MX2009005979A - Derivados de quinolina antibacterianos. - Google Patents

Derivados de quinolina antibacterianos.

Info

Publication number
MX2009005979A
MX2009005979A MX2009005979A MX2009005979A MX2009005979A MX 2009005979 A MX2009005979 A MX 2009005979A MX 2009005979 A MX2009005979 A MX 2009005979A MX 2009005979 A MX2009005979 A MX 2009005979A MX 2009005979 A MX2009005979 A MX 2009005979A
Authority
MX
Mexico
Prior art keywords
compounds
quinoline derivatives
pharmaceutically acceptable
treatment
bacterial infection
Prior art date
Application number
MX2009005979A
Other languages
English (en)
Inventor
Koenraad Jozef Lodewijk Marcel Andries
Anil Koul
Jerome Emile Georges Guillemont
Ismet Dorange
Magali Madeleine Simone Motte
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37909392&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009005979(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2009005979A publication Critical patent/MX2009005979A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

La presente invención está relacionada con nuevos derivados sustituidos de quinolina de acuerdo a la Fórmula general (la) o Fórmula general (Ib): (ver fórmulas Ia, Ib) incluyendo cualquier forma estereoquímicamente isomérica de las mismas, un N-óxido de las mismas, una sal farmacéuticamente aceptable de las mismas o un solvato de las mismas; los compuestos reivindicados son útiles para el tratamiento de una infección bacteriana; también se reivindican una composición que comprende un portador farmacéuticamente aceptable y, como ingrediente activo, una cantidad terapéuticamente efectiva de los compuestos reivindicados, el uso de los compuestos o composiciones reivindicados para la fabricación de un medicamento para el tratamiento de una infección bacteriana y un procedimiento para preparar los compuestos reivindicados.
MX2009005979A 2006-12-06 2007-12-04 Derivados de quinolina antibacterianos. MX2009005979A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125510 2006-12-06
PCT/EP2007/063314 WO2008068268A1 (en) 2006-12-06 2007-12-04 Antibacterial quinoline derivatives

Publications (1)

Publication Number Publication Date
MX2009005979A true MX2009005979A (es) 2009-06-16

Family

ID=37909392

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009005979A MX2009005979A (es) 2006-12-06 2007-12-04 Derivados de quinolina antibacterianos.

Country Status (32)

Country Link
US (1) US8293732B2 (es)
EP (1) EP2099760B1 (es)
JP (1) JP5466012B2 (es)
KR (3) KR101908350B1 (es)
CN (1) CN101547905B (es)
AP (1) AP2670A (es)
AR (1) AR064147A1 (es)
BR (1) BRPI0719939B8 (es)
CA (1) CA2668517C (es)
CL (1) CL2007003515A1 (es)
CY (1) CY1114384T1 (es)
DK (1) DK2099760T3 (es)
EA (1) EA022344B1 (es)
ES (1) ES2407824T3 (es)
HK (1) HK1137433A1 (es)
HR (1) HRP20130372T1 (es)
IL (2) IL199078A (es)
JO (1) JO2970B1 (es)
ME (1) ME01521B (es)
MX (1) MX2009005979A (es)
MY (1) MY150411A (es)
NO (1) NO342095B1 (es)
NZ (1) NZ577128A (es)
PL (1) PL2099760T3 (es)
PT (1) PT2099760E (es)
RS (1) RS52753B (es)
SG (1) SG10201405650SA (es)
SI (1) SI2099760T1 (es)
TW (1) TWI396536B (es)
UA (1) UA101306C2 (es)
WO (1) WO2008068268A1 (es)
ZA (1) ZA200903946B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2970B1 (en) * 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
EP2841426B1 (en) 2012-04-27 2016-09-28 Janssen Pharmaceutica N.V. Antibacterial quinoline derivatives
IN2014MN02364A (es) 2012-04-27 2015-08-14 Janssen Pharmaceutica Nv
BR122023025283A2 (pt) 2016-03-07 2024-02-20 The Global Alliance For Tb Drug Dev Inc Compostos antibacterianos e seus usos
US11857352B2 (en) 2016-09-06 2024-01-02 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998018326A1 (en) * 1996-10-28 1998-05-07 Department Of The Army, U.S. Government Compounds, compositions and methods for treating antibiotic-resistant infections
US6103905A (en) 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
AP2421A (en) 2002-07-25 2012-06-08 Janssen Pharmaceutica Nl Quinoline derivatives and their use as mycobacterial inhibitors.
EP1711492B1 (en) 2004-01-23 2008-04-16 Janssen Pharmaceutica N.V. Substituted quinolines and their use as mycobacterial inhibitors
CN1909907B (zh) 2004-01-23 2010-06-23 詹森药业有限公司 喹啉衍生物及其在制备分枝杆菌抑制剂中的用途
ATE395336T1 (de) 2004-01-29 2008-05-15 Janssen Pharmaceutica Nv Chinolinderivate zur verwendung als inhibitoren von mycobakterien
EA010651B1 (ru) * 2004-05-28 2008-10-30 Янссен Фармацевтика Н.В. Применение замещенных хинолиновых производных для лечения заболеваний, вызываемых микобактериями, резистентными к лекарственным средствам
NZ553693A (en) 2004-09-28 2012-05-25 Janssen Pharmaceutica Nv A bacterial ATP synthase binding domain
EE05394B1 (et) * 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis
EE05697B1 (et) 2005-06-08 2014-02-17 Janssen Pharmaceutica N.V. Kinoliini derivaadid kui antibakteriaalsed toimeained
JO2752B1 (en) 2005-06-28 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JP5193857B2 (ja) 2005-06-28 2013-05-08 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗菌剤としてのキノリン誘導体
JO2970B1 (en) * 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives

Also Published As

Publication number Publication date
HK1137433A1 (en) 2010-07-30
EP2099760A1 (en) 2009-09-16
BRPI0719939B1 (pt) 2020-11-17
ME01521B (me) 2014-04-20
IL241548B (en) 2018-03-29
CA2668517C (en) 2016-01-12
KR20090090339A (ko) 2009-08-25
AP2670A (en) 2013-05-15
MY150411A (en) 2014-01-15
NO20092536L (no) 2009-08-24
TWI396536B (zh) 2013-05-21
KR101574642B1 (ko) 2015-12-04
EP2099760B1 (en) 2013-02-20
US8293732B2 (en) 2012-10-23
EA022344B1 (ru) 2015-12-30
CA2668517A1 (en) 2008-06-12
TW200838530A (en) 2008-10-01
BRPI0719939A2 (pt) 2014-03-11
SG10201405650SA (en) 2014-11-27
WO2008068268A1 (en) 2008-06-12
CN101547905B (zh) 2015-01-28
NO342095B1 (no) 2018-03-19
ZA200903946B (en) 2010-08-25
JO2970B1 (en) 2016-03-15
US20100029679A1 (en) 2010-02-04
SI2099760T1 (sl) 2013-06-28
EA200970536A1 (ru) 2009-10-30
AR064147A1 (es) 2009-03-18
ES2407824T3 (es) 2013-06-14
BRPI0719939B8 (pt) 2021-05-25
AP2009004871A0 (en) 2009-06-30
PL2099760T3 (pl) 2013-07-31
KR20150126737A (ko) 2015-11-12
NZ577128A (en) 2012-01-12
CL2007003515A1 (es) 2008-07-11
AU2007328888A1 (en) 2008-06-12
IL241548A0 (en) 2015-11-30
CY1114384T1 (el) 2016-08-31
HRP20130372T1 (en) 2013-05-31
CN101547905A (zh) 2009-09-30
KR101908350B1 (ko) 2018-10-16
RS52753B (en) 2013-08-30
PT2099760E (pt) 2013-05-06
KR20170003741A (ko) 2017-01-09
UA101306C2 (en) 2013-03-25
DK2099760T3 (da) 2013-05-13
JP5466012B2 (ja) 2014-04-09
IL199078A (en) 2015-10-29
JP2010511669A (ja) 2010-04-15

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