CN101506210A - 2-苯氧基嘧啶酮类似物 - Google Patents

2-苯氧基嘧啶酮类似物 Download PDF

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Publication number
CN101506210A
CN101506210A CNA2007800309530A CN200780030953A CN101506210A CN 101506210 A CN101506210 A CN 101506210A CN A2007800309530 A CNA2007800309530 A CN A2007800309530A CN 200780030953 A CN200780030953 A CN 200780030953A CN 101506210 A CN101506210 A CN 101506210A
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China
Prior art keywords
compound
alkyl
fluorophenyl
salt
hydrate
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Pending
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CNA2007800309530A
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English (en)
Chinese (zh)
Inventor
R·贝克赛-瓦特拉姆
S·M·凯普托斯蒂
J·徐
B·L·谢纳尔
M·戈什
C·A·布卢姆
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Neurogen Corp
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Neurogen Corp
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Publication of CN101506210A publication Critical patent/CN101506210A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nutrition Science (AREA)
  • Communicable Diseases (AREA)
CNA2007800309530A 2006-08-23 2007-08-22 2-苯氧基嘧啶酮类似物 Pending CN101506210A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82325806P 2006-08-23 2006-08-23
US60/823,258 2006-08-23

Related Child Applications (1)

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CN201410468406.2A Division CN104292229A (zh) 2006-08-23 2007-08-22 2-苯氧基嘧啶酮类似物

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CN101506210A true CN101506210A (zh) 2009-08-12

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CN201410468406.2A Pending CN104292229A (zh) 2006-08-23 2007-08-22 2-苯氧基嘧啶酮类似物

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US (2) US8003656B2 (enExample)
EP (1) EP2061794B1 (enExample)
JP (1) JP5421108B2 (enExample)
KR (1) KR20090043583A (enExample)
CN (2) CN101506210A (enExample)
AU (1) AU2007288203B2 (enExample)
BR (1) BRPI0716582A2 (enExample)
CA (1) CA2660957C (enExample)
CO (1) CO6150167A2 (enExample)
CR (1) CR10675A (enExample)
EA (1) EA200900330A1 (enExample)
ES (1) ES2399928T3 (enExample)
GT (1) GT200900040A (enExample)
IL (1) IL197043A0 (enExample)
MA (1) MA30720B1 (enExample)
MX (1) MX2009002066A (enExample)
NI (1) NI200900023A (enExample)
NO (1) NO20091182L (enExample)
SV (1) SV2009003173A (enExample)
TW (1) TW200825089A (enExample)
WO (1) WO2008024438A2 (enExample)
ZA (1) ZA200901163B (enExample)

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CA2660957C (en) 2016-10-11
US8759361B2 (en) 2014-06-24
CO6150167A2 (es) 2010-04-20
EP2061794B1 (en) 2012-12-05
ZA200901163B (en) 2010-08-25
KR20090043583A (ko) 2009-05-06
AU2007288203B2 (en) 2013-01-17
BRPI0716582A2 (pt) 2013-10-08
US8003656B2 (en) 2011-08-23
WO2008024438A3 (en) 2008-11-27
JP2010502576A (ja) 2010-01-28
ES2399928T3 (es) 2013-04-04
EA200900330A1 (ru) 2009-08-28
GT200900040A (es) 2010-03-16
MA30720B1 (fr) 2009-09-01
JP5421108B2 (ja) 2014-02-19
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