CY1114384T1 - Αντιβακτηριακα παραγωγα κινολινης - Google Patents

Αντιβακτηριακα παραγωγα κινολινης

Info

Publication number
CY1114384T1
CY1114384T1 CY20131100403T CY131100403T CY1114384T1 CY 1114384 T1 CY1114384 T1 CY 1114384T1 CY 20131100403 T CY20131100403 T CY 20131100403T CY 131100403 T CY131100403 T CY 131100403T CY 1114384 T1 CY1114384 T1 CY 1114384T1
Authority
CY
Cyprus
Prior art keywords
compounds
kinolin
producers
antibacterial
pharmaceutically acceptable
Prior art date
Application number
CY20131100403T
Other languages
English (en)
Inventor
Jérôme Emile Georges Guillemont
Ismet Dorange
Magali Madeleine Simone Motte
Koenraad Jozef Lodewijk Marcel Andries
Anil Koul
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37909392&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1114384(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of CY1114384T1 publication Critical patent/CY1114384T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε νέα υποκατεστημένα παράγωγα κινολίνης σύμφωνα με το γενικό Τύπο (Ia) ή το Τύπο (Ib): συμπεριλαμβάνοντας οποιαδήποτε στερεοχημικώς ισομερή μορφή αυτών, ένα Ν-οξείδιο αυτών, ένα φαρμακευτικώς αποδεκτό άλας αυτών ή ένα επιδιαλυτωμένο σύμπλοκο αυτών. Οι ενώσεις που αξιώνονται είναι χρήσιμες στη θεραπευτική αντιμετώπιση μίας βακτηριακής λοίμωξης. Επίσης, αξιώνεται μία σύνθεση που περιλαμβάνει ένα φαρμακευτικώς αποδεκτό φορέα και, ως δραστικό συστατικό, μία θεραπευτικώς αποτελεσματική ποσότητα των ενώσεων που αξιώνονται, η χρήση των ενώσεων που αξιώνονται ή των συνθέσεων για την παρασκευή ενός φαρμάκου για τη θεραπευτική αντιμετώπιση μίας βακτηριακής λοίμωξης και μία διαδικασία για την παρασκευή των ενώσεων που αξιώνονται.
CY20131100403T 2006-12-06 2013-05-17 Αντιβακτηριακα παραγωγα κινολινης CY1114384T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125510 2006-12-06
EP07847812A EP2099760B1 (en) 2006-12-06 2007-12-04 Antibacterial quinoline derivatives

Publications (1)

Publication Number Publication Date
CY1114384T1 true CY1114384T1 (el) 2016-08-31

Family

ID=37909392

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100403T CY1114384T1 (el) 2006-12-06 2013-05-17 Αντιβακτηριακα παραγωγα κινολινης

Country Status (32)

Country Link
US (1) US8293732B2 (el)
EP (1) EP2099760B1 (el)
JP (1) JP5466012B2 (el)
KR (3) KR101908350B1 (el)
CN (1) CN101547905B (el)
AP (1) AP2670A (el)
AR (1) AR064147A1 (el)
BR (1) BRPI0719939B8 (el)
CA (1) CA2668517C (el)
CL (1) CL2007003515A1 (el)
CY (1) CY1114384T1 (el)
DK (1) DK2099760T3 (el)
EA (1) EA022344B1 (el)
ES (1) ES2407824T3 (el)
HK (1) HK1137433A1 (el)
HR (1) HRP20130372T1 (el)
IL (2) IL199078A (el)
JO (1) JO2970B1 (el)
ME (1) ME01521B (el)
MX (1) MX2009005979A (el)
MY (1) MY150411A (el)
NO (1) NO342095B1 (el)
NZ (1) NZ577128A (el)
PL (1) PL2099760T3 (el)
PT (1) PT2099760E (el)
RS (1) RS52753B (el)
SG (1) SG10201405650SA (el)
SI (1) SI2099760T1 (el)
TW (1) TWI396536B (el)
UA (1) UA101306C2 (el)
WO (1) WO2008068268A1 (el)
ZA (1) ZA200903946B (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2970B1 (en) * 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
CN104254527B (zh) 2012-04-27 2017-05-31 詹森药业有限公司 抗菌的喹啉衍生物
CN104254528B (zh) 2012-04-27 2017-06-06 詹森药业有限公司 抗菌的喹啉衍生物
KR102355154B1 (ko) * 2016-03-07 2022-01-26 더 글로벌 얼라이언스 포 티비 드러그 디벨롭먼트, 잉크. 항박테리아 화합물 및 그의 용도
US11857352B2 (en) 2016-09-06 2024-01-02 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0936866A4 (en) * 1996-10-28 2001-04-11 Dept Of The Army Us Government COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING ANTIBIOTIC RESIST INFECTIONS
US6103905A (en) 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
CN1325475C (zh) * 2002-07-25 2007-07-11 詹森药业有限公司 喹啉衍生物及其作为分枝杆菌抑制剂的应用
SG166019A1 (en) 2004-01-23 2010-11-29 Janssen Pharmaceutica Nv Quinoline derivatives and use thereof as mycobacterial inhibitors
ES2306082T3 (es) 2004-01-23 2008-11-01 Janssen Pharmaceutica Nv Quinolinas sustituidas y su utilizacion como inhibidores micobacterianos.
KR101160183B1 (ko) 2004-01-29 2012-06-26 얀센 파마슈티카 엔.브이. 마이코박테리아 저해제로서 사용하기 위한 퀴놀린 유도체
CN1976704B (zh) * 2004-05-28 2012-12-05 詹森药业有限公司 取代的喹啉衍生物在治疗耐药性分枝杆菌性疾病中的用途
KR101539021B1 (ko) 2004-09-28 2015-07-23 얀센 파마슈티카 엔.브이. 박테리아 ａｔｐ 합성효소 결합 부분
EE05394B1 (et) * 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis
CA2528849C (en) 2005-06-08 2014-01-14 Janssen Pharmaceutica N.V. Quinoline derivatives as antibacterial agents
WO2007000434A1 (en) 2005-06-28 2007-01-04 Janssen Pharmaceutica N.V. Quinoline derivatives as antibacterial agents
JO2752B1 (en) 2005-06-28 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2970B1 (en) * 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives

Also Published As

Publication number Publication date
AP2009004871A0 (en) 2009-06-30
JP2010511669A (ja) 2010-04-15
BRPI0719939B1 (pt) 2020-11-17
AU2007328888A1 (en) 2008-06-12
UA101306C2 (en) 2013-03-25
US20100029679A1 (en) 2010-02-04
ME01521B (me) 2014-04-20
IL241548A0 (en) 2015-11-30
KR20150126737A (ko) 2015-11-12
US8293732B2 (en) 2012-10-23
CN101547905B (zh) 2015-01-28
PL2099760T3 (pl) 2013-07-31
JP5466012B2 (ja) 2014-04-09
WO2008068268A1 (en) 2008-06-12
BRPI0719939B8 (pt) 2021-05-25
SI2099760T1 (sl) 2013-06-28
AR064147A1 (es) 2009-03-18
CA2668517C (en) 2016-01-12
CL2007003515A1 (es) 2008-07-11
NO342095B1 (no) 2018-03-19
KR20090090339A (ko) 2009-08-25
IL241548B (en) 2018-03-29
KR20170003741A (ko) 2017-01-09
SG10201405650SA (en) 2014-11-27
HK1137433A1 (en) 2010-07-30
EP2099760B1 (en) 2013-02-20
NZ577128A (en) 2012-01-12
EP2099760A1 (en) 2009-09-16
TWI396536B (zh) 2013-05-21
HRP20130372T1 (en) 2013-05-31
PT2099760E (pt) 2013-05-06
ZA200903946B (en) 2010-08-25
EA022344B1 (ru) 2015-12-30
MY150411A (en) 2014-01-15
EA200970536A1 (ru) 2009-10-30
DK2099760T3 (da) 2013-05-13
BRPI0719939A2 (pt) 2014-03-11
JO2970B1 (en) 2016-03-15
KR101908350B1 (ko) 2018-10-16
TW200838530A (en) 2008-10-01
CA2668517A1 (en) 2008-06-12
NO20092536L (no) 2009-08-24
CN101547905A (zh) 2009-09-30
IL199078A (en) 2015-10-29
KR101574642B1 (ko) 2015-12-04
AP2670A (en) 2013-05-15
RS52753B (en) 2013-08-30
ES2407824T3 (es) 2013-06-14
MX2009005979A (es) 2009-06-16

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