CN101466725B - 作为心血管病症药剂的雄甾烷和雄甾烯的氨基衍生物 - Google Patents

作为心血管病症药剂的雄甾烷和雄甾烯的氨基衍生物 Download PDF

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Publication number
CN101466725B
CN101466725B CN200780022229.3A CN200780022229A CN101466725B CN 101466725 B CN101466725 B CN 101466725B CN 200780022229 A CN200780022229 A CN 200780022229A CN 101466725 B CN101466725 B CN 101466725B
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CN
China
Prior art keywords
hydrochloride
aminoethoxyimino
compound
androstane
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN200780022229.3A
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English (en)
Chinese (zh)
Other versions
CN101466725A (zh
Inventor
阿尔贝托·切里
马尔科·托里
西尔维亚·阿尔马罗利
莱昂纳多·班菲
朱塞佩·比安基
朱利奥·卡萨纳
帕特里夏·法拉利
罗莎玛丽亚·米凯莱蒂
西蒙娜·斯普托雷
玛丽亚·皮亚·扎帕维尼亚
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Publication of CN101466725A publication Critical patent/CN101466725A/zh
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Publication of CN101466725B publication Critical patent/CN101466725B/zh
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN200780022229.3A 2006-04-13 2007-04-11 作为心血管病症药剂的雄甾烷和雄甾烯的氨基衍生物 Expired - Fee Related CN101466725B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06112598.5 2006-04-13
EP06112598 2006-04-13
PCT/EP2007/053524 WO2007118832A2 (en) 2006-04-13 2007-04-11 Amino derivatives of androstanes and androstenes as medicaments for cardiovascular disorders

Publications (2)

Publication Number Publication Date
CN101466725A CN101466725A (zh) 2009-06-24
CN101466725B true CN101466725B (zh) 2014-06-25

Family

ID=37268538

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200780022229.3A Expired - Fee Related CN101466725B (zh) 2006-04-13 2007-04-11 作为心血管病症药剂的雄甾烷和雄甾烯的氨基衍生物

Country Status (16)

Country Link
US (1) US8609644B2 (https=)
EP (1) EP2004668B1 (https=)
JP (1) JP5438503B2 (https=)
KR (1) KR101424046B1 (https=)
CN (1) CN101466725B (https=)
AR (1) AR060427A1 (https=)
AU (1) AU2007239518B2 (https=)
BR (1) BRPI0709943A2 (https=)
CA (1) CA2649175C (https=)
EA (1) EA015257B1 (https=)
ES (1) ES2405625T3 (https=)
MX (1) MX2008012942A (https=)
PL (1) PL2004668T3 (https=)
PT (1) PT2004668E (https=)
TW (1) TWI392682B (https=)
WO (1) WO2007118832A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
JP5290189B2 (ja) * 2006-11-30 2013-09-18 エンディース エルエルシー ６−アルコキシアルキルエストラジオール誘導体およびその使用
HUE027408T2 (en) * 2009-03-23 2016-10-28 Sigma Tau Ind Farmaceuti Proteinuria, 5ß, 14β-androstane derivatives for the treatment of glomerulosclerosis and renal failure
WO2010149666A1 (en) 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
JP2019508424A (ja) * 2016-03-02 2019-03-28 パセオン オーストリア ゲーエムベーハー ウント ツェーオー カーゲー １７（２０）−エン ｂ−セコステロイドの生産のためのプロセスと中間体
JP7648538B2 (ja) * 2019-04-27 2025-03-18 ヘルス リサーチ インコーポレイテッド 前立腺癌の治療のためのクマリン修飾アンドロゲン
DK3805243T3 (da) * 2019-10-09 2024-01-02 Windtree Therapeutics Inc Androstanderivater med aktivitet som rene eller hovedsageligt rene stimulatorer af serca2a til behandling af hjertesvigt
CN111040012B (zh) * 2019-12-27 2022-04-15 山东安弘制药有限公司 一种依西美坦螺环氧乙烷杂质的制备方法
CN120718029A (zh) * 2025-06-20 2025-09-30 湖南中医药大学 一种天然产物6-hhs的制备方法
CN121471044B (zh) * 2026-01-09 2026-03-20 苏州大学 一种二氯化钴催化合成亚砜亚胺胍类化合物的方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB868303A (en) * 1956-09-08 1961-05-17 Syntex Sa New cyclopentanophenanthrene derivatives and process for the production thereof
US3013009A (en) * 1959-04-10 1961-12-12 Searle & Co Optionally 17-alkylated and 7-oxygenated androst (an and 5-en)-3-ol aminoalkyl esters and ethers
US3120515A (en) * 1962-05-31 1964-02-04 Sterling Drug Inc 5-cyano steroids, their preparation, and derivatives thereof
GB1042292A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd 5ª‡-hydroxy-6ª‰-amino steroids and the preparation thereof
US5144017A (en) * 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
EP0825197A2 (en) * 1996-08-19 1998-02-25 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. New 6-hydroxy and 6-oxo-anstro-stane derivatives active on the cardiovascular system and pharmaceutical compositions containing same

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
US3210386A (en) * 1961-01-09 1965-10-05 Upjohn Co 3-aminoethers of 3beta-hydroxy androstanes
DE1187236B (de) 1961-03-28 1965-02-18 Searle & Co Verfahren zur Herstellung von 17beta-Aminosteroiden
US5522847A (en) * 1993-06-18 1996-06-04 Kalis; Amy G. Pacifier with novelty electronic display
US5662685A (en) * 1996-08-13 1997-09-02 Uhler; Gary S. Sound producing pacifier
US6066161A (en) * 1997-07-26 2000-05-23 Parella; Nicole D. X. Baby pacifier apparatus with remote control locator
DE19906159A1 (de) * 1999-02-09 2000-08-10 Schering Ag 16-Hydroxyestratriene als selektiv wirksame Estrogene
ES2307064T3 (es) * 2003-11-26 2008-11-16 Bayer Schering Pharma Aktiengesellschaft Prevencion y tratamiento de enfermedades cardiacas hipertensivas por los estrogenos selectivos 8beta-vinil-estra-1,3,5(10)-trien-3,17beta-diol y 17beta-fluor-9alfa-vinil-estra-1,3,5(10)-trien-3,16alfa-diol.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB868303A (en) * 1956-09-08 1961-05-17 Syntex Sa New cyclopentanophenanthrene derivatives and process for the production thereof
US3013009A (en) * 1959-04-10 1961-12-12 Searle & Co Optionally 17-alkylated and 7-oxygenated androst (an and 5-en)-3-ol aminoalkyl esters and ethers
GB1042292A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd 5ª‡-hydroxy-6ª‰-amino steroids and the preparation thereof
US3120515A (en) * 1962-05-31 1964-02-04 Sterling Drug Inc 5-cyano steroids, their preparation, and derivatives thereof
US5144017A (en) * 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
EP0825197A2 (en) * 1996-08-19 1998-02-25 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. New 6-hydroxy and 6-oxo-anstro-stane derivatives active on the cardiovascular system and pharmaceutical compositions containing same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Ayhan Ulubelen et al..Cardioactive terpenoids and a new rearranged diterpene from salvia syriaca.《Planta Med.》.2000,第66卷627-629. *
Kyosuke Temma et al..Effects of progesterone derivatives on sodium pump activity and force of myocardial contraction in isolated guinea pig heart.《Research communications in Chemical pathology and pharmacology》.1983,第41卷(第1期),51-63. *
Le Men J et al..Chemistry and pharmacology of hemi synthetic compounds for cardio vascular activity derivatives of paravallarine a naturally accurring steriod.《Chimica Therapeutica》.1970,第5卷(第1期),41-54. *
Sergio De Munari et al..Structure-based design and synthesis of novel potent Na+,K+-ATPase inhibitors derived from a 5α,14α-androstane scarffold as positive inotropic compounds.《J. Med. Chem.》.2003,第46卷(第17期),3644-3654. *

Also Published As

Publication number Publication date
JP2009533392A (ja) 2009-09-17
EP2004668A2 (en) 2008-12-24
BRPI0709943A2 (pt) 2011-08-02
HK1134821A1 (en) 2010-05-14
MX2008012942A (es) 2008-10-17
WO2007118832A2 (en) 2007-10-25
PT2004668E (pt) 2013-04-30
US20110053902A1 (en) 2011-03-03
ES2405625T3 (es) 2013-05-31
AU2007239518A1 (en) 2007-10-25
US8609644B2 (en) 2013-12-17
CA2649175C (en) 2015-01-27
CN101466725A (zh) 2009-06-24
CA2649175A1 (en) 2007-10-25
JP5438503B2 (ja) 2014-03-12
WO2007118832A3 (en) 2008-04-17
EA015257B1 (ru) 2011-06-30
EA200870434A1 (ru) 2009-04-28
TWI392682B (zh) 2013-04-11
TW200804406A (en) 2008-01-16
KR20080111532A (ko) 2008-12-23
AU2007239518B2 (en) 2012-03-15
EP2004668B1 (en) 2013-03-13
AU2007239518A2 (en) 2008-11-27
PL2004668T3 (pl) 2013-07-31
AR060427A1 (es) 2008-06-18
KR101424046B1 (ko) 2014-07-28

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