CN108030093A - A kind of sobering-up composition and preparation method and application - Google Patents
A kind of sobering-up composition and preparation method and application Download PDFInfo
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- CN108030093A CN108030093A CN201810000716.XA CN201810000716A CN108030093A CN 108030093 A CN108030093 A CN 108030093A CN 201810000716 A CN201810000716 A CN 201810000716A CN 108030093 A CN108030093 A CN 108030093A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention belongs to functional health product technical field, especially, is related to a kind of sobering-up composition, and further discloses its preparation method and application.Sobering-up composition of the present invention, it is main component using camellia oil extract and Peppermint essential oil, it can speed up and the harmful substance acetaldehyde produced in alcohol is decomposed, and discharge it external, and the special dietary needed for human body cell is replenished in time, the sobering-up composition can reduce inhibitor of the ethanol in gastrointestinal absorption, and then accelerating alcohol metabolism, reduce the purpose that accumulation of the acetaldehyde in human body produces toxic action, assist in brain and liver cell normal work, enable a person to keep clearheaded during drinking, prevent from producing headache after drinking, it is dizzy, local skin allergy, the symptom after drinking such as digestive discomfort, dispelling effects of alcohol is good.
Description
Technical field
The invention belongs to functional health product technical field, especially, is related to a kind of sobering-up composition, and further disclose
Its preparation method and application.
Background technology
One of human civilization custom widely known for a long time when drinking, most people had the custom drunk or behavior, but wine
Essence abuse and alcohol dependence also become the public health problem of getting worse in the world today.Especially with the at full speed of economy
Development, increasingly busy animation, especially excessively treats caused harm of drinking with courtesy, is more caused to people's health potential
Threat.
After alcohol enters human body, mostly entered by esophagus in stomach, subsequently enter enteron aisle, stomach and enteron aisle are absorbed
Alcohol amount respectively may be about 25% and 75%, and the speed that is absorbed and ratio are with whetheing there is food and slightly difference in stomach and intestine.
Usually interior when 0.5-3 is small after drinking, alcohol can be finished by absorption.Absorbed alcohol can remain untouched into blood, from door
Artery reaches heart by liver, is then added to whole body great circulation system.Under normal conditions, oxidation of the alcohol in human body and
Drainage rate is more slow, so alcohol is usually accumulated in blood and each tissue after being absorbed, wherein having can pass through less than 5%
Unoxidized form is directly discharged through kidney, skin, respiratory system, and remaining 95% has to carry out by the enzyme system of liver
Oxidative metabolism.Since everyone gastrointestinal absorption ability and liver metabolism ability are different, capacity for liquor between people has also been resulted in not
Together.That is, the first aggrieved organ drunk beyond one's capacity is exactly liver, alcohol passes through alcohol dehydrogenase point first in liver
Solve and pass through the action breaks of acetaldehyde dehydrogenase again into acetic acid for acetaldehyde, acetaldehyde, acetic acid, which further decomposes, produces energy or Jie
Enter synthctic fat.Above-mentioned metabolism species, acetaldehyde is maximum to human body toxic action, and causes people's dizziness headache, nausea weak
Arch-criminal, and acetic acid is harmless to human body.In addition, the toxic substances such as oxygen radical can be also produced in alcohol metabolism,
Promote lipid peroxidation, and cause liver plasma membrane completely to sexually revise the function that a step of going forward side by side influences cell, gather toxicant
Collection is in the cell；Liver metabolism product damage at the same time can cause peroxidatic reaction of lipid, promote the formation of free radical, suppress at the same time
Biosynthesis as the glutathione of endogenous oxygen free radical scavenger.It is a variety of to relieve the effect of alcohol in order to alleviate the harm drunk and brought
Product comes into being.
But more than existing commercially available solution drinks health products based on chemical classes product, although to relieving the effect of alcohol with certain work(
Effect, but its injury of corresponding side effect to liver and kidney is also very big；And other functional health products, or dispelling effects of alcohol are unknown
It is aobvious, either mouthfeel it is bad either expensive or because single take measure it is excessive cause to carry and the convenience taken not
It is good, these be difficult to meet to drink comprehensively market the needs of.In addition, wrong relieve the effect of alcohol method and some solutions that some nets pass
Not only wine product does not reach the original intention relieved the effect of alcohol, or even is instead done harm to by it, or even the metabolism burden of liver can be also aggravated, can not had safely
Effect solves the problems, such as health care after drinking.
The content of the invention
The present invention provides a kind of sobering-up composition, and its preparation method and application are further disclosed.
To achieve the above object, the present invention proposes a kind of sobering-up composition, including camellia oil extract and peppermint essence
Oil.
The volume ratio of the camellia oil extract and the Peppermint essential oil is 1：0.002-0.01.
The volume ratio of the camellia oil extract and the Peppermint essential oil is 1：0.006.
The camellia oil extract is made as follows：
(1) take tea seed to peel off, collect camellia seed kernel, crush, it is spare；
(2) camellia seed kernel is added into containing enzyme aqueous solution, is handled under nitrogen atmosphere, the camellia seed kernel
It is 1 with the mass ratio containing enzyme aqueous solution：5-10, the mass concentration containing enzyme preparation in enzyme aqueous solution are 2-4wt%；With
Enzymatic treatment liquid is collected afterwards, and low temperature drying to moisture content is less than 5%；
(3) treated tea seed is subjected to low-temperature physics cold press using cold pressing expeller, obtains camellia oil crude oil；
(4) gained camellia oil crude oil is subjected to vacuum dehydration, and carries out plate-frame filtering, up to required camellia oil extract
Thing.
In the step (2), it is 1 that the enzyme preparation, which includes mass ratio,：1 serine easterase and glucose isomerase.
It is obtained according to common process, addition customary adjuvant the invention also discloses a kind of by the sobering-up composition
Alcohol-neutralize healthy product.
It is conventional according to common process, addition by the sobering-up composition the invention also discloses a kind of alcohol-neutralize healthy product
Auxiliary material is made.
The method of the alcohol-neutralize healthy product is prepared the invention also discloses a kind of, including takes a selected amount of camellia oil to carry
The step of taking thing and Peppermint essential oil to be mixed, and customary adjuvant is added, according to common process, it is made clinically acceptable
Health products.
The method for preparing the alcohol-neutralize healthy product, further include preparation needed for camellia oil extract the step of, specifically
Including：
(1) take tea seed to peel off, collect camellia seed kernel, crush, it is spare；
(2) camellia seed kernel is added into containing enzyme aqueous solution, is handled under nitrogen atmosphere, the camellia seed kernel
It is 1 with the mass ratio containing enzyme aqueous solution：5-10, the mass concentration containing enzyme preparation in enzyme aqueous solution are 2-4wt%；With
Enzymatic treatment liquid is collected afterwards, and low temperature drying to moisture content is less than 5%；
(3) treated tea seed is subjected to low-temperature physics cold press using cold pressing expeller, obtains camellia oil crude oil；
(4) gained camellia oil crude oil is subjected to vacuum dehydration, and carries out plate-frame filtering, up to required camellia oil extract
Thing.
In the step (3), the cold press step enters to squeeze 70-80 DEG C of temperature in order to control.
Sobering-up composition of the present invention, is main component using camellia oil extract and Peppermint essential oil, be can speed up pair
Harmful substance-the acetaldehyde produced in alcohol is decomposed, and is discharged it in vitro, and the spy needed for human body cell is replenished in time
Different nutrition, the sobering-up composition can reduce inhibitor of the ethanol in gastrointestinal absorption, they are by strengthening the protection of gastric mucosa
The permeability of effect or reduction gastric mucosa absorbs to reduce ethanol, achievees the purpose that to protect stomach and mitigates liver metabolism burden；
The activity of alcohol dehydrogenase and acetaldehyde dehydrogenase is effectively facilitated with this product, and then accelerating alcohol metabolism, reduction acetaldehyde exist
Accumulation in human body produces the purpose of toxic action, assists in brain and liver cell normal work, enables a person to drinking
Keep clearheaded during wine, prevent from producing headache, dizzy, local skin allergy, digestive discomfort etc. symptom after drinking after drinking, solve
Wine effect is good.
Camellia oil extract is obtained using specific enzymolysis and low-temperature cold-squeezing in sobering-up composition of the present invention, is carried
The active ingredient taken can effectively play its effect relieved the effect of alcohol.
Embodiment
In order to make the foregoing objectives, features and advantages of the present invention clearer and more comprehensible, with reference to embodiment
The present invention is described in further detail.
The extraction of 1 camellia oil extract of embodiment
Essentially from peasant household from adopting and from the buying of tea oil tree base, tea seed is needed by testing tea seed in the present invention
Receive, store 5-7d after metering, drying and cooling, be generally stored in 0 DEG C -30 DEG C of temperature environment, and using after vegetable seeds
The biochemical basis of ripe effect, promotes tea seed after-ripening, and it is 600t/d to draft tea seed drying scale.
The extraction of camellia oil extract, specifically comprises the following steps described in the present embodiment：
(1) tea seed of drying storage storage carries out stone, magnetic separation deferrization through seed selection, cleaning classification, separation of peeling off；In advance
Tea seed after processing is peeled off, and it is mainly oil tea shell to peel off and produce solid waste, and Kernel-hull separation is carried out after shelling, collects oil
Tea seed kernel, crushes, and 40-60 mesh sieves for subsequent use；
(2) camellia seed kernel after crushing is added into containing enzyme aqueous solution, is handled under nitrogen atmosphere, it is described
Camellia seed kernel is 1 with the mass ratio containing enzyme aqueous solution：8, the mass concentration containing enzyme preparation in enzyme aqueous solution is
3wt%；It is 1 that the enzyme preparation, which includes mass ratio,：1 serine easterase and glucose isomerase, then collects enzymatic treatment liquid, and low
Warm (35 DEG C) dryings to moisture content is less than 5%；
(3) treated tea seed is subjected to low-temperature physics cold press using cold pressing expeller, controlled into squeezing temperature 70-80
DEG C, avoid tea-seed oil caused by high temperature from darkening, loss of effective components etc., obtains camellia oil crude oil；
(4) gained camellia oil crude oil is subjected to vacuum dehydration, andante frame mistake of going forward side by side according to prior art process for refining
Filter, up to required camellia oil extract.
The extraction of 2 camellia oil extract of embodiment
The extraction of camellia oil extract, specifically comprises the following steps described in the present embodiment：
(1) tea seed of drying storage storage carries out stone, magnetic separation deferrization through seed selection, cleaning classification, separation of peeling off；In advance
Tea seed after processing is peeled off, and it is mainly oil tea shell to peel off and produce solid waste, and Kernel-hull separation is carried out after shelling, collects oil
Tea seed kernel, crushes, and 40-60 mesh sieves for subsequent use；
(2) camellia seed kernel after crushing is added into containing enzyme aqueous solution, is handled under nitrogen atmosphere, it is described
Camellia seed kernel is 1 with the mass ratio containing enzyme aqueous solution：5, the mass concentration containing enzyme preparation in enzyme aqueous solution is
2wt%；It is 1 that the enzyme preparation, which includes mass ratio,：1 serine easterase and glucose isomerase, then collects enzymatic treatment liquid, and low
Warm (35 DEG C) dryings to moisture content is less than 5%；
(3) treated tea seed is subjected to low-temperature physics cold press using cold pressing expeller, controlled into squeezing temperature 70-80
DEG C, avoid tea-seed oil caused by high temperature from darkening, loss of effective components etc., obtains camellia oil crude oil；
(4) gained camellia oil crude oil is subjected to vacuum dehydration, andante frame mistake of going forward side by side according to prior art process for refining
Filter, up to required camellia oil extract.
The extraction of 3 camellia oil extract of embodiment
The extraction of camellia oil extract, specifically comprises the following steps described in the present embodiment：
(1) tea seed of drying storage storage carries out stone, magnetic separation deferrization through seed selection, cleaning classification, separation of peeling off；In advance
Tea seed after processing is peeled off, and it is mainly oil tea shell to peel off and produce solid waste, and Kernel-hull separation is carried out after shelling, collects oil
Tea seed kernel, crushes, and 40-60 mesh sieves for subsequent use；
(2) camellia seed kernel after crushing is added into containing enzyme aqueous solution, is handled under nitrogen atmosphere, it is described
Camellia seed kernel is 1 with the mass ratio containing enzyme aqueous solution：10, the mass concentration containing enzyme preparation in enzyme aqueous solution is
4wt%；It is 1 that the enzyme preparation, which includes mass ratio,：1 serine easterase and glucose isomerase, then collects enzymatic treatment liquid, and low
Warm (35 DEG C) dryings to moisture content is less than 5%；
(3) treated tea seed is subjected to low-temperature physics cold press using cold pressing expeller, controlled into squeezing temperature 70-80
DEG C, avoid tea-seed oil caused by high temperature from darkening, loss of effective components etc., obtains camellia oil crude oil；
(4) gained camellia oil crude oil is subjected to vacuum dehydration, andante frame mistake of going forward side by side according to prior art process for refining
Filter, up to required camellia oil extract.
4 oral liquor for sobering from wine of embodiment
Sobering-up composition described in the present embodiment, including volume ratio are 1：0.006 embodiment 1 be made camellia oil extract and
Peppermint essential oil (delicatessen food level Peppermint essential oil).
Oral liquor for sobering from wine described in the present embodiment is made with the sobering-up composition, is specifically included and is mixed according to selected volume ratio
Conjunction is made 10ml oral liquids, sterile filling, to obtain the final product.
5 oral liquor for sobering from wine of embodiment
Sobering-up composition described in the present embodiment, including volume ratio are 1：0.002 embodiment 2 be made camellia oil extract and
Peppermint essential oil (delicatessen food level Peppermint essential oil).
Oral liquor for sobering from wine described in the present embodiment is made with the sobering-up composition, is specifically included and is mixed according to selected volume ratio
Conjunction is made 10ml oral liquids, sterile filling, to obtain the final product.
6 oral liquor for sobering from wine of embodiment
Sobering-up composition described in the present embodiment, including volume ratio are 1：0.01 embodiment 3 be made camellia oil extract and
Peppermint essential oil (delicatessen food level Peppermint essential oil).
Oral liquor for sobering from wine described in the present embodiment is made with the sobering-up composition, is specifically included and is mixed according to selected volume ratio
Conjunction is made 10ml oral liquids, sterile filling, to obtain the final product.
Embodiment 7 is relieved the effect of alcohol soft capsule
Sobering-up composition described in the present embodiment, including volume ratio are 1：0.006 embodiment 1 be made camellia oil extract and
Peppermint essential oil (delicatessen food level Peppermint essential oil).
The soft capsule that relieves the effect of alcohol described in the present embodiment is made with the sobering-up composition, is specifically included and is taken institute according to selected volume
Camellia oil extract and Peppermint essential oil are stated, customary adjuvant is added, soft capsule is made according to routine techniques.Embodiment 8 is relieved the effect of alcohol tablet
Sobering-up composition described in the present embodiment, including volume ratio are 1：0.006 embodiment 1 be made camellia oil extract and
Peppermint essential oil (delicatessen food level Peppermint essential oil).
The tablet that relieves the effect of alcohol described in the present embodiment is made with the sobering-up composition, specifically include taken according to selected volume it is described
Camellia oil extract and Peppermint essential oil, add customary adjuvant, tablet are made according to routine techniques.
9 antialcoholism capsule agent of embodiment
Sobering-up composition described in the present embodiment, including volume ratio are 1：0.006 embodiment 1 be made camellia oil extract and
Peppermint essential oil (delicatessen food level Peppermint essential oil).
Antialcoholism capsule described in the present embodiment is made with the sobering-up composition, specifically include taken according to selected volume it is described
Camellia oil extract and Peppermint essential oil, add customary adjuvant, capsule are made according to routine techniques.
1 oral liquor for sobering from wine of comparative example
Oral liquor for sobering from wine described in this comparative example is identical with 4 scheme of embodiment, it is differed only in, the camellia oil extract
Extraction step in, handled with cellulase.
2 oral liquor for sobering from wine of comparative example
Oral liquor for sobering from wine described in this comparative example is identical with 4 scheme of embodiment, it is differed only in, the camellia oil extract
For delicatessen food level cold press camellia oil.
Experimental example dispelling effects of alcohol is tested
Kunming mice 40 is taken, ♀ ♂ are fifty-fifty, are randomly divided into 5 groups, and I groups are blank group, and II groups are control group, and III is experiment
Group, IV-V groups are comparative example group.
Experiment starts, and I groups and II groups irrigate physiological saline 0.2ml/10g weight, and II groups perfusion embodiment 4, which is made, relieves the effect of alcohol
Oral liquid 0.2ml/10g weight, IV-V groups pay close attention to oral liquor for sobering from wine 0.2ml/10g weight in comparative example 1-2 respectively.
After 30min, I group gavage physiological saline 0.2ml/10g weight, the equal gavage white wine of II-V groups (56 °), each group exists respectively
Venous blood samples, gas chromatography measure Ethanol concentration in rat blood are grouped after gavage white wine 30min, 60min, 90min, 150min.
The assay method of ethanol in blood concentration：
(1) ethanol standard curve making：
Chromatographic condition：GC-10A type gas chromatographs, chromatographic column are DB-5 capillary columns (30m × 0.25mm, 0.25 μm)；
Column temperature is temperature programming, and initial temperature is 50 DEG C, is increased to 150 DEG C with 10 DEG C/min, keeps 5min；Detector and injection port temperature
Spend for 200 DEG C；Nitrogen flow rate is 80mL/min, hydrogen 50mL/min, air 50mL/min；
Take absolute ethyl alcohol, be configured to 1.0,2.0,4.0,5.0,7.5,10.0,12.0, the ethanol standard of 15.0g/L uses
Liquid, draws above-mentioned 2.0 μ L of ethanol standard solution sample introduction respectively, and using concentration as abscissa, peak area draws standard for ordinate
Curve；
(2) whole blood 0.3mL to be measured is taken, is placed in 25mL volumetric flasks, 200g/L trichloroacetic acid 3mL are added after being diluted with water,
Constant volume, centrifugation, takes 2.0 μ L of supernatant to be injected into chromatograph, obtains peak height value, it is dense that corresponding ethanol quality is checked in from standard curve
Degree.
Alcohol content in mouse body is measured in above-mentioned experimental group respectively, is recorded in table 1 below.
1 each group mouse different time concentration of alcohol of table compares
| Numbering | 30min | 60min | 90min | 150min |
| I groups | 0 | 0 | 0 | 0 |
| II groups | 0.70 | 0.96 | 1.01 | 0.94 |
| III groups | 0.65 | 0.71 | 0.75 | 0.66 |
| IV group | 0.68 | 0.85 | 0.93 | 0.88 |
| V groups | 0.69 | 0.91 | 0.98 | 0.90 |
From data in table, traditional Chinese medicine anti-inebriation beverage of the present invention can significantly reduce the concentration of alcohol in mouse blood of drinking,
Illustrate that alcohol-neutralize healthy product of the present invention has preferable antialcoholism action.
The embodiment of the present invention is described in detail above, specific case used herein to the principle of the present invention and
Embodiment is set forth, and the explanation of above example is only intended to help to understand method and its core concept of the invention；
Meanwhile for those of ordinary skill in the art, according to the thought of the present invention, can in specific embodiments and applications
There is change part, in conclusion this specification content should not be construed as limiting the invention.
Claims (10)
1. a kind of sobering-up composition, it is characterised in that including camellia oil extract and Peppermint essential oil.
2. sobering-up composition according to claim 1, it is characterised in that the camellia oil extract and the Peppermint essential oil
Volume ratio be 1：0.002-0.01.
3. sobering-up composition according to claim 2, it is characterised in that the camellia oil extract and the Peppermint essential oil
Volume ratio be 1：0.006.
4. according to claim 1-3 any one of them sobering-up compositions, it is characterised in that the camellia oil extract is according to such as
Lower section method is made：
(1) take tea seed to peel off, collect camellia seed kernel, crush, it is spare；
(2) camellia seed kernel is added into containing enzyme aqueous solution, is handled under nitrogen atmosphere, the camellia seed kernel and institute
The mass ratio containing enzyme aqueous solution is stated as 1：5-10, the mass concentration containing enzyme preparation in enzyme aqueous solution are 2-4wt%；Then receive
Collect enzymatic treatment liquid, and low temperature drying to moisture content is less than 5%；
(3) treated tea seed is subjected to low-temperature physics cold press using cold pressing expeller, obtains camellia oil crude oil；
(4) gained camellia oil crude oil is subjected to vacuum dehydration, and carries out plate-frame filtering, up to required camellia oil extract.
5. sobering-up composition according to claim 4, it is characterised in that in the step (2), the enzyme preparation includes matter
Amount is than being 1：1 serine easterase and glucose isomerase.
6. by claim 1-5 any one of them sobering-up compositions, according to common process, customary adjuvant, obtained solution are added
Wine health products.
7. a kind of alcohol-neutralize healthy product, it is characterised in that by claim 1-5 any one of them sobering-up compositions, according to routine
Technique, addition customary adjuvant are made.
A kind of 8. method for preparing alcohol-neutralize healthy product described in claim 7, it is characterised in that including taking a selected amount of camellia
The step of oil extract and Peppermint essential oil are mixed, and customary adjuvant is added, according to common process, being made can clinically connect
The health products received.
9. the method according to claim 8 for preparing the alcohol-neutralize healthy product, it is characterised in that further include mountain needed for preparation
The step of tea oil extract, specifically include：
(1) take tea seed to peel off, collect camellia seed kernel, crush, it is spare；
(2) camellia seed kernel is added into containing enzyme aqueous solution, is handled under nitrogen atmosphere, the camellia seed kernel and institute
The mass ratio containing enzyme aqueous solution is stated as 1：5-10, the mass concentration containing enzyme preparation in enzyme aqueous solution are 2-4wt%；Then receive
Collect enzymatic treatment liquid, and low temperature drying to moisture content is less than 5%；
(3) treated tea seed is subjected to low-temperature physics cold press using cold pressing expeller, obtains camellia oil crude oil；
(4) gained camellia oil crude oil is subjected to vacuum dehydration, and carries out plate-frame filtering, up to required camellia oil extract.
10. the method according to claim 9 for preparing the alcohol-neutralize healthy product, it is characterised in that in the step (3),
The cold press step enters to squeeze 70-80 DEG C of temperature in order to control.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674057A (en) * | 2019-02-19 | 2019-04-26 | 广东金妮宝科技发展有限公司 | A kind of oily cream and preparation method thereof that relieves the effect of alcohol of liver-protecting and stomach-protecting |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1194145A (en) * | 1997-03-21 | 1998-09-30 | 杨春 | Sobering health drink |
| CN1380016A (en) * | 2001-07-26 | 2002-11-20 | 王刚 | Dealcoholization health-preserving beverage |
| CN101496854A (en) * | 2008-11-24 | 2009-08-05 | 浙江珍世堂生物科技有限公司 | Chinese medicine sobering-up composition and Chinese medicine sobering-up beverage |
| CN102379936A (en) * | 2011-11-08 | 2012-03-21 | 浙江省林业科学研究院 | Process for producing alcoholism-relieving and liver-protecting soft capsule |
| CN107158118A (en) * | 2017-05-27 | 2017-09-15 | 江西中医药大学 | Solid beverage with anti-alcoholic function and sobering-up function and preparation method thereof |
-
2018
- 2018-01-02 CN CN201810000716.XA patent/CN108030093A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1194145A (en) * | 1997-03-21 | 1998-09-30 | 杨春 | Sobering health drink |
| CN1380016A (en) * | 2001-07-26 | 2002-11-20 | 王刚 | Dealcoholization health-preserving beverage |
| CN101496854A (en) * | 2008-11-24 | 2009-08-05 | 浙江珍世堂生物科技有限公司 | Chinese medicine sobering-up composition and Chinese medicine sobering-up beverage |
| CN102379936A (en) * | 2011-11-08 | 2012-03-21 | 浙江省林业科学研究院 | Process for producing alcoholism-relieving and liver-protecting soft capsule |
| CN107158118A (en) * | 2017-05-27 | 2017-09-15 | 江西中医药大学 | Solid beverage with anti-alcoholic function and sobering-up function and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 杜华楠 等: ""酶解冷榨法制取野玫瑰籽油的研究"", 《中国油脂》 * |
| 黄世敬 等主编: "《古今解酒醒酒妙验方》", 31 December 2013 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674057A (en) * | 2019-02-19 | 2019-04-26 | 广东金妮宝科技发展有限公司 | A kind of oily cream and preparation method thereof that relieves the effect of alcohol of liver-protecting and stomach-protecting |
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