CN101479258A - 作为磷脂酰肌醇3-激酶抑制剂的噻唑基脲类衍生物 - Google Patents

作为磷脂酰肌醇3-激酶抑制剂的噻唑基脲类衍生物 Download PDF

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Publication number
CN101479258A
CN101479258A CNA2007800243105A CN200780024310A CN101479258A CN 101479258 A CN101479258 A CN 101479258A CN A2007800243105 A CNA2007800243105 A CN A2007800243105A CN 200780024310 A CN200780024310 A CN 200780024310A CN 101479258 A CN101479258 A CN 101479258A
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compound
formula
phenyl
alkyl
methyl
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CNA2007800243105A
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Chinese (zh)
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I·布鲁斯
G·魏茨施密特
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
CNA2007800243105A 2006-06-26 2007-06-25 作为磷脂酰肌醇3-激酶抑制剂的噻唑基脲类衍生物 Pending CN101479258A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0612630.4A GB0612630D0 (en) 2006-06-26 2006-06-26 Organic compounds
GB0612630.4 2006-06-26

Publications (1)

Publication Number Publication Date
CN101479258A true CN101479258A (zh) 2009-07-08

Family

ID=36803903

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800243105A Pending CN101479258A (zh) 2006-06-26 2007-06-25 作为磷脂酰肌醇3-激酶抑制剂的噻唑基脲类衍生物

Country Status (12)

Country Link
US (1) US7799810B2 (https=)
EP (1) EP2035413A2 (https=)
JP (1) JP4944954B2 (https=)
KR (1) KR20090024294A (https=)
CN (1) CN101479258A (https=)
AU (1) AU2007264033A1 (https=)
BR (1) BRPI0713784A2 (https=)
CA (1) CA2655568A1 (https=)
GB (1) GB0612630D0 (https=)
MX (1) MX2008016358A (https=)
RU (1) RU2009102270A (https=)
WO (1) WO2008000421A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0725888B2 (ja) 1986-09-17 1995-03-22 旭化成工業株式会社 エ−テルチオエ−テル−芳香族スルホン系共重合体及びその製造方法
JP5688367B2 (ja) 2008-08-29 2015-03-25 トポターゲット・アクティーゼルスカブＴｏｐｏＴａｒｇｅｔ Ａ／Ｓ 新規なウレアおよびチオウレア誘導体
UA104147C2 (uk) * 2008-09-10 2014-01-10 Новартис Аг Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
AU2009322187B2 (en) * 2008-12-04 2015-02-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Phosphatidylinositol-3-kinase p110 delta-targeted drugs in the treatment of CNS disorders
US20120165309A1 (en) 2009-02-12 2012-06-28 Astellas Pharma Inc. Hetero ring derivative
WO2011048936A1 (ja) 2009-10-19 2011-04-28 大正製薬株式会社 アミノチアゾール誘導体
KR101759762B1 (ko) 2010-08-10 2017-07-19 아스텔라스세이야쿠 가부시키가이샤 헤테로환 화합물
CN103476410B (zh) * 2011-01-11 2020-02-21 戴麦里克斯生物科学有限公司 联合疗法
DK2790705T3 (en) 2011-12-15 2018-03-12 Novartis Ag Use of inhibitors of the activity or function of PI3K
KR20160062178A (ko) * 2013-10-17 2016-06-01 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 호흡기 질병의 치료를 위한 ｐｉ３ｋ 억제제

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI314928B (en) * 2002-02-28 2009-09-21 Novartis A 5-phenylthiazole derivatives and use as pi3 kinase inhibitors
TW200519106A (en) 2003-05-02 2005-06-16 Novartis Ag Organic compounds
TWI334868B (en) * 2003-06-03 2010-12-21 Nippon Kayaku Kk [1,2,4] triazoro [1,5-a] pyrimidine-2-ylurea derivative and use thereof
GB0320197D0 (en) * 2003-08-28 2003-10-01 Novartis Ag Organic compounds
GB0423653D0 (en) 2004-10-25 2004-11-24 Piramed Ltd Pharmaceutical compounds

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Publication number Publication date
JP4944954B2 (ja) 2012-06-06
WO2008000421A3 (en) 2008-05-22
RU2009102270A (ru) 2010-08-10
BRPI0713784A2 (pt) 2012-10-30
EP2035413A2 (en) 2009-03-18
JP2009541387A (ja) 2009-11-26
US7799810B2 (en) 2010-09-21
WO2008000421A2 (en) 2008-01-03
CA2655568A1 (en) 2008-01-03
MX2008016358A (es) 2009-01-16
GB0612630D0 (en) 2006-08-02
US20100120865A1 (en) 2010-05-13
AU2007264033A1 (en) 2008-01-03
KR20090024294A (ko) 2009-03-06

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Application publication date: 20090708