CN101431994A - CBx大麻素受体调节剂作为钾通道调节剂的用途 - Google Patents

CBx大麻素受体调节剂作为钾通道调节剂的用途 Download PDF

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Publication number
CN101431994A
CN101431994A CNA2007800151866A CN200780015186A CN101431994A CN 101431994 A CN101431994 A CN 101431994A CN A2007800151866 A CNA2007800151866 A CN A2007800151866A CN 200780015186 A CN200780015186 A CN 200780015186A CN 101431994 A CN101431994 A CN 101431994A
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CN
China
Prior art keywords
phenyl
chloro
amide
carboxylic acid
dihydro
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Pending
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CNA2007800151866A
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English (en)
Chinese (zh)
Inventor
J·安特尔
P-C·格雷戈里
J·H·M·兰格
M·菲恩格斯
D·赖歇
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Abbott Products GmbH
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Solvay Pharmaceuticals GmbH
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Publication date
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Publication of CN101431994A publication Critical patent/CN101431994A/zh
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    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2007800151866A 2006-04-27 2007-04-20 CBx大麻素受体调节剂作为钾通道调节剂的用途 Pending CN101431994A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06113190 2006-04-27
EP06113190.0 2006-04-27

Publications (1)

Publication Number Publication Date
CN101431994A true CN101431994A (zh) 2009-05-13

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CNA2007800151866A Pending CN101431994A (zh) 2006-04-27 2007-04-20 CBx大麻素受体调节剂作为钾通道调节剂的用途

Country Status (10)

Country Link
EP (1) EP2012775A1 (ru)
JP (1) JP2009534440A (ru)
CN (1) CN101431994A (ru)
AR (1) AR060626A1 (ru)
AU (1) AU2007245734A1 (ru)
CA (1) CA2650567A1 (ru)
MX (1) MX2008013285A (ru)
RU (1) RU2008146591A (ru)
TW (1) TW200812576A (ru)
WO (1) WO2007125049A1 (ru)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103547263A (zh) * 2010-11-18 2014-01-29 詹里恩探索公司 对于治疗代谢性疾病，包括肥胖症和糖尿病有用的大麻素受体拮抗剂/反相激动剂
CN106138053A (zh) * 2015-04-28 2016-11-23 上海市同济医院 一种化合物在制备治疗帕金森病的药物中的应用
CN107007597A (zh) * 2012-05-31 2017-08-04 菲尼克斯药品股份公司 作为孤儿核受体RORγ调节物的经甲酰胺或磺酰胺取代的噻唑及相关衍生物的制药用途

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200827346A (en) 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
TW200836719A (en) 2007-02-12 2008-09-16 Astrazeneca Ab Chemical compounds
MX343949B (es) * 2011-09-29 2016-11-30 Ono Pharmaceutical Co Derivado de fenilo.
BR112015024897A2 (pt) 2013-03-26 2017-07-18 Ono Pharmaceutical Co derivado de fenila
EP3109237A1 (en) 2015-06-22 2016-12-28 AnaMar AB Novel 5-ht2 antagonists
WO2021087127A1 (en) * 2019-10-29 2021-05-06 Corbus Pharmaceuticals, Inc. Cannabinoids and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003063758A2 (en) * 2002-01-31 2003-08-07 Pharmos Corporation Bicyclic cb2 cannabinoid receptor ligands
GB0402356D0 (en) * 2004-02-03 2004-03-10 Glaxo Group Ltd Novel compounds

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103547263A (zh) * 2010-11-18 2014-01-29 詹里恩探索公司 对于治疗代谢性疾病，包括肥胖症和糖尿病有用的大麻素受体拮抗剂/反相激动剂
CN103547263B (zh) * 2010-11-18 2015-12-09 詹里恩探索公司 对于治疗代谢性疾病，包括肥胖症和糖尿病有用的大麻素受体拮抗剂/反相激动剂
CN107007597A (zh) * 2012-05-31 2017-08-04 菲尼克斯药品股份公司 作为孤儿核受体RORγ调节物的经甲酰胺或磺酰胺取代的噻唑及相关衍生物的制药用途
CN106138053A (zh) * 2015-04-28 2016-11-23 上海市同济医院 一种化合物在制备治疗帕金森病的药物中的应用
CN106138053B (zh) * 2015-04-28 2019-04-09 上海市同济医院 一种化合物在制备治疗帕金森病的药物中的应用

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Publication number Publication date
MX2008013285A (es) 2008-10-24
JP2009534440A (ja) 2009-09-24
WO2007125049A1 (en) 2007-11-08
TW200812576A (en) 2008-03-16
RU2008146591A (ru) 2010-06-10
EP2012775A1 (en) 2009-01-14
AU2007245734A1 (en) 2007-11-08
AR060626A1 (es) 2008-07-02
CA2650567A1 (en) 2007-11-08

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