CN101535326B - 被苄基取代的1,4-苯并硫杂*-1,1-二氧化物衍生物、其制备方法、含有所述化合物的药物以及其用途 - Google Patents
被苄基取代的1,4-苯并硫杂*-1,1-二氧化物衍生物、其制备方法、含有所述化合物的药物以及其用途 Download PDFInfo
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- CN101535326B CN101535326B CN2007800424399A CN200780042439A CN101535326B CN 101535326 B CN101535326 B CN 101535326B CN 2007800424399 A CN2007800424399 A CN 2007800424399A CN 200780042439 A CN200780042439 A CN 200780042439A CN 101535326 B CN101535326 B CN 101535326B
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- HVVYZLLAWVVCCS-CSJZFZDTSA-M CCCCC(CCCC)(CS(C(/C(/[C@H]1c2cccc(NC(N[C@@H]([C@@H]([C@H]3OCc4ccccc4)O)O[C@H](COS([O-])(=O)=O)[C@H]3O)=O)c2)=C\C(\N(C)C)=C/C)=C)(=O)=O)[C@@H]1O Chemical compound CCCCC(CCCC)(CS(C(/C(/[C@H]1c2cccc(NC(N[C@@H]([C@@H]([C@H]3OCc4ccccc4)O)O[C@H](COS([O-])(=O)=O)[C@H]3O)=O)c2)=C\C(\N(C)C)=C/C)=C)(=O)=O)[C@@H]1O HVVYZLLAWVVCCS-CSJZFZDTSA-M 0.000 description 1
- RDBHJJOWBIBYDM-DQBAQLDXSA-N CCCC[C@](CC)(CS(c(c([C@H]1c2cccc(NC(N[C@@H]([C@@H]([C@H]3OCc4ccccc4)O)O[C@H](COCc4ccccc4)[C@H]3O)=O)c2)c2)ccc2N(C)C)(=O)=O)[C@@H]1O Chemical compound CCCC[C@](CC)(CS(c(c([C@H]1c2cccc(NC(N[C@@H]([C@@H]([C@H]3OCc4ccccc4)O)O[C@H](COCc4ccccc4)[C@H]3O)=O)c2)c2)ccc2N(C)C)(=O)=O)[C@@H]1O RDBHJJOWBIBYDM-DQBAQLDXSA-N 0.000 description 1
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- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
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- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
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- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
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- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006053635A DE102006053635B4 (de) | 2006-11-14 | 2006-11-14 | Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| DE102006053635.5 | 2006-11-14 | ||
| PCT/EP2007/009393 WO2008058628A1 (de) | 2006-11-14 | 2007-10-30 | Neue mit benzylresten substituierte 1,4-benzothiepin-1,1-dioxidderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101535326A CN101535326A (zh) | 2009-09-16 |
| CN101535326B true CN101535326B (zh) | 2012-10-31 |
Family
ID=39092812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800424399A Active CN101535326B (zh) | 2006-11-14 | 2007-10-30 | 被苄基取代的1,4-苯并硫杂*-1,1-二氧化物衍生物、其制备方法、含有所述化合物的药物以及其用途 |
Country Status (37)
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2282991B1 (de) * | 2008-05-02 | 2018-01-24 | Sanofi-Aventis Deutschland GmbH | Verfahren zur herstellung von 1,4-benzothiepin-1,1-dioxidderivaten |
| US9339480B2 (en) | 2008-11-26 | 2016-05-17 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of obesity and diabetes |
| US20110294767A1 (en) * | 2010-05-26 | 2011-12-01 | Satiogen Pharmaceuticals, Inc. | Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| KR101898610B1 (ko) | 2010-08-31 | 2018-09-14 | 서울대학교산학협력단 | ＰＰＡＲδ 활성물질의 태자 재프로그래밍 용도 |
| LT2637668T (lt) | 2010-11-04 | 2016-09-12 | Albireo Ab | Ibat inhibitoriai kepenų ligoms gydyti |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2771003B1 (en) | 2011-10-28 | 2017-04-19 | Lumena Pharmaceuticals LLC | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
| KR20190135545A (ko) * | 2011-10-28 | 2019-12-06 | 루메나 파마수티컬즈, 인코포레이티드 | 고담혈증 및 담즙 정체성 간 질환 치료용 담즙산 재순환 억제제 |
| JO3301B1 (ar) | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
| KR20220082931A (ko) | 2014-06-25 | 2022-06-17 | 이에이 파마 가부시키가이샤 | 고형 제제 및 그의 착색 방지 또는 착색 감소 방법 |
| EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
| US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
| US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| WO2017138878A1 (en) | 2016-02-09 | 2017-08-17 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| CA3011565C (en) | 2016-02-09 | 2024-01-02 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| CA3071182A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | Cholestyramine pellets, oral cholestyramine formulations and use thereof |
| WO2019032026A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | CHOLESTYRAMINE GRANULES, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE |
| CN112449637B (zh) | 2018-06-05 | 2024-03-19 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
| US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| MY209425A (en) | 2018-06-20 | 2025-07-08 | Albireo Ab | Crystal modifications of odevixibat |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| EP3841123A2 (en) | 2018-08-23 | 2021-06-30 | Seagen Inc. | Anti-tigit antibodies |
| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
| HRP20230039T1 (hr) | 2019-02-06 | 2023-06-09 | Albireo Ab | Benzotiadiazepinski spojevi i njihova uporaba kao modulatora žučnih kiselina |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| JP7562546B2 (ja) | 2019-02-12 | 2024-10-07 | ミルム ファーマシューティカルズ インコーポレイテッド | 胆汁うっ滞性肝疾患を有する小児対象の成長を増加させる方法 |
| ES3029063T3 (en) | 2019-12-04 | 2025-06-23 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
| ES2972045T3 (es) | 2019-12-04 | 2024-06-10 | Albireo Ab | Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar |
| CR20220315A (es) | 2019-12-04 | 2022-10-26 | Albireo Ab | Compuestos de benzoti(di)azepina y su uso como moduladores del ácido biliar |
| US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
| ES2973355T3 (es) | 2019-12-04 | 2024-06-19 | Albireo Ab | Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar |
| EP4188541B1 (en) | 2020-08-03 | 2024-12-25 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
| AU2021379076A1 (en) | 2020-11-12 | 2023-06-08 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
| CA3198216A1 (en) | 2020-12-04 | 2022-06-09 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| JP2025516153A (ja) | 2022-04-22 | 2025-05-27 | アルビレオ・アクチボラグ | Ａｓｂｔ阻害剤の皮下投与 |
| WO2023237728A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
| KR20250110930A (ko) | 2022-12-09 | 2025-07-21 | 알비레오 에이비 | 신장 질병 치료용 asbt 억제제 |
| WO2024243023A1 (en) * | 2023-05-19 | 2024-11-28 | Mirum Pharmaceuticals, Inc. | Pharmaceutical compositions comprising 2,3,4,5-tetrahydro-benzothiepin-1,1-dioxide derivatives and the use thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1305487A (zh) * | 1998-06-10 | 2001-07-25 | 阿文蒂斯药物德国有限公司 | 苯并硫杂环庚三烯－1,1－二氧化物类衍生物、其制备方法、含有这些化合物的组合物及其应用 |
| CN1639140A (zh) * | 2001-09-07 | 2005-07-13 | 阿斯特拉曾尼卡有限公司 | 用于治疗高脂血症的苯并硫氮杂䓬衍生物 |
| CN1655792A (zh) * | 2001-08-22 | 2005-08-17 | 安万特医药德国有限公司 | 1,4－苯并硫杂䓬－1,1－二氧化物衍生物与其它活性成分的组合产物及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| CA2464685A1 (en) | 2001-11-02 | 2003-05-15 | G.D. Searle Llc | Novel mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (asbt) and taurocholate uptake |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| DE102005033099A1 (de) | 2005-07-15 | 2007-01-18 | Sanofi-Aventis Deutschland Gmbh | Neues 1,4-Benzothiazepin-1,1-Dioxidderivat mit verbesserten Eigenschaften, Verfahren zu dessen Herstellung, diese Verbindung enthaltende Arzneimittel und dessen Verwendung |
-
2006
- 2006-11-14 DE DE102006053635A patent/DE102006053635B4/de not_active Expired - Fee Related
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2007
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305487A (zh) * | 1998-06-10 | 2001-07-25 | 阿文蒂斯药物德国有限公司 | 苯并硫杂环庚三烯－1,1－二氧化物类衍生物、其制备方法、含有这些化合物的组合物及其应用 |
| CN1655792A (zh) * | 2001-08-22 | 2005-08-17 | 安万特医药德国有限公司 | 1,4－苯并硫杂䓬－1,1－二氧化物衍生物与其它活性成分的组合产物及其用途 |
| CN1639140A (zh) * | 2001-09-07 | 2005-07-13 | 阿斯特拉曾尼卡有限公司 | 用于治疗高脂血症的苯并硫氮杂䓬衍生物 |
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