ECSP088527A - 3-aminociclopentanocarboxamidas como moduladores de receptores de quimioquinas - Google Patents

3-aminociclopentanocarboxamidas como moduladores de receptores de quimioquinas

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Publication number
ECSP088527A
ECSP088527A EC2008008527A ECSP088527A ECSP088527A EC SP088527 A ECSP088527 A EC SP088527A EC 2008008527 A EC2008008527 A EC 2008008527A EC SP088527 A ECSP088527 A EC SP088527A EC SP088527 A ECSP088527 A EC SP088527A
Authority
EC
Ecuador
Prior art keywords
chemiokin
aminociclopentanocarboxamids
receptors modulators
receptors
compounds
Prior art date
Application number
EC2008008527A
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English (en)
Inventor
Chu Biao Xue
Original Assignee
Incyte Corp
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Application filed by Incyte Corp filed Critical Incyte Corp
Publication of ECSP088527A publication Critical patent/ECSP088527A/es

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Abstract

La presente invención se refiere a compuestos de fórmula I: (consta gráfico) que son moduladores de receptores de quimioquinas. Los compuestos de la invención, y las composiciones de los mismos, son útiles en el tratamiento de enfermedades relacionadas con la expresión y/o actividad de receptores de quimioquinas.
EC2008008527A 2005-12-21 2008-06-12 3-aminociclopentanocarboxamidas como moduladores de receptores de quimioquinas ECSP088527A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75232005P 2005-12-21 2005-12-21
US75247705P 2005-12-21 2005-12-21

Publications (1)

Publication Number Publication Date
ECSP088527A true ECSP088527A (es) 2008-07-30

Family

ID=38126410

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EC2008008527A ECSP088527A (es) 2005-12-21 2008-06-12 3-aminociclopentanocarboxamidas como moduladores de receptores de quimioquinas

Country Status (21)

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US (2) US7700624B2 (es)
EP (1) EP1971576A2 (es)
JP (1) JP2009520809A (es)
KR (1) KR20080070868A (es)
AP (1) AP2008004487A0 (es)
AR (1) AR058402A1 (es)
AU (1) AU2006327823A1 (es)
BR (1) BRPI0620073A2 (es)
CA (1) CA2634636A1 (es)
CR (1) CR10060A (es)
EA (1) EA200801220A1 (es)
EC (1) ECSP088527A (es)
IL (1) IL191602A0 (es)
MA (1) MA30077B1 (es)
ME (1) MEP1008A (es)
NL (1) NL2000380C2 (es)
NO (1) NO20082285L (es)
RS (1) RS20080246A (es)
TW (1) TW200734323A (es)
UY (1) UY30052A1 (es)
WO (1) WO2007072201A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL376925A1 (pl) * 2002-11-27 2006-01-09 Incyte Corporation Pochodne 3-aminopirolidyny jako modulatory receptorów chemokiny
AU2005234596B8 (en) * 2004-04-13 2011-06-16 Incyte Holdings Corporation Piperazinylpiperidine derivatives as chemokine receptor antagonists
GEP20094843B (en) * 2004-06-28 2009-11-25 Incyte Corp 3-aminocyclopentane carboxamides as modulators of chemokine receptors
US8067457B2 (en) 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
WO2007053499A2 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
MEP1008A (xx) * 2005-12-21 2010-02-10 Incyte Corp 3-aminociklopentankarboksamidi kao modulatori receptora hemokina
US7910108B2 (en) 2006-06-05 2011-03-22 Incyte Corporation Sheddase inhibitors combined with CD30-binding immunotherapeutics for the treatment of CD30 positive diseases
CA2743030C (en) 2008-11-26 2013-10-22 Pfizer Inc. 3-aminocyclopentanecarboxamides as chemokine receptor modulators
WO2012171863A1 (en) * 2011-06-16 2012-12-20 Boehringer Ingelheim International Gmbh New selective ccr2 antagonists
TW201613864A (en) 2014-02-20 2016-04-16 Takeda Pharmaceutical Novel compounds
CR20170076A (es) 2014-08-04 2017-06-26 Nuevolution As Derivados de pirimidima sustituidos con heterociclilo opcionalmente condensados útiles para el tratamiento de enfermedades inflamatorias, metabólicas, oncológicas y autoinmunitarias
AU2020408107B2 (en) 2019-12-20 2026-04-23 Nuevolution A/S Compounds active towards nuclear receptors
AU2020405446A1 (en) 2019-12-20 2022-05-26 Nuevolution A/S Compounds active towards nuclear receptors
US11613532B2 (en) 2020-03-31 2023-03-28 Nuevolution A/S Compounds active towards nuclear receptors
EP4126874A1 (en) 2020-03-31 2023-02-08 Nuevolution A/S Compounds active towards nuclear receptors
CN119968355A (zh) 2022-10-07 2025-05-09 橘生药品工业株式会社 环戊烷化合物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811310A (en) 1986-09-30 1998-09-22 Albert Einstein College Of Medicine Of Yeshiva Univ. The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease
WO1995015973A1 (en) 1993-12-06 1995-06-15 Cytel Corporation Cs-1 peptidomimetics, compositions and methods of using the same
US5510332A (en) 1994-07-07 1996-04-23 Texas Biotechnology Corporation Process to inhibit binding of the integrin α4 62 1 to VCAM-1 or fibronectin and linear peptides therefor
WO1996001644A1 (en) 1994-07-11 1996-01-25 Athena Neurosciences, Inc. Inhibitors of leukocyte adhesion
GB9524630D0 (en) 1994-12-24 1996-01-31 Zeneca Ltd Chemical compounds
WO1996031206A2 (en) 1995-04-07 1996-10-10 Warner-Lambert Company Flavones and coumarins as agents for the treatment of atherosclerosis
DE69833654T2 (de) 1997-05-29 2006-12-14 Merck & Co., Inc. (A New Jersey Corp.) Biarylalkansäuren in der verwendung als zelladhäsionsinhibitoren
EP1001764A4 (en) 1997-05-29 2005-08-24 Merck & Co Inc HETEROCYCLIC AMIDE COMPOUNDS AS INHIBITORS OF CELL ADHESION
DE69820614T2 (de) 1997-05-30 2004-09-30 Celltech Therapeutics Ltd., Slough Entzündungshemmende tyrosin-derivate
AU2004215409B2 (en) * 2003-02-24 2008-11-20 Merck Sharp & Dohme Corp. Aminocyclopentyl fused heterotricylicamide modulators of chemokine receptor activity
US20060183731A1 (en) * 2003-07-15 2006-08-17 Min Ge 7 and 8 membered heterocyclic cyclopentyl benzylamide modulators of chemokine receptor activity
CA2551869A1 (en) 2004-01-02 2005-07-28 Merck & Co., Inc. Alkylamino, arylamino, and sulfonamido cyclopentyl amide modulators of chemokine receptor activity
EP1742915A4 (en) * 2004-04-26 2009-12-02 Merck & Co Inc TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKIN RECEPTOR ACTIVITY
JP2007537264A (ja) * 2004-05-11 2007-12-20 インサイト コーポレイション ケモカインレセプタのモジュレータとしての３−（４−ヘテロアリールシクロヘキシルアミノ）シクロペンタンカルボキサミド
EP1763347A4 (en) * 2004-06-28 2009-05-20 Incyte Corp 3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS
GEP20094843B (en) * 2004-06-28 2009-11-25 Incyte Corp 3-aminocyclopentane carboxamides as modulators of chemokine receptors
MEP1008A (xx) * 2005-12-21 2010-02-10 Incyte Corp 3-aminociklopentankarboksamidi kao modulatori receptora hemokina

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IL191602A0 (en) 2009-02-11
WO2007072201A2 (en) 2007-06-28
US7700624B2 (en) 2010-04-20
BRPI0620073A2 (pt) 2011-11-01
MEP1008A (xx) 2010-02-10
RS20080246A (sr) 2009-07-15
CA2634636A1 (en) 2007-06-28
CR10060A (es) 2008-07-17
MA30077B1 (fr) 2008-12-01
NL2000380A1 (nl) 2007-06-25
US20100203039A1 (en) 2010-08-12
WO2007072201A3 (en) 2007-10-04
AU2006327823A1 (en) 2007-06-28
US20070149532A1 (en) 2007-06-28
EP1971576A2 (en) 2008-09-24
AP2008004487A0 (en) 2008-06-30
AR058402A1 (es) 2008-01-30
JP2009520809A (ja) 2009-05-28
TW200734323A (en) 2007-09-16
NL2000380C2 (nl) 2007-11-28
UY30052A1 (es) 2007-07-31
EA200801220A1 (ru) 2008-12-30
KR20080070868A (ko) 2008-07-31

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