CN101496854A - Chinese medicine sobering-up composition and Chinese medicine sobering-up beverage - Google Patents

Chinese medicine sobering-up composition and Chinese medicine sobering-up beverage Download PDF

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CN101496854A
CN101496854A CNA2008101623517A CN200810162351A CN101496854A CN 101496854 A CN101496854 A CN 101496854A CN A2008101623517 A CNA2008101623517 A CN A2008101623517A CN 200810162351 A CN200810162351 A CN 200810162351A CN 101496854 A CN101496854 A CN 101496854A
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chinese medicine
water
extract
quality
filtrate
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CNA2008101623517A
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CN101496854B (en
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陈海军
李小龙
冯旭俊
谢乾程
姚桃女
钱立棋
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浙江珍世堂生物科技有限公司
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Abstract

The invention provides a traditional Chinese medicine anti-inebriation composition, and a traditional Chinese medicine anti-inebriation beverage prepared by the composition. The composition comprises the following components in portion by mass: 4 to 8 portions of kudzuvine root, 0.5 to 1.5 portions of licorice, 0.5 to 1.5 portions of red jujube, 1 to 3 portions of Chinese wolfberry, 1 to 3 portions of Hang Zhou white chrysanthemum flower, and 0.5 to 1.5 portions of dried orange peel. The traditional Chinese medicine anti-inebriation beverage prepared by the traditional Chinese medicine composition is prepared from the following raw materials in portion by mass: 1 to 3 portions of traditional Chinese medicine extract, 6.5 to 8.5 portions of water, 0.01 to 0.03 portion of mussel extract, 0.5 to 1.5 portions of white sugar, and 0.005 to 0.02 portion of sodium benzoate. The traditional Chinese medicine anti-inebriation composition and the anti-inebriation beverage have the advantages of better anti-inebriation function, good taste, rich nutritive value, and definite health-care function.

Description

A kind of Chinese medicine sobering-up composition and traditional Chinese medicine anti-inebriation beverage
(1) technical field
The present invention relates to a kind of Chinese medicine sobering-up composition, and the traditional Chinese medicine anti-inebriation beverage of utilizing said composition to make.
(2) background technology
Since ancient times, drinking is one of colourful life content of people.Particularly along with the China market expanding economy, the increased and social dinner party of business activity increases gradually, and it is not that the situation healthy with influencing the alcohol user is of common occurrence that heavy drinking causes health.Therefore market demand has the health product of antialcoholism function, with hardship of separating insobriety with protect after drinking healthy of people.
(3) summary of the invention
The object of the invention provides a kind of Chinese medicine sobering-up composition that relieves the effect of alcohol effective, and the traditional Chinese medicine anti-inebriation beverage of utilizing the said composition preparation.
The technical solution used in the present invention is:
A kind of Chinese medicine sobering-up composition, described composition quality proportioning is as follows:
4~8 parts of Radix Puerariaes
0.5~1.5 part in Radix Glycyrrhizae
0.5~1.5 part of Fructus Jujubae
1~3 part of Fructus Lycii
1~3 part of Flos Chrysanthemi
0.5~1.5 part of Pericarpium Citri Reticulatae.
Radix Puerariae, another name Radix puerariae, Pachyrhizua angulatus, Radix Puerariae, kudzu are the root of legume pueraria lobata Pueraria lobata (Willd.) ohwi.Contain multiple flavones ingredient, main active is big legumin (daidzein), daidzin (daidzin), puerarin (puerarin), puerarin-7-xyloside (puerarin-7-xyloside) etc.Radix Puerariae is cool in nature, sweet in the mouth, suffering.Having induces sweat brings down a fever, promote the production of body fluid, and rash, the merit of yang invigorating antidiarrheal arrogates to oneself that to control wine long-pending.Compendium of Material Medica is carried: Radix Puerariae, and cool in nature, gas is put down, sweet in the mouth, tool heat clearing away, pathogenic fire reducing, all effects of toxin expelling, this " all poison " has acute alcoholism when containing." property of medicine opinion " of the Tang Dynasty Zhen Quan, record Radix Puerariae " whetting the appetite, alcoholic intoxication " clearly proposes Radix Puerariae and has the antialcoholic effect.
Radix Glycyrrhizae, dry root and rhizome for glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L, contain a lot of chemical constituents, but with glycyrrhizin (Glycyrrhizin), enoxolone (glycyrrhertinic acid) is main.The Radix Glycyrrhizae sweet in the mouth is flat, gives birth to the little cold of product, processs the product tepor, and is nontoxic, can go into the heart, spleen, stomach, lung meridian.The invigorating middle warmer of function QI invigorating, relieving spasm to stop pain, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.Process usefulness, control weakness of the spleen and stomach, lack of appetite is indigestion and loss of appetite, stomachache loose stool, overstrain heating, consumptive lung disease cough, shortness of breath and palpitation; Give birth to usefulness, control laryngopharynx swelling and pain, ulcer sores, the poison of antidote food.Shennong's Herbal is classified Radix Glycyrrhizae as top grade, says that Radix Glycyrrhizae has the merit of hard muscles and bones, longue meat, times strength and detoxifcation, and energy treating disorders in five ZANG-organs six internal organs cold and heat pathogen and incised wound are swollen." Mingyi Bielu " say Radix Glycyrrhizae can warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, cough-relieving quench the thirst, separate hundred poison of drug.
Fructus Jujubae is a kind of nutrient excellent product, is described as " king of BAIGUO ".Fructus Jujubae contains the necessary kind vitamin of human bodies such as abundant vitamin A, B, C and 18 seed amino acids, mineral, wherein the content of vitamin C (ascorbic acid) is unexpectedly up to Fructus Vitis viniferae, Fructus Mali pumilae 70~80 times, the content of Citrin is also very high, and these two kinds of vitamin all have certain effect to anti-cancer and prophylaxis of hypertension, hyperlipidemia.Put down in writing according to the Huangdi's Internal Classics Compendium of Material Medica: Fructus Jujubae has the effect that QI invigorating is supported kidney, blood-enriching face-nourishing, tonifying liver blood pressure lowering, soothing nerves, tonifying yang, controlled the asthenia damage.Abundant cyclic adenosine monophosphate, the catechuic acid of content has unique anti-cancer blood pressure lowering effect in the Fructus Jujubae, so Fructus Jujubae is splendid tonic food.Modern pharmacology finds also that simultaneously Fructus Jujubae can improve monokaryon---the phagocytic function of phagocyte system in the body, the liver protecting is arranged, the effect of physical strength reinforcing.
Fructus Lycii is the mature fruit of dicotyledon medicine matrimony vine of solanaceae plant.The Fructus Lycii sweet in the mouth is flat.The Compendium of Material Medica record: " nourishing the liver makes eye bright for Fructus Lycii, kidney-tonifying sperm-generating, hard smart bone, and fatigue taking away, easily color bleaches, and makes eye bright and calms the nerves, and makes us long-lived." in recent years; Fructus Lycii is attracted attention by Chinese scholars as the famous and precious resource of dietotherapeutic; particularly domestic many scholars have carried out many fruitful work in the aspects such as chemical constituent, structure and functional evaluation as Fructus Lycii in the research field of Fructus Lycii; studied the chemical constituent and the functional factor of Fructus Lycii with modern medical theory and instrumental method, these research datas show that Fructus Lycii is not only nutritious but also have many-sided health function really.
Flos Chrysanthemi is the dry capitulum of feverfew chrysanthemum Chrysanthemum morifolium Ramat..Main branch Flos Chrysanthemi, Herba Tagetis Patulae, Herba Dendranthematis indici.Yellow, Bai Liangju have that dispelling wind and heat pathogens, suppressing the hyperactive liver make eye bright, the effect of heat-clearing and toxic substances removing.Flos Chrysanthemi sweet in the mouth, heat clearing away power slightly a little less than, be longer than suppressing the hyperactive liver and make eye bright; The Herba Tagetis Patulae bitter in the mouth, the power that expels the heat-evil is stronger, is usually used in dispelling wind and heat pathogens; The Flos Chrysanthemi Indici flavor is very bitter, and the strength of heat-clearing and toxic substances removing is very strong.Flos Chrysanthemi sweet in the mouth hardship is slightly cold.Return lung, Liver Channel.Diffusing wind heat clearing away, suppressing the hyperactive liver makes eye bright.Be used for anemopyretic cold, it is dizzy to have a headache, conjunctival congestion and swelling pain, and eyes is dim-sighted.
Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Pericarpium Citri Reticulatae bitter in the mouth, suffering, temperature.Return lung, spleen channel.Pericarpium Citri Reticulatae contains compositions such as volatile oil, hesperidin, vitamin B, C, and its contained volatile oil has gentle stimulation to gastrointestinal tract, but the secretion of facilitating digestion liquid is got rid of pneumatosis in the intestinal tube, stimulating appetite.Pericarpium Citri Reticulatae also is a conventional Chinese medicine simply, has spleen invigorating, the drying dampness to eliminate phlegm of ventilation, the effect of separating greasy lasting, stopping nausea and vomiting by lowering the adverse flow of QI.
Preferably, described Chinese medicine sobering-up composition quality proportioning is as follows:
5 parts of Radix Puerariaes
0.5 part in Radix Glycyrrhizae
1 part of Fructus Jujubae
1.5 parts of Fructus Lyciis
1.5 parts of Flos Chrysanthemis
0.5 part of Pericarpium Citri Reticulatae.
A kind of traditional Chinese medicine anti-inebriation beverage of described Chinese medicine composition preparation, described traditional Chinese medicine anti-inebriation beverage is made by the following raw material of quality proportioning:
1~3 part of Chinese medicine extract
6.5~8.5 parts in water
0.01~0.03 part of Carnis Anodonta seu crislaria extract
0.5~1.5 part of white sugar
0.005~0.02 part of sodium benzoate
Described Chinese medicine extract prepares as follows:
Get 4~8 parts of (mass parts of Radix Puerariae of recipe quantity earlier, down together), 0.5~1.5 part in Radix Glycyrrhizae, 0.5~1.5 part of Fructus Jujubae, adding quality down in 80~100 ℃ is Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that the Pericarpium Citri Reticulatae mixture quality is 5~15 times carried out water extraction 0.5~2 hour, and then add 1~3 part of the Fructus Lycii of recipe quantity, 1~3 part of Flos Chrysanthemi, 0.5~1.5 part of Pericarpium Citri Reticulatae, mending quality is Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that Pericarpium Citri Reticulatae mixture gross mass is 3~10 times, extracted again 0.5~1.5 hour, obtain aqueous extract, leave standstill and get the filtration of supernatant 100~200 orders, obtain filtrate 1, adding quality in the filtering residue again is Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that Pericarpium Citri Reticulatae mixture gross mass is 6~10 times, 80~100 ℃ of water are carried 1~2 hour, leave standstill, filter, collect filtrate 2, filtrate 1 and filtrate 2 are mixed, being concentrated into relative density is 1.05~1.08, centrifugal, get supernatant liquid filtering, obtain filter 23, be Chinese medicine extract;
Described Carnis Anodonta seu crislaria extract prepares as follows:
Get the Carnis Anodonta seu crislaria of abdominal foot part, adding quality is its water of 2~5 times, 80~90 ℃ of heating in water bath 2~4 hours, supernatant is got in cooling, centrifugal, in 50~60 ℃ of water-baths, added the alkaline protease (Alcalase) of 0.15~1.5AU/kg Carnis Anodonta seu crislaria or compound protease (protamex) enzymolysis 10~15 hours, centrifuging and taking supernatant ultrafiltration, concentrated gets concentrated solution, with 75~95% (v/v) ethanol precipitate with ethanol of 2~4 times of volumes, it is dry to get precipitation, obtains described Carnis Anodonta seu crislaria extract;
Described traditional Chinese medicine anti-inebriation beverage prepares as follows:
Get Chinese medicine extract, water, Carnis Anodonta seu crislaria extract, white sugar, the sodium benzoate of formula ratio, mix the post-heating dissolving, seethed with excitement 0.5~2 hour, cool off, leave standstill, filter, get filtrate, be described traditional Chinese medicine anti-inebriation beverage.
Preferably, described traditional Chinese medicine anti-inebriation beverage is made by the following raw material of quality proportioning:
1.46 parts of Chinese medicine extract
Water 7.5. part
0.03 part of Carnis Anodonta seu crislaria extract
1 part of white sugar
0.01 part of sodium benzoate;
Described Chinese medicine extract prepares as follows:
With Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae mixes, the adding quality is a Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that Pericarpium Citri Reticulatae mixture gross mass is 7 times, soak after 60 minutes, be heated to 90 ℃, decocting 60 minutes adds Fructus Lycii again, Flos Chrysanthemi and Pericarpium Citri Reticulatae, mending quality is Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that Pericarpium Citri Reticulatae mixture gross mass is 5 times, keep 90 ℃, decocting in water 60 minutes filters, collection obtains filtrate 1, filtering residue 1 adds the water that quality is 10 times of filtering residue 1 quality again, and 90 ℃ of decocting in water 60 minutes filter, collection obtains filtrate 2, merging filtrate 1 and filtrate 2 are left standstill, and get supernatant liquid filtering and obtain filtrate 3, it is 1.06 that filtrate 3 is concentrated into relative density, cooling is Chinese medicine extraction liquid, described Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi and Pericarpium Citri Reticulatae mass ratio are 5:0.5:1:1.5:1.5:0.5;
Described Carnis Anodonta seu crislaria extract prepares as follows:
Get the Carnis Anodonta seu crislaria of abdominal foot part, adding quality is its water of 4 times, 90 ℃ of heating in water bath 3 hours, supernatant is got in cooling, centrifugal, the compound protease enzymolysis 15 hours that in 55 ℃ of water-baths, adds the 0.5AU/kg Carnis Anodonta seu crislaria, centrifuging and taking supernatant ultrafiltration, concentrated gets concentrated solution, with 95% ethanol precipitate with ethanol of 3 times of volumes, it is dry to get precipitation, obtains described Carnis Anodonta seu crislaria extract;
Described traditional Chinese medicine anti-inebriation beverage prepares as follows:
Get Chinese medicine extract, water, Carnis Anodonta seu crislaria extract, white sugar, the sodium benzoate of formula ratio, mix the post-heating dissolving, seethed with excitement 1 hour, be cooled to room temperature, leave standstill 2~3 hours after-filtration, get filtrate, be described traditional Chinese medicine anti-inebriation beverage.
Beneficial effect of the present invention is mainly reflected in: Chinese medicine sobering-up composition of the present invention and alcohol-decomposing beverage, have antialcoholism action preferably, and taste is good and nutritive value abundant, also has certain function of health care.
(4) specific embodiment
The present invention is described further below in conjunction with specific embodiment, but protection scope of the present invention is not limited in this:
Embodiment 1:
Chinese medicine composition amount proportioning:
6 parts of Radix Puerariaes, 1 part in Radix Glycyrrhizae, 2 parts of Fructus Jujubaes,
2 parts of Fructus Lyciis, 2 parts of Flos Chrysanthemis, 1 part of Pericarpium Citri Reticulatae;
The traditional Chinese medicine anti-inebriation beverage raw material mass mixture ratio:
1.46 parts of Chinese medicine extract
7.5 parts in water
0.03 part of Carnis Anodonta seu crislaria extract
1 part of white sugar
0.01 part of sodium benzoate;
(1) Chinese medicine extract preparation:
Radix Puerariae 0.5kg, Radix Glycyrrhizae 0.05kg, Fructus Jujubae 0.1kg are mixed, add the water of 7kg, soak after 60 minutes, be heated to 90 ℃, decocting in water 60 minutes adds Fructus Lycii 0.15kg, Flos Chrysanthemi 0.15kg and Pericarpium Citri Reticulatae 0.05kg again, mends the water of 8kg, keep 90 ℃, decocting in water 60 minutes filters, and collects and obtains filtrate 1, filtering residue 1 adds the water of 10kg again, 90 ℃ of decocting in water 60 minutes filter, and collect and obtain filtrate 2, merging filtrate 1 and filtrate 2, being concentrated into relative density is 1.06, leaves standstill, filters, and obtains filtrate 3, filtrate 3 centrifuging and taking supernatant are Chinese medicine extract;
(2) Carnis Anodonta seu crislaria extract preparation:
1. the Carnis Anodonta seu crislaria after freezing is placed in the digester steaming and decocting to thaw, abdominal foot partly can separate with visceral mass after 10 minutes, gets the abdominal foot part then, removes the fleshing slag;
2. get the water that abdominal foot part Carnis Anodonta seu crislaria 2kg adds 10kg, placed 90 ℃ of water-bath internal heating 3 hours, the centrifugal fleshing slag that removes in cooling back stays supernatant;
3. supernatant added 1AU compound protease (enzyme 2.5AU/g alive, letter Bioisystech Co., Ltd of Novi) enzymolysis 15 hours in the water-bath of about 55 ℃ of temperature;
4. the centrifugal partially protein of removing; By ultrafiltration system, concentrated solution is collected in the permeate discharging with the supernatant after centrifugal;
5. concentrated solution 2L promptly gets Carnis Anodonta seu crislaria extract with 95% (v/v) ethanol precipitate with ethanol 24 hours, precipitation oven dry, the pulverizing in cold closet (5 ℃) of 6L.
(3) traditional Chinese medicine anti-inebriation beverage preparation:
Get Chinese medicine extract 14.6kg, water 75kg, Carnis Anodonta seu crislaria extract 0.3kg, white sugar 10kg, sodium benzoate 0.1kg, mix the post-heating dissolving, seethed with excitement 1 hour, be cooled to room temperature, leave standstill 3 hours after-filtration, get filtrate, be described traditional Chinese medicine anti-inebriation beverage.
Embodiment 2:
Chinese medicine composition amount proportioning:
4 parts of Radix Puerariaes, 1 part in Radix Glycyrrhizae, 1 part of Fructus Jujubae,
2 parts of Fructus Lyciis, 1 part of Flos Chrysanthemi, 1 part of Pericarpium Citri Reticulatae;
The traditional Chinese medicine anti-inebriation beverage raw material mass mixture ratio:
2 parts of Chinese medicine extract
6.46 parts in water
0.03 part of Carnis Anodonta seu crislaria extract
1.5 parts of white sugar
0.01 part of sodium benzoate;
(1) Chinese medicine extract preparation:
Radix Puerariae 0.4kg, Radix Glycyrrhizae 0.1kg, Fructus Jujubae 0.1kg are mixed, add the water of 12kg, soak after 90 minutes, be heated to 85 ℃, decocting in water 90 minutes adds Fructus Lycii 0.2kg, Flos Chrysanthemi 0.1kg and Pericarpium Citri Reticulatae 0.1kg again, mends 3kg water, keep 85 ℃, decocting in water 90 minutes filters, and collects and obtains filtrate 1, filtering residue 1 adds the water of 8kg again, 85 ℃ of decocting in water 90 minutes filter, and collect and obtain filtrate 2, merging filtrate 1 and filtrate 2, being concentrated into relative density is 1.06, leaves standstill, filters, and obtains filtrate 3, filtrate 3 centrifuging and taking supernatant are Chinese medicine extract;
(2) Carnis Anodonta seu crislaria extract preparation:
1. the Carnis Anodonta seu crislaria after freezing is placed in the digester steaming and decocting to thaw, abdominal foot partly can separate with visceral mass after 8 minutes, gets the abdominal foot part then, removes the meat slag;
2. get the water that abdominal foot part Carnis Anodonta seu crislaria 1kg adds 4kg, placed 90 ℃ of water-bath internal heating 4 hours, the centrifugal fleshing slag that removes in cooling back stays supernatant;
3. supernatant added 0.3AU compound protease (enzyme 2.5AU/g alive, letter Bioisystech Co., Ltd of Novi) enzymolysis 15 hours in the water-bath of about 50 ℃ of temperature;
4. the centrifugal partially protein of removing; Supernatant after centrifugal is by ultrafiltration system, and concentrated solution is collected in the permeate discharging;
5. concentrated solution 0.5L promptly gets Carnis Anodonta seu crislaria extract with 85% (v/v) ethanol precipitate with ethanol 48 hours, precipitation oven dry, the pulverizing in cold closet (2 ℃) of 2L.
(3) traditional Chinese medicine anti-inebriation beverage preparation:
Get Chinese medicine extract 2kg, water 6.46kg, Carnis Anodonta seu crislaria extract 0.03kg, white sugar 1.5kg, sodium benzoate 0.01kg, mix the post-heating dissolving, seethed with excitement 1 hour, be cooled to room temperature, leave standstill 2 hours after-filtration, get filtrate, be described traditional Chinese medicine anti-inebriation beverage.
Embodiment 3:
Chinese medicine composition amount proportioning:
4 parts of Radix Puerariaes, 0.5 part in Radix Glycyrrhizae, 1.5 parts of Fructus Jujubaes,
2 parts of Fructus Lyciis, 1.5 parts of Flos Chrysanthemis, 0.5 part of Pericarpium Citri Reticulatae;
The traditional Chinese medicine anti-inebriation beverage raw material mass mixture ratio:
1 part of Chinese medicine extract
7.46 parts in water
0.03 part of Carnis Anodonta seu crislaria extract
1.5 parts of white sugar
0.01 part of sodium benzoate;
(1) Chinese medicine extract preparation:
Radix Puerariae 0.4kg, Radix Glycyrrhizae 0.05kg, Fructus Jujubae 0.15kg are mixed, add the water of 10kg, soak after 60 minutes, be heated to 95 ℃, decocting in water 60 minutes adds Fructus Lycii 0.2kg, Flos Chrysanthemi 0.15kg and Pericarpium Citri Reticulatae 0.05kg again, mends the water of 6kg, keep 95 ℃, decocting in water 60 minutes filters, and collects and obtains filtrate 1, filtering residue 1 adds the water of 8kg again, 95 ℃ of decocting in water 60 minutes filter, and collect and obtain filtrate 2, merging filtrate 1 and filtrate 2, being concentrated into relative density is 1.05, leaves standstill, filters, and obtains filtrate 3, filtrate 3 centrifuging and taking supernatant are Chinese medicine extract;
(2) Carnis Anodonta seu crislaria extract preparation:
1. the Carnis Anodonta seu crislaria after freezing is placed in the digester steaming and decocting to thaw, abdominal foot partly can separate with visceral mass after 10 minutes, gets the abdominal foot part then, removes the fleshing slag;
2. get the water that abdominal foot part Carnis Anodonta seu crislaria 1kg adds 3kg, placed 80~90 ℃ of water-bath internal heating 4 hours, the centrifugal fleshing slag that removes in cooling back stays supernatant;
3. supernatant is in the water-bath of about 60 ℃ of temperature, adds alkaline protease (enzyme live 3AU/g, letter Bioisystech Co., Ltd of the Novi) enzymolysis 10 hours of 0.6AU;
4. the centrifugal partially protein of removing; By ultrafiltration system, concentrated solution is collected in the permeate discharging with the supernatant after centrifugal;
5. concentrated solution 0.4L promptly gets Carnis Anodonta seu crislaria extract with 90% ethanol precipitate with ethanol 48 hours, precipitation oven dry, the pulverizing in cold closet (5 ℃) of 0.8L.
(3) traditional Chinese medicine anti-inebriation beverage preparation:
Get Chinese medicine extract 1kg, water 7.46kg, Carnis Anodonta seu crislaria extract 0.03kg, white sugar 1.5kg, sodium benzoate 0.01kg, mix the post-heating dissolving, seethed with excitement 1 hour, be cooled to room temperature, leave standstill 3 hours after-filtration, get filtrate, be described traditional Chinese medicine anti-inebriation beverage.
Embodiment 4: the effect of relieving the effect of alcohol experiment
Experimental technique: get 40 of kunming mices, ♀ ♂ half and half is divided into 5 groups at random, and the I group is matched group for blank group, II group, and III~V group is experimental group; The experiment beginning, I group and II group are all poured into normal saline 0.2ml/10g body weight, and III~V group is poured into embodiment 1~3 alcohol-decomposing beverage 0.2ml/10g body weight respectively; Behind the 30min, the I group is irritated stomach normal saline 0.2ml/10g body weight, and II~V group is all irritated stomach Chinese liquor (56 °), and each organizes the venous blood samples that divides into groups respectively, concentration of alcohol in the gas chromatography determination blood after irritating stomach Chinese liquor 30min, 60min, 90min, 150min.
The mensuration of ethanol in blood concentration:
(1) ethanol standard curve making:
Chromatographic condition: GC-10A type gas chromatograph, chromatographic column are DB-5 capillary column (30m * 0.25mm, 0.25 μ m); Column temperature is temperature programming, and initial temperature is 50 ℃, is increased to 150 ℃ with 10 ℃/min, keeps 5min; Detector and injector temperature are 200 ℃; Nitrogen flow rate is 80mL/min, and hydrogen is 50mL/min, and air is 50mL/min.
Get dehydrated alcohol, be mixed with 1.0,2.0,4.0,5.0,7.5,10.0,12.0, the ethanol standard of 15.0g/L is used liquid, and draw above-mentioned ethanol standard respectively and use liquid sample introduction 2.0 μ L, be abscissa with concentration, peak area is a vertical coordinate drawing standard curve.
(2) get whole blood 0.3mL to be measured, place the 25mL volumetric flask, add 200g/L trichloroacetic acid 3mL behind the thin up, standardize solution, centrifugal, get supernatant 2.0 μ L and be injected in the chromatograph, get the peak height value, check in corresponding ethanol mass concentration from standard curve.
(3) experimental result and conclusion:
Experimental result sees Table 1:
Table 1: each organizes mice different time concentration of alcohol relatively
By data in the table as can be known, traditional Chinese medicine anti-inebriation beverage of the present invention can significantly reduce the concentration of alcohol in the mouse blood of drinking, and illustrates that traditional Chinese medicine anti-inebriation beverage of the present invention has antialcoholism action preferably.

Claims (5)

1. Chinese medicine sobering-up composition, described composition quality proportioning is as follows:
4~8 parts of Radix Puerariaes
0.5~1.5 part in Radix Glycyrrhizae
0.5~1.5 part of Fructus Jujubae
1~3 part of Fructus Lycii
1~3 part of Flos Chrysanthemi
0.5~1.5 part of Pericarpium Citri Reticulatae.
2. Chinese medicine sobering-up composition as claimed in claim 1 is characterized in that described composition quality joins
Such as following:
5 parts of Radix Puerariaes
0.5 part in Radix Glycyrrhizae
1 part of Fructus Jujubae
1.5 parts of Fructus Lyciis
1.5 parts of Flos Chrysanthemis
0.5 part of Pericarpium Citri Reticulatae.
3. the traditional Chinese medicine anti-inebriation beverage of the described Chinese medicine composition preparation of a claim 1, described Chinese medicine relieves the effect of alcohol
Beverage is made by the following raw material of quality proportioning:
1~3 part of Chinese medicine extract
6.5~8.5 parts in water
0.01~0.03 part of Carnis Anodonta seu crislaria extract
0.5~1.5 part of white sugar
0.005~0.02 part of sodium benzoate;
Described Chinese medicine extract prepares as follows:
Get 4~8 parts of the Radix Puerariaes of recipe quantity earlier, 0.5~1.5 part in Radix Glycyrrhizae, 0.5~1.5 part of Fructus Jujubae, adding quality down in 80~100 ℃ is Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that the Pericarpium Citri Reticulatae mixture quality is 5~15 times carried out water extraction 0.5~2 hour, and then add 1~3 part of the Fructus Lycii of recipe quantity, 1~3 part of Flos Chrysanthemi, 0.5~1.5 part of Pericarpium Citri Reticulatae, mending quality is Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that Pericarpium Citri Reticulatae mixture gross mass is 3~10 times, extracted again 0.5~1.5 hour, obtain aqueous extract, leave standstill and get the filtration of supernatant 100~200 orders, obtain filtrate 1, adding quality in the filtering residue again is Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that Pericarpium Citri Reticulatae mixture gross mass is 6~10 times, 80~100 ℃ of water are carried 1~2 hour, leave standstill, filter, collect filtrate 2, filtrate 1 and filtrate 2 are mixed, be concentrated into relative density and be 1.05~1.08, centrifugal, get supernatant liquid filtering, obtain filter 23, be Chinese medicine extract;
Described Carnis Anodonta seu crislaria extract prepares as follows:
Get abdominal foot part Carnis Anodonta seu crislaria, adding quality is the water of 2~5 times of abdominal foot part Carnis Anodonta seu crislaria quality, 80~90 ℃ of heating in water bath 2~4 hours, supernatant is got in cooling, centrifugal, in 50~60 ℃ of water-baths, added the alkaline protease of 0.15~1.5AU/kg Carnis Anodonta seu crislaria or compound protease enzymolysis 10~15 hours, centrifugal, get the supernatant ultrafiltration, concentrate, get 75~95% ethanol precipitate with ethanol of concentrated solution with 2~4 times of volumes, it is dry to get precipitation, obtains described Carnis Anodonta seu crislaria extract;
Described traditional Chinese medicine anti-inebriation beverage prepares as follows:
Get Chinese medicine extract, water, Carnis Anodonta seu crislaria extract, white sugar, the sodium benzoate of formula ratio, mix the post-heating dissolving, seethed with excitement 0.5~2 hour, cool off, leave standstill, filter, get filtrate, be described traditional Chinese medicine anti-inebriation beverage.
4. traditional Chinese medicine anti-inebriation beverage as claimed in claim 3 is characterized in that: described antiseptic is a sodium benzoate, and the consumption of described sodium benzoate is 0.05%~0.2%.
5. traditional Chinese medicine anti-inebriation beverage as claimed in claim 3 is characterized in that: described traditional Chinese medicine anti-inebriation beverage is made by the following raw material of quality proportioning:
1.46 parts of Chinese medicine extract
7.5 parts in water
0.03 part of Carnis Anodonta seu crislaria extract
1 part of white sugar
0.01 part of sodium benzoate;
Described Chinese medicine extraction liquid prepares as follows:
With Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae mixes, the adding quality is a Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that Pericarpium Citri Reticulatae mixture gross mass is 7 times, soak after 60 minutes, be heated to 90 ℃, decocting 60 minutes adds Fructus Lycii again, Flos Chrysanthemi and Pericarpium Citri Reticulatae, mending quality is Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi, the water that Pericarpium Citri Reticulatae mixture gross mass is 5 times, keep 90 ℃, decocting in water 60 minutes filters, collection obtains filtrate 1, filtering residue 1 adds the water that quality is 10 times of filtering residue 1 quality again, and 90 ℃ of decocting in water 60 minutes filter, collection obtains filtrate 2, merging filtrate 1 and filtrate 2 are left standstill, and get supernatant liquid filtering and obtain filtrate 3, it is 1.06 that filtrate 3 is concentrated into relative density, cooling is Chinese medicine extraction liquid, described Radix Puerariae, Radix Glycyrrhizae, Fructus Jujubae, Fructus Lycii, Flos Chrysanthemi and Pericarpium Citri Reticulatae mass ratio are 5:0.5:1:1.5:1.5:0.5;
Described Carnis Anodonta seu crislaria extract prepares as follows:
Get the Carnis Anodonta seu crislaria of abdominal foot part, adding quality is the water of 4 times of abdominal foot part Carnis Anodonta seu crislaria quality, 90 ℃ of heating in water bath 3 hours, supernatant is got in cooling, centrifugal, adds the compound protease enzymolysis 15 hours of 0.5AU/kg Carnis Anodonta seu crislaria 55 ℃ of water-baths, centrifuging and taking supernatant ultrafiltration, concentrated, get the 95% ethanol precipitate with ethanol of concentrated solution, get the precipitation drying, obtain described Carnis Anodonta seu crislaria extract with 3 times of volumes;
Described traditional Chinese medicine anti-inebriation beverage prepares as follows:
Get Chinese medicine extraction liquid, water, Carnis Anodonta seu crislaria extract, white sugar, the sodium benzoate of formula ratio, mix the post-heating dissolving, seethed with excitement 1 hour, be cooled to room temperature, leave standstill 3 hours after-filtration, get filtrate, be described traditional Chinese medicine anti-inebriation beverage.
CN 200810162351 2008-11-24 2008-11-24 Chinese medicine sobering-up composition and Chinese medicine sobering-up beverage CN101496854B (en)

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CN102433247A (en) * 2011-11-21 2012-05-02 张发胜 Wine mate and wine mixing utensil for same
CN103040690A (en) * 2013-01-23 2013-04-17 浙江康恩贝制药股份有限公司 Preparation method of water soluble chrysanthemum morifolium ramat extract
CN103734830A (en) * 2014-01-01 2014-04-23 蔡建中 Traditional Chinese medicine mixed extraction liquid
CN103751416A (en) * 2014-01-01 2014-04-30 蔡建中 Manufacturing method of traditional Chinese medicine mixed extract solution
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CN103767031A (en) * 2014-01-24 2014-05-07 蔡建中 Crocodile beverage
CN104351415A (en) * 2014-10-20 2015-02-18 安徽益方堂生物工程有限公司 Antialcoholic tea containing radix puerariae and preparation method of antialcoholic tea
CN104642641A (en) * 2014-01-06 2015-05-27 广西梧州三鹤药业有限公司 Dealcoholic healthcare composition
CN104689267A (en) * 2013-12-04 2015-06-10 青岛润鑫伟业科贸有限公司 Traditional Chinese medicinal composition for alcohol effect relieving and stomach nourishing
CN105942509A (en) * 2016-05-16 2016-09-21 陈臻 Sobering and liver protecting liquid
CN106962934A (en) * 2017-04-27 2017-07-21 合肥工业大学 A kind of alcohol-decomposing beverage based on Tea Saponin
CN108030093A (en) * 2018-01-02 2018-05-15 袁浩卿 A kind of sobering-up composition and preparation method and application
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CN102433247A (en) * 2011-11-21 2012-05-02 张发胜 Wine mate and wine mixing utensil for same
CN102433247B (en) * 2011-11-21 2013-08-14 潍坊美日新生物科技有限公司 Wine mate
CN103040690A (en) * 2013-01-23 2013-04-17 浙江康恩贝制药股份有限公司 Preparation method of water soluble chrysanthemum morifolium ramat extract
CN104689267A (en) * 2013-12-04 2015-06-10 青岛润鑫伟业科贸有限公司 Traditional Chinese medicinal composition for alcohol effect relieving and stomach nourishing
CN103751416B (en) * 2014-01-01 2017-04-19 蔡建中 Manufacturing method of traditional Chinese medicine mixed extract solution
CN103751416A (en) * 2014-01-01 2014-04-30 蔡建中 Manufacturing method of traditional Chinese medicine mixed extract solution
CN103734830A (en) * 2014-01-01 2014-04-23 蔡建中 Traditional Chinese medicine mixed extraction liquid
CN104642641A (en) * 2014-01-06 2015-05-27 广西梧州三鹤药业有限公司 Dealcoholic healthcare composition
CN103767030A (en) * 2014-01-24 2014-05-07 蔡建中 Preparation method of crocodile beverage
CN103767031A (en) * 2014-01-24 2014-05-07 蔡建中 Crocodile beverage
CN104351415A (en) * 2014-10-20 2015-02-18 安徽益方堂生物工程有限公司 Antialcoholic tea containing radix puerariae and preparation method of antialcoholic tea
CN105942509A (en) * 2016-05-16 2016-09-21 陈臻 Sobering and liver protecting liquid
CN106962934A (en) * 2017-04-27 2017-07-21 合肥工业大学 A kind of alcohol-decomposing beverage based on Tea Saponin
CN108030093A (en) * 2018-01-02 2018-05-15 袁浩卿 A kind of sobering-up composition and preparation method and application
CN108271963A (en) * 2018-04-23 2018-07-13 浙江民生健康科技有限公司 A kind of herbal beverage and preparation method thereof with antialcoholism action

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Inventor after: Li Xiaolong

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