SV2009003173A - Analogos de 2-fenoxipirimidinonas ref. 66513-sv (72021) - Google Patents
Analogos de 2-fenoxipirimidinonas ref. 66513-sv (72021)Info
- Publication number
- SV2009003173A SV2009003173A SV2009003173A SV2009003173A SV2009003173A SV 2009003173 A SV2009003173 A SV 2009003173A SV 2009003173 A SV2009003173 A SV 2009003173A SV 2009003173 A SV2009003173 A SV 2009003173A SV 2009003173 A SV2009003173 A SV 2009003173A
- Authority
- SV
- El Salvador
- Prior art keywords
- phenoxypirimidinone
- analogs
- receiver
- ref
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- AIDS & HIV (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
Abstract
SE PROVEEN ANÁLOGOS DE 2-FENOXIPIRIMIDINONA, DE LA FORMULA: (VER FORMULA); EN DONDE LAS VARIABLES SON COMO SE DESCRIBE AQUÍ; DICHOS COMPUESTOS SON LIGANDOS QUE SE PUEDEN USAR PARA MODULAR ACTIVIDAD DE RECEPTOR ESPECIFICA IN VIVO O IN VITRO, Y SON PARTICULARMENTE ÚTILES EN EL TRATAMIENTO DE CONDICIONES ASOCIADAS CON ACTIVACIÓN DE RECEPTOR PATOLÓGICA EN HUMANOS, ANIMALES DE COMPAÑÍA DOMESTICADOS Y ANIMALES DE GANADO; SE PROVEEN COMPOSICIONES FARMACÉUTICAS Y MÉTODOS PARA USAR DICHOS COMPUESTOS PARA TRATAR ESOS TRASTORNOS, COMO LO SON LOS MÉTODOS PARA USAR DICHOS LIGANDOS PARA ESTUDIOS DE LOCALIZACIÓN DE RECEPTOR
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82325806P | 2006-08-23 | 2006-08-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
SV2009003173A true SV2009003173A (es) | 2010-08-10 |
Family
ID=39107411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SV2009003173A SV2009003173A (es) | 2006-08-23 | 2009-02-20 | Analogos de 2-fenoxipirimidinonas ref. 66513-sv (72021) |
Country Status (22)
Country | Link |
---|---|
US (2) | US8003656B2 (es) |
EP (1) | EP2061794B1 (es) |
JP (1) | JP5421108B2 (es) |
KR (1) | KR20090043583A (es) |
CN (2) | CN104292229A (es) |
AU (1) | AU2007288203B2 (es) |
BR (1) | BRPI0716582A2 (es) |
CA (1) | CA2660957C (es) |
CO (1) | CO6150167A2 (es) |
CR (1) | CR10675A (es) |
EA (1) | EA200900330A1 (es) |
ES (1) | ES2399928T3 (es) |
GT (1) | GT200900040A (es) |
IL (1) | IL197043A0 (es) |
MA (1) | MA30720B1 (es) |
MX (1) | MX2009002066A (es) |
NI (1) | NI200900023A (es) |
NO (1) | NO20091182L (es) |
SV (1) | SV2009003173A (es) |
TW (1) | TW200825089A (es) |
WO (1) | WO2008024438A2 (es) |
ZA (1) | ZA200901163B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0509573D0 (en) * | 2005-05-11 | 2005-06-15 | Merck Sharp & Dohme | Therapeutic compounds |
ES2399928T3 (es) | 2006-08-23 | 2013-04-04 | Neurogen Corporation | Análogos de 2-fenoxipirimidinona |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
EP3043784B9 (en) | 2013-09-09 | 2019-11-20 | Peloton Therapeutics, Inc. | Aryl ethers and uses thereof |
WO2016023830A1 (en) * | 2014-08-11 | 2016-02-18 | Hydra Biosciences, Inc. | Pyrido[2,3-d]pyrimidine-2,4(1h,3h)-dione derivatives |
WO2016145032A1 (en) | 2015-03-11 | 2016-09-15 | Peloton Therapeutics, Inc. | Compositions for use in treating pulmonary arterial hypertension |
WO2016144825A1 (en) | 2015-03-11 | 2016-09-15 | Peloton Therapeutics, Inc. | Aromatic compounds and uses thereof |
WO2016145045A1 (en) | 2015-03-11 | 2016-09-15 | Peloton Therapeutics, Inc. | Compositions for use in treating glioblastoma |
US10155726B2 (en) | 2015-03-11 | 2018-12-18 | Peloton Therapeutics, Inc. | Substituted pyridines and uses thereof |
WO2016168510A1 (en) | 2015-04-17 | 2016-10-20 | Peloton Therapeutics, Inc. | Combination therapy of a hif-2-alpha inhibitor and an immunotherapeutic agent and uses thereof |
EP3908308A4 (en) * | 2019-01-08 | 2023-03-22 | Texas Tech University System | SMALL MOLECULES ANALOGS OF THE E4ORF1 PROTEIN IN THE TREATMENT AND PREVENTION OF METABOLIC DISORDERS |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
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US5124331A (en) | 1988-03-02 | 1992-06-23 | Yoshitomi Pharmaceutical Industries, Ltd. | 3,4-dihydrothieno[2,3-d]pyrimidine compounds and their pharmaceutical use |
US5202328A (en) | 1991-03-06 | 1993-04-13 | Merck & Co., Inc. | Substituted fused pyrimidinones |
PT807633E (pt) | 1996-05-15 | 2003-02-28 | Pfizer | Novas pirimidin-4-onas substituidas em 2,3, e fundidas com heteroarilo em (5,6) |
DE69808282T2 (de) | 1997-05-08 | 2003-05-15 | Aventis Cropscience Uk Ltd | Verwendung von Thienopyrimidinen als Fungizide |
US6627755B1 (en) | 1997-06-09 | 2003-09-30 | Pfizer Inc | Quinazolin-4-one AMPA antagonists |
IL125950A0 (en) | 1997-09-05 | 1999-04-11 | Pfizer Prod Inc | Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy |
US6323208B1 (en) | 1997-09-05 | 2001-11-27 | Pfizer Inc | Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones |
WO2002026718A2 (en) | 2000-09-29 | 2002-04-04 | Millennium Pharmaceutical, Inc. | Bicyclic pyrimidin-4-one based inhibitors of factor xa |
MXPA03004926A (es) | 2001-02-14 | 2005-02-14 | Warner Lambert Co | Inhibidores de metaloproteinasas de matriz basados en pirimidinonas fusionadas. |
KR20030083755A (ko) | 2001-03-26 | 2003-10-30 | 노파르티스 아게 | 동통 치료를 위한 바닐로이드 수용체 길항제로서의 용도를위한 융합 피리딘 유도체 |
ATE298009T1 (de) * | 2001-09-28 | 2005-07-15 | Daimler Chrysler Ag | Hochfester duplex-/triplex-leichtbaustahl und seine verwendung |
US20050154230A1 (en) | 2001-12-26 | 2005-07-14 | Bayer Healthcare Ag | Urea derivatives |
AU2003241453A1 (en) | 2002-05-17 | 2003-12-02 | Janssen Pharmaceutica N.V. | Aminotetralin-derived urea modulators of vanilloid vr1 receptor |
WO2003106435A1 (en) | 2002-06-18 | 2003-12-24 | Sankyo Company, Limited | Fused-ring pyrimidin-4(3h)-one derivatives, processes for the preparation and uses thereof |
WO2004028440A2 (en) | 2002-09-24 | 2004-04-08 | Bayer Healthcare Ag | Vr1 antagonists for the treatment of urological disorders |
GB0223730D0 (en) | 2002-10-11 | 2002-11-20 | Novartis Ag | Organic compounds |
WO2004037176A2 (en) | 2002-10-21 | 2004-05-06 | Bristol-Myers Squibb Company | Quinazolinones and derivatives thereof as factor xa inhibitors |
JP4887139B2 (ja) | 2003-03-25 | 2012-02-29 | 武田薬品工業株式会社 | ジペプチジルペプチダーゼインヒビター |
US20070135454A1 (en) | 2003-11-14 | 2007-06-14 | Tracy Bayliss | Bicyclic pyrimidin-4(3h)-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1-receptor(vr1) |
GB0326633D0 (en) | 2003-11-14 | 2003-12-17 | Merck Sharp & Dohme | Therapeutic agents |
US7544803B2 (en) * | 2004-01-23 | 2009-06-09 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
GB0412769D0 (en) | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
AR051596A1 (es) * | 2004-10-26 | 2007-01-24 | Irm Llc | Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios |
GB0509573D0 (en) * | 2005-05-11 | 2005-06-15 | Merck Sharp & Dohme | Therapeutic compounds |
US20090298856A1 (en) * | 2005-05-11 | 2009-12-03 | Rebecca Elizabeth Brown | 2,3 Substituted fused bicyclic pyrimidin-4(3H)-ones modulating the function of the vanilliod-1receptor (VR1) |
CN1318429C (zh) * | 2005-07-25 | 2007-05-30 | 华中师范大学 | 具有杀菌活性的取代噻吩并[3',2':5,6]吡啶并[4,3-d]嘧啶-4(3H)-酮及制备 |
TWI409070B (zh) | 2005-11-04 | 2013-09-21 | Hydra Biosciences Inc | 用於調節trpv3功能之化合物 |
ES2399928T3 (es) | 2006-08-23 | 2013-04-04 | Neurogen Corporation | Análogos de 2-fenoxipirimidinona |
JP2010501571A (ja) | 2006-08-23 | 2010-01-21 | ニューロジェン・コーポレーション | ハロアルキル−置換ピリミジノン誘導体 |
EP2094704A4 (en) | 2006-11-06 | 2010-12-08 | Neurogen Corp | CIS-CYCLOHEXYL SUBSTITUTED PYRIMIDINONE DERIVATIVES |
WO2008156607A1 (en) | 2007-06-12 | 2008-12-24 | Neurogen Corporation | Substituted pyrimidinones |
WO2009100403A1 (en) | 2008-02-07 | 2009-08-13 | Neurogen Corporation | Substituted aryl pyrimidinones |
WO2009121036A2 (en) | 2008-03-27 | 2009-10-01 | Neurogen Corporation | Substituted aryl pyrimidinone derivatives |
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2007
- 2007-08-22 ES ES07811503T patent/ES2399928T3/es active Active
- 2007-08-22 CN CN201410468406.2A patent/CN104292229A/zh active Pending
- 2007-08-22 TW TW096131019A patent/TW200825089A/zh unknown
- 2007-08-22 JP JP2009525630A patent/JP5421108B2/ja not_active Expired - Fee Related
- 2007-08-22 KR KR1020097005810A patent/KR20090043583A/ko not_active Application Discontinuation
- 2007-08-22 ZA ZA200901163A patent/ZA200901163B/xx unknown
- 2007-08-22 CA CA2660957A patent/CA2660957C/en not_active Expired - Fee Related
- 2007-08-22 EA EA200900330A patent/EA200900330A1/ru unknown
- 2007-08-22 AU AU2007288203A patent/AU2007288203B2/en not_active Ceased
- 2007-08-22 WO PCT/US2007/018654 patent/WO2008024438A2/en active Application Filing
- 2007-08-22 MX MX2009002066A patent/MX2009002066A/es unknown
- 2007-08-22 EP EP07811503A patent/EP2061794B1/en active Active
- 2007-08-22 US US11/895,286 patent/US8003656B2/en active Active
- 2007-08-22 BR BRPI0716582-0A2A patent/BRPI0716582A2/pt not_active IP Right Cessation
- 2007-08-22 CN CNA2007800309530A patent/CN101506210A/zh active Pending
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2009
- 2009-02-15 IL IL197043A patent/IL197043A0/en unknown
- 2009-02-20 SV SV2009003173A patent/SV2009003173A/es not_active Application Discontinuation
- 2009-02-20 NI NI200900023A patent/NI200900023A/es unknown
- 2009-02-23 GT GT200900040A patent/GT200900040A/es unknown
- 2009-03-18 CO CO09028167A patent/CO6150167A2/es unknown
- 2009-03-20 CR CR10675A patent/CR10675A/es not_active Application Discontinuation
- 2009-03-20 NO NO20091182A patent/NO20091182L/no not_active Application Discontinuation
- 2009-03-23 MA MA31732A patent/MA30720B1/fr unknown
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2011
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Also Published As
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AU2007288203A1 (en) | 2008-02-28 |
ZA200901163B (en) | 2010-08-25 |
BRPI0716582A2 (pt) | 2013-10-08 |
US8759361B2 (en) | 2014-06-24 |
KR20090043583A (ko) | 2009-05-06 |
CA2660957C (en) | 2016-10-11 |
JP5421108B2 (ja) | 2014-02-19 |
CN104292229A (zh) | 2015-01-21 |
EA200900330A1 (ru) | 2009-08-28 |
AU2007288203B2 (en) | 2013-01-17 |
EP2061794B1 (en) | 2012-12-05 |
CN101506210A (zh) | 2009-08-12 |
US8003656B2 (en) | 2011-08-23 |
JP2010502576A (ja) | 2010-01-28 |
ES2399928T3 (es) | 2013-04-04 |
TW200825089A (en) | 2008-06-16 |
MX2009002066A (es) | 2009-03-06 |
IL197043A0 (en) | 2009-11-18 |
CA2660957A1 (en) | 2008-02-28 |
EP2061794A4 (en) | 2010-09-08 |
WO2008024438A3 (en) | 2008-11-27 |
US20120208829A1 (en) | 2012-08-16 |
EP2061794A2 (en) | 2009-05-27 |
CO6150167A2 (es) | 2010-04-20 |
MA30720B1 (fr) | 2009-09-01 |
CR10675A (es) | 2009-04-17 |
NO20091182L (no) | 2009-05-14 |
GT200900040A (es) | 2010-03-16 |
NI200900023A (es) | 2010-03-05 |
WO2008024438A2 (en) | 2008-02-28 |
US20090069347A1 (en) | 2009-03-12 |
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