CN101468198A - Soluble powder for treating mixed infection of livestock and poultry caused by bacteria and coccidian - Google Patents
Soluble powder for treating mixed infection of livestock and poultry caused by bacteria and coccidian Download PDFInfo
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- CN101468198A CN101468198A CNA2007100602307A CN200710060230A CN101468198A CN 101468198 A CN101468198 A CN 101468198A CN A2007100602307 A CNA2007100602307 A CN A2007100602307A CN 200710060230 A CN200710060230 A CN 200710060230A CN 101468198 A CN101468198 A CN 101468198A
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- soluble powder
- poultry
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- mixed infection
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- 244000144977 poultry Species 0.000 title claims abstract description 20
- 239000000843 powder Substances 0.000 title claims abstract description 14
- 208000003322 Coinfection Diseases 0.000 title claims abstract description 11
- 241000894006 Bacteria Species 0.000 title abstract description 10
- 241000224483 Coccidia Species 0.000 title abstract 3
- 244000144972 livestock Species 0.000 title description 4
- 239000003814 drug Substances 0.000 claims abstract description 21
- NGIVTUVVBWOTNT-UHFFFAOYSA-N sodium;(4-aminophenyl)sulfonyl-(4,6-dimethylpyrimidin-2-yl)azanide Chemical compound [Na+].CC1=CC(C)=NC([N-]S(=O)(=O)C=2C=CC(N)=CC=2)=N1 NGIVTUVVBWOTNT-UHFFFAOYSA-N 0.000 claims abstract description 20
- 208000003495 Coccidiosis Diseases 0.000 claims abstract description 17
- 206010023076 Isosporiasis Diseases 0.000 claims abstract description 17
- 239000002671 adjuvant Substances 0.000 claims description 19
- ZSZFUDFOPOMEET-UHFFFAOYSA-N 2-(4-chlorophenyl)-2-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]acetonitrile Chemical compound C1=CC(Cl)=CC=C1C(C#N)C1=C(Cl)C=C(N2C(NC(=O)C=N2)=O)C=C1Cl ZSZFUDFOPOMEET-UHFFFAOYSA-N 0.000 claims description 15
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 15
- 229960000248 diclazuril Drugs 0.000 claims description 15
- YKQOSKADJPQZHB-RGYSVOEGSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(6r,9s,12r,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydr Chemical compound CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)C([C@@H](C)O)NC(=O)[C@@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O YKQOSKADJPQZHB-RGYSVOEGSA-N 0.000 claims description 15
- 230000000844 anti-bacterial effect Effects 0.000 claims description 11
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 9
- 229960001031 glucose Drugs 0.000 claims description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 208000001848 dysentery Diseases 0.000 abstract description 7
- 208000011580 syndromic disease Diseases 0.000 abstract description 6
- 108010078777 Colistin Proteins 0.000 abstract description 5
- 241001465754 Metazoa Species 0.000 abstract description 5
- 235000013305 food Nutrition 0.000 abstract description 5
- 230000000968 intestinal effect Effects 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 4
- 208000015181 infectious disease Diseases 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 239000003242 anti bacterial agent Substances 0.000 abstract description 2
- 229940088710 antibiotic agent Drugs 0.000 abstract description 2
- 230000008901 benefit Effects 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 229960001127 colistin sulfate Drugs 0.000 abstract 2
- ZESIAEVDVPWEKB-ORCFLVBFSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O ZESIAEVDVPWEKB-ORCFLVBFSA-N 0.000 abstract 2
- 201000006549 dyspepsia Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 16
- 208000035861 hematochezia Diseases 0.000 description 5
- 241000287828 Gallus gallus Species 0.000 description 4
- 230000029087 digestion Effects 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 238000003113 dilution method Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 208000035143 Bacterial infection Diseases 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 208000022362 bacterial infectious disease Diseases 0.000 description 3
- 229960003346 colistin Drugs 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 description 3
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 description 3
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 description 3
- 239000011593 sulfur Substances 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 230000001165 anti-coccidial effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 206010034107 Pasteurella infections Diseases 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000223996 Toxoplasma Species 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000008570 general process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 201000005115 pasteurellosis Diseases 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 description 1
- 229960004306 sulfadiazine Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000003918 triazines Chemical class 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a soluble powder which is used for treating mixed infection of domestic animal bacterium and coccidia, which comprises colistin sulfate, sulfadimidine sodium, dliclazuril and supplementary material. The medicine of the invention, which is taken as antibiotics medicine, is mainly used for intestinal syndromes of dysentery, hemafecia, food indigestion, etc., wherein the syndromes are caused by gram-negative bacterium and coccidian. The invention adopts three medicines of sulfadimidine sodium, colistin sulfate and dliclazuril for using together. When the soluble powder is acted on the sensitive bacteria infection, the soluble powder can also be used for treating coccidiosis of poultry. The soluble powder has the advantages of excellent oral absorption, higher safety, and suitability for the generalization and application in stock raising production.
Description
Technical field
The invention belongs to field of veterinary, particularly relate to a kind of soluble powder that is used for the treatment of poultry antibacterial and coccidiosis mixed infection.
Background technology
Along with the expansion of intensive culture scale, the disease of the each side of poultry is more and more serious.Simultaneously because the abuse of antibiotics aspect livestock and poultry cultivation makes the problem of Resistant strain also serious day by day.
Because the outburst of the collective of fowl bacterial disease and parasitic disease usually has a strong impact on poultry weightening finish and efficiency of feed utilization, and the poultry laying rate is reduced, the carcass quality degradation, even cause a considerable amount of death, influenced raiser's economic benefit.The bacterial disease of poultry more complicated in Production of Livestock and Poultry, the kind of disease is a lot, has single bacterially, also has antibacterial and mycoplasma mixed infection to cause that M ﹠ M does not wait.Coccidiosis also becomes a big problem of puzzlement poultry producer, usually because of preventing and malpractice causes secondary infection.
Summary of the invention
Based on above-mentioned situation, the object of the present invention is to provide a kind of soluble powder that is used for the treatment of poultry antibacterial and coccidiosis mixed infection
The object of the present invention is achieved like this: represent to be respectively colistine sulfate 3.5%-4.5% with percentage by weight, sulfadimidine sodium 2%-3%, diclazuril 0.03%-0.07%, adjuvant 92.43%-94.47%.
Described adjuvant comprises: anhydrous glucose, oral glucose are preferably anhydrous glucose.
In order to obtain better effect, preferred ingredient is: colistine sulfate 4%, sulfadimidine sodium 2.5%, diclazuril 0.05%, adjuvant 93.45%.
The present invention can adopt the general process of industry, equipment preparation.The following method preparation of preferred employing comprises step:
Earlier colistine sulfate, sulfadimidine sodium and diclazuril and used adjuvant are pulverized, pulverized back mistake 60 mesh sieves; The adjuvant of getting colistine sulfate, sulfadimidine sodium and diclazuril and equivalent with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture; With mixture and remaining adjuvant mix homogeneously, mixture is crossed 80 order fine screens three times, promptly.
Colistine sulfate:, gram negative bacterias such as escherichia coli, Salmonella, pasteurellosis bacillus, dysentery bacterium are had stronger antibacterial action for narrow spectrum antibacterial.Sterilization mechanism is the infringement bacterial cell membrane, increases its permeability, and the interior aminoacid of thalline, purine, pyrimidine etc. are leaked outside, and also can influence caryoplasm and ribosome function, causes antibacterial death.
Sulfadimidine sodium: antibacterial action than sulfadiazine slightly a little less than, but coccidiosis and toxoplasma are had inhibitory action, untoward reaction is little, holds time longer in the intravital valid density of poultry.
Diclazuril: for triazines New-type wide-spectrum anticoccidial drug, have the effect of killing coccidiosis, all there is effect in each stage that coccidiosis is grown, is to act on the strongest a kind of anticoccidial drug at present.
Medicine of the present invention is a Tri-Biocin, is mainly used in the caused dysentery of gram negative bacteria and coccidiosis, has blood in stool, intestinal syndrome such as food digestion is bad.
In order to verify the therapeutic effect of medicine of the present invention, get medicine of the present invention and do the clinical efficacy test at Jinghai county chicken house.Get the chicken that suffers from colibacillosis, simultaneously also with dysentery, the symptom of having blood in stool, the visible worm's ovum of the feces of the ill chicken of microscopy, use medicine of the present invention to treat, 1g/L water, logotype 5 days was a course of treatment, most of trouble chicken is cured after the course of treatment, and effective percentage all reaches more than 96%.
Beneficial effect: as can be seen by clinical trial, medicine of the present invention curative effect aspect treatment livestock and poultry bacterial infection and coccidiosis disease is certain, the present invention fills a prescription and adopts sulfadimidine sodium, colistine sulfate and three kinds of compatibility of drugss of diclazuril to use, when acting on the sensitive organism infection, also can be used for treating the coccidiosis of fowl and control its secondary infection.Oral absorption is good, has higher safety, is suitable for applying in animal husbandry is produced.
The specific embodiment
Embodiment 1: earlier colistine sulfate 35g, sulfadimidine sodium 20g, diclazuril 3g and used adjuvant anhydrous glucose 942g are pulverized, pulverize back mistake 60 mesh sieves; The adjuvant of getting colistine sulfate, sulfadimidine sodium and equivalent with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture; With mixture and remaining adjuvant mix homogeneously, mixture is crossed 80 order fine screens three times, promptly get the about 1000g of soluble powder, wherein sulfur acid colistin 35g, sulfadimidine sodium 20g, diclazuril 3g.
Tri-Biocin.Be mainly used in the caused dysentery of gram negative bacteria and coccidiosis, have blood in stool, intestinal syndrome such as food digestion is bad.Usage and dosage: poultry: add in every premium on currency in this medicine 1.2g or the every kilogram of feed and add this medicine 2.4g; Domestic animal: add this medicine 1.2g in every kilogram of feed, free choice feeding, logotype 3-5 days is a course of treatment, the serious symptom doubled amount is used.
Embodiment 2: earlier colistine sulfate 40g, sulfadimidine sodium 25g, diclazuril 5g and used adjuvant anhydrous glucose 930g are pulverized, pulverize back mistake 60 mesh sieves; The adjuvant of getting colistine sulfate, sulfadimidine sodium and equivalent with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture; With mixture and remaining adjuvant mix homogeneously, mixture is crossed 80 order fine screens three times, promptly get the about 1000g of soluble powder, wherein sulfur acid colistin 40g, sulfadimidine sodium 25g, diclazuril 5g.
Tri-Biocin.Be mainly used in the caused dysentery of gram negative bacteria and coccidiosis, have blood in stool, intestinal syndrome such as food digestion is bad.Usage and dosage: poultry: add in every premium on currency in this medicine 1g or the every kilogram of feed and add this medicine 2g; Domestic animal: add this medicine 1g in every kilogram of feed, free choice feeding, logotype 3-5 days is a course of treatment, the serious symptom doubled amount is used.
Embodiment 3: earlier colistine sulfate 45g, sulfadimidine sodium 30g, diclazuril 7g and used adjuvant anhydrous glucose 975g are pulverized, pulverize back mistake 60 mesh sieves; The adjuvant of getting colistine sulfate, sulfadimidine sodium and equivalent with equivalent progressively increase the dilution method dilution, mixes, mistake 60 order fine screens three times obtain mixture; With mixture and remaining adjuvant mix homogeneously, mixture is crossed 80 order fine screens three times, promptly get the about 1000g of soluble powder, wherein sulfur acid colistin 45g, sulfadimidine sodium 30g, diclazuril 7g.
Tri-Biocin.Be mainly used in the caused dysentery of gram negative bacteria and coccidiosis, have blood in stool, intestinal syndrome such as food digestion is bad.Usage and dosage: poultry: add in every premium on currency in this medicine 0.9g or the every kilogram of feed and add this medicine 1.7g; Domestic animal: add this medicine 0.9g in every kilogram of feed, free choice feeding, logotype 3-5 days is a course of treatment, the serious symptom doubled amount is used.
Claims (3)
1, a kind of soluble powder that is used for the treatment of poultry antibacterial and coccidiosis mixed infection is characterized in that the medicine that medicine of the present invention comprises is: colistine sulfate, sulfadimidine sodium, diclazuril, adjuvant.
2, a kind of soluble powder that is used for the treatment of poultry antibacterial and coccidiosis mixed infection according to claim 1, it is characterized in that: represent to be respectively colistine sulfate 3.5%-4.5% with percentage by weight, sulfadimidine sodium 2%-3%, diclazuril 0.03%-0.07%, adjuvant 92.43%-94.47%, described adjuvant comprises: anhydrous glucose, oral glucose etc. are preferably anhydrous glucose.
3, a kind of soluble powder that is used for the treatment of poultry antibacterial and coccidiosis mixed infection according to claim 1, it is characterized in that: preferred ingredient is: colistine sulfate 4%, sulfadimidine sodium 2.5%, diclazuril 0.05%, adjuvant 93.45%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100602307A CN101468198A (en) | 2007-12-26 | 2007-12-26 | Soluble powder for treating mixed infection of livestock and poultry caused by bacteria and coccidian |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100602307A CN101468198A (en) | 2007-12-26 | 2007-12-26 | Soluble powder for treating mixed infection of livestock and poultry caused by bacteria and coccidian |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101468198A true CN101468198A (en) | 2009-07-01 |
Family
ID=40826162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100602307A Pending CN101468198A (en) | 2007-12-26 | 2007-12-26 | Soluble powder for treating mixed infection of livestock and poultry caused by bacteria and coccidian |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101468198A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101954084A (en) * | 2010-09-06 | 2011-01-26 | 北京大北农动物保健科技有限责任公司 | Medicinal composition for treating mixed infection in livestock and poultry and preparation method thereof |
-
2007
- 2007-12-26 CN CNA2007100602307A patent/CN101468198A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101954084A (en) * | 2010-09-06 | 2011-01-26 | 北京大北农动物保健科技有限责任公司 | Medicinal composition for treating mixed infection in livestock and poultry and preparation method thereof |
| CN101954084B (en) * | 2010-09-06 | 2015-06-17 | 北京大北农动物保健科技有限责任公司 | Medicinal composition for treating mixed infection in livestock and poultry and preparation method thereof |
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Open date: 20090701 |