T1 (de) * | 2002-07-25 | 2010-04-15 | Janssen Pharmaceutica Nv | Chinolinderivate und deren verwendung als mycobakterielle inhibitoren |
| EA011277B1 (ru) | 2004-01-23 | 2009-02-27 | Янссен Фармацевтика Н.В. | Производные хинолина и их применение в качестве ингибиторов микобактерий |
| EA011359B1 (ru) | 2004-01-23 | 2009-02-27 | Янссен Фармацевтика Н.В. | Замещенные хинолины и их применение в качестве микобактериальных ингибиторов |
| CA2554049C (en) | 2004-01-29 | 2012-12-18 | Janssen Pharmaceutica N.V. | Quinoline derivatives for use as mycobacterial inhibitors |
| PL1753427T3 (pl) * | 2004-05-28 | 2008-09-30 | Janssen Pharmaceutica Nv | Zastosowanie podstawionych pochodnych chinoliny do leczenia chorób wywoływanych przez prątki lekooporne |
| PL1797115T3 (pl) | 2004-09-28 | 2017-12-29 | Janssen Pharmaceutica N.V. | Domena wiążąca bakteryjnej syntazy ATP |
| EE05394B1 (et) * | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
| CA2528849C (en) | 2005-06-08 | 2014-01-14 | Janssen Pharmaceutica N.V. | Quinoline derivatives as antibacterial agents |
| JO2752B1 (en) | 2005-06-28 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
| KR101329587B1 (ko) | 2005-06-28 | 2013-11-15 | 얀센 파마슈티카 엔.브이. | 항균제로서의 퀴놀린 유도체 |
| JO2683B1 (en) * | 2006-12-06 | 2013-03-03 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
| JO2970B1 (en) * | 2006-12-06 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline antibacterial derivatives |
-
2007
- 2007-11-29 JO JO2007505A patent/JO2970B1/en active
- 2007-12-04 MX MX2009005979A patent/MX2009005979A/es active IP Right Grant
- 2007-12-04 KR KR1020097012242A patent/KR101574642B1/ko active Active
- 2007-12-04 SG SG10201405650SA patent/SG10201405650SA/en unknown
- 2007-12-04 PT PT78478120T patent/PT2099760E/pt unknown
- 2007-12-04 CA CA2668517A patent/CA2668517C/en active Active
- 2007-12-04 CN CN200780044895.7A patent/CN101547905B/zh active Active
- 2007-12-04 DK DK07847812.0T patent/DK2099760T3/da active
- 2007-12-04 ES ES07847812T patent/ES2407824T3/es active Active
- 2007-12-04 NZ NZ577128A patent/NZ577128A/en unknown
- 2007-12-04 EA EA200970536A patent/EA022344B1/ru unknown
- 2007-12-04 WO PCT/EP2007/063314 patent/WO2008068268A1/en not_active Ceased
- 2007-12-04 HR HRP20130372TT patent/HRP20130372T1/hr unknown
- 2007-12-04 EP EP07847812A patent/EP2099760B1/en active Active
- 2007-12-04 MY MYPI20092286 patent/MY150411A/en unknown
- 2007-12-04 AP AP2009004871A patent/AP2670A/xx active
- 2007-12-04 ME MEP-2013-43A patent/ME01521B/me unknown
- 2007-12-04 US US12/516,249 patent/US8293732B2/en active Active
- 2007-12-04 UA UAA200904217A patent/UA101306C2/ru unknown
- 2007-12-04 KR KR1020167037101A patent/KR20170003741A/ko not_active Ceased
- 2007-12-04 JP JP2009539739A patent/JP5466012B2/ja active Active
- 2007-12-04 PL PL07847812T patent/PL2099760T3/pl unknown
- 2007-12-04 SI SI200731214T patent/SI2099760T1/sl unknown
- 2007-12-04 KR KR1020157031291A patent/KR101908350B1/ko active Active
- 2007-12-04 RS RS20130165A patent/RS52753B/sr unknown
- 2007-12-04 BR BRPI0719939A patent/BRPI0719939B8/pt active IP Right Grant
- 2007-12-05 AR ARP070105440A patent/AR064147A1/es unknown
- 2007-12-05 TW TW096146215A patent/TWI396536B/zh active
- 2007-12-05 CL CL200703515A patent/CL2007003515A1/es unknown
-
2009
- 2009-06-02 IL IL199078A patent/IL199078A/en active IP Right Grant
- 2009-06-05 ZA ZA200903946A patent/ZA200903946B/xx unknown
- 2009-07-06 NO NO20092536A patent/NO342095B1/no unknown
-
2013
- 2013-05-17 CY CY20131100403T patent/CY1114384T1/el unknown
-
2015
- 2015-09-10 IL IL241548A patent/IL241548B/en active IP Right Grant
Also Published As
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| JP5466011B2 (ja) | 抗菌性キノリン誘導体 | |
| CN101547907B (zh) | 抗菌的喹啉衍生物 | |
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| AU2013254670B2 (en) | Antibacterial quinoline derivatives | |
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| AU2007328888B2 (en) | Antibacterial quinoline derivatives | |
| HK1137433B (en) | Antibacterial quinoline derivatives | |
| HK1208437B (zh) | 抗菌的喹啉衍生物 |
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