CN101428132B - Chinese medicinal composition for treating hyperlipemia and preparation thereof - Google Patents
Chinese medicinal composition for treating hyperlipemia and preparation thereof Download PDFInfo
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- CN101428132B CN101428132B CN2008103063702A CN200810306370A CN101428132B CN 101428132 B CN101428132 B CN 101428132B CN 2008103063702 A CN2008103063702 A CN 2008103063702A CN 200810306370 A CN200810306370 A CN 200810306370A CN 101428132 B CN101428132 B CN 101428132B
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Abstract
The invention relates to a drug for treating hyperlipidemia and a preparation method thereof. The drug is prepared by the following pharmaceutical raw materials: ginkgo leaf, hawthorn leaf, cassia seed, turmeric root-tuber, Mongolian snakegourd root, danshen root, sanchi, oriental waterplantain rhizome and prepared tuber fleeceflower root. The preparation steps thereof are as follows: 1) the sanchi is taken and smashed into fine powder, the ginkgo leaf and the hawthorn leaf are additionally taken and smashed into coarse powder, the percolation is carried out, percolate is collected, the recovery of ethanol with the reduced pressure is carried out, then the dilution, the removal of pigments and the separation of a water layer are carried out, ethyl acetate is used for shaking extraction, and the ethyl acetate is recovered with the reduced pressure from extract liquid and concentrated till the ethyl acetate is dry; 2) the cassia seed, the turmeric root-tuber, the Mongolian snakegourd root, the danshen root, the oriental waterplantain rhizome and the prepared tuber fleeceflower root are taken, 80 percent ethanol is used for reflux for two times, filtrate is merged, and the ethanol is recovered and vacuum-concentrated to a clear paste with the relative density of 1.40 and the temperature of 50 DEG C; and 3) the various medicine residues after the ethanol extraction are merged, then water is added for carrying out three times of decoction, decocted liquid is merged and filtered, then the standing is carried out, supernatant fluid is taken and concentrated to a thick paste, an extract of the step 2 and the sanchi powder are further added for even mixing, the mixture is dried at the temperature of 60 DEG C and then ground to the fine powder with 100 meshes, and the packaging into capsules with 0.5g is finally carried out for preparation.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of hyperlipemia, referring in particular to the Chinese herbal medicine is a kind of medicine for the treatment of hyperlipemia of preparation of raw material and preparation method thereof.
Background technology
Go through treatment and observation over several years according to us to hyperlipemia, find that the western medical treatment hyperlipemia adopts blood pressure lowering, blood fat reducing to close the method for controlling mostly, truly have certain curative effect, but most of patients is taken for a long time and can be produced such as side effect such as digestive tract discomfort, Cyklokapren rising, myasthenia, dizziness, skin pruritus, and curative effect is non-constant, thereby incured loss through delay patient's optimal treatment phase, lured that artificial antibody weakens, and has stayed invisible hidden danger into.
Summary of the invention
The objective of the invention is to be improved, innovate at shortcoming that exists in the background technology and problem, provide a kind of promotion intestinal cholesterol to drain, suppress enteral and external source cholesterol absorption, suppress the synthetic of cholesterol, triglyceride, blood stasis dispellingization is turbid, replenishing QI to invigorate the spleen, suppressing the hyperactive liver and subsiding YANG, clearing away heat-damp and promoting diuresis, YIN nourishing are supported kidney, the intestinal stasis relieving of invigorating blood circulation, promoted blood circulation and nourish blood, and calms down the inner membrance speckle, repairs blood vessel, the conditioning body fluid balance increases antibody and a kind of medicine for the treatment of hyperlipemia of having no side effect.
Another object of the present invention provides the preparation method of this medicine.
The present invention is made by following bulk drugs:
Folium Ginkgo 200-260 part, Folium Crataegi 200-260 part, Semen Cassiae 230-290 part, Radix Curcumae 230-290 part, Radix Trichosanthis 200-260 part, Radix Salviae Miltiorrhizae 150-170 part, Radix Notoginseng 150-170 part, Rhizoma Alismatis 150-190 part, Radix Polygoni Multiflori Preparata 200-260 part.
The optimum amount of each crude drug of the present invention is:
230 parts of Folium Ginkgos, 230 parts of Folium Crataegi, 260 parts of Semen Cassiaes, 260 parts of Radix Curcumaes, 230 parts of Radix Trichosanthis, 160 parts of Radix Salviae Miltiorrhizaes, 160 parts of Radix Notoginseng, 170 parts of Rhizoma Alismatis, 230 parts of Radix Polygoni Multiflori Preparatas.
Preparation method of the present invention comprises the following steps:
1) gets Radix Notoginseng powder and be broken into 100 order fine powders, other gets Folium Ginkgo, Folium Crataegi is broken into coarse powder, with ethanol is that solvent carries out percolation, collect the liquid decompression recycling ethanol of filtering, the water gaging dilution such as add after, add the oil ether and remove pigment, divide water-yielding stratum, extract with the ethyl acetate jolting, extracting solution reclaim under reduced pressure ethyl acetate, and be concentrated into dried;
2) depend on pine torch, Radix Curcumae, Radix Trichosanthis, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Radix Polygoni Multiflori Preparata with 80% alcohol reflux secondary, 4 hours for the first time, 3 hours for the second time, merging filtrate reclaimed ethanol, and concentrating under reduced pressure is that relative density is 50 ℃ of clear paste of 1.40;
3) decoct with water three times after above-mentioned each medicinal residues after alcohol extraction merge, first and second time each 3 hours, 2 hours for the third time, collecting decoction left standstill 12 hours after filtering, get supernatant concentration and become the thick paste shape, add the extract and the Radix Notoginseng powder of step 2 again, mixing, carry out drying back facing-up below the temperature at 60 ℃ and become 100 order fine powders, be distributed into the 0.5g capsule.
The inventor acts on and only continually develops motherland's medicine and pharmacology treasure-house, deeply probing into sage of the pasts' merit benefit is not contrary to, treating both the principal and secondary aspects of a disease, not only treating the disease affected but also anti-not sick medical science rule, selected phytosterol and the anthraquinones of including, triterpene, chrysophanic acid, bisflavone, Tanshinone I, II and unsaturated fatty acid, active polysaccharide and multivitamin chemical compound, regulate the flow of vital energy and promote blood circulation, blood circulation promoting and blood stasis dispelling, driving wet dispel turbid, the smooth network of warming the meridian, significantly cholesterol reducing, triglyceride, anticoagulant, reduce whole blood viscosity, suppress the enteral cholesterol absorption, prevent that effectively the endarterium speckle from forming, the elaboration of regulating body fluid balance is mixed with this medicine, absorb with nutrition-retaining, improve cardiac muscle, the health care blood vessel strengthens health.
The present invention selects pure Chinese herbal medicine to make, and makes each efficacy of drugs produce synergism these drug regimens, thereby reaches the purpose of effective treatment hyperlipemia, and the medicine of wherein selecting for use respectively has following effect:
Folium Ginkgo: astringe the lung and relieving asthma, promoting blood circulation, removing blood stasis and relieving pain, reduces serum cholesterol at anticoagulant; Folium Crataegi: blood circulation promoting and blood stasis dispelling, regulate the flow of vital energy and promote blood circulation, increase the gastric juice digestive enzyme, blood vessel dilating, cholesterol reducing; Semen Cassiae: clearing away heat to improve acuity of vision, loosening bowel to relieve constipation includes phytosterol and anthraquinones, can suppress the inner membrance speckle and form; Radix Curcumae: promoting QI circulation for relieving depression, the removing heat from blood removing blood stasis with potent drugs, depressed liver-energy dispersing and function of gallbladder promoting can prevent that the inner membrance speckle from forming; Radix Trichosanthis: clearing away heat and promoting production of body fluid, row is dense in detumescence, energy cholesterol reducing, triglyceride; Radix Salviae Miltiorrhizae: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow clears away heart-fire that it is tired to fall, blood fat reducing anticoagulant, the expansion peripheral blood vessel increases myocardial contraction; Radix Notoginseng: the hemostasis of becoming silted up of loosing, subduing swelling and relieving pain can stop the absorption of cholesterol and triglyceride; Rhizoma Alismatis: clearing away damp-heat, diuresis can disturb absorption and the dispersion and the drainage of cholesterol, blood fat reducing; Radix Polygoni Multiflori Preparata: the invigorating the liver and kidney benefiting essence-blood, loosening bowel to relieve constipation can promote intestinal peristalsis promoting, quickens cholesterol and drains, and reduces the absorption of cholesterol, blood fat reducing.
The present invention has following beneficial effect:
1, blood stasis dispellingization is turbid, and clearing away heat and resolving stagnation of food activates the body vigor.Include chrysophanic acid, triterpene, citrate compound, can increase the gastric juice digestive enzyme, promote intestinal peristalsis promoting, reduce the absorption of cholesterol, the drainage of increased excretions of cholesterol, environmental protection.
2, replenishing QI to invigorate the spleen is regulated the flow of vital energy and is promoted blood circulation, and improves immunity.Include phytosterol and anthraquinones, can suppress the rising of serum cholesterol, prevent that the inner membrance speckle from forming, and has the curative effect of remarkable blood fat reducing, and have no side effect.
3, nourishing YIN and benefiting blood, the warming the meridian YANG hyperactivity suppressing is regulated body fluid balance.Include unsaturated fatty acid and flavone compound, can improve the body cardiovascular system, and the effect of remarkable cholesterol reducing and triglyceride is arranged.
4, hepatoprotective reinforces the kidney, and promotes antibody.Include phytoprotein, aminoacid, active polysaccharide class and multivitamin can reduce the body oxygen consumption, delaying human body caducity, reduces blood viscosity at anticoagulant, and obviously cholesterol reducing and low-density lipoprotein white level improve hdl level, thereby reach the effect of remarkable blood fat reducing.
Treatment case of the present invention:
Example 1: week certain, the woman, 48 years old, be diagnosed as hyperlipemia through hospital, just obey the Western medicine three months of lipanthyl, Xuezhikang one class, raise through looking into the transaminase, and do not have improvement.Back clothes the present invention, each 4, every day three times, one month is a course of treatment, serve on three courses of treatment, detects TG, TC through hospital and all take a favorable turn, and HDL-C has obvious rising, and it is normal substantially to look into renal function, liver function transaminase, and routine blood test is normal.Four courses of treatment of follow-up clothes, patient's self-induction is obviously recovered, eyelid periphery xanthoma planum and the pale brown color pimple of neck body also disappear substantially, all belong to normally through check detection serum total cholesterol, serum levels of triglyceride, HDL-C, renal function, liver function, routine blood test, basic complete, and do not have bounce-back.
Example 2: the Wang, the man, 51 years old, suffered from hyperlipemia 1 year, originally by taking blood fat reducing one class Western medicine, the commentaries on classics of not getting better, and the transaminase raises to some extent.Change clothes the present invention, each 4, every day three times, one month is a course of treatment, serve on three courses of treatment.T-CHOL raises through having a blood test clearly, and serum levels of triglyceride has decline, and renal function, liver function are all normal.Continue and obey four courses of treatment, patient is conscious to be clearly better, and pale brown color pimple of limbs and facial xanthoma planum disappear substantially.The back clothes the present invention that continues that keeps healthy detected once every six months, serum total cholesterol, serum levels of triglyceride, HDL-C and renal function, and liver function all belongs to normally, basic rehabilitation.
Example 3: Lee, the woman, 53 years old, suffered from atherosclerosis 1 year, begin to take Western medicine and keep, nothing is clearly better, oral the present invention, each 4, every day three times, one month is a course of treatment, serve on three courses of treatment, on inspection, take an evident turn for the better, four courses of treatment of follow-up clothes,, basic complete through CT examination.
Example 4: Chen, the man, 54 years old, suffered from carotid artery narrowing 8 months, send institute to require to do Intimectomy, family members disagree with and perform an operation.Oral the present invention, each 4, every day three times, one month is a course of treatment, serve on three courses of treatment, defines through ultrasound wave and magnetic resonance angiography to be clearly better, and has effectively prevented the generation of cerebral infarction, four courses of treatment of follow-up clothes, on inspection, basic complete.
The specific embodiment
Embodiment one:
1) gets the 150g Radix Notoginseng powder and be broken into 100 order fine powders, get Folium Ginkgo 200g, Folium Crataegi 200g is broken into coarse powder, with ethanol is that solvent carries out percolation, collect the liquid decompression recycling ethanol of filtering, the water gaging dilution such as add after, add the oil ether and remove pigment, divide water-yielding stratum, extract with the ethyl acetate jolting, extracting solution reclaim under reduced pressure ethyl acetate, and be concentrated into dried;
2) depend on that pine torch 230g, Radix Curcumae 230g, Radix Trichosanthis 200g, Radix Salviae Miltiorrhizae 150g, Rhizoma Alismatis 150g, Radix Polygoni Multiflori Preparata 200g are with 80% alcohol reflux secondary, 4 hours for the first time, 3 hours for the second time, merging filtrate, reclaim ethanol, concentrating under reduced pressure is that relative density is 50 ℃ of clear paste of 1.40;
3) decoct with water three times after above-mentioned each medicinal residues after alcohol extraction merge, first and second time each 3 hours, 2 hours for the third time, collecting decoction left standstill 12 hours after filtering, get supernatant concentration and become the thick paste shape, add the extract and the Radix Notoginseng powder of step 2 again, mixing, carry out drying back facing-up below the temperature at 60 ℃ and become 100 order fine powders, be distributed into the 0.5g capsule.
Embodiment two:
1) gets the 160g Radix Notoginseng powder and be broken into 100 order fine powders, get Folium Ginkgo 230g, Folium Crataegi 230g is broken into coarse powder, with ethanol is that solvent carries out percolation, collect the liquid decompression recycling ethanol of filtering, the water gaging dilution such as add after, add the oil ether and remove pigment, divide water-yielding stratum, extract with the ethyl acetate jolting, extracting solution reclaim under reduced pressure ethyl acetate, and be concentrated into dried;
2) depend on that pine torch 260g, Radix Curcumae 260g, Radix Trichosanthis 230g, Radix Salviae Miltiorrhizae 160g, Rhizoma Alismatis 170g, Radix Polygoni Multiflori Preparata 230g are with 80% alcohol reflux secondary, 4 hours for the first time, 3 hours for the second time, merging filtrate, reclaim ethanol, concentrating under reduced pressure is that relative density is 50 ℃ of clear paste of 1.40;
3) decoct with water three times after above-mentioned each medicinal residues after alcohol extraction merge, first and second time each 3 hours, 2 hours for the third time, collecting decoction left standstill 12 hours after filtering, get supernatant concentration and become the thick paste shape, add the extract and the Radix Notoginseng powder of step 2 again, mixing, carry out drying back facing-up below the temperature at 60 ℃ and become 100 order fine powders, be distributed into the 0.5g capsule.
Embodiment three:
1) gets the 170g Radix Notoginseng powder and be broken into 100 order fine powders, get Folium Ginkgo 260g, Folium Crataegi 260g is broken into coarse powder, with ethanol is that solvent carries out percolation, collect the liquid decompression recycling ethanol of filtering, the water gaging dilution such as add after, add the oil ether and remove pigment, divide water-yielding stratum, extract with the ethyl acetate jolting, extracting solution reclaim under reduced pressure ethyl acetate, and be concentrated into dried;
2) depend on that pine torch 290g, Radix Curcumae 290g, Radix Trichosanthis 260g, Radix Salviae Miltiorrhizae 170g, Rhizoma Alismatis 190g, Radix Polygoni Multiflori Preparata 260g are with 80% alcohol reflux secondary, 4 hours for the first time, 3 hours for the second time, merging filtrate, reclaim ethanol, concentrating under reduced pressure is that relative density is 50 ℃ of clear paste of 1.40;
3) decoct with water three times after above-mentioned each medicinal residues after alcohol extraction merge, first and second time each 3 hours, 2 hours for the third time, collecting decoction left standstill 12 hours after filtering, get supernatant concentration and become the thick paste shape, add the extract and the Radix Notoginseng powder of step 2 again, mixing, carry out drying back facing-up below the temperature at 60 ℃ and become 100 order fine powders, be distributed into the 0.5g capsule.
Embodiment of the present invention only is the description that preferred implementation of the present invention is carried out; be not that design of the present invention and scope are limited; do not breaking away under the preceding topic of design philosophy of the present invention; engineers and technicians make technical scheme of the present invention in this area various modification and improvement; all should fall into protection scope of the present invention; the technology contents that the present invention asks for protection all is documented in claims.
Claims (3)
1. medicine for the treatment of hyperlipemia is characterized in that it is to be made by following bulk drugs:
Folium Ginkgo 200-260 part, Folium Crataegi 200-260 part, Semen Cassiae 230-290 part, Radix Curcumae 230-290 part, Radix Trichosanthis 200-260 part, Radix Salviae Miltiorrhizae 150-170 part, Radix Notoginseng 150-170 part, Rhizoma Alismatis 150-190 part and Radix Polygoni Multiflori Preparata 200-260 part.
2. a kind of medicine for the treatment of hyperlipemia according to claim 1, wherein the optimum amount of each crude drug is:
230 parts of 230 parts of Folium Ginkgos, 230 parts of Folium Crataegi, 260 parts of Semen Cassiaes, 260 parts of Radix Curcumaes, 230 parts of Radix Trichosanthis, 160 parts of Radix Salviae Miltiorrhizaes, 160 parts of Radix Notoginseng, 170 parts of Rhizoma Alismatis and Radix Polygoni Multiflori Preparatas.
3. the preparation method of claim 1 or 2 described medicines, it comprises the following steps:
1) gets Radix Notoginseng powder and be broken into 100 order fine powders, other gets Folium Ginkgo, Folium Crataegi is broken into coarse powder, with ethanol is that solvent carries out percolation, collect the liquid decompression recycling ethanol of filtering, the water gaging dilution such as add after, add the oil ether and remove pigment, divide water-yielding stratum, extract with the ethyl acetate jolting, extracting solution reclaim under reduced pressure ethyl acetate, and be concentrated into dried;
2) depend on pine torch, Radix Curcumae, Radix Trichosanthis, Radix Salviae Miltiorrhizae, Rhizoma Alismatis and Radix Polygoni Multiflori Preparata with 80% alcohol reflux secondary, 4 hours for the first time, 3 hours for the second time, merging filtrate reclaimed ethanol, and concentrating under reduced pressure is that relative density is 50 ℃ of clear paste of 1.40;
3) decoct with water three times after above-mentioned each medicinal residues after alcohol extraction merge, first and second time each 3 hours, 2 hours for the third time, collecting decoction left standstill 12 hours after filtering, get supernatant concentration and become the thick paste shape, add the extract and the Radix Notoginseng powder of step 2 again, mixing, carry out drying back facing-up below the temperature at 60 ℃ and become 100 order fine powders, be distributed into the 0.5g capsule.
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| CN2008103063702A CN101428132B (en) | 2008-12-19 | 2008-12-19 | Chinese medicinal composition for treating hyperlipemia and preparation thereof |
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| CN2008103063702A CN101428132B (en) | 2008-12-19 | 2008-12-19 | Chinese medicinal composition for treating hyperlipemia and preparation thereof |
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| CN101428132B true CN101428132B (en) | 2010-12-01 |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102716428A (en) * | 2012-07-05 | 2012-10-10 | 南京中医药大学 | Traditional Chinese medicine composite for treating anti-atherosclerosis |
| CN103239525B (en) * | 2013-05-23 | 2014-11-05 | 山西省肿瘤研究所 | Blood activating and lipid lowering medicinal liquor and preparation method thereof |
| CN103330119A (en) * | 2013-06-07 | 2013-10-02 | 青岛银龄美海洋生物科技有限公司 | Health-care food for accessorily reducing blood fat |
| CN103478777A (en) * | 2013-08-15 | 2014-01-01 | 当涂县瑞龙果树种植专业合作社 | Production method of soy sauce flavor type blood fat reducing healthcare melon seeds |
| CN103585366A (en) * | 2013-09-09 | 2014-02-19 | 洛阳市洛铜医院 | Medicine for treating ischemic hyperlipidemia and preparation method thereof |
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|---|---|---|---|---|
| CN1077354A (en) * | 1992-12-16 | 1993-10-20 | 石道元 | Cardiovascular health-care function food additives and preparation method thereof |
| CN1356113A (en) * | 2000-11-28 | 2002-07-03 | 袁曙光 | Process for preparing Chinese medicine to treat cardiovascular and cerebrovascular diseases |
| CN1771988A (en) * | 2005-11-16 | 2006-05-17 | 张文芳 | Two-leaf composition for treating cardiac and cerebral vascular diseases |
| CN101167838A (en) * | 2006-11-06 | 2008-04-30 | 张文武 | Traditional Chinese medicinal preparation for treating coronary heart disease and angina pectoris and its preparing process |
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2008
- 2008-12-19 CN CN2008103063702A patent/CN101428132B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1077354A (en) * | 1992-12-16 | 1993-10-20 | 石道元 | Cardiovascular health-care function food additives and preparation method thereof |
| CN1356113A (en) * | 2000-11-28 | 2002-07-03 | 袁曙光 | Process for preparing Chinese medicine to treat cardiovascular and cerebrovascular diseases |
| CN1771988A (en) * | 2005-11-16 | 2006-05-17 | 张文芳 | Two-leaf composition for treating cardiac and cerebral vascular diseases |
| CN101167838A (en) * | 2006-11-06 | 2008-04-30 | 张文武 | Traditional Chinese medicinal preparation for treating coronary heart disease and angina pectoris and its preparing process |
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