CN101496854B - Chinese medicine sobering-up composition and Chinese medicine sobering-up beverage - Google Patents
Chinese medicine sobering-up composition and Chinese medicine sobering-up beverage Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine anti-inebriation composition, and a traditional Chinese medicine anti-inebriation beverage prepared by the composition. The composition comprises the following components in portion by mass: 4 to 8 portions of kudzuvine root, 0.5 to 1.5 portions of licorice, 0.5 to 1.5 portions of red jujube, 1 to 3 portions of Chinese wolfberry, 1 to 3 portions of Hang Zhou white chrysanthemum flower, and 0.5 to 1.5 portions of dried orange peel. The traditional Chinese medicine anti-inebriation beverage prepared by the traditional Chinese medicine composition is prepared from the following raw materials in portion by mass: 1 to 3 portions of traditional Chinese medicine extract, 6.5 to 8.5 portions of water, 0.01 to 0.03 portion of mussel extract, 0.5 to 1.5 portions of white sugar, and 0.005 to 0.02 portion of sodium benzoate. The traditional Chinese medicine anti-inebriation composition and the anti-inebriation beverage have the advantages of better anti-inebriation function, good taste, rich nutritive value, and definite health-care function.
Description
(1) technical field
The present invention relates to a kind of Chinese medicinal alcoholism-relieving compositions, and the traditional Chinese medicine anti-inebriation beverage of utilizing said composition to make.
(2) background technology
Since ancient times, drinking is one of colourful life content of people.Particularly along with the China market expanding economy, the increased and social dinner party of business activity increases gradually, and it is not that the situation healthy with affecting the alcohol user is of common occurrence that heavy drinking causes health.Therefore market demand has the health product of antialcoholism function, with hardship of separating insobriety with protect after drinking healthy of people.
(3) summary of the invention
The object of the invention is to provide a kind of Chinese medicinal alcoholism-relieving compositions of relieving the effect of alcohol effective, and the traditional Chinese medicine anti-inebriation beverage of utilizing the said composition preparation.
The technical solution used in the present invention is:
A kind of Chinese medicinal alcoholism-relieving compositions, described composition quality proportioning is as follows:
4～8 parts of Radix Puerariaes
0.5～1.5 part, Radix Glycyrrhizae
0.5～1.5 part of Fructus Jujubae
1～3 part of Fructus Lycii
1～3 part of Flos Chrysanthemi
0.5～1.5 part of Pericarpium Citri Reticulatae.
Radix Puerariae, another name Radix puerariae, Pachyrhizua angulatus, Radix Puerariae, Pueraria lobata are the root of legume pueraria lobata Pueraria lobata (Willd.) ohwi.Contain multiple flavones ingredient, main active is Dai (daidzein), daidzin (daidzin), puerarin (puerarin), puerarin-7-xyloside (puerarin-7-xyloside) etc.Radix Puerariae is cool in nature, sweet in the mouth, suffering.Having induces sweat brings down a fever, promote the production of body fluid, and rash, the merit of yang invigorating antidiarrheal arrogates to oneself that to control wine long-pending.Compendium of Material Medica is carried: Radix Puerariae, and cool in nature, gas is put down, sweet in the mouth, tool heat clearing away, pathogenic fire reducing, all effects of toxin expelling, this " all poison " has acute alcoholism when containing." property of medicine opinion " of the Tang Dynasty Zhen Quan, record Radix Puerariae " whetting the appetite, alcoholic intoxication " clearly proposes Radix Puerariae and has the effect of relieving the effect of alcohol.
Radix Glycyrrhizae, dry root and rhizome for glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L, contain a lot of chemical compositions, but with glycyrrhizin (Glycyrrhizin), enoxolone (glycyrrhertinic acid) is main.The Radix Glycyrrhizae sweet in the mouth is flat, and the product of giving birth to are little cool, process the product tepor, and are nontoxic, can enter the heart, spleen, stomach, lung meridian.The invigorating middle warmer of function QI invigorating, relieving spasm to stop pain, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.Process use, control weakness of the spleen and stomach, lack of appetite is indigestion and loss of appetite, the loose stool of suffering from abdominal pain, overstrain heating, consumptive lung disease cough, shortness of breath and palpitation; Give birth to use, control laryngopharynx swelling and pain, ulcer sores, the poison of antidote food.Shennong's Herbal is classified Radix Glycyrrhizae as top grade, says that Radix Glycyrrhizae has the merit of hard muscles and bones, longue meat, times strength and detoxifcation, and energy treating disorders in five ZANG-organs six internal organs cold and heat pathogen and incised wound are swollen." Mingyi Bielu " say Radix Glycyrrhizae can warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, cough-relieving quench the thirst, separate hundred poison of drug.
Fructus Jujubae is a kind of nutrient excellent product, is described as " king of BAIGUO ".Fructus Jujubae contains the necessary kind vitamin of the human bodies such as abundant vitamin A, B, C and 18 seed amino acids, mineral, wherein the content of vitamin C (ascorbic acid) is unexpectedly up to Fructus Vitis viniferae, Fructus Mali pumilae 70～80 times, the content of Citrin is also very high, and these two kinds of vitamin have certain effect to anti-cancer and prophylaxis of hypertension, hyperlipidemia.Put down in writing according to the Huangdi's Internal Classics Compendium of Material Medica: Fructus Jujubae has the effect that QI invigorating is supported kidney, blood-enriching face-nourishing, tonifying liver blood pressure lowering, soothing nerves, tonifying yang, controlled the asthenia damage.In Fructus Jujubae, the cyclic adenosine monophosphate of rich content, catechuic acid have unique anti-cancer antihypertensive effect, therefore Fructus Jujubae is splendid tonic food.Modern pharmacology is also discovery simultaneously, and Fructus Jujubae can improve monokaryon---the phagocytic function of mononuclear phagocyte system in body, the liver protecting is arranged, the effect of physical strength reinforcing.
Fructus Lycii is the mature fruit of dicotyledon medicine matrimony vine of solanaceae plant.The Fructus Lycii sweet in the mouth is flat.The Compendium of Material Medica record: " nourishing the liver makes eye bright for Fructus Lycii, kidney-tonifying sperm-generating, hard smart bone, and fatigue taking away, easily color, bleach, and makes eye bright and calm the nerves, and makes us long-lived." in recent years; Fructus Lycii is attracted attention by Chinese scholars as the famous and precious resource of dietotherapeutic; particularly many fruitful work have been carried out in domestic many scholars aspects such as chemical composition, structure and functional evaluation as Fructus Lycii in the research field of Fructus Lycii; studied chemical composition and the functional factor of Fructus Lycii with modern medical theory and instrumental method, and these research datas show that Fructus Lycii is not only nutritious but also really have many-sided health function.
Flos Chrysanthemi is the dry capitulum of feverfew chrysanthemum Chrysanthemum morifolium Ramat..Main minute Flos Chrysanthemi, Herba Tagetis Patulae, Herba Dendranthematis indici.Yellow, Bai Liangju have that dispelling wind and heat pathogens, suppressing the hyperactive liver make eye bright, the effect of heat-clearing and toxic substances removing.Flos Chrysanthemi sweet in the mouth, heat clearing away power slightly a little less than, be longer than suppressing the hyperactive liver and make eye bright; The Herba Tagetis Patulae bitter in the mouth, the power that expels the heat-evil is stronger, is usually used in dispelling wind and heat pathogens; The Flos Chrysanthemi Indici flavor is very bitter, and the strength of heat-clearing and toxic substances removing is very strong.The Flos Chrysanthemi sweet in the mouth is bitter, is slightly cold.Return lung, Liver Channel.Loose wind heat clearing away, suppressing the hyperactive liver makes eye bright.Be used for anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.
Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Pericarpium Citri Reticulatae bitter in the mouth, suffering, temperature.Return lung, spleen channel.Pericarpium Citri Reticulatae contains the compositions such as volatile oil, hesperidin, vitamin B, C, and its contained volatile oil has gentle stimulation to gastrointestinal tract, but pneumatosis in intestinal tube is got rid of in the secretion of facilitating digestion liquid, increases appetite.Pericarpium Citri Reticulatae is also conventional Chinese medicine simply, has the greasy lasting of spleen invigorating, drying dampness to eliminate phlegm, solution of ventilation, the effect of stopping nausea and vomiting by lowering the adverse flow of QI.
Preferably, described Chinese medicinal alcoholism-relieving composition quality proportioning is as follows:
5 parts of Radix Puerariaes
0.5 part, Radix Glycyrrhizae
1 part of Fructus Jujubae
1.5 parts of Fructus Lyciis
1.5 parts of Flos Chrysanthemis
0.5 part of Pericarpium Citri Reticulatae.
A kind of traditional Chinese medicine anti-inebriation beverage of described Chinese medicine composition preparation, described traditional Chinese medicine anti-inebriation beverage is made by the following raw material of quality proportioning:
1～3 part of Chinese medicine extract
6.5～8.5 parts, water
0.01～0.03 part of Carnis Anodonta seu crislaria extract
0.5～1.5 part of white sugar
0.005～0.02 part of sodium benzoate
Described Chinese medicine extract prepares as follows:
first get 4～8 parts of (mass parts of Radix Puerariae of recipe quantity, lower same), 0.5～1.5 part, Radix Glycyrrhizae, 0.5～1.5 part of Fructus Jujubae, adding quality under 80～100 ℃ is Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that the Pericarpium Citri Reticulatae mixture quality is 5～15 times carried out water extraction 0.5～2 hour, and then add 1～3 part of the Fructus Lycii of recipe quantity, 1～3 part of Flos Chrysanthemi, 0.5～1.5 part of Pericarpium Citri Reticulatae, filling into quality is Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that Pericarpium Citri Reticulatae mixture gross mass is 3～10 times, extracted again 0.5～1.5 hour, obtain aqueous extract, standing supernatant 100～200 orders of getting filter, obtain filtrate 1, adding quality in filtering residue is Radix Puerariae again, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that Pericarpium Citri Reticulatae mixture gross mass is 6～10 times, 80～100 ℃ of water extractions 1～2 hour, standing, filter, collect filtrate 2, filtrate 1 and filtrate 2 are mixed, being concentrated into relative density is 1.05～1.08, centrifugal, get supernatant liquid filtering, obtain filter 23, be Chinese medicine extract,
Described Carnis Anodonta seu crislaria extract prepares as follows:
Get the Carnis Anodonta seu crislaria of abdominal foot part, adding quality is its water of 2～5 times, 80～90 ℃ of heating in water bath 2～4 hours, cooling, centrifugal, get supernatant, added the alkaline protease (Alcalase) of 0.15～1.5AU/kg Carnis Anodonta seu crislaria or compound protease (protamex) enzymolysis 10～15 hours in 50～60 ℃ of water-baths, centrifuging and taking supernatant ultrafiltration, concentrated gets concentrated solution, with 75～95% (v/v) ethanol precipitate with ethanol of 2～4 times of volumes, get precipitation dry, obtain described Carnis Anodonta seu crislaria extract;
Described traditional Chinese medicine anti-inebriation beverage prepares as follows:
Get Chinese medicine extract, water, Carnis Anodonta seu crislaria extract, white sugar, the sodium benzoate of formula ratio, mix the post-heating dissolving, seethed with excitement 0.5～2 hour, cooling, standing, filter, get filtrate, be described traditional Chinese medicine anti-inebriation beverage.
Preferably, described traditional Chinese medicine anti-inebriation beverage is made by the following raw material of quality proportioning:
1.46 parts of Chinese medicine extract
Water 7.5. part
0.03 part of Carnis Anodonta seu crislaria extract
1 part of white sugar
0.01 part of sodium benzoate;
Described Chinese medicine extract prepares as follows:
with Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae mixes, adding quality is Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that Pericarpium Citri Reticulatae mixture gross mass is 7 times, soak after 60 minutes, be heated to 90 ℃, decocting 60 minutes, add again Fructus Lycii, Flos Chrysanthemi and Pericarpium Citri Reticulatae, filling into quality is Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that Pericarpium Citri Reticulatae mixture gross mass is 5 times, keep 90 ℃, decocting in water 60 minutes, filter, collection obtains filtrate 1, it is the water of 10 times of filtering residue 1 quality that filtering residue 1 adds quality again, 90 ℃ of decocting in water 60 minutes, filter, collection obtains filtrate 2, merging filtrate 1 and filtrate 2, standing, get supernatant liquid filtering and obtain filtrate 3, it is 1.06 that filtrate 3 is concentrated into relative density, cooling, be Chinese medicine extraction liquid, described Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi and Quality of Pericarpium are than being 5:0.5:1:1.5:1.5:0.5,
Described Carnis Anodonta seu crislaria extract prepares as follows:
Get the Carnis Anodonta seu crislaria of abdominal foot part, adding quality is its water of 4 times, 90 ℃ of heating in water bath 3 hours, cooling, centrifugal, get supernatant, the compound protease enzymolysis 15 hours that adds the 0.5AU/kg Carnis Anodonta seu crislaria in 55 ℃ of water-baths, centrifuging and taking supernatant ultrafiltration, concentrated gets concentrated solution, with 95% ethanol precipitate with ethanol of 3 times of volumes, get precipitation dry, obtain described Carnis Anodonta seu crislaria extract;
Described traditional Chinese medicine anti-inebriation beverage prepares as follows:
Get Chinese medicine extract, water, Carnis Anodonta seu crislaria extract, white sugar, the sodium benzoate of formula ratio, mix the post-heating dissolving, seethed with excitement 1 hour, be cooled to room temperature, filter after standing 2～3 hours, get filtrate, be described traditional Chinese medicine anti-inebriation beverage.
Beneficial effect of the present invention is mainly reflected in: Chinese medicinal alcoholism-relieving compositions of the present invention and alcohol-decomposing beverage, have antialcoholism action preferably, and taste is good and nutritive value abundant, also has certain health-care effect.
(4) specific embodiment
The present invention is described further below in conjunction with specific embodiment, but protection scope of the present invention is not limited in this:
Embodiment 1:
Chinese medicine composition amount proportioning:
6 parts of Radix Puerariaes, 1 part, Radix Glycyrrhizae, 2 parts of Fructus Jujubaes,
2 parts of Fructus Lyciis, 2 parts of Flos Chrysanthemis, 1 part of Pericarpium Citri Reticulatae;
The traditional Chinese medicine anti-inebriation beverage raw material mass mixture ratio:
1.46 parts of Chinese medicine extract
7.5 parts, water
0.03 part of Carnis Anodonta seu crislaria extract
1 part of white sugar
0.01 part of sodium benzoate;
(1) Chinese medicine extract preparation:
Radix Puerariae 0.5kg, Radix Glycyrrhizae 0.05kg, Fructus Jujubae 0.1kg are mixed, add the water of 7kg, soak after 60 minutes, be heated to 90 ℃, decocting in water 60 minutes, then add Fructus Lycii 0.15kg, Flos Chrysanthemi 0.15kg and Pericarpium Citri Reticulatae 0.05kg, fill into the water of 8kg, keep 90 ℃, decocting in water 60 minutes filters, and collects and obtains filtrate 1, filtering residue 1 adds the water of 10kg again, 90 ℃ of decocting in water 60 minutes filter, and collect and obtain filtrate 2, merging filtrate 1 and filtrate 2, being concentrated into relative density is 1.06, and standing, filtration obtains filtrate 3, filtrate 3 centrifuging and taking supernatant are Chinese medicine extract;
(2) Carnis Anodonta seu crislaria extract preparation:
1. the Carnis Anodonta seu crislaria after freezing is placed in the interior steaming and decocting of digester and thaws, after 10 minutes, abdominal foot partly can separate with visceral mass, then gets the abdominal foot part, except the fleshing slag;
2. get the water that abdominal foot part Carnis Anodonta seu crislaria 2kg adds 10kg, be placed in 90 ℃ of water-baths and heated 3 hours, cooling rear centrifugal except the fleshing slag, stay supernatant;
3. supernatant in the water-bath of 55 ℃ of left and right of temperature, added 1AU compound protease (enzyme 2.5AU/g alive, letter Bioisystech Co., Ltd of Novi) enzymolysis 15 hours;
4. centrifugal remove portion protein; By ultrafiltration system, concentrated solution is collected in the permeate discharging with the supernatant after centrifugal;
5. concentrated solution 2L with 95% (v/v) ethanol precipitate with ethanol 24 hours, precipitation oven dry, the pulverizing in cold closet (5 ℃) of 6L, namely gets Carnis Anodonta seu crislaria extract.
(3) traditional Chinese medicine anti-inebriation beverage preparation:
Get Chinese medicine extract 14.6kg, water 75kg, Carnis Anodonta seu crislaria extract 0.3kg, white sugar 10kg, sodium benzoate 0.1kg, mix the post-heating dissolving, seethed with excitement 1 hour, be cooled to room temperature, filter after standing 3 hours, get filtrate, be described traditional Chinese medicine anti-inebriation beverage.
Embodiment 2:
Chinese medicine composition amount proportioning:
4 parts of Radix Puerariaes, 1 part, Radix Glycyrrhizae, 1 part of Fructus Jujubae,
2 parts of Fructus Lyciis, 1 part of Flos Chrysanthemi, 1 part of Pericarpium Citri Reticulatae;
The traditional Chinese medicine anti-inebriation beverage raw material mass mixture ratio:
2 parts of Chinese medicine extract
6.46 parts, water
0.03 part of Carnis Anodonta seu crislaria extract
1.5 parts of white sugar
0.01 part of sodium benzoate;
(1) Chinese medicine extract preparation:
Radix Puerariae 0.4kg, Radix Glycyrrhizae 0.1kg, Fructus Jujubae 0.1kg are mixed, add the water of 12kg, soak after 90 minutes, be heated to 85 ℃, decocting in water 90 minutes, then add Fructus Lycii 0.2kg, Flos Chrysanthemi 0.1kg and Pericarpium Citri Reticulatae 0.1kg, fill into 3kg water, keep 85 ℃, decocting in water 90 minutes filters, and collects and obtains filtrate 1, filtering residue 1 adds the water of 8kg again, 85 ℃ of decocting in water 90 minutes filter, and collect and obtain filtrate 2, merging filtrate 1 and filtrate 2, being concentrated into relative density is 1.06, and standing, filtration obtains filtrate 3, filtrate 3 centrifuging and taking supernatant are Chinese medicine extract;
(2) Carnis Anodonta seu crislaria extract preparation:
1. the Carnis Anodonta seu crislaria after freezing is placed in the interior steaming and decocting of digester and thaws, after 8 minutes, abdominal foot partly can separate with visceral mass, then gets the abdominal foot part, removes the meat slag;
2. get the water that abdominal foot part Carnis Anodonta seu crislaria 1kg adds 4kg, be placed in 90 ℃ of water-baths and heated 4 hours, cooling rear centrifugal except the fleshing slag, stay supernatant;
3. supernatant in the water-bath of temperature 50 C left and right, added 0.3AU compound protease (enzyme 2.5AU/g alive, letter Bioisystech Co., Ltd of Novi) enzymolysis 15 hours;
4. centrifugal remove portion protein; Supernatant after centrifugal is by ultrafiltration system, and concentrated solution is collected in the permeate discharging;
5. concentrated solution 0.5L with 85% (v/v) ethanol precipitate with ethanol 48 hours, precipitation oven dry, the pulverizing in cold closet (2 ℃) of 2L, namely gets Carnis Anodonta seu crislaria extract.
(3) traditional Chinese medicine anti-inebriation beverage preparation:
Get Chinese medicine extract 2kg, water 6.46kg, Carnis Anodonta seu crislaria extract 0.03kg, white sugar 1.5kg, sodium benzoate 0.01kg, mix the post-heating dissolving, seethed with excitement 1 hour, be cooled to room temperature, filter after standing 2 hours, get filtrate, be described traditional Chinese medicine anti-inebriation beverage.
Embodiment 3:
Chinese medicine composition amount proportioning:
4 parts of Radix Puerariaes, 0.5 part, Radix Glycyrrhizae, 1.5 parts of Fructus Jujubaes,
2 parts of Fructus Lyciis, 1.5 parts of Flos Chrysanthemis, 0.5 part of Pericarpium Citri Reticulatae;
The traditional Chinese medicine anti-inebriation beverage raw material mass mixture ratio:
1 part of Chinese medicine extract
7.46 parts, water
0.03 part of Carnis Anodonta seu crislaria extract
1.5 parts of white sugar
0.01 part of sodium benzoate;
(1) Chinese medicine extract preparation:
Radix Puerariae 0.4kg, Radix Glycyrrhizae 0.05kg, Fructus Jujubae 0.15kg are mixed, add the water of 10kg, soak after 60 minutes, be heated to 95 ℃, decocting in water 60 minutes, then add Fructus Lycii 0.2kg, Flos Chrysanthemi 0.15kg and Pericarpium Citri Reticulatae 0.05kg, fill into the water of 6kg, keep 95 ℃, decocting in water 60 minutes filters, and collects and obtains filtrate 1, filtering residue 1 adds the water of 8kg again, 95 ℃ of decocting in water 60 minutes filter, and collect and obtain filtrate 2, merging filtrate 1 and filtrate 2, being concentrated into relative density is 1.05, and standing, filtration obtains filtrate 3, filtrate 3 centrifuging and taking supernatant are Chinese medicine extract;
(2) Carnis Anodonta seu crislaria extract preparation:
1. the Carnis Anodonta seu crislaria after freezing is placed in the interior steaming and decocting of digester and thaws, after 10 minutes, abdominal foot partly can separate with visceral mass, then gets the abdominal foot part, except the fleshing slag;
2. get the water that abdominal foot part Carnis Anodonta seu crislaria 1kg adds 3kg, be placed in 80～90 ℃ of water-baths and heated 4 hours, cooling rear centrifugal except the fleshing slag, stay supernatant;
3. supernatant is in the water-bath of about temperature 60 C, adds alkaline protease (enzyme live 3AU/g, letter Bioisystech Co., Ltd of the Novi) enzymolysis 10 hours of 0.6AU;
4. centrifugal remove portion protein; By ultrafiltration system, concentrated solution is collected in the permeate discharging with the supernatant after centrifugal;
5. concentrated solution 0.4L with 90% ethanol precipitate with ethanol 48 hours, precipitation oven dry, the pulverizing in cold closet (5 ℃) of 0.8L, namely gets Carnis Anodonta seu crislaria extract.
(3) traditional Chinese medicine anti-inebriation beverage preparation:
Get Chinese medicine extract 1kg, water 7.46kg, Carnis Anodonta seu crislaria extract 0.03kg, white sugar 1.5kg, sodium benzoate 0.01kg, mix the post-heating dissolving, seethed with excitement 1 hour, be cooled to room temperature, filter after standing 3 hours, get filtrate, be described traditional Chinese medicine anti-inebriation beverage.
Embodiment 4: the effect of relieving the effect of alcohol experiment
Experimental technique: get 40 of kunming mices, ♀ ♂ half and half is divided into 5 groups at random, and the I group is matched group for blank group, II group, and III～V group is experimental group; The experiment beginning, I group and II group are all poured into normal saline 0.2ml/10g body weight, and III～V group is poured into respectively embodiment 1～3 alcohol-decomposing beverage 0.2ml/10g body weight; After 30min, I group gavage normal saline 0.2ml/10g body weight, II～V organizes equal gavage Chinese liquor (56 °), and each organizes the venous blood samples that divides into groups respectively, gas chromatography determination Ethanol concentration in rat blood after gavage Chinese liquor 30min, 60min, 90min, 150min.
The mensuration of ethanol in blood concentration:
(1) ethanol standard curve making:
Chromatographic condition: GC-10A type gas chromatograph, chromatographic column are DB-5 capillary column (30m * 0.25mm, 0.25 μ m); Column temperature is temperature programming, and initial temperature is 50 ℃, is increased to 150 ℃ with 10 ℃/min, keeps 5min; Detector and injector temperature are 200 ℃; Nitrogen flow rate is 80mL/min, and hydrogen is 50mL/min, and air is 50mL/min.
Get dehydrated alcohol, be mixed with the ethanol standard solution of 1.0,2.0,4.0,5.0,7.5,10.0,12.0,15.0g/L, draw respectively above-mentioned ethanol standard solution sample introduction 2.0 μ L, take concentration as abscissa, peak area is vertical coordinate drawing standard curve.
(2) get whole blood 0.3mL to be measured, be placed in the 25mL volumetric flask, add 200g/L trichloroacetic acid 3mL after thin up, standardize solution, centrifugal, get supernatant 2.0 μ L and be injected in chromatograph, get the peak height value, check in corresponding ethanol mass concentration from standard curve.
(3) experimental result and conclusion:
Experimental result sees Table 1:
Table 1: each organizes mice different time concentration of alcohol relatively
By data in table as can be known, traditional Chinese medicine anti-inebriation beverage of the present invention can significantly reduce the concentration of alcohol in the mouse blood of drinking, and illustrates that traditional Chinese medicine anti-inebriation beverage of the present invention has antialcoholism action preferably.
Claims (2)
1. traditional Chinese medicine anti-inebriation beverage, described traditional Chinese medicine anti-inebriation beverage is made by the following raw material of quality proportioning:
Described Chinese medicine extract prepares as follows:
first get 4～8 parts of the Radix Puerariaes of recipe quantity, 0.5～1.5 part, Radix Glycyrrhizae, 0.5～1.5 part of Fructus Jujubae, adding quality under 80～100 ℃ is Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that the Pericarpium Citri Reticulatae mixture quality is 5～15 times carried out water extraction 0.5～2 hour, and then add 1～3 part of the Fructus Lycii of recipe quantity, 1～3 part of Flos Chrysanthemi, 0.5～1.5 part of Pericarpium Citri Reticulatae, filling into quality is Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that Pericarpium Citri Reticulatae mixture gross mass is 3～10 times, extracted again 0.5～1.5 hour, obtain aqueous extract, standing supernatant 100～200 orders of getting filter, obtain filtrate 1, adding quality in filtering residue is Radix Puerariae again, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that Pericarpium Citri Reticulatae mixture gross mass is 6～10 times, 80～100 ℃ of water extractions 1～2 hour, standing, filter, collect filtrate 2, filtrate 1 and filtrate 2 are mixed, being concentrated into relative density is 1.05～1.08, centrifugal, get supernatant liquid filtering, obtain filter 23, be Chinese medicine extract,
Described Carnis Anodonta seu crislaria extract prepares as follows:
Get abdominal foot part Carnis Anodonta seu crislaria, adding quality is the water of 2～5 times of abdominal foot part Carnis Anodonta seu crislaria quality, 80～90 ℃ of heating in water bath 2～4 hours, cooling, centrifugal, get supernatant, added the alkaline protease of 0.15～1.5AU/kg Carnis Anodonta seu crislaria or compound protease enzymolysis 10～15 hours in 50～60 ℃ of water-baths, centrifugal, get supernatant ultrafiltration, concentrated, get concentrated solution with 75～95% ethanol precipitate with ethanol of 2～4 times of volumes, get precipitation dry, obtain described Carnis Anodonta seu crislaria extract;
Described traditional Chinese medicine anti-inebriation beverage prepares as follows:
Get Chinese medicine extract, water, Carnis Anodonta seu crislaria extract, white sugar, the sodium benzoate of formula ratio, mix the post-heating dissolving, seethed with excitement 0.5～2 hour, cooling, standing, filter, get filtrate, be described traditional Chinese medicine anti-inebriation beverage.
2. traditional Chinese medicine anti-inebriation beverage as claimed in claim 1, it is characterized in that: described traditional Chinese medicine anti-inebriation beverage is made by the following raw material of quality proportioning:
Described Chinese medicine extract prepares as follows:
with Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae mixes, adding quality is Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that Pericarpium Citri Reticulatae mixture gross mass is 7 times, soak after 60 minutes, be heated to 90 ℃, decocting 60 minutes, add again Fructus Lycii, Flos Chrysanthemi and Pericarpium Citri Reticulatae, filling into quality is Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that Pericarpium Citri Reticulatae mixture gross mass is 5 times, keep 90 ℃, decocting in water 60 minutes, filter, collection obtains filtrate 1, it is the water of 10 times of filtering residue 1 quality that filtering residue 1 adds quality again, 90 ℃ of decocting in water 60 minutes, filter, collection obtains filtrate 2, merging filtrate 1 and filtrate 2, standing, get supernatant liquid filtering and obtain filtrate 3, it is 1.06 that filtrate 3 is concentrated into relative density, cooling, be Chinese medicine extract, described Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi and Quality of Pericarpium ratio are 5: 0.5: 1: 1.5: 1.5: 0.5,
Described Carnis Anodonta seu crislaria extract prepares as follows:
Get the Carnis Anodonta seu crislaria of abdominal foot part, adding quality is the water of 4 times of abdominal foot part Carnis Anodonta seu crislaria quality, 90 ℃ of heating in water bath 3 hours, cooling, centrifugal, get supernatant, add the compound protease enzymolysis 15 hours of 0.5AU/kg Carnis Anodonta seu crislaria 55 ℃ of water-baths, centrifuging and taking supernatant ultrafiltration, concentrated, get concentrated solution with 95% ethanol precipitate with ethanol of 3 times of volumes, get the precipitation drying, obtain described Carnis Anodonta seu crislaria extract; Described traditional Chinese medicine anti-inebriation beverage prepares as follows:
Get Chinese medicine extract, water, Carnis Anodonta seu crislaria extract, white sugar, the sodium benzoate of formula ratio, mix the post-heating dissolving, seethed with excitement 1 hour, be cooled to room temperature, filter after standing 3 hours, get filtrate, be described traditional Chinese medicine anti-inebriation beverage.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102433247B (en) * | 2011-11-21 | 2013-08-14 | 潍坊美日新生物科技有限公司 | Wine mate |
| CN103040690A (en) * | 2013-01-23 | 2013-04-17 | 浙江康恩贝制药股份有限公司 | Preparation method of water soluble chrysanthemum morifolium ramat extract |
| CN104689267A (en) * | 2013-12-04 | 2015-06-10 | 青岛润鑫伟业科贸有限公司 | Traditional Chinese medicinal composition for alcohol effect relieving and stomach nourishing |
| CN103751416B (en) * | 2014-01-01 | 2017-04-19 | 蔡建中 | Manufacturing method of traditional Chinese medicine mixed extract solution |
| CN103734830A (en) * | 2014-01-01 | 2014-04-23 | 蔡建中 | Traditional Chinese medicine mixed extraction liquid |
| CN104642641A (en) * | 2014-01-06 | 2015-05-27 | 广西梧州三鹤药业有限公司 | Dealcoholic healthcare composition |
| CN103767031A (en) * | 2014-01-24 | 2014-05-07 | 蔡建中 | Crocodile beverage |
| CN103767030A (en) * | 2014-01-24 | 2014-05-07 | 蔡建中 | Preparation method of crocodile beverage |
| CN104351415A (en) * | 2014-10-20 | 2015-02-18 | 安徽益方堂生物工程有限公司 | Antialcoholic tea containing radix puerariae and preparation method of antialcoholic tea |
| CN105942509A (en) * | 2016-05-16 | 2016-09-21 | 陈臻 | Sobering and liver protecting liquid |
| CN106962934A (en) * | 2017-04-27 | 2017-07-21 | 合肥工业大学 | A kind of alcohol-decomposing beverage based on Tea Saponin |
| CN108030093A (en) * | 2018-01-02 | 2018-05-15 | 袁浩卿 | A kind of sobering-up composition and preparation method and application |
| CN108271963B (en) * | 2018-04-23 | 2021-06-15 | 浙江民生健康科技有限公司 | A herbal beverage with hangover relieving effect, and its preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1316504A (en) * | 2000-04-04 | 2001-10-10 | 哈尔滨三九龙滨酒厂 | Technology for preparing spirit able to protect liver by preventing chemical demage to liver |
| CN1543830A (en) * | 2003-11-19 | 2004-11-10 | 程学斌 | Pueraria flower tea for relieving or neutralizing the effect of alcohol |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1316504A (en) * | 2000-04-04 | 2001-10-10 | 哈尔滨三九龙滨酒厂 | Technology for preparing spirit able to protect liver by preventing chemical demage to liver |
| CN1543830A (en) * | 2003-11-19 | 2004-11-10 | 程学斌 | Pueraria flower tea for relieving or neutralizing the effect of alcohol |
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